Search

The prevalence of essential hypertension increases consistently among middle-aged and older adults in China. Aims of this study are to explore the impact of Tai Chi and square dance, which are popular in China, on antihypertensive effects and cardiovascular disease risk factors in patients with essential hypertension.Patients with essential hypertension were randomly assigned to either a Tai Chi group, a square dance group or a control group. Blood pressure, cardiorespiratory fitness, and cardiovascular disease risk factors were measured at baseline and at the end of the 12-week intervention. The duration and frequency of both intervention exercises were 60 minutes per session, and 5 sessions per week.A total of 144 participants (59.89±6.85 years, 34.72% male) completed the study. The repeated-measures analysis of variance demonstrated a significant effect of time on BMI, systolic and diastolic blood pressure, and cardiorespiratory fitness in patients with essential hypertension (P0.05), whereas no significant effect was observed on waist-to-hip ratio and body fat percentage (P0.05). Post hoc analyses showed that only intervention groups had significant differences in blood pressure and cardiorespiratory fitness compared to the control group, while Tai Chi had greater effect sizes than square dance.Both Tai Chi and square dance can promote cardiorespiratory fitness and reduce BMI and blood pressure among patients with essential hypertension, whereas there was no significant difference between the two exercises. However, both Tai Chi and square dance were ineffective in reducing some of the cardiovascular disease risk factors.

The mechanical properties of thermally conductive composites are the key to realize their applications. Strength of materials is of significance, furthermore the toughness of materials also should attract more concern. Actually, few researchers have reported the simultaneous improvement of strength and toughness of anisotropic thermally and electrically conductive composites. Therefore, this study aims to obviously improve the in-plane thermal and electrical conductivities of nylon composites, which display superior tensile strength and toughness, compared to other thermally conductive composites. The nylon composite papers, prepared through a facile method involving vacuum-assisted filtration and compression molding processes, present a laminate structure and compact graphene nanoplatelet (GNP) stacks inside composites. On account of the special structure, the nylon composite papers show a super-high in-plane thermal conductivity of 16.0 W m−1 K−1 and electrical conductivity of 18.0 S cm−1 at a filler loading of 14.6 wt%. Surprisingly, the composite papers still exhibit a high strength of 48.3 MPa, which is comparable to that of a pure nylon film. In addition, the elongation at break of the composite paper with 14.6 wt% GNPs is as high as 34.2%, ultimately endowing the composite papers with a good toughness of 13.15 MJ m−3. The nylon composite papers successfully achieve the integration of excellent thermal and electrical conductivities, and superior strength and toughness, showing huge application values in the field of intelligent electronic device.

Composites with high thermal conductivity and excellent electromagnetic interference (EMI) shielding performance are in urgent demand in the fields of wireless communication technologies and portable intelligent electronic devices. However, it remains a great challenge to simultaneously improve thermal conductivity and EMI shielding effectiveness (SE) for polymer composites. This work reports a feasible and scaled method relating to vacuum-assisted filtration and compression-molding to fabricate nylon/graphene nanoplatelet (GNP) composite papers using commercial nylon gauze and GNPs. The results show that the composite papers exhibit good flexibility and multifunctional performances. At 11.8 wt% GNPs, the three-layered composite nylon/GNP paper, which had a thickness of about 180 μm, showed high thermal and electrical conductivities of 15.8 W m−1 K−1 and 24.3 S cm−1, respectively, and an outstanding EMI SE of 58.1 dB at the X-band (8.2–12.4 GHz). The compromise of thermal conductivity and EMI SE of the composite paper is much greater than that of other multifunctional composites reported in the literature. Specifically, the composite papers also show greatly enhanced hydrophobicity and flame resistance and satisfactory mechanical properties. To sum up, this work paves the way for the real engineering application of nylon-based composite papers in next-generation electronic devices.

Photothermoelectric (PTE) conversion can achieve the recovery of low-quality light or heat efficiently. Much effort has been devoted to the exploitation of the inorganic heterogeneous asynchronous (separate) PTE conversion system. Here, a full organic PTE film with a pseudobilayer architecture (PBA) according to the homogeneous synchronous (all-in-one) PTE conversion hypothesis was prepared via successive drop-casting a PEDOT:PSS/helical carbon nanotube (HCNT) mixture and PEDOT:PSS onto a vacuum ultraviolet treated substrate. Our results prove that the heptagon-pentagon pairs embedded in HCNTs promote a denser arrangement of the molecular chains of PEDOT, which enhances the crystallinity and affects the thermoelectric properties. The weak connection and hollow structure of HCNTs inhibit the dissipation of heat, and the

Objective To explore the clinical significance of detecting CD4+ T cell ATP and subgroup count in patients with liver cancer recurrence after liver transplantation. Methods From November 2015 to November 2018, 84 patients with primary liver cancer underwent orthotopic liver transplantation in Shanghai Changzheng Hospital were selected and then divided into recurrence group (n=42) and non-recurrence group (n=42) according to whether the tumor recurred. Peripheral blood samples were collected on the day of diagnosis and 1, 3, 6 months after recurrence. ATP content in CD4+ T lymphocytes was detected using ImmuKnowTM immune cell function assay kit, subgroup counts were detected using IOTest. Results ATP content of CD4+ T lymphocytes in patients with liver cancer recurrence after liver transplantation was significantly lower than that in patients without recurrence at the day of diagnosis of recurrence, and 1, 3, 6 months after recurrence (P

Polymer nanocomposites filled with one-dimensional “reelable” carbon-based nanoparticles can exhibit a high dielectric constant (e′) with a small quantity of nanoparticles. However, this kind of na...

Multifunctional phase change materials (PCMs) are highly desirable for the thermal management of miniaturized and integrated electronic devices. However, the development of flexible PCMs possessing heat energy storage, shape memory, and adjustable electromagnetic interference (EMI) shielding properties under complex conditions remains a challenge. Herein, the multifunctional PCM composites were prepared by encapsulating poly(ethylene glycol) (PEG) into porous MXene/silver nanowire (AgNW) hybrid sponges by vacuum impregnation. Melamine foams (MFs) were chosen as a template to coat with MXene/AgNW (MA) to construct a continuous electrical/thermal conductive network. The MF@MA/PEG composites showed a high latent heat (141.3 J/g), high dimension retention ratio (96.8%), good electrical conductivity (75.3 S/m), and largely enhanced thermal conductivity (2.6 times of MF/PEG). Moreover, by triggering the phase change of the PEG, the sponges displayed a significant photoinduced shape memory function with a high shape fixation ratio (∼100%) and recovery ratio (∼100%). Interestingly, the EMI shielding effectiveness (SE) can be adjusted from 12.4 to 30.5 dB by a facile compression-recovery process based on shape memory properties. Furthermore, a finite element simulation was conducted to emphasize the advantage of the MF@MA/PEG composites in the thermal management of chips. Such flexible PCM composites with high latent heat storage, light-actuated shape memory, and adjustable EMI shielding functions exhibit great potential as smart thermal management materials in military and aerospace applications.

Strong rigidity, low thermal conductivity, and short of multi-driven capabilities of form-stable phase change materials (FSPCMs) have limited their practical utilization. Herein, we report a shape-adaptable FSPCM with the coinstantaneous light/electro-driven shape memory properties and light/electro-to-thermal energy storage performance. The FSPCM is fabricated by incorporating the poly(ethylene glycol) (PEG) into the cellulose nanofiber/graphene nanoplatelet (GNP) hybrid-coated melamine foam (CG@MF). The CG@MF/PEG FSPCMs show a good encapsulation effect, enhanced thermal conductivity, and large melting enthalpy (178.9 J g-1). Due to the high elasticity of MF and the excellent photothermal conversion and electrical conductivity of the GNP network, the CG@MF/PEG FSPCMs exhibit a remarkable light/electro-driven shape memory effect by activating the phase change process of PEG. Meanwhile, the CG@MF/PEG FSPCMs can effectively convert light or electric energy into heat energy and reposit the converted energy during the phase change process. Furthermore, the CG@MF/PEG FSPCMs possess excellent multiresponsive self-adhesion properties. A light-sensitive, shape-adaptable, and thermal-insulating container is further explored. This study provides routes toward the development of multiresponsive shape-adaptable FSPCMs for energy storage applications.

Electrically conductive polymer composites (CPCs) are potential alternatives to conventional strain gauges due to their tunable sensitivity and strain ranges. Currently, to achieve very high piezoresistive sensitivity in thermoplastic-based CPCs with Gauge factors

A fast light-actuated shape memory polymer (SMP) composite with greatly enhanced photothermal conversion and mechanical stiffness was prepared by incorporating gold nanoparticle/reduced graphene oxide (AuNP-RGO) hybrids into cross-linked poly(e-caprolactone) (PCL). The AuNP-RGO hybrids with AuNPs uniformly anchored on RGO sheets were obtained in a water/n-butylamine system. Due to the homogeneous dispersion of AuNP-RGO in PCL matrix and the synergistic effect of photothermal conversion, the AuNP-RGO hybrids imparted the PCL with fast near-infrared (NIR) light-actuated shape recovery effect, and the light-actuated shape recovery speed could be accelerated via the increase of AuNP loading on RGO sheets. Moreover, the SMP composites possessed high shape recovery stress due to the incorporation of AuNP-RGO, thus they could be used as heavy-lift actuators. This SMP composites with enhanced light responsivity and mechanical properties are believed to have great potential in many fields such as light energy harvesting and remote-controlled actuators.

Polymeric dielectric materials recently attract much attention due to their good comprehensive performances. However, it is still challenging to prepare polymeric dielectric materials with high dielectric constant, low dielectric loss and high breakdown strength. In this work, insulated polyimide (PI) interlayer with nanoscale thickness was coated on the surface of barium titanate (BaTiO3, BT) through the in-situ polymerization and subsequent thermal imidization treatment. The hybrid nanoparticles exhibited the typical ‘core-shell’-like structure with strong interfacial interaction between BT and PI. Different from the serious aggregation of BT nanoparticles, the PI@BT nanoparticles exhibited good dispersion in the poly(vinylidene fluoride) (PVDF) composite. There was strong interfacial interaction between PI and PVDF, which resulted in the decrease of crystallinity of the PVDF matrix at relatively high filler content. The flexible PVDF/PI@BT composites exhibited largely enhanced dielectric constant, suppressed dielectric loss and enhanced breakdown strength compared with the common PVDF/BT composites. It was suggested that the intense interfacial polarization at the interface between PI and BT contributed to the largely enhanced dielectric constant while the reduced interfacial polarization at the interface between PI and PVDF contributed to the suppressed dielectric loss. This work demonstrates that the nanoengineering of the interface between BT and PVDF using PI is an alternative way to fabricate the dielectric materials with excellent comprehensive performances.

In this work, three kinds of boron nitride (BN) particles with different sizes were combined with carbon nanotubes (CNTs) to prepare the poly(vinylidene fluoride) (PVDF) composites. The dispersion states and the hybrid network structure of fillers were investigated. The results showed that the dispersion states of CNTs were greatly influenced by the size of BN particles. Relatively high density of hybrid network structure of fillers was obtained in the ternary composites containing the smallest BN particles (0.16 μm), while the composites containing the biggest BN platelets (22.02 μm) showed the low density of the hybrid network structure. Thermal conductivity measurements showed that BN particles with moderate size (8.70 μm) were the most appropriate filler to construct the highly efficient thermal conductive path with CNTs and in this condition, the ternary composites exhibited the highest thermal conductivity.

Phase change materials (PCMs) have wide applications in many fields and they are thought to be one of the highest potential materials in the future. Developing advanced PCMs faces various problems, such as low thermal conductivity, poor shape stability and single energy conversion pattern, etc. In this work, novel composite PCMs were fabricated based on the commercial melamine foam (MF) incorporated by the graphene oxide (GO) and graphene nanoplatelets (GNPs). After hydrothermal reaction and carbonization, the composite aerogel still maintained the three-dimensional (3D) composite framework structure with reduced GO (rGO) and GNPs covering on the carbonized MF framework. The composite PCM samples exhibited high shape stability without leakage under the load of 265 times of its own mass at temperature much higher than the phase change temperature of paraffin wax (PW), high phase change enthalpy retention rate (nearly 100% of PW), high thermal conductivity (1.46 W/m·K) and electrical conductivity (2.787 S/cm) at a filler content of 4.89 wt%. Moreover, the composite PCM samples have excellent light-to-thermal and electric-to-thermal energy conversion abilities, which endow the composite PCMs with great potential in diverse applications, such as the energy saving and heat preservation of building and temperature protection of microelectronic devices, etc.

Polyamide-based composites with segregated Carbon nanotube (CNT) network were prepared to achieve a high dielectric constant with an ultralow loading of CNTs. Specially, the polypropylene (PP) was introduced into the segregated CNT network to tailor the CNT dispersion. More importantly, the PP layer formed between two neighbored CNTs can enhance the interfacial polarization and suppress the electron conduction, leading to a higher dielectric constant while maintaining the dielectric loss at a low level. In this work, CNT segregated structure was firstly applied to achieve polymer composites with high dielectric constant but low loss.

Polystyrene (PS) composites containing graphene nanoplatelets (GNPs) and carbon nanofibers (CNFs) were prepared through solution compounding processing. The results showed that more compact network structure was formed in the ternary PS/GNP/CNF composites, and the composites exhibited apparently enhanced heat resistance compared with the pure PS sample. Conductive properties measurements showed that largely reduced percolation threshold was achieved for the ternary PS/GNP/CNF composites. Furthermore, the PS/GNP/CNF composites had good thermal conductivity. At GNP content of 2 vol% and CNF content of 5.5 vol%, the thermal conductivity was enhanced to 1.12 W/mK, which was 522% higher than that of the pure PS sample. The potential application of the PS composites as the material of heat radiator was also evaluated, and the results showed that the composites exhibited excellent heat transferring ability. This work indicates that the PS/GNP/CNF composites may be used in the field relating to high temperature and load conditions.

Phase change materials (PCMs) exhibit great potential applications in many fields, such as energy-saving building, solar energy harvesting, waste heat utilization, constant temperature protection and thermal management of microelectronic devices. In this work, we proposed a facile and novel method to prepare the composite PCMs. Through the combination of pre-refrigeration and freeze-drying techniques using the microcrystalline cellulose (MCC)/graphene nanoplatelets (GNPs) hydrogels, which were firstly prepared through solution compounding, gelling and solvent exchanging successively, the porous MCC/GNP aerogels with highly oriented stacking of MCC/GNP were successfully obtained. The composite PCMs based on the highly anisotropic MCC/GNP aerogel and polyethylene glycol (PEG) exhibited relatively high thermal conductivity (1.03 W/mK) at low GNP content (1.51 wt%), high latent heat (182.6 J/g) which was 99.84% of pure PEG, excellent encapsulation ability and mechanical stability. Further results showed that the composite PCMs exhibited excellent solar energy harvesting/electrical energy transformation, storage and release abilities. In addition, a simple heating device was designed to verify the application of the composite PCMs as the temperature protection element. The measurements showed that the presence of the PCMs prevented the rapidly rising of temperature during the heating process while maintained the temperature at relatively high level in a long time during the cooling process.

Developing highly efficient and multifunctional membranes toward oil adsorption and oil/water separation is of significance in oily wastewater treatment. Herein, a novel electrospun composite membrane with dual-scaled porous structure and nanoraised structure on each fiber was fabricated through electrospinning using biodegradable polylactide (PLA) and magnetic γ-Fe2O3 nanoparticles. The PLA/γ-Fe2O3 composite membranes show high porosity (>90%), superhydrophobic and superlipophilic performances with CH2I2 contact angle of 0°, good water adhesion ability like water droplets on a petal surface, excellent anti-icing performance, and good mechanical properties with a tensile strength of 1.31 MPa and a tensile modulus of 11.65 MPa. The superlipophilicity and dual-scaled porous structure endow the composite membranes with ultrahigh oil adsorption capacity up to 268.6 g/g toward motor oil. Furthermore, the composite membranes also show high oil permeation flux up to 2925 L/m2 h under the force of gravity. Even for oil/water emulsion, the composite membranes have high separation efficiency. We expect that the PLA/γ-Fe2O3 composite membranes can be used in oily wastewater treatment under various conditions through one-off adsorption or continuous oil/water separation, especially under low environmental temperature condition.

Polymer dielectric composites have widespread applications in many fields ranging from energy storage, microelectronic devices, and sensors to power driven systems, etc. and attract much attention of researchers. However, it is still challenging to prepare advanced polymer dielectric composites with a high dielectric constant (e′), low dielectric loss (tan δ) and simultaneously high breakdown strength (Ebd). In this work, conductive polypyrrole (PPy) nanoparticles were in situ synthesized in a reaction system containing the common barium titanate (BaTiO3, BT) or hydroxylated BaTiO3 (BTOH) particles, and then the PPy@BT and PPy@BTOH composite particles were incorporated into poly(vinylidene fluoride) (PVDF) to prepare the composites. The morphologies and microstructures of the PPy@BT and PPy@BTOH composite particles and the corresponding PVDF composites were comparatively investigated. The results showed that the PPy@BTOH composite particles had a ‘mulberry’-like morphology with a rough surface and the self-assembled structure could be maintained in the PVDF composites, which was apparently different from the PVDF/PPy@BT composites, in which most of the PPy nanoparticles dissociatively dispersed in the PVDF matrix. Electrical conductivity measurements showed that at high particle content (≥20 wt%), the PPy@BTOH composite particles endowed the composites with lower electrical conductivity compared with the PPy@BT composite particles. Dielectric property measurements showed that the ‘mulberry’-like PPy@BTOH composite particles endowed the PVDF composites with extremely high e′, ultralow tan δ and high Ebd compared with the PVDF/PPy@BT composites with dissociatively dispersed PPy nanoparticles and BaTiO3 particles. The polarization and loss mechanisms of the composites were then proposed based on the morphologies and the microstructures of the composites. This work provides an alternative way to fabricate functional dielectric particles through trace functional groups inducing in situ polymerization of conductive polymers, and these particles can be used to fabricate advanced dielectric composites.

Phase change materials (PCMs) exhibit wide application prospects in many fields related to energy utilization and management and attract increasing interest. In this work, through the graphene oxide (GO)-assisted dispersion technology, GO/boron nitride (BN) nanosheets were incorporated into melamine foam and successfully deposited on the surface of the foam framework after hydrothermal reaction. Through the following freeze-drying and carbonization treatment, the composite MF/rGO/BN aerogels were obtained with integrated hybrid rGO/BN frameworks. The composite PCMs were prepared through encapsulating polyethylene glycol (PEG) within the hybrid aerogels. The encapsulation stability and thermal properties of the composite PCMs were systematically investigated. The composite PCM sample containing the highest content of rGO/BN exhibited excellent encapsulation stability, high thermal conductivity (up to 0.79 W m-1 K-1), high phase change enthalpy (160.7 J g-1) with the retention of 90.8% of the pure PEG, and excellent chemical and thermal stability. Further results clearly showed that the composite PCMs had excellent light-to-heat energy transition ability and could be used as a thermal management component to suppress the overheating of devices during the operation process, or to supply energy for thermoelectric devices under emergency conditions to ensure a continuous power supply sustained for a certain time until the safeguard procedures are adopted.

ObjectiveTo explore the appropriate dosage of levothyroxine treatment for congenital hypothyroidism patients based on thyroid function.Methods116 patients who were regularly followed up in our endocrine clinic during January 2010 to December 2020 were allocated in 4 groups in terms of their thyroid function (group A: TSH ≥ 100mIU/L, group B: 20mIU/L ≤ TSH6.6pmol/L). The initial dosage of levothyroxine was individualized given to each patient based upon their TSH level and adjusted according to their thyroid function at every follow-up time point. The levothyroxine dosage at each time point of groups was compared, the thyroid function after treatment, physical and neurological development of different groups were also assessed.ResultsExcept for the first month after initial levothyroxine treatment, there was a statistical difference in thyroid function between groups (p ConclusionCompared to recommend dosage, individualized Levothyroxine dosage could also obtain the same therapeutic effect while may reduce the risk of drug overdose.

To investigate the clinical features and prognostic factors of acute lymphoblastic leukemia (ALL) children with P2RY8-CRLF2 gene rearrangement.A total of 108 children with B-cell ALL (B-ALL) were diagnosed and systematically treated according to Chinese Children's Leukemia Group (CCLG) -ALL 2008 in our hospital from January 2016 to December 2016. The 108 patients were divided into two groups according to the result of mutiplex polymerase chain reaction: group with P2RY8-CRLF2 gene rearrangement and group without P2RY8-CRLF2 gene rearrangement. The ALL children with P2RY8-CRLF2 gene rearrangement were all treated by CCLG-ALL 2008 high-risk group (HR) regimens, and the ALL children in group without P2RY8-CRLF2 gene rearrangement received different intensity chemotherapy according to clinical risk classification.Five (4 male and 1 female) out of 108 patients with B-ALL had P2RY8-CRLF2 gene rearrangement. In the 5 B-ALL patients with P2RY8-CRLF2 gene rearrangement, the median age of the was 4 (2-6) years old and the median WBC count was 26.2 (2.46-525.1)×10The early treatment response and prognosis of ALL children with P2RY8-CRLF2 gene rearrangement are worse, and more effective protocol is needed for this subtype patients.P2RY8-CRLF2重排的急性淋巴细胞白血病儿童的临床特征及预后分析.探讨P2RY8-CRLF2重排急性淋巴细胞白血病（ALL）儿童的临床特征及预后.2016年1-12月确诊并按照中国儿童白血病协作组（CCLG）-ALL 2008（CCGL-ALL 2008）方案规范治疗的108例B细胞型ALL（B-ALL）患儿，根据有无P2RY8-CRLF2重排分为P2RY8-CRLF2重排组和P2RY8-CRLF2阴性组。P2RY8-CRLF2重排组患儿均接受CCLG-ALL 2008高危组（HR）方案治疗，P2RY8-CRLF2阴性组患儿则按临床危险度分型接受不同强度化疗.共检出P2RY8-CRLF2重排B-ALL患儿5例（4.6%），男4例，女1例，初诊中位年龄4（2-6） 岁，初诊白细胞计数中位数26.12（2.46-525.1）×10伴有P2RY8-CRLF2融合基因阳性的ALL儿童早期治疗反应较差，预后不良，仍需要探索更有效的治疗方法.

Helical carbon nanotube (HCNT) is a vital member of carbon nanomaterials, but little effort was devoted to explore its unique characteristics and applications during the past few decades. Here, we report an organic thermoelectric composite with an excellent photothermoelectric (PTE) effect by conformally wrapping polypyrrole (PPy) on the intricate surface of HCNTs, which have been confirmed to have remarkable near-infrared (NIR) photothermal conversion capability and ultralow heat transportation characteristics. The results indicate that with the increasing HCNT content, PPy shell thickness reduces and exhibits denser as well as partial orientation, while the inter-ring angle slowly decreases and the bipolaron becomes dominant in carrier composition gradually. Consequently, the Seebeck coefficient increases monotonically, whereas the electrical conductivity remains nearly invariant. The final composite combines the benign thermoelectric properties, excellent photothermal response performance, and the lowest thermal conductivity of the carbon-based thermoelectric composite yet reported (0.064 W m-1 K-1). A single strip NIR light-stimulated adjustable delay switch was designed and fabricated, with the open-circuit voltage and short-circuit current under a 400 mW cm-2 NIR-stimulated approach to 720 μV and 62 nA with the discrepancy of consecutive periodic output signals less than 4.2%, exhibiting incredible stability and reliability and demonstrating the highest output voltage of a single strip among the reported organic PTE composite at room temperature. Our work fills in a gap of HCNT research, which hitherto existed in the PTE and thermoelectric field.

To investigate the clinical effect and safety of Chinese Children's Leukemia Group (CCLG)-ALL 2008 (high risk group) protocol in the treatment with childhood Mixed phenotype acute leukemia (MPAL).The clinical data of 15 new diagnosed patients with MPAL treated in our hospital from January 2013 to December 2017 were retrospectively analyzed, and received CCLG-ALL 2008 (high risk group) protocol chemotherapy.One patient gave up treatment after diagnosed, and 14 children with MPAL after induction remission chemotherapy, 3 patients gave up, and 5 patients received consolidation chemotherapy, and 6 patients received allogeneic hematopoietic stem cell transplantation (allo-HSCT). The complete remission (CR) rate was 85.7% at d33 of induction remission chemotherapy. The serious adverse event and treatment-related mortality (TRM) rate was 71.4% and 14.3%, respectively. The recurrence rate was 21.4% and the median time of relapse was 12(9.7-18.4) months. Except for 4 patients who gave up treatment, the 5-year event-free survival (EFS) rate in the other 11 patients was (54.5±15.0)%. The 5 years EFS of 4 patients who received consolidation chemotherapy was significantly lower than the 6 patients who received allo-HSCT after CR (25.0%±21.7% vs 83.3%±15.2%, P=0.033).The CCLG-ALL2008 (for high-risk group) protocol in treatment of children with MPAL can get a high CR rate, but also with a high incidence of SAE. The patients received allo-HSCT after CR may have a good prognosis.CCLG-ALL 2008(高危组)方案治疗儿童混合表型急性白血病的疗效及安全性分析.总结中国儿童白血病协作组（CCLG）-ALL2008（高危组）方案治疗儿童混合表型急性白血病（MPAL）的疗效及安全性.回顾性分析2013年1月到2017年12月本院收治的15例初诊MPAL患儿的临床资料，给予CCLG-ALL 2008（高危组）方案治疗.1例诊断后即放弃治疗，14例诱导缓解治疗后，3例放弃继续治疗，5例继续规则化疗，6例接受异基因造血干细胞移植（allo-HSCT）。诱导缓解治疗第33天完全缓解（CR）率为85.7%；严重不良事件发生率71.4%，治疗相关死亡率为14.3%；复发率21.4%，复发中位时间12（9.7-18.4）个月。除了4例放弃治疗患儿，其他11例患儿5年无事件生存（EFS）率为（54.5±15.0）%；6例诱导后接受HSCT和 4例只接受巩固化疗患儿5年EFS率分别为（83.3±15.2）%和（25.0±21.7）%，差异有统计学意义（P=0.033）.儿童MPAL接受CCLG-ALL2008（高危组）方案化疗，诱导缓解率较高，但严重不良事件发生率亦高，缓解后行allo-HSCT可改善远期预后.

The hybrid networks of cellulose nanocrystals (CNCs) and graphene nanoplatelets (GNPs) were constructed in polyethylene glycol (PEG) through the common solution compounding processing, in which GNPs provided the thermally conductive path while CNCs restricted the leakage of PEG during the phase transition. The results showed that CNCs greatly enhanced the shape stability of the composite phase change materials (PCMs) while thermal conductivity was still maintained at high level. At the contents of 8 wt% (CNCs) and 4 wt% (GNPs), the enthalpy of the composite PCM was 145.5 J/g, which was 88 % of pure PEG, and the thermal conductivity was 2.018±0.067 W/m K about 563.7 % higher than that of pure PEG. Furthermore, the composite PCMs exhibited outstanding light-thermal and electro-thermal conversion capabilities. Furthermore, the composite PCMs could be designed as the temperature stabilizing component exhibiting intelligent adaptive thermal management role, providing stable temperature condition for electronic devices in extreme environment.

Tailoring the distribution of nanoparticles and further constructing effective microcapacitors in polymer blends are important issues for developing high-performance polymer dielectric nanocomposites. The common method to control the selective localization of nanoparticles in an immiscible polymer blend is relatively difficult and it easily results in the accumulation of nanoparticles in one component, which usually leads to a dramatic increase of the dielectric loss in the nanocomposites. In this work, a novel strategy based on step-by-step crystallization has been proposed to tailor the refined distribution and dispersion of carbon nanotubes (CNTs) in a melt-miscible blend poly(butylene succinate)/poly(vinylidene fluoride) (PBS/PVDF) through the crystallization-induced phase separation and the engineered interfacial affinity between CNTs and polymer components to acquire high dielectric constant and low dielectric loss. The results reveal that PBS is excluded along the growth front of PVDF spherulites and locates in the margin areas of PVDF spherulites during the step-by-step crystallization process. Moreover, because of the higher interfacial interaction between CNTs and PBS, CNTs are located in the PBS-rich domain, resulting in a high concentration of CNTs in the interspherulites of PVDF. Thus, the dielectric constants of the nanocomposites are greatly improved by nearly 5-24 times compared with the nanocomposites achieved by quick cooling and, simultaneously, the dielectric loss of the nanocomposites is still maintained at a low level. This work shows that the step-by-step crystallization method can be used to fabricate the nanocomposites with a synergistic increase in the dielectric performance due to the formation of a refined microcapacitor assembly. To the best of our knowledge, this is the first report to show that the dielectric constant of the nanocomposites can be greatly enhanced just through the crystallization-optimized distribution and dispersion of CNTs in immiscible polymer blends, and it possibly gives a new technical route for the fabrication of advanced dielectric composites.

Organic phase change materials (OPCMs) play a great role in energy management owing to their large phase change enthalpy, but their intrinsic low thermal conductivity (TC) and bad encapsulation severely restrict their applications. To overcome these problems, we developed a novel but feasible method to fabricate a graphene nanoplatelet (GNP) aerogel with compact and oriented stacking in-plane walls and many through-plane bridges via melamine foam (MF) and cellulose nanofiber (CNF) co-mediated assembly of GNPs. After impregnating paraffin wax (PW), the composite PCMs exhibit a high TC of 1.42 W m−1 K−1 at only a GNP content of 4.1 wt%, increasing by 407% compared with pure PW, and simultaneously nearly no reduction of the phase change enthalpy of PW. Meanwhile, this kind of composite PCM can not only show excellent light-to-thermal and electric-to-thermal transition ability, but also be applied in delay switch devices with satisfactory results.

Shape memory polymers (SMPs) are a type of smart materials that can recover to the original shape from a set temporary shape under external stimulus, but SMPs are prone to be damaged during repeated deformation and recovery. Therefore, it is of great significance to improve the self-healing ability of SMPs. In this work, ethylene-vinyl acetate copolymer (EVA)/polycaprolactone (PCL)/polypyrrole (PPy) blend composites were prepared via simple melt blending. In this system, PPy nanoparticles, as photothermal fillers, selectively distributed in the PCL component, enable the EVA/PCL blend with a co-continuous structure to exhibit excellent photo-induced shape memory performance with a shape recovery ratio of 100%. Thanks to the excellent photothermal effect of PPy nanoparticles and the melting and recrystallization behaviors of linear EVA and PCL chains, the blend composites also exhibit outstanding photo-induced self-healing performance for different forms of damage, and the considerable healing efficiencies for the bent, scratched and cut samples reach 85.68%, 94.63% and 86.49%, respectively. Compared with the traditional thermal-induced self-healing shape memory composites, near infrared (NIR) irradiation can not only remotely manipulate the shape memory behavior of these composites, but also can accurately and selectively heal the damaged areas without distinct impact on the performance of intact areas. The above dual functions, along with the comprehensive performances and simple preparation process of these materials, enable the EVA/PCL/PPy blend composites to be the ideal candidates for many potential applications, including soft robots, smart packaging, biomedical devices, etc.

In this work, novel functionalized poly( l -lactide) (F-PLLA) porous fibers were fabricated through electrospinning using the PLLA/methylene chloride (CH2Cl2)/N,N-dimethylformamide (DMF) solution containing diethylenetriamine (DETA) and γ-aminopropyltriethoxysilane (KH-550). The effects of PLLA, DETA and KH-550 contents on the morphologies of the electrospun fibers were systematically investigated, and the results showed that at PLLA, DETA and KH-550 contents of 20% w/v, 2 wt% and 3 wt%, respectively, the electrospun F-PLLA fibers exhibited the homogeneous distribution of fiber diameters and the homogeneous porous structure on the fiber surface. Nitrogen-containing groups were successfully introduced to the electrospun fibers, which induced the great improvement of the hydrophilicity of the membrane surface. Adsorption measurements showed that the electrospun F-PLLA membrane had good adsorption ability toward Congo red (CR), and the adsorption capacity at room temperature was enhanced in 16 times compared with the common PLLA fiber membrane, and the maximum adsorption capacity was 135.7 mg g−1. Furthermore, the adsorption behavior could be well described by the pseudo second-order model. Oil/water separating measurements showed that the electrospun F-PLLA membrane exhibited high separation efficiency and the maximum water fluxes were 2018 and 1861 L m−2 h−1 in separating non-emulsified and emulsified oil/water system under atmospheric pressure, respectively.