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45 results on '"Jing, Xiaoqian"'

1. Impact of China’s Green Finance Development on the Upgrading of Industrial Structure Based on Spatial Panel Model

Author

Zhou, Yingying, Jing, Xiaoqian, Lei, Fengyi, Jin, Jing, Lu, Fengran, Appolloni, Andrea, Series Editor, Caracciolo, Francesco, Series Editor, Ding, Zhuoqi, Series Editor, Gogas, Periklis, Series Editor, Huang, Gordon, Series Editor, Nartea, Gilbert, Series Editor, Ngo, Thanh, Series Editor, Striełkowski, Wadim, Series Editor, Bhunia, Amalendu, editor, Gong, John, editor, and Zhang, Ran, editor

Published
2024
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10. Data from Cell-Cycle–Dependent Phosphorylation of PRPS1 Fuels Nucleotide Synthesis and Promotes Tumorigenesis

Author

Jing, Xiaoqian, primary, Wang, Xiong-jun, primary, Zhang, Tao, primary, Zhu, Wencheng, primary, Fang, Yi, primary, Wu, Haoxuan, primary, Liu, Xinyu, primary, Ma, Ding, primary, Ji, Xiaopin, primary, Jiang, Yimei, primary, Liu, Kun, primary, Chen, Xianze, primary, Shi, Yi, primary, Zhang, Yaqi, primary, Shi, Minmin, primary, Qiu, Weihua, primary, and Zhao, Ren, primary

Published
2023
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12. Supplementary Data from Cell-Cycle–Dependent Phosphorylation of PRPS1 Fuels Nucleotide Synthesis and Promotes Tumorigenesis

Author

Jing, Xiaoqian, primary, Wang, Xiong-jun, primary, Zhang, Tao, primary, Zhu, Wencheng, primary, Fang, Yi, primary, Wu, Haoxuan, primary, Liu, Xinyu, primary, Ma, Ding, primary, Ji, Xiaopin, primary, Jiang, Yimei, primary, Liu, Kun, primary, Chen, Xianze, primary, Shi, Yi, primary, Zhang, Yaqi, primary, Shi, Minmin, primary, Qiu, Weihua, primary, and Zhao, Ren, primary

Published
2023
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20. Efficient Generation of RNA Secondary Structure Prediction Algorithm Under PAR Framework

Author

Shi, Haihe and Jing, Xiaoqian

Subjects
ComputingMethodologies_PATTERNRECOGNITION, PAR platform, algorithm component library, Plant culture, generative programming, Plant Science, RNA secondary structure prediction algorithm, feature modeling, SB1-1110, Original Research
Abstract

Prediction of RNA secondary structure is an important part of bioinformatics genomics research. Mastering RNA secondary structure can help us to better analyze protein synthesis, cell differentiation, metabolism, and genetic processes and thus reveal the genetic laws of organisms. Comparative sequence analysis, support vector machine, centroid method, and other algorithms in RNA secondary structure prediction algorithms often use dynamic programming algorithm to predict RNA secondary structure because of their huge time and space consumption and complex data structure. In this article, the domain of RNA secondary structure prediction algorithm based on dynamic programming (DP-SSP) is analyzed in depth, and the domain features are modeled. According to the generative programming method, the DP-SSP algorithm components are interactively designed. With the support of PAR platform, the DP-SSP algorithm component library is formally realized. Finally, the concrete algorithm is generated through component assembly, which improves the efficiency and reliability of algorithm development.

Published
2021

26. Corrigendum to “Targeting autophagy enhances apatinib-induced apoptosis via endoplasmic reticulum stress for human colorectal cancer” [Cancer Lett. 431 (2018) 105–114]

Author

Cheng, Xi, primary, Feng, Haoran, additional, Wu, Haoxuan, additional, Jin, Zhijian, additional, Shen, Xiaonan, additional, Kuang, Jie, additional, Huo, Zhen, additional, Chen, Xianze, additional, Gao, Haoji, additional, Ye, Feng, additional, Ji, Xiaopin, additional, Jing, Xiaoqian, additional, Zhang, Yaqi, additional, Zhang, Tao, additional, Qiu, Weihua, additional, and Zhao, Ren, additional

Published
2019
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27. Cell-Cycle–Dependent Phosphorylation of PRPS1 Fuels Nucleotide Synthesis and Promotes Tumorigenesis

Author

Jing, Xiaoqian, primary, Wang, Xiong-jun, additional, Zhang, Tao, additional, Zhu, Wencheng, additional, Fang, Yi, additional, Wu, Haoxuan, additional, Liu, Xinyu, additional, Ma, Ding, additional, Ji, Xiaopin, additional, Jiang, Yimei, additional, Liu, Kun, additional, Chen, Xianze, additional, Shi, Yi, additional, Zhang, Yaqi, additional, Shi, Minmin, additional, Qiu, Weihua, additional, and Zhao, Ren, additional

Published
2019
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30. Targeting autophagy enhances apatinib-induced apoptosis via endoplasmic reticulum stress for human colorectal cancer

Author

Cheng, Xi, primary, Feng, Haoran, additional, Wu, Haoxuan, additional, Jin, Zhijian, additional, Shen, Xiaonan, additional, Kuang, Jie, additional, Huo, Zhen, additional, Chen, Xianze, additional, Gao, Haoji, additional, Ye, Feng, additional, Ji, Xiaopin, additional, Jing, Xiaoqian, additional, Zhang, Yaqi, additional, Zhang, Tao, additional, Qiu, Weihua, additional, and Zhao, Ren, additional

Published
2018
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33. Effects of Metal Ions on Sb2Se3Thin Films and Their Photoelectric Properties

Author

Guo, Yaxin, Jing, Xiaoqian, Cai, Dayuan, Li, Dongyun, Wang, Rui, Wang, Fan, Ge, Hongliang, and Xu, Yang

Abstract

Sb2Se3is a new type of semiconductor material with excellent photoelectric properties. However, it suffers from poor carrier transport and separation abilities, significantly hindering its development. Metal-ion doping has been identified as an effective solution to address the low carrier concentration issue in Sb2Se3, leading to a substantial increase in the carrier concentration. This study employed a simple, cost-effective hydrothermal method to prepare antimony selenide films and introduced Mg2+conducting ions to enhance the transport and separation abilities of the carriers. The effects of Mg2+metal ions on the phase structure, morphology, and photoelectric properties of antimony selenide films were investigated. The results demonstrate that Mg2+doping promotes the lengthwise growth of antimony selenide rods and facilitates carrier transfer, enabling the efficient separation of photogenerated carriers. Among the different doping levels tested, 0.1 mmol of Mg2+doping exhibited the best photoelectric performance.

Published
2024
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41. Derepression of LOXL4inhibits liver cancer growth by reactivating compromised p53

Author

Shao, Jialiang, Lu, Jiongjiong, Zhu, Wencheng, Yu, Hua, Jing, Xiaoqian, Wang, Yi-Lin, Wang, Xiang, and Wang, Xiong-Jun

Abstract

TP53is the most frequently mutated gene in human cancer, whereas tumors with wild-type TP53develop alternative strategies to survive. Identifying new regulators of p53 reactivation would greatly contribute to the development of cancer therapies. After screening the entire genome in liver cancer cells, we identified lysyl oxidase-like 4 (LOXL4) as a novel regulator for p53 activation. We found that 5-azacytidine (5-aza-CR) induces LOXL4upregulation, with LOXL4 subsequently binding the basic domain of p53 via its low-isoelectric point region. The interaction between LOXL4 and p53 induces the reactivation of compromised p53, resulting in cell death. Furthermore, the nude mouse xenograft model showed that the 5-aza-CR-dependent LOXL4-p53 axis reduces tumor growth. A positive correlation between LOXL4 expression and overall survival in liver cancer patients with wild-type p53 tumors was observed. In conclusion, we found that 5-aza-CR-induced LOXL4 upregulation reactivates wild-type p53 and triggers cell death, which blocks liver cancer development.

Published
2019
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44. [Factors affecting the difficulty of laparoscopy-assisted triple-port anterior resection].

Author

Wu H, Zhang T, Chen X, Jing X, Cheng X, Song Z, Zhu L, He Y, Ji X, Zhang H, and Zhao R

Subjects
Aged, Anal Canal, Case-Control Studies, Female, Humans, Male, Middle Aged, Rectal Neoplasms diagnostic imaging, Retrospective Studies, Treatment Outcome, Laparoscopy methods, Rectal Neoplasms surgery
Abstract

Objective: To explore the factors affecting the operative difficulty of triple-port laparoscopic surgery (TLS) in anterior resection., Methods: A retrospective case-control study was carried out. Clinical and MRI imaging data of 106 colorectal cancer cases undergoing TLS anterior resection at Department of Colorectal Surgery of Ruijin Hospital between 2013 and 2016 were retrospectively analyzed., Inclusion Criteria: (1) patients receiving TLS anterior resection (Dixon operation); (2) preoperative stageI( to III( malignant tumor;(3) distance of 5-15 cm from inferior margin of tumor to anal verge; and (4) available preoperative rectal MRI., Exclusion Criteria: (1) patients receiving preoperative adjuvant therapy; (2) patients with low rectal cancer or with local advanced disease; (3) T4b tumor. Rectal MRI was introduced to measure the structure of pelvis. In sagittal view, superior margin of the first sacral vertebrae, superior margin of the third sacral vertebrae, apex of coccyx, and the line of superior margin of pubic symphysis were used to form a pentagon. The 5 lines were marked as N, O, P, Q, R, and the 5 included angles were marked as angle 1, 2, 3, 4, 5. Organs (uterus and prostate) and tumor (transverse diameter, longitudinal diameter, section area, lesion length, distance to circumference cutting edge) were also measured on MRI. The operative time was applied to be the indicator of operative difficulty and patients were divided into 2 groups according to median operative time. Baseline information (age, gender, BMI, distance from inferior margin of tumor to anal verge, operative history, length of tumor), preoperative tumor staging, and MRI measurements (pelvis, tumor, uterus, prostate), etc were compared between two groups. Factors affecting operative difficulty of TLS were analyzed with logistic regression model., Results: Of 106 enrolled patients, 73 were male and 33 female with mean age of (59.8±12.2) years and mean BMI of (22.8±3.3) kg/m 2 ; 25 patients had previous abdominal surgery; distance from inferior margin of tumor to anal verge was (7.4±2.0) cm and the tumor diameter was (3.7±1.4) cm; 24, 36 and 46 patients were in stage I(, II( and III( respectively. All operations were completed successfully. The median number of harvested lymph node was 13(11-16); the median length of distal resection margin was 2.5(2.0-3.1) cm; the median operative time was 2.0(1.5-2.6) hours; the median intraoperative blood loss was 50(0-100) ml; the median time to liquid diet was 4(3-5) days; the median hospital stay was 7(6-10) days. Ten cases (9.4%) developed complications within 30 days after surgery. Patients were divided into ≤2 h group and > 2 h group according to median operative time, and both groups had 53 patients. As compared to ≤2 h group, >2 h group had shorter distance from inferior margin of tumor to anal verge [(6.8 ± 1.5) cm vs. (8.0 ± 2.4) cm, t = 3.174, P = 0.004], lower ratio of (R+N)/(O+P)(1.61±0.27 vs. 1.73±0.19, t = 2.494, P = 0.014), larger transverse distance of tumor [(3.45±0.72) cm vs. (3.05±0.89) cm, t = 0.224, P = 0.027]. Multivariate logistic regression analysis showed the distance from inferior margin of tumor to anal verge was the independent factor affecting operative difficulty(OR=0.584, 95%CI:0.429-0.796, P = 0.001)., Conclusions: Surgeons may have less difficulty in performing TLS anterior resection for patients with longer distance from inferior margin of tumor to anal verge. In preoperative assessment of operative difficulty of TLS, comprehensive evaluation should be performed. Distance from inferior margin of tumor to anal verge should be regarded as the main factor, and MRI (R+N)/(O+P) and transverse diameter of tumor should be used as important reference, leading to reasonable choice of cases for TLS and smooth pass of study curve.

Published
2018

45. Cortactin promotes colorectal cancer cell proliferation by activating the EGFR-MAPK pathway.

Author

Zhang X, Liu K, Zhang T, Wang Z, Qin X, Jing X, Wu H, Ji X, He Y, and Zhao R

Subjects
Animals, Cell Line, Tumor, Cell Proliferation physiology, Colorectal Neoplasms pathology, HCT116 Cells, HT29 Cells, Heterografts, Humans, Male, Mice, Colorectal Neoplasms enzymology, Cortactin metabolism, ErbB Receptors metabolism, MAP Kinase Signaling System
Abstract

Cortactin (CTTN) is overexpressed in various tumors, including head and neck squamous cell carcinoma and colorectal cancer (CRC), and can serve as a biomarker of cancer metastasis. We observed that CTTN promotes cancer cell proliferation in vitro and increases CRC tumor xenograft growth in vivo. CTTN expression increases EGFR protein levels and enhances the activation of the MAPK signaling pathway. CTTN expression also inhibits the ubiquitin-mediated degradation of EGFR by suppressing the coupling of c-Cbl with EGFR. CoIP experiments indicate CTTN can interact with c-Cbl in CRC cells. These results demonstrate that CTTN promotes the proliferation of CRC cells and suppresses the degradation of EGFR.

Published
2017
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