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The major problems of TiO_2 photocatalyst are easy aggregation and deactivation, and obvious difficulty in separation. In order to overcome some of the drawbacks of TiO_2 photocatalyst in suspension, zeolite(NaY) molecular sieves were used to support TiO_2. The preparation conditions of TiO_2/NaY composite photocatalyst were optimized in this research. Moreover, the effect of NaY on crystal type, phase transition temperature and photocatalytic properties was investigated, and the influence of TiO_2/NaY on the degradation of organic waste water was analyzed. The results indicate that the TiO_2/NaY composite photocatalyst exhibits the optimal photocatalytic activity under the conditions of TiO_2 loading of 35%, sintering temperature of 500 °C, roasting time of 2 h and catalyst dosage of 0.08 g(methylene blue solution of 100 mL). When methylene blue solution of an initial concentration of 20 mg/L was treated for 0.5 h with TiO_2/NaY composite photocatalyst, the photocatalytic degradation rate was 95.42%, 22.3% higher than that of TiO_2. High stability, high ultraviolet light transmission and regular microporous and cage structure of NaY is conducive to not only recycle of TiO_2 but also improvement of photocatalytic activity of TiO_2.

Chronic infections can lead to carcinogenesis through inflammation-related mechanisms. Chronic infection of the human gastric mucosa with Helicobacter pylori is a well-known risk factor for gastric cancer. However, the mechanisms underlying H. pylori-induced gastric carcinogenesis are incompletely defined. We aimed to screen and clarify the functions of long noncoding RNAs (lncRNAs) that are differentially expressed in H. pylori-related gastric cancer. We found that lncRNA SNHG17 was upregulated by H. pylori infection and markedly increased the levels of double-strand breaks (DSBs). SNHG17 overexpression correlated with poor overall survival in patients with gastric cancer. The recruitment of NONO by overabundant nuclear SNHG17, along with the role of cytoplasmic SNHG17 as a decoy for miR-3909, which regulates Rad51 expression, shifted the DSB repair balance from homologous recombination toward nonhomologous end joining. Notably, during chronic H. pylori infection, SNHG17 knockdown inhibited chromosomal aberrations. Our findings suggest that spatially independent deregulation of the SNHG17/NONO and SNHG17/miR-3909/RING1/Rad51 pathways upon H. pylori infection promotes tumorigenesis in gastric cancer by altering the DNA repair system, which is critical for the maintenance of genomic stability. Upregulation of SNHG17 by H. pylori infection might be an undefined link between cancer and inflammation., Introduction Gastric cancer is among the most common malignancies; it is the third leading cause of cancer-associated mortality worldwide and is a serious threat to public health (1). Many factors [...]

Oncolytic virus therapy is perhaps the next major breakthrough in cancer treatment following the success in immunotherapy using immune checkpoint inhibitors. However, the potential oncolytic ability of the recombinant newcastle disease virus (NDV) Anhinga strain carried with tumor necrosis factor‐related apoptosis inducing ligand (TRAIL) has not been fully explored at present. In the present study, the recombinant NDV/Anh‐TRAIL that secretes soluble TRAIL was constructed and the experiment results suggested NDV/Anh‐TRAIL as a promising candidate for glioma therapy. Growth kinetic and TRAIL secreted quantity of recombinant NDV/Anh‐TRAIL virus were measured. Cytotoxic and cell apoptosis were analyzed for its anti‐glioma therapy in vitro. Nude mice were used for the in vivo evaluation. Both tumor volume and mice behavior after injection were observed. The recombinant virus replicated with the same kinetics as the parental virus and the highest expression of TRAIL (77.8 ng/L) was found at 48 hours. The 3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyltetrazolium bromide, a tetrazole and flow cytometry data revealed that the recombinant NDV/Anh‐TRAIL (56.1 ± 8.2%) virus could induce a more severe apoptosis rate, when compared with the NDV wild type (37.2 ± 7.0%) and mock (7.0 ± 1.8%) groups (P <.01), in U251 cells. Furthermore, in the present animal study, the average tumor volume was smaller in the NDV/Anh‐TRAIL group (97.21 mm3), when compared with the NDV wild type (205.03 mm3, P <.05) and PBS (310.30 mm3, P <.01) groups. Highlights: NDV/Anh‐TRAIL exerts an obvious result in U251 glioma therapeutic effect in vitro and in vivo. Anhinga strain could be an effectual vector for tumor therapy. NDV/Anh‐TRAIL could become a potent candidate for clinical treatment especially for glioma. [ABSTRACT FROM AUTHOR]

• A uniform 2D SERS-active plasmonic metal NP-CsPbX 3 hybrid films were fabricated. • The effects of different CsPbX 3 QDs on SERS activity of hybrid films were studied. • Depressed plasmonic decay for electromagnetic field enhancement was achieved. • Hybrid films achieved sensitive and multiple veterinary drug residues detection. Sensitive and multiple veterinary drug residues detection is of important for food safety. Herein, uniform plasmonic Au nanobipyramids@Ag nanorods (Au NBP@Ag NR)-CsPbX 3 films with strong surface-enhanced Raman scattering (SERS) activity were constructed. The effects of different CsPbX 3 (X = Cl, Br, I, or mixed halogens) quantum dots (QDs) on the SERS performances of plasmonic metal NP films were investigated. CsPbI 3 QDs with large dielectric constant could be served as the dielectric media to retard the attenuation of electromagnetic evanescent wave, inducing strong electromagnetic strength for SERS enhancement. Plasmon-induced metal-to-perovskite interfacial charge transfer transition also contributed to SERS enhancement. SERS-active plasmonic Au NBP@Ag NR-CsPbI 3 films had excellent sensitivity and high reproducibility for quantitative, accurate and multiple detection of chloramphenicol, diazepam and malachite green in food matrix. This work deepened the understanding of the SERS enhancement mechanisms of plasmonic metal NP-perovskite hybrid heterostructures, showing potential prospects in food safety monitoring. [ABSTRACT FROM AUTHOR]

Chronic infections can lead to carcinogenesis through inflammation-related mechanisms. Chronic infection of the human gastric mucosa with Helicobacter pylori is a well-known risk factor for gastric cancer. However, the mechanisms underlying H. pylori-induced gastric carcinogenesis are incompletely defined. We aimed to screen and clarify the functions of long noncoding RNAs (lncRNAs) that are differentially expressed in H. pylori-related gastric cancer. We found that lncRNA SNHG17 was upregulated by H. pylori infection and markedly increased the levels of double-strand breaks (DSBs). SNHG17 overexpression correlated with poor overall survival in patients with gastric cancer. The recruitment of NONO by overabundant nuclear SNHG17, along with the role of cytoplasmic SNHG17 as a decoy for miR-3909, which regulates Rad51 expression, shifted the DSB repair balance from homologous recombination toward nonhomologous end joining. Notably, during chronic H. pylori infection, SNHG17 knockdown inhibited chromosomal aberrations. Our findings suggest that spatially independent deregulation of the SNHG17/NONO and SNHG17/miR-3909/RING1/Rad51 pathways upon H. pylori infection promotes tumorigenesis in gastric cancer by altering the DNA repair system, which is critical for the maintenance of genomic stability. Upregulation of SNHG17 by H. pylori infection might be an undefined link between cancer and inflammation. [ABSTRACT FROM AUTHOR]

The photocatalytic efficiency of TiO 2 is reduced by rapid electron-hole recombination. An effective approach to address this limitation is to have TiO 2 doped with various metal ions or heteroatoms. Herein, we prepared a series of Li + -doped TiO 2 nanoparticles showing high photocatalytic activities through the sol-gel method. The samples were characterized by X-ray diffraction (XRD) and surface area analyses. Effects of Li + doping on the Brunauer-Emmett-Teller (BET) surface area, crystallite size, phase transformation temperature, and phase composition were studied. The results showed that Li + doping can promote the generation of the rutile crystal phase in TiO 2 , lower the anatase-to-rutile transformation temperature, and generate the mixed-crystal effect. The photocatalytic degradation of methyl orange (MO) was used as a probe reaction to evaluate the photoactivity of the nanoparticles. Parameters affecting the photocatalytic efficiency, including the Li + doping amount, calcination temperature, and catalyst amount, as well as the kinetics of the photocatalytic process toward the degradation of MO, were investigated. The mixed-crystal TiO 2 , which was doped with 1.0 mol % Li + and calcined at 550 °C containing 27.1% rutile and 72.9% anatase phase, showed a 2.2-fold increase in the photoactivity on the basis of the rate constant of MO decomposition as compared with the undoped TiO 2 . The existence of a definite quantity of rutile phase could effectively inhibit the recombination of the electron-hole pairs, thus promoting photocatalytic activity., Competing Interests: The authors declare no competing financial interest., (© 2020 American Chemical Society.)

Professor HE Tianyou's unique understanding and treatment characteristics for intractahle facial paralysis are introduced. In clinical practice professor HE highly values acupoint selection and manipulation application, and integrates Chinese and western medicine to flexibly choose acupoints and formulate prescriptions according to syndrome differentiation and location differentiation, besides, he creates several specialized manipulation methods including "tug-of war opposite acupuncture method" and "tractive flash cupping". Based on strengthening body and dredging collaterals. more attention is given on stimulation to local paralyzed facial nerves; meanwhile acupuncture and medication are combined to improve clinical efficacy. During the treatment, the important role of psychological counseling on patient's anxiety is emphasized, and comprehensive treatment is given physically and psychologically in order to achieve the purpose of total rehabilitation.