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22 results on '"Jing, Junzhan"'

3. Integrated electrophysiological and genomic profiles of single cells reveal spiking tumor cells in human glioma

Author

Curry, Rachel Naomi, primary, Ma, Qianqian, additional, McDonald, Malcolm F, additional, Ko, Yeunjung, additional, Srivastava, Snigdha, additional, Chin, Pey-Shyuan, additional, He, Peihao, additional, Lozzi, Brittney, additional, Jing, Junzhan, additional, Athukuri, Prazwal, additional, Wang, Su, additional, Harmanci, Arif O, additional, Arenkiel, Benjamin, additional, Jiang, Xiaolong, additional, Deneen, Benjamin, additional, Rao, Ganesh, additional, and Serin Harmanci, Akdes, additional

Published
2024
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12. Identification of functional immune and neuronal tumour cells in glioma

Author

Curry, Rachel Naomi, primary, McDonald, Malcolm F., additional, Ma, Qianqian, additional, Meyer, Jochen, additional, Aiba, Isamu, additional, Lozzi, Brittney, additional, Cervantes, Alexis, additional, Ko, Yeunjung, additional, Luna-Figueroa, Estefania, additional, Choi, Dong-Joo, additional, Lee, Zhung-Fu, additional, Jing, Junzhan, additional, Harmanci, Arif O., additional, Rosenbaum, Anna, additional, He, Peihao, additional, Mohila, Carrie, additional, Jalali, Ali, additional, Noebels, Jeffrey, additional, Jiang, Xiaolong, additional, Deneen, Benjamin, additional, Rao, Ganesh, additional, and Harmanci, Akdes Serin, additional

Published
2022
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17. Neurexophilin4 is a selectively expressed α-neurexin ligand that modulates specific cerebellar synapses and motor functions

Author

Meng, Xiangling, primary, McGraw, Christopher M, additional, Wang, Wei, additional, Jing, Junzhan, additional, Yeh, Szu-Ying, additional, Wang, Li, additional, Lopez, Joanna, additional, Brown, Amanda M, additional, Lin, Tao, additional, Chen, Wu, additional, Xue, Mingshan, additional, Sillitoe, Roy V, additional, Jiang, Xiaolong, additional, and Zoghbi, Huda Y, additional

Published
2019
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18. Author response: Neurexophilin4 is a selectively expressed α-neurexin ligand that modulates specific cerebellar synapses and motor functions

Author

Meng, Xiangling, primary, McGraw, Christopher M, additional, Wang, Wei, additional, Jing, Junzhan, additional, Yeh, Szu-Ying, additional, Wang, Li, additional, Lopez, Joanna, additional, Brown, Amanda M, additional, Lin, Tao, additional, Chen, Wu, additional, Xue, Mingshan, additional, Sillitoe, Roy V, additional, Jiang, Xiaolong, additional, and Zoghbi, Huda Y, additional

Published
2019
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19. Direct Reprogramming of Fibroblasts via a Chemically Induced XEN-like State

Author

Li, Xiang, primary, Liu, Defang, additional, Ma, Yantao, additional, Du, Xiaomin, additional, Jing, Junzhan, additional, Wang, Lipeng, additional, Xie, Bingqing, additional, Sun, Da, additional, Sun, Shaoqiang, additional, Jin, Xueqin, additional, Zhang, Xu, additional, Zhao, Ting, additional, Guan, Jingyang, additional, Yi, Zexuan, additional, Lai, Weifeng, additional, Zheng, Ping, additional, Huang, Zhuo, additional, Chang, Yanzhong, additional, Chai, Zhen, additional, Xu, Jun, additional, and Deng, Hongkui, additional

Published
2017
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20. Small-Molecule-Driven Direct Reprogramming of Mouse Fibroblasts into Functional Neurons

Author

Li, Xiang, primary, Zuo, Xiaohan, additional, Jing, Junzhan, additional, Ma, Yantao, additional, Wang, Jiaming, additional, Liu, Defang, additional, Zhu, Jialiang, additional, Du, Xiaomin, additional, Xiong, Liang, additional, Du, Yuanyuan, additional, Xu, Jun, additional, Xiao, Xiong, additional, Wang, Jinlin, additional, Chai, Zhen, additional, Zhao, Yang, additional, and Deng, Hongkui, additional

Published
2015
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21. Molecular logic for cellular specializations that initiate the auditory parallel processing pathways.

Author

Jing J, Hu M, Ngodup T, Ma Q, Lau SN, Ljungberg C, McGinley MJ, Trussell LO, and Jiang X

Abstract

The cochlear nuclear complex (CN), the starting point for all central auditory processing, comprises a suite of neuronal cell types that are highly specialized for neural coding of acoustic signals, yet molecular logic governing cellular specializations remains unknown. By combining single-nucleus RNA sequencing and Patch-seq analysis, we reveal a set of transcriptionally distinct cell populations encompassing all previously observed types and discover multiple new subtypes with anatomical and physiological identity. The resulting comprehensive cell-type taxonomy reconciles anatomical position, morphological, physiological, and molecular criteria, enabling the determination of the molecular basis of the remarkable cellular phenotypes in the CN. In particular, CN cell-type identity is encoded in a transcriptional architecture that orchestrates functionally congruent expression across a small set of gene families to customize projection patterns, input-output synaptic communication, and biophysical features required for encoding distinct aspects of acoustic signals. This high-resolution account of cellular heterogeneity from the molecular to the circuit level illustrates molecular logic for cellular specializations and enables genetic dissection of auditory processing and hearing disorders with unprecedented specificity.

Published
2024
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22. Integrated electrophysiological and genomic profiles of single cells reveal spiking tumor cells in human glioma.

Author

Curry RN, Ma Q, McDonald MF, Ko Y, Srivastava S, Chin PS, He P, Lozzi B, Athukuri P, Jing J, Wang S, Harmanci AO, Arenkiel B, Jiang X, Deneen B, Rao G, and Harmanci AS

Abstract

Prior studies have described the complex interplay that exists between glioma cells and neurons, however, the electrophysiological properties endogenous to tumor cells remain obscure. To address this, we employed Patch-sequencing on human glioma specimens and found that one third of patched cells in IDH mutant (IDH mut ) tumors demonstrate properties of both neurons and glia by firing single, short action potentials. To define these hybrid cells (HCs) and discern if they are tumor in origin, we developed a computational tool, Single Cell Rule Association Mining (SCRAM), to annotate each cell individually. SCRAM revealed that HCs represent tumor and non-tumor cells that feature GABAergic neuron and oligodendrocyte precursor cell signatures. These studies are the first to characterize the combined electrophysiological and molecular properties of human glioma cells and describe a new cell type in human glioma with unique electrophysiological and transcriptomic properties that are likely also present in the non-tumor mammalian brain.

Published
2024
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