17 results on '"Jin-Zhou, Zhu"'
Search Results
2. Using circulating O-sulfotyrosine in the differential diagnosis of acute kidney injury and chronic kidney disease
- Author
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Shuai Chen, Yong-Hua Liu, Dao-Peng Dai, Zheng-Bin Zhu, Yang Dai, Zhi-Ming Wu, Li-Ping Zhang, Zhi-Feng Duan, Lin Lu, Feng-Hua Ding, Jin-Zhou Zhu, and Rui-Yan Zhang
- Subjects
Acute kidney injury ,Chronic kidney disease ,Metabolite ,Tyrosine O-sulfation ,O-sulfotyrosine ,Renal dysfunction ,Diseases of the genitourinary system. Urology ,RC870-923 - Abstract
Abstract Background Sulfation of tyrosine, yielding O-sulfotyrosine, is a common but fixed post-translational modification in eukaryotes. Patients with increased circulating O-sulfotyrosine levels experience a faster decline in renal function with progression to end-stage renal disease (ESRD). In the present study, we measured serum O-sulfotyrosine levels in individuals with chronic kidney disease (CKD) and acute kidney injury (AKI) to explore its ability to differentiate AKI from CKD. Methods A total of 135 patients (20 with AKI and 115 with CKD) were recruited prospectively for liquid chromatography-mass spectrometry assessment of circulating O-sulfotyrosine. We also studied C57BL/6 mice with CKD after 5/6 nephrectomy (Nx). Blood samples were drawn from the tail vein on Day 1, 3, 5, 7, 14, 30, 60, and 90 after CKD. Serum separation and characterization of creatinine, blood urea nitrogen (BUN), and O-sulfotyrosine was performed. Thus, the time-concentration curves of the O-sulfotyrosine level demonstrate the variation of kidney dysfunction. Results The serum levels of O-sulfotyrosine were markedly increased in patients with CKD compared with AKI. Median O-sulfotyrosine levels in CKD patients versus AKI, respectively, were as follows:243.61 ng/mL(interquartile range [IQR] = 171.90–553.86) versus 126.55 ng/mL (IQR = 48.19–185.03, P = 0.004). In patients with CKD, O-sulfotyrosine levels were positively correlated with creatinine, BUN, and Cystatin C (r = 0.63, P
- Published
- 2021
- Full Text
- View/download PDF
3. Pancreatic cancer incidence and mortality patterns in 2006-2015 and prediction of the epidemiological trend to 2025 in China
- Author
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Min-Yue, Yin, Li-Ting, Xi, Lu, Liu, Jin-Zhou, Zhu, Li-Juan, Qian, and Chun-Fang, Xu
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General Medicine - Abstract
Due to dietary patterns, the aging population, and other high-risk factors, the occurrence of pancreatic cancer (PC) has been rapidly increasing in China.To present the epidemiological trends of PC in China over the past decade and the estimated trend in 2025 and to compare the international differences in PC morbidity and mortality.This study used a series of nationally representative data from the National Central Cancer Registry of China (NCCR), the International Agency for Research on Cancer and the Institute for Health Metrics and Evaluation databases. Age-standardized data of the PC incidence and mortality from 2006 to 2015 in China were extracted from the NCCR database. Linear regression models were used to estimate the incidence and mortality rates of PC in 2025.The age-standardized rates of PC in China increased from 3.65 per 100000 in 2006 to 4.31 per 100000 in 2015 and were estimated to reach up to 5.52 per 100000 in 2025. The mortality went from 3.35 per 100000 in 2006 to 3.78 per 100000 in 2015, estimated to reach up to 4.6 per 100000 in 2025. The number of new cases and deaths was low before 45 years and the peak age of onset was 85-89 years. The incidence and mortality rates in men were higher than those in women regardless of the region in China. In addition, the incidence and mortality rates in China were higher than the average level around the world. Likewise, disability-adjusted life years attributed to PC in China were 197.22 years per 100000, above the average level around the world.This study presented an increasing trend of PC in China and differences in morbidity, mortality and disability-adjusted life years between Chinese and global populations. Efforts need to be made to decrease the PC incidence and improve patient outcomes.
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- 2022
4. Probabilistic load flow with correlated wind power sources using a frequency and duration method
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Yan Zhang and Jin-Zhou Zhu
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Wind power ,Markov chain ,business.industry ,Computer science ,020209 energy ,020208 electrical & electronic engineering ,Monte Carlo method ,Energy Engineering and Power Technology ,Markov process ,02 engineering and technology ,Electric power system ,symbols.namesake ,Latin hypercube sampling ,Control and Systems Engineering ,Control theory ,0202 electrical engineering, electronic engineering, information engineering ,symbols ,Probability distribution ,Electrical and Electronic Engineering ,business ,Random variable - Abstract
Probabilistic load flow (PLF) is an important tool in power system planning and operation. One limitation of conventional PLF is that only the probability information of random variables is obtained as a reference for related analyses. Frequency and duration information often plays an important role in power system assessment. In this study, a frequency and duration method for PLF with correlated wind power sources and loads is proposed based on Latin hypercube sampling (LHS), Nataf transformation, and Markov chains. In the proposed method, the spatial and temporal correlations among wind power sources and loads are addressed using Nataf transformation and Markov chains, which are incorporated into the LHS framework to solve the PLF problem with frequency and duration quantities. With the proposed method, not only the probability information but also the frequency and duration information of the random output variables in a PLF problem can be efficiently and accurately obtained. The performance of the proposed PLF method is verified using comparative tests on three modified test systems.
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- 2019
5. Increased carbamylation level of HDL in end-stage renal disease: carbamylated-HDL attenuated endothelial cell function
- Author
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Jia Teng Sun, Zheng Bin Zhu, Rui Yan Zhang, Jin Zhou Zhu, Hui Han, Jing Wei Ni, Ke Yang, Lin Lu, and Nan Chen
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Male ,0301 basic medicine ,medicine.medical_specialty ,Physiology ,Angiogenesis ,030204 cardiovascular system & hematology ,End stage renal disease ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,High-density lipoprotein ,Internal medicine ,medicine ,Humans ,Scavenger receptor ,Cyanates ,Aged ,biology ,Aryldialkylphosphatase ,business.industry ,Paraoxonase ,Endothelial Cells ,nutritional and metabolic diseases ,Kinase insert domain receptor ,Middle Aged ,Scavenger Receptors, Class B ,Vascular Endothelial Growth Factor Receptor-2 ,Endothelial stem cell ,030104 developmental biology ,Endocrinology ,chemistry ,Case-Control Studies ,biology.protein ,Kidney Failure, Chronic ,Female ,lipids (amino acids, peptides, and proteins) ,Lipoproteins, HDL ,business ,Signal Transduction ,Lipoprotein - Abstract
It is thought that carbamylated modification plays a crucial role in the development and progression of cardiovascular disease (CVD) in patients with end-stage renal disease (ESRD). However, information on the biological effects of carbamylated high-density lipoprotein (C-HDL) in ESRD is poor. The present study investigated the carbamylation level of HDL in ESRD and the effects of C-HDL on endothelial repair properties. HDL was isolated from healthy control subjects ( n = 22) and patients with ESRD ( n = 30). The carbamylation level of HDL was detected using ELISA. Isolated C-HDL for use in tissue culture experiments was carbamylated in vitro to a similar extent to that observed in ESRD. Human arterial endothelial cells were treated with C-HDL or native HDL to assess their migration, proliferation, and angiogenesis properties. HDL-associated paraoxonase 1 activity was also determined by spectrophotometry assay. Compared with healthy control subjects, the carbamylation level of HDL in ESRD patients was increased and positively correlated with blood urea concentration. In vitro, C-HDL significantly inhibited migration, angiogenesis, and proliferation in endothelial cells. Mechanistic studies revealed that HDL-associated paraoxonase 1 activity was decreased and negatively correlated with the carbamylation level of HDL in ESRD patients. In addition, C-HDL suppressed the expression of VEGF receptor 2 and scavenger receptor class B type I signaling pathways in endothelial cells. In conclusion, the present study identified a significantly increased carbamylation level of HDL in ESRD. Furthermore, C-HDL inhibited endothelial cell repair functions.
- Published
- 2016
6. A Markov chain based method for probabilistic load flow with wind power
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Yan Zhang, Teng Zhao, and Jin-Zhou Zhu
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Wind power ,Markov chain ,Basis (linear algebra) ,business.industry ,Computer science ,020209 energy ,Markov process ,02 engineering and technology ,Wind speed ,Convolution ,symbols.namesake ,Distribution function ,Control theory ,0202 electrical engineering, electronic engineering, information engineering ,symbols ,business ,Random variable - Abstract
On the basis of Markov chain, this paper proposes a frequency and duration method for probabilistic load flow (PLF) analysis with wind power by improving the probability-frequency distribution function (PFDF) method. With this proposed method, the probability, frequency, and duration information of random output variables in the PLF problem can be efficiently computed by convolution and addition operation of PFDFs for random input variables. A numerical test on the modified IEEE-RTS79 grid verifies the effectiveness of the proposed method.
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- 2017
7. Regional photovoltaic installed capacity forecasting based on granger causality test and grey support vector machine
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Teng Zhao, Jin-Zhou Zhu, and Yan Zhang
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Computer science ,business.industry ,020209 energy ,Dimensionality reduction ,Photovoltaic system ,02 engineering and technology ,Support vector machine ,Nameplate capacity ,Granger causality ,Sunshine duration ,0202 electrical engineering, electronic engineering, information engineering ,Econometrics ,Electricity ,Time series ,business - Abstract
Forecasting results of regional photovoltaic (PV) installed capacity can provide important references for electric utilities and energy authorities. This paper proposes a three-step forecasting methodology of regional PV installed capacity. The first step is to study the relationship between regional PV installed capacity and a series of potential factors using co-integration analysis and Granger causality test; second, dimensionality reduction of influential factors is carried out by principal component analysis; in the last step, a grey support vector machine forecasting model is constructed based on the outcome of influential factors reduction. The example of Shanghai is given to illustrate the proposed methodology. Results show that factors such as electricity consumption, and generating cost of PV are closely related to PV installed capacity, nevertheless, sunshine duration and average temperature are not the Granger reasons for it; these findings are of great importance to the forecasting of 2016∼2030 PV installed capacity in Shanghai.
- Published
- 2017
8. Betatrophin provides a new insight into diabetes treatment and lipid metabolism (Review)
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Youming Li, Jin‑Zhou Zhu, and Chao‑Hui Yu
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business.industry ,Betatrophin ,General Neuroscience ,Regulator ,Lipid metabolism ,Articles ,General Medicine ,medicine.disease ,Bioinformatics ,Molecular medicine ,Diabetes Therapy ,General Biochemistry, Genetics and Molecular Biology ,Insulin resistance ,Diabetes mellitus ,Medicine ,General Pharmacology, Toxicology and Pharmaceutics ,business ,Function (biology) - Abstract
Replenishing the insulin-producing β-cell mass is considered to be a potential cure for diabetes. A recent study identified a secreted protein, known as betatrophin, which potently induces pancreatic β-cell proliferation. Notably, a number of studies reportedly identified betatrophin, which is also known as lipasin, atypical angiopoietin-like 8 and refeeding-induced fat and liver protein, and considered to be a novel regulator in lipid metabolism according to the studies. The identification of betatrophin was considered to create novel opportunities for potential diabetes therapy. In the present study, the current knowledge of betatrophin is reviewed, with regards to its character and function in lipid homeostasis and pancreatic β-cell proliferation.
- Published
- 2014
9. [Not Available]
- Author
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Jin-Zhou, Zhu, Chun-Xiao, Li, Yi-Ning, Dai, De-Jian, Zhao, Zhi-Yun, Fang, Xing-Yong, Wan, Hua-Tuo, Zhu, Yu-Ming, Wang, Chao-Hui, Yu, and You-Ming, Li
- Subjects
Adult ,Male ,Metabolic Syndrome ,Angiopoietin-like Proteins ,Adipokines ,Anthropometry ,Angiopoietin-Like Protein 8 ,Case-Control Studies ,Peptide Hormones ,Humans ,Female ,Middle Aged - Abstract
la betatrofina es una novedosa adipoquina que provoca la proliferación de células β pancreáticas e interviene en el metabolismo de los lípidos. Objetivos: el propósito de este estudio es evaluar el papel de la betatrofina en el síndrome metabólico.se llevó a cabo un estudio hospitalario de casos y controles según sexo y edad. El nivel de betatrofina en suero fue evaluado mediante ensayo por inmunoabsorción ligado a enzimas. Se midieron las concentraciones en suero de 12 adipoquinas para evaluar las asociaciones con la betatrofina usando los kits comerciales Adipokine Magnetic Bead Panel. Los análisis estadísticos incluyeron correlación bivariada, análisis de curva ROC y análisis de regresión lineal multivariable.el nivel de betatrofina en suero fue más elevado en pacientes con síndrome metabólico (997,36 ± 475,92 pg/ml, p = 0,001) que en los controles (735,35 ± 526,51 pg/ml). Frente al tercil más bajo, el tercil más alto del nivel de betatrofina mostró una asociación con mayor riesgo de síndrome metabólico (odds ratio ajustado = 3,521, intervalo de confianza [IC] 95% [1,191-10,413], p = 0,023). Se desarrolló la curva ROC de betatrofina para pronosticar la presencia de síndrome metabólico (área bajo la curva ROC = 0,682 [95% IC, 0,597-0,767], p0,001). Además, la betatrofina mostró correlación con distintos parámetros, como edad (r = 0,286, p0,001), índice de masa corporal (r = 0,160, p = 0,046), índice cintura-cadera (r = 0,241, p = 0,002), lipoproteína de alta densidad (r = -0,167, p = 0,037), lipoproteína de baja densidad (r = -0,195, p = 0,015), glucosa plasmática en ayunas (r = 0,266, p = 0,001), hemoglobina A1C (r = 0,314, p0,001), índice de resistencia a la insulina mediante HOMA (r = 0,272, p = 0,001) y diversas adipoquinas, entre ellas resistina (r = 0,571, p0,001), interleucina-8 (r = 0,435, p0,001), factor de necrosis tumoral alfa (r = 0,295, p = 0,011) y lipocalina-2 (r = 0,346, p = 0,003).este estudio demuestra que la betatrofina en suero desempeña una importante labor en el síndrome metabólico, implicando la regulación del metabolismo de la glucosa y los lípidos y la inflamación.
- Published
- 2016
10. Serum betatrophin level increased in subjects with metabolic syndrome: a case-control study
- Author
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Jin-Zhou, Zhu, Chun-Xiao, Li, Yi-Ning, Dai, De-Jian, Zhao, Zhi-Yun, Fang, Xing-Yong, Wan, Hua-Tuo, Zhu, Yu-Ming, Wang, Chao-Hui, Yu, and You-Ming, Li
- Subjects
Síndrome metabólico ,Betatrophin ,Hepatokine ,Adipokine ,Hepatoquina ,Angiopoeitin-like 8 (ANGPTL8) ,Angiopoyetina-8 (ANGPTL8) ,Adipoquina ,Metabolic syndrome ,Betatrofina - Abstract
Background: Betatrophin is a novel adipokine that provokes pancreatic β-cell proliferation and is involved in lipid metabolism. Aims: This study aims to evaluate the role of serum betatrophin in metabolic syndrome (MetS). Methods: A hospital-based, age-/gender-matched case control study was conducted. The serum betatrophin level was evaluated by enzyme-linked immunosorbent assay. Serum concentrations of 12 adipokines were measured to assess their associations with serum betatrophin, using commercial Adipokine Magnetic Bead Panel kits. Statistical analyses included bivariate correlation, receiver operating characteristic (ROC) curve, and multivariate stepwise linear regression. Results: Serum betatrophin showed a higher level in MetS patients (997.36 ± 475.92 pg/ml, p = 0.001) compared with controls (735.35 ± 526.51 pg/ml). Compared with the lowest tertile, the highest tertile of serum betatrophin level indicated an association with higher risk of MetS (adjusted odds ratio = 3.521, 95% confidence interval [CI] [1.191-10.413], p = 0.023). ROC curve of betatrophin was developed to predict the presence of MetS (area under ROC = 0.682 [95% CI, 0.597-0.767], p < 0.001). Furthermore, betatrophin correlated with several parameters, e.g. age (r = 0.286, p < 0.001), body mass index (r = 0.160, p = 0.046), waist-to-hip ratio (r = 0.241, p = 0.002), high-density lipoprotein cholesterol (r = -0.167, p = 0.037), low-density lipoprotein cholesterol (r = -0.195, p = 0.015), fasting plasma glucose (r = 0.266, p = 0.001), hemoglobin A1C (r = 0.314, p < 0.001), homeostasis model assessment of insulin resistance (r = 0.272, p = 0.001), and various adipokines, e.g. resistin (r = 0. 571, p < 0.001), interleukin-8 (r = 0.435, p < 0.001), tumor necrosis factor-α (r = 0.295, p = 0.011) and lipocalin-2 (r = 0.346, p = 0.003). Conclusions: This study supports that serum betatrophin plays an important role in MetS, involving the regulations of glucose and lipid metabolism and inflammation. Introducción: la betatrofina es una novedosa adipoquina que provoca la proliferación de células β pancreáticas e interviene en el metabolismo de los lípidos. Objetivos: el propósito de este estudio es evaluar el papel de la betatrofina en el síndrome metabólico. Método: se llevó a cabo un estudio hospitalario de casos y controles según sexo y edad. El nivel de betatrofina en suero fue evaluado mediante ensayo por inmunoabsorción ligado a enzimas. Se midieron las concentraciones en suero de 12 adipoquinas para evaluar las asociaciones con la betatrofina usando los kits comerciales Adipokine Magnetic Bead Panel. Los análisis estadísticos incluyeron correlación bivariada, análisis de curva ROC y análisis de regresión lineal multivariable. Resultados: el nivel de betatrofina en suero fue más elevado en pacientes con síndrome metabólico (997,36 ± 475,92 pg/ml, p = 0,001) que en los controles (735,35 ± 526,51 pg/ml). Frente al tercil más bajo, el tercil más alto del nivel de betatrofina mostró una asociación con mayor riesgo de síndrome metabólico (odds ratio ajustado = 3,521, intervalo de confianza [IC] 95% [1,191-10,413], p = 0,023). Se desarrolló la curva ROC de betatrofina para pronosticar la presencia de síndrome metabólico (área bajo la curva ROC = 0,682 [95% IC, 0,597-0,767], p < 0,001). Además, la betatrofina mostró correlación con distintos parámetros, como edad (r = 0,286, p < 0,001), índice de masa corporal (r = 0,160, p = 0,046), índice cintura-cadera (r = 0,241, p = 0,002), lipoproteína de alta densidad (r = -0,167, p = 0,037), lipoproteína de baja densidad (r = -0,195, p = 0,015), glucosa plasmática en ayunas (r = 0,266, p = 0,001), hemoglobina A1C (r = 0,314, p < 0,001), índice de resistencia a la insulina mediante HOMA (r = 0,272, p = 0,001) y diversas adipoquinas, entre ellas resistina (r = 0,571, p < 0,001), interleucina-8 (r = 0,435, p < 0,001), factor de necrosis tumoral alfa (r = 0,295, p = 0,011) y lipocalina-2 (r = 0,346, p = 0,003). Conclusiones: este estudio demuestra que la betatrofina en suero desempeña una importante labor en el síndrome metabólico, implicando la regulación del metabolismo de la glucosa y los lípidos y la inflamación.
- Published
- 2016
11. Is national socioeconomic status related to prevalence of irritable bowel syndrome?
- Author
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Jin-Zhou, Zhu, Tian-Lian, Yan, Chao-Hui, Yu, Xing-Yong, Wan, Yu-Ming, Wang, and You-Ming, Li
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Adult ,Irritable Bowel Syndrome ,Male ,China ,Sex Factors ,Social Class ,Age Factors ,Linear Models ,Prevalence ,Humans ,Female ,Middle Aged ,Databases, Bibliographic - Abstract
There are a multitude of cross-sectional surveys that provide the prevalence of irritable bowel syndrome (IBS) in the community. However, the data regarding the influence of socioeconomic status on prevalence of IBS were sparse. This study is to investigate the possible relation between human development and prevalence of IBS, at national level.EMBASE Classic, EMBASE, and MEDLINE were searched (until October 2013) to identify population-based studies that reported prevalence of IBS. Human Development Index (HDI) was chosen to assess socioeconomic status at national level.Firstly, no correlation was observed between prevalence of IBS and national HDI (P = 0.848). Specifically, there was no statistical significance in prevalence between developing and developed countries (P = 0.319). Moreover, prevalence of IBS failed to witness a downtrend in worldwide over the past two decades. Interestingly, the ratio of female/male prevalence was correlated with national HDI according to linear regression analysis (r = 0.395), and the ratio in the developing was significant lower than that in the developed (P = 0.0394). Lastly, except methods of data collection (P0.000), it shows no difference between developing and developed countries in diagnostic criteria, IBS subtypes, and age distribution (P = 0.119, 0.327, and 0.845 respectively).This study is the first time to investigate the relation between IBS prevalence and national socioeconomic status, with consideration of years, gender, and other factors. It demonstrates that national development is not a direct indicator for prevalence of IBS.
- Published
- 2014
12. Increased serum level of CTRP1 is associated with low coronary collateralization in stable angina patients with chronic total occlusion
- Author
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Rui Yan Zhang, Qi Zhang, Weifeng Shen, Lin Lu, Ying Shen, Feng Wu, Qiu Jing Chen, Zong Gui Wu, Zhu Hui Liu, Jian Hu, Zhen Sun, and Jin Zhou Zhu
- Subjects
Aortic valve disease ,Male ,medicine.medical_specialty ,Collateral Circulation ,Autopsy ,Total occlusion ,Stable angina ,Coronary artery disease ,Bicuspid aortic valve ,Internal medicine ,medicine ,Humans ,Angina, Stable ,Aged ,medicine.diagnostic_test ,business.industry ,Proteins ,Magnetic resonance imaging ,Middle Aged ,medicine.disease ,Coronary Vessels ,Stenosis ,Cross-Sectional Studies ,Coronary Occlusion ,Chronic Disease ,cardiovascular system ,Cardiology ,Female ,Cardiology and Cardiovascular Medicine ,business - Abstract
aortic valve disease: classification by cardiovascular magnetic resonance. Heart 2010;96:1233–40. [8] Roberts WC. The congenitally bicuspid aortic valve: a study of 85 autopsy cases. Am J Cardiol 1970;26(1):72–83. [9] Fedak PW, Verma S, David TE, Leask RL, Weisel RD, Butany J. Clinical and pathophysiological implications of a bicuspid aortic valve. Circulation 2002;106(8):900–4. [10] Robicsek F, Thubrikar MJ, Cook JW, Fowler B. The congenitally bicuspid aortic valve: how does it function? Why does it fail? Ann Thorac Surg 2004;77:177–85. [11] Thanassoulis G, Campbell CY, Owens DS, et al. Genetic associations with valvular calcification and aortic stenosis. N Engl J Med 2013;368:503–12.
- Published
- 2014
13. Safety and efficacy of polymer-free paclitaxel-eluting microporous stent in real-world practice: 1-year follow-up of the SERY-I registry
- Author
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Rui-Yan, Zhang, Qi, Zhang, Jin-Zhou, Zhu, Liang-Long, Chen, Chen-Yun, Zhang, Xu-Chen, Zhou, Yong, Yuan, Zhi-Xiong, Zhong, Lang, Li, Jian, Qiu, Wei, Wang, Xi-Ming, Chen, Zhi-Jian, Yang, Jin-Chuan, Yan, Shao-Liang, Chen, Yu-Qing, Hou, Yan-Qing, Wu, Hai-Ming, Luo, Jian-Ping, Qiu, Li, Zhu, Yan, Wang, Guo-Sheng, Fu, Jian-An, Wang, Kang-Hua, Ma, Yue-Hui, Yin, Dai-Fu, Zhang, Xue-Song, Hu, Guo-Ying, Zhu, and Wei-Feng, Shen
- Subjects
Paclitaxel ,Humans ,Drug-Eluting Stents ,Angioplasty, Balloon, Coronary - Published
- 2012
14. Serum betatrophin level increased in subjects with metabolic syndrome: a case-control study.
- Author
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Jin-Zhou Zhu, Chun-Xiao Li, Yi-Ning Dai, Zhi-Yun Fang, Xing-Yong Wan, Hua-Tuo Zhu, Yu-Ming Wang, Chao-Hui Yu, You-Ming Li, and De-Jian Zhao
- Subjects
- *
METABOLIC syndrome , *ADIPOKINES , *ANGIOPOIETIN-like proteins , *ENZYME-linked immunosorbent assay , *RECEIVER operating characteristic curves , *REGRESSION analysis - Abstract
Background: Betatrophin is a novel adipokine that provokes pancreatic β-cell proliferation and is involved in lipid metabolism. Aims: This study aims to evaluate the role of serum betatrophin in metabolic syndrome (MetS). Methods: A hospital-based, age-/gender-matched case control study was conducted. The serum betatrophin level was evaluated by enzyme- linked immunosorbent assay. Serum concentrations of 12 adipokines were measured to assess their associations with serum betatrophin, using commercial Adipokine Magnetic Bead Panel kits. Statistical analyses included bivariate correlation, receiver operating characteristic (ROC) curve, and multivariate stepwise linear regression. Results: Serum betatrophin showed a higher level in MetS patients (997.36 ± 475.92 pg/ml, p = 0.001) compared with controls (735.35 ± 526.51 pg/ml). Compared with the lowest tertile, the highest tertile of serum betatrophin level indicated an association with higher risk of MetS (adjusted odds ratio = 3.521, 95% confidence interval [CI] [1.191-10.413], p = 0.023). ROC curve of betatrophin was developed to predict the presence of MetS (area under ROC = 0.682 [95% CI, 0.597-0.767], p < 0.001). Furthermore, betatrophin correlated with several parameters, e.g. age (r = 0.286, p < 0.001), body mass index (r = 0.160, p = 0.046), waist-to-hip ratio (r = 0.241, p = 0.002), high-density lipoprotein cholesterol (r = -0.167, p = 0.037), low-density lipoprotein cholesterol (r = -0.195, p = 0.015), fasting plasma glucose (r = 0.266, p = 0.001), hemoglobin A1C (r = 0.314, p < 0.001), homeostasis model assessment of insulin resistance (r = 0.272, p = 0.001), and various adipokines, e.g. resistin (r = 0.571, p < 0.001), interleukin-8 (r = 0.435, p < 0.001), tumor necrosis factor-α (r = 0.295, p = 0.011) and lipocalin-2 (r = 0.346, p = 0.003). Conclusions: This study supports that serum betatrophin plays an important role in MetS, involving the regulations of glucose and lipid metabolism and inflammation. [ABSTRACT FROM AUTHOR]
- Published
- 2016
15. Betatrophin provides a new insight into diabetes treatment and lipid metabolism (Review).
- Author
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JIN-ZHOU ZHU, CHAO-HUI YU, and YOU-MING LI
- Subjects
- *
TREATMENT of diabetes , *PANCREATIC beta cells , *PEPTIDE hormones , *LIPID metabolism , *CELL proliferation - Abstract
Replenishing the insulin-producing β-cell mass is considered to be a potential cure for diabetes. A recent study identified a secreted protein, known as betatrophin, which potently induces pancreatic β-cell proliferation. Notably, a number of studies reportedly identified betatrophin, which is also known as lipasin, atypical angiopoietin-like 8 and refeeding-induced fat and liver protein, and considered to be a novel regulator in lipid metabolism according to the studies. The identification of betatrophin was considered to create novel opportunities for potential diabetes therapy. In the present study, the current knowledge of betatrophin is reviewed, with regards to its character and function in lipid homeostasis and pancreatic β-cell proliferation. [ABSTRACT FROM AUTHOR]
- Published
- 2014
- Full Text
- View/download PDF
16. Clinical guidelines of non-alcoholic fatty liver disease: A systematic review.
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Zhu JZ, Hollis-Hansen K, Wan XY, Fei SJ, Pang XL, Meng FD, Yu CH, and Li YM
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- Algorithms, Evidence-Based Medicine, Gastroenterology methods, Gastroenterology standards, Humans, International Cooperation, Treatment Outcome, Non-alcoholic Fatty Liver Disease therapy, Practice Guidelines as Topic
- Abstract
Aim: To perform a systematic review to grade guidelines and present recommendations for clinical management of non-alcoholic fatty liver disease (NAFLD)., Methods: A database search was conducted on PubMed for guidelines published before May 2016, supplemented by reviewing relevant websites. The Appraisal of Guidelines for Research and Evaluation (ARGEE) Instrument II was a tool designed to appraise the methodological rigor and transparency in which a clinical guideline is developed and it is used internationally. It was used to appraise the quality of guidelines in this study. The inclusion criteria include: clinical NAFLD guidelines for adults, published in English, and released by governmental agencies or key organizations., Results: Eleven guidelines were included in this study. Since 2007, guidelines have been released in Asia (3 in China, 1 in South Korea, and 1 in Japan), Europe (1 in Italy), America (1 in United States and 1 in Chile) and three international agencies [European associations joint, Asia-Pacific Working Party and World Gastroenterology Organization (WGO)]. Using the ARGEE II instrument, we found US 2012 and Europe 2016 had the highest scores, especially in the areas of rigor of development and applicability. Additionally, Italy 2010 and Korea 2013 also presented comprehensive content, rigorous procedures and good applicability. And WGO 2014 offered various algorithms for clinical practice. Lastly, a practical algorithm for the clinical management was developed, based on the recommended guidelines., Conclusion: This is the first systematic review of NAFLD guidelines. It may yield insights for physicians and policy-makers in the development and application of guidelines., Competing Interests: Conflict-of-interest statement: All authors have no conflict of interest related to the manuscript.
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- 2016
- Full Text
- View/download PDF
17. Prevalence of fatty liver disease and the economy in China: A systematic review.
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Zhu JZ, Zhou QY, Wang YM, Dai YN, Zhu J, Yu CH, and Li YM
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- Adolescent, Adult, Aged, China epidemiology, Female, Humans, Linear Models, Male, Middle Aged, Non-alcoholic Fatty Liver Disease diagnosis, Prevalence, Residence Characteristics, Risk Factors, Sex Distribution, Sex Factors, Young Adult, Gross Domestic Product, Non-alcoholic Fatty Liver Disease economics, Non-alcoholic Fatty Liver Disease epidemiology, Socioeconomic Factors
- Abstract
Aim: To investigate the relationship between the economy and the adult prevalence of fatty liver disease (FLD) in mainland China., Methods: Literature searches on the PubMed and Chinese National Knowledge Infrastructure databases were performed to identify eligible studies published before July 2014. Records were limited to cross-sectional surveys or baseline surveys of longitudinal studies that reported the adult prevalence of FLD and recruited subjects from the general population or community. The gross domestic product (GDP) per capita was chosen to assess the economic status. Multiple linear regression and Loess regression were chosen to fit the data and calculate the 95%CIs. Fitting and overfitting of the models were considered in choosing the appropriate models., Results: There were 27 population-based surveys from 26 articles included in this study. The pooled mean prevalence of FLD in China was 16.73% (95%CI: 13.92%-19.53%). The prevalence of FLD was correlated with the GDP per capita and survey years in the country (adjusted R (2) = 0.8736, P GDP per capita = 0.00426, P years = 0.0000394), as well as in coastal areas (R (2) = 0.9196, P GDP per capita = 0.00241, P years = 0.00281). Furthermore, males [19.28% (95%CI: 15.68%-22.88%)] presented a higher prevalence than females [14.1% (95%CI: 11.42%-16.61%), P = 0.0071], especially in coastal areas [21.82 (95%CI: 17.94%-25.71%) vs 17.01% (95%CI: 14.30%-19.89%), P = 0.0157]. Finally, the prevalence was predicted to reach 20.21% in 2020, increasing at a rate of 0.594% per year., Conclusion: This study reveals a correlation between the economy and the prevalence of FLD in mainland China.
- Published
- 2015
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