Search

Remote sensing wave observation data are crucial when analyzing ocean waves, the main external force of coastal disasters. Nevertheless, it has limitations in accuracy when used in low-wind environments. Therefore, this study collected the raw data from MIROS Wave and Current Radar (MWR) and wave radar at the Ieodo Ocean Research Station (IORS) and applied the optimal filter by combining filters provided by MIROS software. The data were validated by a comparison with South Jeju ocean buoy data. The results showed it maintained accuracy for significant wave height, but errors were observed in significant wave periods and extreme waves. Hence, this study used an artificial neural network (ANN) to improve these errors. The ANN was generalized by separating the data into training and test datasets through stratified sampling, and the optimal model structure was derived by adjusting the hyperparameters. The application of ANN effectively improved the accuracy in significant wave periods and high wave conditions. Consequently, this study reproduced past wave data by enhancing the reliability of the MWR, contributing to understanding wave generation and propagation in storm conditions, and improving the accuracy of wave prediction. On the other hand, errors persisted under high wave conditions because of wave shadow effects, necessitating more data collection and future research.

Abstract The interaction between the microbial environment and the host is important for immune homeostasis. Recent research suggests that microbiota dysbiosis can be involved in respiratory diseases. Emphysema is a chronic inflammatory disease, but it is unclear whether dysbiosis caused by antibiotics can affect disease progression. Here, we tried to elucidate the effect of systemic antibiotics on smoking-exposed emphysema models. In this study, the antibiotic mixture caused more alveolar destruction and airspace expansion in the smoking group than in the smoking only or control groups. This emphysema aggravation as a result of antibiotic exposure was associated with increased levels of inflammatory cells, IL-6, IFNγ and protein concentrations in bronchoalveolar lavage fluid. Proteomics analysis indicated that autophagy could be involved in antibiotic-associated emphysema aggravation, and increased protein levels of LC3B, atg3, and atg7 were identified by Western blotting. In microbiome and metabolome analyses, the composition of the gut microbiota was different with smoking and antibiotic exposure, and the levels of short-chain fatty acids (SCFAs), including acetate and propionate, were reduced by antibiotic exposure. SCFA administration restored emphysema development with reduced inflammatory cells, IL-6, and IFNγ and decreased LC3B, atg3, and atg7 levels. In conclusion, antibiotics can aggravate emphysema, and inflammation and autophagy may be associated with this aggravation. This study provides important insight into the systemic impact of microbial dysbiosis and the therapeutic potential of utilizing the gut microbiota in emphysema.

This study investigates the variability of coastal currents off the east coast of Korea, specifically in the Wangdolcho area of the East/Japan Sea, from June 2021 to October 2022. The observations revealed significant fluctuations in depth-averaged current velocity, with a peak of 0.81 m/s in August 2021 and a minimum of −0.05 m/s in August 2022. These year-to-year variations highlight the complex dynamics of coastal currents influenced by regional wind patterns and mesoscale eddies. In the summer of 2021, the development of offshore eddies, coupled with variable alongshore wind stress, led to increased current velocities and alternating upwelling and downwelling conditions, resulting in abrupt changes in current intensity. Conversely, in the summer of 2022, the negative vorticity in the Korea Strait and negative wind stress curl along the coast likely caused the East Korean Warm Current to shift further offshore, resulting in a weakened southward flow along the coast. This study emphasizes the need for long-term monitoring to better understand the coastal current dynamics and their environmental impacts. The anticipated completion of the Wangdolcho Ocean Research Station is expected to greatly improve monitoring capabilities, providing continuous and comprehensive data that will enhance our understanding of coastal currents and their broader impacts on the marine environment.

Abstract Due to the cold water temperatures, the East China Sea (ECS) is usually unfavorable for typhoon development. Recently, in a rare event, Typhoon Bavi (2020) reached major typhoon status and became the strongest typhoon in the ECS in the past decade. Based on in situ observations and model simulations, we discover that this typhoon is fueled by a marine heatwave, which creates a very warm ocean condition with sea surface temperature (SST) exceeding 30 °C. Also, because of suppressed typhoon-induced SST cooling caused by the shallow water depth (41 m) and strong salinity stratification (river runoff) within the ECS, the SST beneath the typhoon remains relatively high and enhances the total heat flux for the typhoon. More interestingly, due to the fair weather ahead of the typhoon, we find that the rapid development of this marine heatwave is likely, in part, attributed to the typhoon itself. As the risks from typhoons and marine heatwaves are heightening under climate change, this study provides important insights into the interaction between typhoons and marine heatwaves.

Abstract The Yellow Sea is one of the world’s most abundant marine resources, providing food and economic benefits to the Korean and Chinese populations. In spring 2020, a decrease in the intensity of phytoplankton bloom was observed. While one study attributed this decline to a decrease in nutrient associated with the COVID-19 pandemic, our previous research proposed weakened thermal stratification accompanied by a surface cooling anomaly as the cause. However, the relationship between the marine environment and ecosystem has not been fully elucidated. Using observations and marine physical-biogeochemical model data, we identified the weakened stratification as a critical factor for suppressing the 2020 spring bloom. Intense vertical mixing hindered the accumulation of nutrient and chlorophyll-a concentrations within the euphotic zone, resulting in a diminished phytoplankton bloom. In contrast, reduced nitrate and phosphate concentrations in 2020 were insignificant compared to those in 2017–2019, despite the notable decline in PM2.5 in March 2020 due to COVID-19. In April 2020, nutrient levels fell within the range of interannual variability based on long-term observations, reflecting a negligible effect on the spring phytoplankton bloom. Our findings provide insight into the importance of marine physical factors on the phytoplankton biomass in the Yellow Sea.

Abstract Transdiaphragmatic intercostal hernia is a rare disease. It is usually caused by trauma and is rarely caused by coughing. Although a few cases of intercostal hernia induced by coughing have been reported, our case of a non traumatic acquired acute transdiaphragmatic intercostal and abdominal hernia induced by coughing is very rare. A 77-year-old woman presented with sudden-onset left lower chest pain after an episode of violent coughing. She had risk factors for intercostal hernia, including obesity, chronic obstructive pulmonary disease, oral steroid use, and diabetes mellitus. Computed tomography showed herniation of the lung and intra-abdominal organs into the thoracic and abdominal wall through a ruptured diaphragm, as well as the intercostal and abdominal muscles. Surgery was completed with interrupted sutures to close the defects after the reduction of the herniated organs. Our experience suggests that careful examinations, including the assessment of risk factors and computed tomography imaging, were essential for establishing an accurate diagnosis, and that the repair of a ruptured diaphragm with simple interrupted sutures without any prosthetic materials seems to be feasible in selected patients with a transdiaphragmatic intercostal hernia.

IntroductionConventional postoperative pain management using an intravenous (IV) patient-controlled approach or thoracic epidural analgesia is suboptimal following minimally invasive repair of the pectus excavatum (MIRPE). Recently, cryoanalgesia has gained popularity owing to its superior pain control outcomes compared to those associated with conventional methods. However, because of its invasiveness, additional instrumentation requirement, and limited effect at early postoperative periods, we hypothesized that serratus anterior plane block (SAPB) could be an effective method for post-repair pain management and a possibly superior alternative.MethodsWe conducted a retrospective cohort study of pediatric patients who had undergone MIRPE between March 2022 and August 2023. We compared the efficacy of pain control in three groups among 74 patients: Group N (conventional pain management, n = 24), Group C (cryoanalgesia, n = 24), and Group S (SAPB, n = 26). Group N received IV patient-controlled analgesia (PCA) and a subcutaneous local anesthetic infusion. Group C received bilateral cryoanalgesia on the fourth and seventh intercostal nerves using a cryoprobe at −80°C for 2 min during the operation and IV-PCA postoperatively. Group S received continuous bilateral SAPB with 0.25% ropivacaine and IV-PCA. The pain levels were measured using the visual analog scale (VAS; resting and dynamic), and the total IV rescue analgesic consumption was determined.ResultsThe three groups had similar baseline characteristics. Group S showed significantly less pain throughout the immediate postoperative course, resting VAS score at 3 h (Group N, 7.21 vs. Group C, 5.75 vs. Group S, 3.81; p

Abstract Although 2020 was the fourth warmest year on record in northern Asia, the cold condition in April 2020 caused severe damage to the agricultural and marine ecosystems in northeastern Asia. Previous studies have indicated that the dipole atmospheric circulation over Siberia and the East Sea (Japan Sea) produced this cold environment with strong northwesterly wind. However, the potential causes of the dipole circulation over northeastern Asia remain unclear. In this study, we found that the East Atlantic/Western Russia (EAWR) pattern and blocking combined to produce the atmospheric structure. The wave train originated from the vorticity forcing of northwestern/central Russia and propagated from Western Europe to the East Sea via the background westerly and northerly winds. In addition, the Siberian blocking days increased eleven times in April 2020 relative to the climatological average, and an easterly (westerly) anomaly was observed over Mongolia–northeastern China (northern Russia). The strong blocking and EAWR pattern led to the robust atmospheric dipole structure with a prevailing northerly flow in April 2020, thereby causing the extreme cold condition over northeastern Asia. Our results provide novel insights into the cause of extreme cold condition in April over northeastern Asia.

Abstract Thoracic sympathetic nerve block (TSNB) has been widely used in the treatment of neuropathic pain. To reduce block failure rates, TSNB is assisted with several modalities including fluoroscopy, computed tomography, and ultrasonography. The present study describes our experience assessing the usefulness of thoracoscopy in TSNB for predicting compensatory hyperhidrosis before sympathectomy in primary hyperhidrosis. From September 2013 to October 2021, TSNB was performed under local anesthesia using a 2-mm thoracoscope in 302 patients with severe primary hyperhidrosis. Among the 302 patients, 294 were included for analysis. The target level of TSNB was T3 in almost all patients. The mean procedure time was 21 min. Following TSNB, the mean temperature of the left and right palms significantly changed from 31.5 to 35.3 °C and from 31.5 to 34.8 °C, respectively. With TSNB, primary hyperhidrosis was relieved in all patients. Pneumothorax occurred in six patients, in which no chest tube insertion was required. One patient developed hemothorax and was discharged the next day after small-bore catheter drainage. Transient ptosis developed in 10 patients and improved within a day in all patients. Our experiences showed that thoracoscopic TSNB is accurate, safe, and feasible to block the thoracic sympathetic nerve in patients with severe primary hyperhidrosis.

Abstract The breasts in women pectus excavatum patients frequently appear to be slanting medially along the inclination of the distorted ribs. This study aims to evaluate changes in the distance between the nipples and to find out whether medially slanting breasts are corrected in women pectus excavatum patients following modified Nuss procedure. This case series analysis enrolled 22 young women patients with pectus excavatum between October 2011 and September 2020. We measured all the patients’ distances from the sternal midline to the right and left nipples, based on chest computerized tomography. We calculated the distances between nipples as being the sum of the right and left distances. The mean age of patients was 16.50 ± 4.73 years, and the follow-up periods were 35.59 ± 20.23 months. The postoperative Haller indices (2.89 ± 0.43) were significantly lower than the preoperative Haller indices (5.14 ± 1.96) (p = 0.000). The distances between the nipples before and after Nuss procedure were 145.17 ± 17.73 mm and 172.29 ± 19.11 mm, which is a significant increase following surgery. (p = 0.000). Our results demonstrated that skeletal correction with modified Nuss procedure in pectus excavatum increased the distance between nipples, indicating that medially slanting breasts had been corrected.

ObjectivePatients with primary spontaneous pneumothorax (PSP) tend to be young, tall, and thin, as do those with pectus excavatum (PE). Notably, the Haller index, which measures the severity of PE, tends also to be higher in patients with PSP, further suggesting a potential predisposing factor for the development of PSP in individuals with PE. This study aimed to share clinical experiences with case series of concomitant PSP and PE and to emphasize the importance of evaluating these two conditions together.MethodsIn this single-center study, we conducted a retrospective records review to identify patients who were diagnosed and treated (including surgical or conservative treatment and follow-up observation) for the diagnosis of PE between July 2011 and February 2023. From these, we selected patients who were diagnosed with both PE and PSP and analyzed their clinical presentations.ResultsAmong a total of 139 patients with PE, there were 8 (5.76%) who had concurrent diagnoses of PE and PSP and who underwent surgery for PSP, PE, or both. The average age of these 8 patients (male:female = 7:1) was 19.38 years. The 8 patients were grouped into four categories based on their clinical scenarios. Group A had 1 patient with PE diagnosed first, followed by the discovery of PSP during evaluation; Group B included 2 patients initially presenting with PSP and subsequently diagnosed with PE during evaluation; Group C consisted of 1 patient who had PSP before undergoing surgical PE correction; and Group D comprised 4 patients who developed PSP after PE correction.ConclusionsThe incidence of PSP in patients with PE was 5.76% (8 out of 139 patients), indicating the importance of vigilant monitoring for PSP prior to PE surgery, and vice versa. Furthermore, the authors recommend close observation for PSP independent of PE surgery, even in the absence of postoperative complications.

The East Asian region is typically characterized by warm and humid conditions from late spring to summer. However, in recent decades, this region has experienced an increase in severe drying conditions, deviating from historical climatological patterns. This study investigated the precipitation − evaporation ( P − E ) trends across land and sea regions in East Asia (EA) during the extended summer season (April–September) from 1980 to 2022, and the key physical processes driving these trends through moisture budget decomposition and numerical experiments. The results reveal pronounced drying trends in southeastern China and the Yellow Sea and parts of the Korea Strait and Korean Peninsula over the past 43 years. The underlying physical processes driving these drying conditions differ between land and sea in EA. In southeastern China, the drying is driven by dynamic processes, particularly moisture divergence related to wind changes. This is linked to anomalous strengthening of descending motion due to the Indo-Pacific warm pool warming induced by both anthropogenic global warming and natural Pacific Decadal Oscillation-like sea surface temperature (SST) patterns. Conversely, drying in the Yellow Sea and adjacent areas is influenced by thermodynamic moisture advection. The altered humidity distribution due to global warming-induced SST patterns, which are higher over the Northwest Pacific marginal sea and lower in inland China, drives dry air transport from inland China to the Yellow Sea via background southwesterly wind. These findings enhance our understanding of the drying trend and their distinct processes in EA’s land and sea areas during the extended summer.

Abstract Primary spontaneous pneumothorax usually occurs in tall and thin young people without an underlying disease or traumatic history. Most patients with pectus excavatum have similar body shapes as patients with pneumothorax. Haller indices of the patients with pneumothorax and pectus excavatum are higher than normal. Pectus excavatum may be a predisposing factor for the development of primary pneumothorax. The Nuss procedure involves inserting a metal bar through the substernal space to correct the pectus excavatum, resulting in a buffalo chest in which both pleural cavities communicate with each other. Therefore, if pneumothorax occurs after the Nuss procedure, it can occur bilaterally. Recently, we encountered a life-threatening case of bilateral tension pneumothoraxes after the Nuss procedure for pectus excavatum, which were not related to surgical complications.

Background/Aims: The objective of this study was to determine the more appropriate wound-closure method by comparing the effectiveness of two methods in a group of patients who underwent ileostomy repair. Methods: The study conducted after obtaining the approval of the Institutional Review Board (IRB) included 58 patients ≥19 years of age who underwent ileostomy at the Department of Surgery at the Presbyterian Medical Center. This was a retrospective, single-center trial. Patients who underwent ileostomy closure between January 2011 and September 2017 were assigned to the primary wound-closure (PC, n=25) group and the purse-string wound-closure (PSC, n=33) group. Post-repair complications, such as wound infection, delayed healing, and patient satisfaction related to wound management, were investigated and compared according to the wound-closure method. Results: The PSC group had a significantly lower surgical site infection rate than the PC group (0% vs. 44%, p30 days was not significantly different (39% vs. 20%, p=0.114). In addition, there were no significant differences in the response to questionnaires on patient satisfaction between the two groups. Conclusions: PSC has a lower surgical site infection rate and the wound-healing delay was not very different from that of PC. Therefore, if patients are at risk of wound infection, such as in severe wound contamination, long operating time, and immunocompromised conditions, we should consider PSC as a wound closure method of choice.

Abstract Cardiothoracic surgery usually causes tissue adhesion on the operation site which increases the risk of complications in the subsequent thoracic surgery including Nuss procedure. Disorders that require cardiothoracic surgery include chest wall deformities such as pectus excavatum, congenital heart diseases, lung diseases such as congenital cystic adenomatiod malformation and bronchopulmonary dysplasia, and congenital diaphragmatic hernia. Recently, we encountered a rare case of combined pectus excavatum and carinatum in a patient with a history of congenital esophageal atresia repair surgery. Commendably, despite tissue adhesion from the previous surgery, a modified Nuss procedure was performed successfully with no complications. We agree that the Nuss procedure is feasible for thoracic deformities in patients with a surgical history of cardiothoracic surgery.

Hourly (2017–2021) to seasonal (2015–2021) inorganic C data were collected at the Ieodo Ocean Research Station (32.07°N and 125.10°E) in the northern East China Sea (ECS), located under the influence of the nutrient-rich Changjiang Diluted Water (CDW). An increase in phytoplankton biomass from April to mid-August (the warming period) equalized much of the temperature-driven increase in the surface pCO2 and thus, made the northern ECS a moderate sink of atmospheric CO2. From November to March (the cooling period), a large pCO2 reduction, driven by a temperature reduction, and a high air–sea CO2 exchange rate, because of high windspeeds, transformed the basin into a substantial CO2 sink, yielding an annual net C uptake of 61.7 g C m–2 yr–1. The effects of biological production and temperature change on seawater pCO2 (and thus, the net air–sea CO2 flux) were decoupled each season and acted in concert to increase the net annual CO2 sink by the region. The present study provided the observational and mechanistic lines of evidence for confirming “continental shelf C pump”—a mechanism in the shallow waters of the continental shelves that accumulate a significant amount of C (via reinforced cooling and promoted biological C uptake) that is transported from the basin surface waters to the interior of the adjacent deep ocean. In the future, an increasing input of anthropogenic nutrients into the northern ECS is likely to make the region a stronger CO2 sink.

Unprecedented retardation of spring water temperature rising during the 2020 pandemic year was identified in the Socheongcho Ocean Research Station within the northeastern basin of the Yellow Sea: an exceptionally high water temperature anomaly in March and a contrasted low-temperature anomaly in May. The slowest temperature evolution was principally caused by the significant increase in latent heat releases in April (117% higher than the climatology of 1982–2019). Strong northwesterly winds generated these exceptional heat fluxes associated with the dipole-like atmospheric circulation pattern over Siberia and the East Sea (Japan Sea). Besides, warm winter water facilitated the enhanced release of latent heat fluxes as a precondition. The oceanic heat redistribution partially supported the cold anomaly in the surface layer up to the middle of May through positive feedback between the low surface temperature and the active entrainment associated with tidal turbulent mixing. The resultant low temperature at the surface weakened the vertical stratification, both impeding the activation of phytoplankton’s photosynthesis albeit under the eutrophic surface layer, consequently resulting in the delayed and suppressed spring bloom during 2020. Since such extreme events are anticipated to occur more frequently under global warming, our results highlight the importance of continuously monitoring multi-disciplinary environmental conditions, climate extremes, and their impact on the Yellow Sea marine ecosystem.

In 2022, record-breaking long-lasting marine heatwaves (MHWs) occurred in the East China Sea (ECS), which persisted for 62 d during boreal summer. This exceeded the average MHWs duration of 10 d by a factor of 6. In addition, 2022 was also recorded as a year of many extreme events throughout Asia, such as summer floods in China and Pakistan, droughts and extreme heat in Europe, raising the question of whether they were caused by a ‘triple-dip’ La Niña, which has persisted since September 2020. Here we examine the key local and remote processes that led to the 2022 MHWs in the ECS using mixed-layer heat budget analysis. During the onset of the MHWs, a salinity-stratified shallow mixed-layer due to the large river discharge from the Yangtze–Huaihe River floods in June created favorable conditions for warm ocean temperature in the ECS. Simultaneously, an anomalous anticyclone maintained by the stationary Rossby wave, which is generated by vorticity forcings in mid-latitudes and thermal forcing in Pakistan, settled in the corresponding region and led to the long-lasting MHWs until Typhoon Hinnamnor began to dissipate the wave in early September. This study improves our understanding of the physical mechanism of flood-related MHWs that have increased with recent climate change.

Background: Recently, the duodenum has garnered interest for its role in treating metabolic diseases, including type 2 diabetes (T2DM). Multiple sessions of external photobiomodulation (PBM) in previous animal studies suggested it resulted in improved hyperglycemia, glucose intolerance, and insulin resistance with a multifactorial mechanism of action, despite the target organ of PBM not being clearly proven. This study aimed to determine whether a single session of a duodenal light-emitting diode (LED) PBM may impact the T2DM treatment in an animal model. Methods: Goto–Kakizaki rats as T2DM models were subjected to PBM through duodenal lumen irradiation, sham procedure, or control in 1-week pilot (630 nm, 850 nm, or 630/850 nm) and 4-week follow-up (630 nm or 630/850 nm) studies. Oral glucose tolerance tests; serum glucagon-like peptide 1 (GLP-1), glucose-dependent insulinotropic polypeptide, and insulin levels; liver chemistry and histology; and gut microbiome in the PBM, sham control, and control groups were evaluated. Results: In the 1-week study, duodenal dual-wavelength (D, 630/850 nm) LED PBM showed improved glucose intolerance, alkaline phosphatase and cholesterol levels, and weight gain than other groups. The D-LED PBM group in the 4-week study also showed improved hyperglycemia and liver enzyme levels, with relatively preserved pancreatic islets and increased serum insulin and GLP-1 levels. Five genera (Bacteroides, Escherichia, Parabacteroides, Allobaculum, and Faecalibaculum) were significantly enriched 1 week after the D-LED PBM. Bacteroides acidifaciens significantly increased, while Lachnospiraceae significantly decreased after 1 week. Conclusion: A single session of D-LED PBM improved hyperglycemia and hepatic parameters through the change of serum insulin, insulin resistance, insulin expression in the pancreatic β-cells, and gut microbiome in T2DM animal models.

Many countries worldwide promote artificial reef projects to increase and preserve fishery resources; however, how artificial reefs form fisheries is unclear. Nevertheless, specific hydraulic features of artificial reefs may attract fish. We selected an underwater reef as a research site to clarify this hypothesis. In this study, environmental conditions around the underwater reef were modeled and quantitatively assessed using numerical analysis. We identified two hydraulic features related to fish attraction: the wake region and the local upwelling region. Their spatial distributions were superimposed on the path of a fishing vessel that was monitored using an automatic identification system (AIS). We showed that various hydraulic characteristics (such as wake region, local upwelling region, and flow velocity) identified in the path of the fishing vessel can be quantitatively evaluated. Increasing amounts of information from the AIS can be used to identify the hydraulic features that attract the most fish and therefore improve the productivities of artificial reefs.

For open ocean environments, it is rare to find continuous, simultaneous air and sea observation records due to the challenges of instrument installation and maintenance. The Ieodo Ocean Research Station (Ieodo ORS), a remote ocean site located in the northern East China Sea with its harsh oceanic and atmospheric environment, provides a platform for the concurrent monitoring of air and sea environments. Since 2014, the Korea Hydrographic and Oceanographic Agency has run the “Ieodo ORS field trip program,” via which researchers are able to stay at the station for a week or more. This work reports technical lessons learned over 5 years from five Ieodo ORS research projects launched in 2016. Over the course of these projects, Ieodo ORS has monitored sea surface temperature, temperature and salinity in the water column, seawater pH, air pollutants, and solar radiation. The purpose of this paper is to facilitate the success of future research activities in similar environments by sharing our experiences and “best practices.”

Abstract Metastatic hepatocellular carcinoma of the sternum is rare and a few cases of surgical resection have been reported. Anterior chest wall reconstruction after radical resection of the sternum and ribs aims to protect the heart and lung from external damage and herniation and restore physiologic stability of the chest wall during respiration. A variety of reconstruction techniques using various materials have been reported, but so far there are no definitive guidelines for the reconstruction of chest wall defects. Recently, we encountered a rare case of metastatic cancer of the sternum from hepatocellular carcinoma in which radical resection of the sternum and ribs, and anterior chest wall reconstruction with acellular dermal matrix and titanium plates were performed.

Background/Aims Methicillin-resistant Staphylococcus aureus bacteremia (MRSAB) is a major bloodstream infection with a high mortality rate. Identification of factors associated with early mortality in MRSAB patients would be useful for predicting prognosis and developing new therapeutic options. Methods A prospective cohort of MRSAB patients was examined between August 2008 and June 2011. Early and late mortality was defined as death within 2 and 28 days of blood culture, respectively. The clinical and microbiological characteristics in the early and late mortality and survival groups were compared. Risk factors associated with severe sepsis or septic shock were also investigated. Results A total of 385 adult MRSAB patients whose S. aureus isolates were available were enrolled; of these patients, 25 patients (6.5%) and 50 (13%) died early and late, respectively. Compared with both the late-mortality group and the survival group, severe sepsis or septic shock was a statistically significant independent risk factor associated with early mortality. Rapidly or ultimately fatal McCabe and Jackson classification (adjusted odds ratio [aOR], 1.94; 95% confidence interval [CI], 1.25 to 3.02) and pneumonia (aOR, 2.04; 95% CI, 1.03 to 4.02) were independently associated with severe sepsis or septic shock. A vancomycin minimum inhibitory concentration (MIC) ≥ 1.5 μg/mL was associated with a reduced incidence of severe sepsis or septic shock (aOR, 0.53; 95% CI, 0.34 to 0.84). Conclusions Severity of illness seems to be the most important risk factor associated with early mortality in MRSAB. Although vancomycin MIC was not independently associated with early mortality, reduced vancomycin susceptibility appears to be linked to reduced disease severity.

We experienced a case of 1 patient who died from rhabdomyolysis-related complications after colonoscopy. A 60-year-old man had undergone an ‘uncomplicated’ colonoscopic polypectomy. Approximately 10 hours following this procedure, the patient complained of increasing left abdominal pain. His computed tomography image showed free gas, but his operative findings revealed no macroscopic perforation or abscess formation. Eight hours after the operation, the patient presented with myoglobulinuria, and we diagnosed the condition to be rhabdomyolysis. Based on this case, we recommend that rhabdomyolysis be added to the list of complications following a colonoscopic procedure. Moreover, for prevention and early treatment, endoscopists should be attentive to the risk factors and signs/symptoms of rhabdomyolysis.

Background: Increased prevalence of antibiotic resistance to Helicobacter pylori (H. pylori) infection worldwide has driven the search for a new therapeutic candidate. Recently, sitafloxacin, a novel 4-quinolone agent, has emerged as a new therapeutic option for H. pylori eradication, in Japan. However, data on its efficacy for H. pylori eradication in Korea are limited. Therefore, we aimed to investigate the therapeutic potential of sitafloxacin as a first-line treatment for patients with Helicobacter infection through gastric tissue culture-based studies. Materials and Methods: We prospectively enrolled treatment-naïve patients with H. pylori infection who visited the Gil Medical Center between March 2015 and March 2018. After obtaining written informed consent from patients, a total of 121 H. pylori strains were collected. We tested the susceptibility of these strains to sitafloxacin, and other antibiotics for Helicobacter eradication, including clarithromycin (CLR), metronidazole (MTZ), amoxicillin (AMX), tetracycline (TET), levofloxacin (LEV), and ciprofloxacin (CIP) using the agar dilution technique. The minimum inhibitory concentration (MIC) of these antibiotics against H. pylori strains were determined. Results: None of the H. pylori strains obtained were resistant to sitafloxacin (MIC > 1, n = 0), while other conventional eradication drugs including CLR, MTZ, AMX, and TET showed 24.8% (n = 30), 30.6% (n = 37), 5.0% (n = 6), and 0.8% (n = 1) resistance, respectively. Compared to the resistance rates of other quinolones (LEV [36.4%, n = 44] and CIP [37.2%, n = 45]), sitafloxacin showed the best antibiotic performance against Helicobacter strains (0%, n = 0). Furthermore, sitafloxacin also inhibited the growth of 14 H. pylori strains (12.4%), which were resistant to both of clarithromycin, and metronidazole, and 27 strains (22.3%) with multidrug resistance. Conclusions: Sitafloxacin might be a new promising candidate for Helicobacter eradication where antibiotic resistance for Helicobacter is an emerging medical burden, such as in Korea.

Mitochondria are essential organelles that are not only responsible for energy production but are also involved in cell metabolism, calcium homeostasis, and apoptosis. Targeting mitochondria is a key strategy for bacteria to subvert host cells’ physiology and promote infection. Helicobacter (H.) pylori targets mitochondria directly. However, mitochondrial genome (mtDNA) polymorphism (haplogroup) is not yet considered an important factor for H. pylori infection. Here, we clarified the association of mitochondrial haplogroups with H. pylori prevalence and the ability to perform damage. Seven mtDNA haplogroups were identified among 28 H. pylori-positive subjects. Haplogroup B was present at a higher frequency and haplotype D at a lower one in the H. pylori population than in that of the H. pylori-negative one. The fibroblasts carrying high-frequency haplogroup displayed a higher apoptotic rate and diminished mitochondrial respiration following H. pylori infection. mtDNA mutations were accumulated more in the H. pylori-positive population than in that of the H. pylori-negative one in old age. Among the mutations, 57% were located in RNA genes or nonsynonymous protein-coding regions in the H. pylori-positive population, while 35% were in the H. pylori-negative one. We concluded that gastric disease caused by Helicobacter virulence could be associated with haplogroups and mtDNA mutations.

One of the most promising techniques for the analysis of Spatio-Temporal ocean wave fields is stereo vision. Indeed, the reconstruction accuracy and resolution typically outperform other approaches like radars, satellites, etc. However, it is computationally expensive so its application is typically restricted to the analysis of short pre-recorded sequences. What prevents such methodology from being truly real-time is the final 3D surface estimation from a scattered, non-equispaced point cloud. Recently, we studied a novel approach exploiting the temporal dependence of subsequent frames to iteratively update the wave spectrum over time. Albeit substantially faster, the unpredictable convergence time of the optimization involved still prevents its usage as a continuously running remote sensing infrastructure. In this work, we build upon the same idea, but investigating the feasibility of a fully data-driven Machine Learning (ML) approach. We designed a novel Convolutional Neural Network that learns how to produce an accurate surface from the scattered elevation data of three subsequent frames. The key idea is to embed the linear dispersion relation into the model itself to physically relate the sparse points observed at different times. Assuming that the scattered data are uniformly distributed in the spatial domain, this has the same effect of increasing the sample density of each single frame. Experiments demonstrate how the proposed technique, even if trained with purely synthetic data, can produce accurate and physically consistent surfaces at five frames per second on a modern PC.

Background/AimsThe increased resistance of Helicobacter pylori to antibiotics has increased the need to develop new treatments for this bacterium. The aim of our study was to identify new drugs with anti-H. pylori activity.Methods : We screened a small molecule library—the library of pharmacologically active compounds (LOPAC), which includes 1,280 pharmacologically active compounds—to identify inhibitors of H. pylori growth. The minimal inhibitory concentrations (MICs) of antibiotics against multidrug-resistant H. pylori strains were determined using the agar dilution method.Results : We identified diphenyleneiodonium (DPI) as a novel anti-H. pylori agent. The MIC values for DPI were

Background/AimsMicroRNAs (miRNAs) regulate gene expression. We assess miRNA regulation by Helicobacter pylori infection and elucidate their role in H. pylori-infected gastric epithelial cells.Methods : The relationship between miRNA expression and DNA methylation was examined. Cells were treated with the nuclear factor-kappaB (NF-κB) inhibitor Bay 11-7082 to determine the relationship between miRNA expression and NF-κB signal transduction.Results : In the negative control cells infected with H. pylori 26695, the expression of six miRNAs was increased, whereas the expression of five miRNAs was decreased. The expression of upregulated miRNAs was increased when the host cells were treated with H. pylori and an NF-κB inhibitor. miR-127-5p, -155, and -181 were associated with increased interleukin 6 (IL-6) secretion in H. pylori infected cells treated with anti-miRNA. The expression of miR-155, -127-5p, -195, -216, -206, and -488 increased by approximately 3-fold following treatment with the methylation inhibitor Aza.Conclusion : sWe found novel miR-NAs in H. pylori-infected negative control cells using miRNA microarrays. Upregulated miRNA expression was inversely related to the transcription of NF-κB. miR-195 and miR-488 appear to play a pivotal role in controlling IL-6 activity in H. pylori infection. miRNA expression in H. pylori infection was affected by methylation.

Background/Aims: Cyclooxygenase-2 (COX-2), 15-hydroxyprostaglandin dehydrogenase (15-PGDH), and microsomal prostaglandin E synthase-1 (mPGEs-1) regulate prostaglandin E₂ (PGE₂) expression and are involved in colon carcinogenesis. We investigated the expression of PGE₂ and its regulating genes in sporadic human colon tumors and matched normal tissues.Methods: Twenty colonic adenomas and 27 colonic adenocarcinomas were evaluated. COX-2 and 15-PGDH expression was quantified by real-time polymerase chain reaction. The expression of PGE₂ and mPGEs-1 was measured using enzyme-linked immunosorbent assay and Western blotting, respectively.Results: The expression of COX-2, mPGEs-1, and PGE₂ did not differ between the adenomas and matched distant normal tissues. 15-PGDH expression was lower in adenomas than in the matched normal colonic tissues (P

Abstract Life-threatening complications including cardiac perforation by the clamp or pectus bar during Nuss procedure have rarely been occurred. A rare case of lung entrapment between the pectus bar and chest wall after Nuss procedure was also reported. Thoracoscopy allows for direct visualization of the operative field, which prevents or promptly perceive these intrathoracic organ injuries. Recently, we encountered a case of penetrating lung injury during the Nuss procedure for pectus excavatum. And we agree with Mennie et al. who concluded thoracoscopic vision during Nuss procedure reduces the risk of major complication. In addition, we would like to emphasize to keep in mind what to check for routines with thoracoscopy during Nuss procedure.

Abstract Cardiac arrest during the Nuss procedure is the most serious complication and is related to cardiac injury by the surgical instruments and pectus bars. To avoid the cardiac injury, there are several techniques with various devices, including crane and wire suture, lifting hook, the Kent or Langenbeck retractor, and the Vacuum Bell device. However, a case of cardiac arrest without direct cardiac injury during the Nuss procedure has been reported in the pectus excavatum patient with coronary-to-pulmonary arterial shunts. Recently, we encountered a case of cardiac arrest without cardiac abnormalities in preoperative studies and cardiac injury during the Nuss procedure.

The Yellow Sea is one of the most productive continental shelves in the world. This large marine ecosystem is experiencing an epochal change in water temperature, stratification, nutrients, and subsequently in ecological diversity. Research-oriented monitoring of these changes requires a sustainable, multi-disciplinary approach. For this purpose, the Korea Institute of Ocean Science and Technology (KIOST) constructed the Socheongcho Ocean Research Station (S-ORS), a steel-framed tower-type platform, in the central Yellow Sea about 50 km off the western coast of the Korean Peninsula. This station is equipped with about forty sensors for interdisciplinary oceanographic observations. Since its construction in 2014, this station has continuously conducted scientific observations and provided qualified time series: physical oceanographic variables such as temperature, salinity, sea level pressure, wave, and current; biogeochemical variables such as chlorophyll-a, photosynthetically active radiation, and total suspended particles; atmospheric variables including air temperature, wind, greenhouse gasses, and air particles including black carbon. A prime advantage is that this platform has provided stable facilities including a wet lab where scientists can stay and experiment on in situ water samples. Several studies are in process to understand and characterize the evolution of environmental signals, including air-sea interaction, marine ecosystems, wave detection, and total suspended particles in the central Yellow Sea. This paper provides an overview of the research facilities, maintenance, observations, scientific achievements, and next steps of the S-ORS with highlighting this station as an open lab for interdisciplinary collaboration on multiscale process studies.