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To date, the use of biomarkers for assessing individual severity of osteoarthritis (OA) is limited, and the correlation of histological scores with biomarkers for individual animals in the destabilization of the medial meniscus (DMM) model of OA has not been well investigated. Accordingly, this study investigated how well representative biomarkers in the DMM model reflected specific changes in individual animals. Rats were randomly divided into the OA group and the sham group. OA model was established by destabilization of the medial meniscus (DMM). After 2,4,6,8,10 and 12 weeks (n=14, each week), the concentrations of CTXII, COMP, C2C, and OC in serum were measured, and cartilage degeneration, osteophytes, and synovial membrane inflammation, typical of OA, were scored using Osteoarthritis Research Society International (OARSI) scoring system. Additionally, the correlation between each biomarker and the specific changes in osteoarthritis was analyzed for individual animals using the Generalized Estimating Equation (GEE). Statistical analysis showed a low correlation between CTXII and osteophyte score of the medial femur (coefficient = -0.0088, p= 0.0103), COMP and osteophyte score of the medial tibia (coefficient = -0.0911, p= 0.0003), and C2C and synovial membrane inflammation scores of the medial femoral (coefficient = 0.054, p= 0.0131). These results suggest that representative OA bio- markers in individual animals in the DMM model did not reflect histological scores well.

To investigate the diagnostic accuracy of radiographic signs for complete discoid lateral meniscus and whether a predictive model combining the radiographic signs can improve its diagnostic accuracy in adults. A total of adult 119 knees with complete discoid lateral meniscus confirmed by arthroscopy and 119 age- and sex-matched knees with normal meniscus were included. The radiographic signs of lateral joint space, fibular head height, lateral tibial spine height, lateral tibial plateau obliquity, lateral femoral condyle squaring, lateral tibial plateau cupping, lateral femoral condyle notching, and the condylar cut-off sign were evaluated. The receiver-operating characteristic (ROC) curves and area under the curve (AUC) were evaluated for best accuracy. A prediction model was developed by multivariable regression with generalized estimating models, and was validated using data from 111 knees of children with complete discoid lateral meniscus and 111 normal controls. The fibular head height, lateral joint space, lateral tibial plateau obliquity, and the condylar cut-off sign were significantly different between the complete discoid lateral meniscus and the normal groups (p

The purpose of this study was to evaluate the most appropriate positioning of anatomical locking plates on the distal tibia.We positioned 4 types of locking plates (3 straight and 1 bayonet) at anterior, middle, and posterior positions on the medial malleolus on both lower limbs of 15 cadavers. We measured the rotational mismatch angle between the tibia and the proximal part of the plate and calculated the plate prominence at each position.The average rotational mismatch angles of a combined group containing all 3 straight plates were 0.3, 16.9, and 29.4 degrees at the anterior, middle, and posterior positions, respectively (P0.001). In the group with 1 bayonet plate, the rotational mismatch angles were -10.5, 0, and 16.7 degrees on average, respectively (P0.001). The average plate prominence for each of the positions (anterior, middle, and posterior) in the group with 3 straight plates were 3.5, 6.9, and 9.4 mm, respectively (P0.001). The average plate prominence in the group with 1 bayonet plate were 5.4, 3.6, and 6.7 mm, respectively (P0.001).We confirmed that anterior placement of the 3 straight locking plates in the distal tibia showed the best fit with regard to rotational alignment and that middle placement of the bayonet locking plates showed best fit. Placement of distal end of the locking plates in inappropriate positions results in a greater risk of rotational mismatch and plate impingement.