1. High Variability of Body Mass Index Is Independently Associated With Incident Heart Failure
- Author
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Chang Liu, Yiyun Chiang, Qin Hui, Jin J. Zhou, Peter W. F. Wilson, Jacob Joseph, and Yan V. Sun
- Subjects
body mass index ,heart failure ,heart failure incidence ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Background Heart failure (HF) is a serious condition with increasing prevalence, high morbidity, and increased mortality. Obesity is an established risk factor for HF. Fluctuation in body mass index (BMI) has shown a higher risk of cardiovascular outcomes. We investigated the association between BMI variability and incident HF. Methods and Results In the UK Biobank, we established a prospective cohort after excluding participants with prevalent HF or cancer at enrollment. A total of 99 368 White participants with ≥3 BMI measures during >2 years preceding enrollment were included, with a median follow‐up of 12.5 years. The within‐participant variability of BMI was evaluated using standardized SD and coefficient of variation. The association of BMI variability with incident HF was assessed using Fine and Gray's competing risk model, adjusting for confounding factors and participant‐specific rate of BMI change. Higher BMI variability measured in both SD and coefficient of variation was significantly associated with higher risk in HF incidence (SD: hazard ratio [HR], 1.05 [95% CI, 1.03–1.08], P
- Published
- 2024
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