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Cai Q, Wang X, Wang S, et al. Int J Nanomedicine. 2020;15:253–262. The Editor and Publisher of International Journal of Nanomedicine wish to retract the published article. Following the authors request to make corrections an investigation found several images within Figure 5 appeared to have been duplicated. In addition, images within Figure 5 were also found to have been duplicated with images from Figure 8 in Cai Q, Wang S, Jin L, et al. Long non-coding RNA GBCDRlnc1 induces chemoresistance of gallbladder cancer cells by activating autophagy. Mol Cancer. 18, 82 (2019). https://doi.org/10.1186/s12943-019-1016-0. Specifically, Figure 5, p62, NIR, appears to have been duplicated with the same image for Figure 5, p62, Dox+NIR. Figure 5, PCNA, Dox+NIR, appears to have been duplicated with the same image for Figure 5, PCNA, CQ+Dox+NIR. Figure 5, Ki-67, Dox, appears to have been duplicated with the same image for Figure 5, Ki-67, CQ-Dox. Figure 5, p62, CQ, appears to have been duplicated with the same image for Figure 8, p62, GBC-SD/Dox Lv-shRNA+Dox from Cai et al, 2019. Figure 5, p62, Dox, appears to have been duplicated with the same image for Figure 8, p62, GBC-SD/Dox Lv-control+Dox from Cai et al, 2019. Figure 5, p62, CQ+Dox, appears to have been duplicated with the same image for Figure 8, ATG5, GBC-SD/Dox Lv-control+Dox from Cai et al, 2019. The authors cooperated with the investigation and provided data associated with the study. However, despite the authors’ assistance, it was still not clear how the images came to be duplicated, and, as we cannot verify the validity of the published work, we are therefore retracting the article and the authors were notified of this. We have been informed in our decision-making by our policy on publishing ethics and integrity and the COPE guidelines on retractions. The retracted article will remain online to maintain the scholarly record, but it will be digitally watermarked on each page as “Retra

Henan Li, Jiangang Zhang, Zhiren Wang, Yuyao Yin, Hua Gao, Ruobing Wang, Longyang Jin, Qi Wang, Chunjiang Zhao, Zhanwei Wang, Hui Wang Department of Clinical Laboratory, Peking University People’s Hospital, Beijing, People’s Republic of ChinaCorrespondence: Hui WangDepartment of Clinical Laboratory, Peking University People’s Hospital, Beijing, 100044, People’s Republic of ChinaTel +86-10-88326300Email whuibj@163.comIntroduction: Colonization of the respiratory tract by Acinetobacter baumannii has been established as an independent risk factor for bacteremia. However, within-host evolution of A. baumannii in bacteremia has not been extensively investigated.Methods: We performed whole-genome sequencing to discover the evolutionary characteristics that accompany the transition from respiratory tract carriage to bloodstream infection in three patients with A. baumannii bacteremia.Results: Within-host genetic diversity was identified. A total of 21 single nucleotide variants (SNVs) were detected. Genic and intergenic evolution occurred particularly in secretion system, DNA recombination, and cell motility genes. Intergenic SNVs occurred more frequently compared to synonymous and non-synonymous SNVs, which indicated potential transcription or translation regulation. Non-synonymous mutations mostly occurred during the transition from respiratory tract carriage to bloodstream infection. Isolates of clonal complex 208 (CC208) had lower substitution rate with approximately 10− 6 nucleotide substitutions per site year− 1, compared with non-CC208 isolates (approximately 10− 5). We found evidence for the occurrence of recombination in one patient. A total of 259 genes were found to be gained or lost during the within-host evolution, and 231 genes were only detected in one patient. Gene function annotation results suggested that most genes (71/259) were related to replication, recombination, and repair. Universal bloodstream specific genes were not found in all thr

Chaoe Zhou,1 Longyang Jin,1 Qi Wang,1 Xiaojuan Wang,1 Fengning Chen,1 Yue Gao,1 Chunjiang Zhao,1 Hongbin Chen,1 Bin Cao,2 Hui Wang1 1Department of Clinical Microbiology, Peking University People’s Hospital, Beijing, People’s Republic of China; 2Department of Pulmonary and Critical Care Medicine, China-Japan Friendship Hospital, National Clinical Research Center for Respiratory Diseases, Beijing, People’s Republic of ChinaCorrespondence: Hui WangDepartment of Clinical Laboratory, Peking University People’s Hospital, Beijing, 100044, People’s Republic of ChinaTel +8688326300Email whuibj@163.comPurpose: Carbapenem-resistant Enterobacterales bloodstream infections (CRE BSIs) have a high mortality. However, an optimal antimicrobial treatment has not been determined. This study was conducted to evaluate the risk factors for mortality and provided potential therapeutic options for treatment of CRE infection.Patients and Methods: We investigated patients with CRE BSIs from 18 hospitals across nine Chinese provinces from January to December 2019. Data were collected from the medical records according to a pre-established questionnaire. Antimicrobial susceptibility testing and DNA sequencing were performed to investigate the characteristics of isolates.Results: A total of 208 patients enrolled; the overall 30-day mortality rate was 46.2%. The causative pathogen was carbapenem-resistant Klebsiella pneumoniae (CRKP) (85.6%). Patients infected by ST11-KL64 CRKP had a high sepsis/septic shock incidence rate (p < 0.05). Sepsis/septic shock, short duration of antimicrobial therapy and empirical using tigecycline were independent risk factors for mortality (p < 0.05 for each risks). Appropriate therapy had better survival benefit than inappropriate therapy (p = 0.003). No difference was identified between monotherapy and combination therapy (p = 0.105). Tigecycline as a frequently used antimicrobial had poor therapeutic

Qiang Cai, 1, 2,* Xinjing Wang, 2,* Shouhua Wang, 1 Longyang Jin, 1 Jun Ding, 3 Di Zhou, 1 Fei Ma 4 1Department of General Surgery, Xinhua Hospital, Shanghai JiaoTong University School of Medicine, Shanghai 200092, People’s Republic of China; 2Department of General Surgery, Shanghai Institute of Digestive Surgery, Ruijin Hospital, Shanghai JiaoTong University School of Medicine, Shanghai 200025, People’s Republic of China; 3Department of Biliary and Pancreatic Surgery, Shanghai Shuguang Hospital Affiliated with Shanghai University of T.C.M., Shanghai 201203, People’s Republic of China; 4Department of Oncology, Xinhua Hospital, Shanghai JiaoTong University School of Medicine, Shanghai Institute for Pediatric Research, Shanghai 200092, People’s Republic of China*These authors contributed equally to this workCorrespondence: Fei MaDepartment of Oncology, Xinhua Hospital, Shanghai JiaoTong University School of Medicine, Shanghai Institute for Pediatric Researh, 1665 Kongjiang Road, Shanghai 200092, People’s Republic of ChinaEmail Mafei@xinhuamed.com.cnDi ZhouDepartment of General Surgery, Xinhua Hospital, Shanghai JiaoTong University School of Medicine, 1665 Kongjiang Road, Shanghai 200092, People’s Republic of ChinaEmail Zhoudi@xinhuamed.com.cnIntroduction: Gallbladder cancer (GBC) is the most common malignancy in biliary tract with extremely poor prognosis. Photothermal therapy (PTT) shows great promises for tumor therapy, which causes tumor cell death via selectively directed heating released by nanoparticles under the near-infrared irradiation. Through degrading damaged organelles and misfolded proteins in autophagosomes, autophagy plays a vital role in maintaining the intracellular homeostasis. The present study attempted to combine chemotherapy and autophagy blocking with PTT.Materials and Methods: We purchased multi-walled carbon nanotubes from Nanostructured and Amorphous Materials and performed PTT usin

This paper has been retracted. Cai Q, Wang X, Wang S, et al. Int J Nanomedicine. 2020;15:253–262. The Editor and Publisher of International Journal of Nanomedicine wish to retract the published article. Following the authors request to make corrections an investigation found several images within Figure 5 appeared to have been duplicated. In addition, images within Figure 5 were also found to have been duplicated with images from Figure 8 in Cai Q, Wang S, Jin L, et al. Long non-coding RNA GBCDRlnc1 induces chemoresistance of gallbladder cancer cells by activating autophagy. Mol Cancer. 18, 82 (2019). https://doi.org/10.1186/s12943-019-1016-0. Specifically, Figure 5, p62, NIR, appears to have been duplicated with the same image for Figure 5, p62, Dox+NIR. Figure 5, PCNA, Dox+NIR, appears to have been duplicated with the same image for Figure 5, PCNA, CQ+Dox+NIR. Figure 5, Ki-67, Dox, appears to have been duplicated with the same image for Figure 5, Ki-67, CQ-Dox. Figure 5, p62, CQ, appears to have been duplicated with the same image for Figure 8, p62, GBC-SD/Dox Lv-shRNA+Dox from Cai et al, 2019. Figure 5, p62, Dox, appears to have been duplicated with the same image for Figure 8, p62, GBC-SD/Dox Lv-control+Dox from Cai et al, 2019. Figure 5, p62, CQ+Dox, appears to have been duplicated with the same image for Figure 8, ATG5, GBC-SD/Dox Lv-control+Dox from Cai et al, 2019. The authors cooperated with the investigation and provided data associated with the study. However, despite the authors’ assistance, it was still not clear how the images came to be duplicated, and, as we cannot verify the validity of the published work, we are therefore retracting the article and the authors were notified of this. We have been informed in our decision-making by our policy on publishing ethics and integrity and the COPE guidelines on retractions. The retracted article will remain online to maintain the scholarly record, but it will be digitally watermarked on