7,134 results on '"Jin, Zhou"'
Search Results
2. Physicochemical parameters combined with sensory and discriminant regression, for quality and sensory characterization of licorice for both food and medicine
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Han, Yuxuan, He, Qiuling, Cheng, Qiuyue, Pang, Xinru, Sun, Yangyang, Zhu, Zhenan, Xie, Kehui, Qian, Siqi, Xu, Yulin, Yu, Shiyin, Li, Qingqing, Liu, Dianzun, Jin, Zhou, Yan, Huan, Zhang, Xuemin, Hou, Zhuoni, and Liang, Zongsuo
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- 2024
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3. Results of mother-to-child transmission in hepatitis B-positive mothers who underwent amniocentesis
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Jin Zhou, Peizhen Zhang, Zhangmin Tan, Chuo Li, Lin Yao, Zhenyan Han, and Yuzhu Yin
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Amniocentesis ,Hepatitis B Virus infection ,Mother-to-child transmission ,Viral load ,Intrauterine infection ,Infectious and parasitic diseases ,RC109-216 - Abstract
Abstract Purpose This study aims to analyze whether undergoing amniocentesis during pregnancy in women diagnosed with hepatitis B virus (HBV) infection leads to HBV transmission to newborns. Methods Retrospective data collection was conducted from June 2019 to November 2022 on expectant mothers positive for hepatitis B surface antigen (HBsAg) who underwent amniocentesis at The Third Affiliated Hospital of Sun Yat-sen University, along with data on their newborns. The study summarized the HBV infection status of newborns born to mothers with different expressions of hepatitis B e antigen (HBeAg), antiviral treatment versus no treatment, and different HBV DNA viral loads before delivery. Results In this study, 346 expectant mothers tested positive for HBsAg, along with 351 newborns (including 5 sets of twins, with 8 infants (2.28%) testing HBsAg-positive at birth. All newborns received dual immunotherapy and were followed up. At 7–12 months, retesting for HBsAg positivity and HBV DNA positivity among infants revealed that out of the infants born with HBsAg positivity, 7 cases had seroconverted to negative, while the remaining infant, who was positive for both HBsAg and HBeAg at birth, tested positive for both HBsAg and HBV DNA at 7–12 months. Thus, one case of vertical transmission of hepatitis B from mother to child occurred in this study. The proportion of infants born with HBsAg + among newborns born to HBeAg-positive mothers (4 cases, 6.06%) was significantly higher than that among newborns born to HBeAg-negative mothers (4 cases, 1.41%) (P 0.05). Among expectant mothers with viral load ≥ 6 log 10 IU/mL before delivery, 3 newborns (30.00%) were manifesting HBsAg positivity at birth, significantly higher than the group with viral load
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- 2024
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4. Single-cell sequencing of the vermiform appendix during development identifies transcriptional relationships with appendicitis in preschool children
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Lingdu Meng, Yifan Yang, Shiwei He, Huifen Chen, Yong Zhan, Ran Yang, Zifeng Li, Jiajie Zhu, Jin Zhou, Yi Li, Lulu Xie, Gong Chen, Shan Zheng, Xiaoying Yao, and Rui Dong
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Vermiform appendix ,Development ,Preschool children ,Appendicitis ,BMP pathway ,IL-17 signaling pathway ,Medicine - Abstract
Abstract Background The development of the human vermiform appendix at the cellular level, as well as its function, is not well understood. Appendicitis in preschool children, although uncommon, is associated with a high perforation rate and increased morbidity. Methods We performed single-cell RNA sequencing (scRNA-seq) on the human appendix during fetal and pediatric stages as well as preschool-age inflammatory appendices. Transcriptional features of each cell compartment were discussed in the developing appendix. Cellular interactions and differentiation trajectories were also investigated. We compared scRNA-seq profiles from preschool appendicitis to those of matched healthy controls to reveal disease-associated changes. Bulk transcriptomic data, immunohistochemistry, and real-time quantitative PCR were used to validate the findings. Results Our analysis identified 76 cell types in total and described the cellular atlas of the developing appendix. We discovered the potential role of the BMP signaling pathway in appendiceal epithelium development and identified HOXC8 and PITX2 as the specific regulons of appendix goblet cells. Higher pericyte coverage, endothelial angiogenesis, and goblet mucus scores together with lower epithelial and endothelial tight junction scores were found in the preschool appendix, which possibly contribute to the clinical features of preschool appendicitis. Preschool appendicitis scRNA-seq profiles revealed that the interleukin-17 signaling pathway may participate in the inflammation process. Conclusions Our study provides new insights into the development of the appendix and deepens the understanding of appendicitis in preschool children. Graphical Abstract
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- 2024
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5. Evolution from a charge-ordered insulator to a high-temperature superconductor in Bi2Sr2(Ca,Dy)Cu2O8+δ
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Changwei Zou, Jaewon Choi, Qizhi Li, Shusen Ye, Chaohui Yin, Mirian Garcia-Fernandez, Stefano Agrestini, Qingzheng Qiu, Xinqiang Cai, Qian Xiao, Xingjiang Zhou, Ke-Jin Zhou, Yayu Wang, and Yingying Peng
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Science - Abstract
Abstract How Cooper pairs form and condense has been the main challenge in the physics of copper-oxide high-temperature superconductors. Great efforts have been made in the ‘underdoped’ region of the phase diagram, through doping a Mott insulator or cooling a strange metal. However, there is still no consensus on how superconductivity emerges when electron-electron correlations dominate and the Fermi surface is missing. To address this issue, here we carry out high-resolution resonant inelastic X-ray scattering and scanning tunneling microscopy studies on prototype cuprates Bi2Sr2Ca0.6Dy0.4Cu2O8+δ near the onset of superconductivity, combining bulk and surface, momentum- and real-space information. We show that an incipient charge order exists in the antiferromagnetic regime down to 0.04 holes per CuO2 unit, entangled with a particle-hole asymmetric pseudogap. The charge order induces an intensity anomaly in the bond-buckling phonon branch, which exhibits an abrupt increase once the system enters the superconducting dome. Our results suggest that the Cooper pairs grow out of a charge-ordered insulating state, and then condense accompanied by an enhanced interplay between charge excitations and electron-phonon coupling.
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- 2024
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6. A Case Report of Asymptomatic Breast Cancer with Abdominal and Cervical Metastases and Literature Review
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Nadiyahainimu·Rehemitula, Lei LI, Jin ZHOU, and Youping CHEN
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Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Published
- 2024
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7. Revisiting azimuthal angular asymmetries in diffractive di-jet production
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Ding Yu Shao, Yu Shi, Cheng Zhang, Jian Zhou, and Ya-jin Zhou
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Deep Inelastic Scattering or Small-x Physics ,Resummation ,Parton Distributions ,Nuclear and particle physics. Atomic energy. Radioactivity ,QC770-798 - Abstract
Abstract We explore the impact of initial state soft gluon radiations on the azimuthal angle asymmetries in photo-production of hard di-jet via coherent diffraction in ultraperipheral heavy ion collisions, as well as in electron-proton (ep) and electron-nucleus (eA) collisions. The primary production mechanism is identified as the diffractive production of two hard jets, accompanied by a collinear gluon emission along the beam direction. In contrast, the diffractive exclusive di-jet production, where the initial state radiation is absent, is suppressed due to color transparency. Our analysis shows that azimuthal asymmetries, traditionally attributed to final state gluon emissions, are reduced by the presence of initial state radiations. The sensitivity of azimuthal asymmetries to both initial and final state radiations suggests that they could provide novel insights into the mechanisms of di-jet production in diffractive processes.
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- 2024
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8. Value of multiparametric magnetic resonance imaging in distinguishing sinonasal lymphoma from sinonasal carcinoma: a case control study
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Chong Liu, Ye Wang, Duo Zhang, Jin Zhou, Yan Wu, Ying Guo, Rui-Chao Liu, and Jin-E Xu
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Magnetic resonance imaging ,Sinonasal ,Lymphoma ,Carcinoma ,Medical technology ,R855-855.5 - Abstract
Abstract Background The study aimed to evaluate the diagnostic efficacy of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and diffusion-weighted imaging (DWI) parameters in distinguishing sinonasal lymphoma from sinonasal carcinoma. Methods Forty-two participants with histologically confirmed sinonasal lymphomas and fifty-two cases of sinonasal carcinoma underwent imaging with a 3.0T MRI scanner. DCE-MRI and DWI were conducted, and various parameters including type of time-intensity curve(TIC), time to peak, peak enhancement, peak contrast enhancement, washout rate, apparent diffusion coefficient (ADC), and relative ADC were measured. Binary logistic regression and receiver operating characteristic (ROC) curve analysis were employed to assess the diagnostic capability of individual and combined indices for differentiating nasal sinus lymphoma from nasal sinus carcinoma. Results Sinonasal lymphoma predominantly exhibited type II TIC(n = 20), whereas sinonasal carcinoma predominantly exhibited type III TIC(n = 23). Significant differences were observed in all parameters except washout ratio (p
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- 2024
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9. Modeling and Validation of Diamagnetic Rotor Levitated by Permanent Magnetics
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Yuanping Xu, Yue Zhang, Jin Zhou, and Chaowu Jin
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Diamagnetic levitation ,Magnetic levitation ,Rotor ,Modeling ,Validation ,Stability ,Ocean engineering ,TC1501-1800 ,Mechanical engineering and machinery ,TJ1-1570 - Abstract
Abstract As an innovative, low-power consuming, and low-stiffness suspension approach, the diamagnetic levitation technique has attracted considerable interest because of its potential applicability in miniaturized mechanical systems. The foundation of a diamagnetic levitation system is mathematical modeling, which is essential for operating performance optimization and stability prediction. However, few studies on systematic mathematical modeling have been reported. In this study, a systematic mathematical model for a disc-shaped diamagnetically levitated rotor on a permanent magnet array is proposed. Based on the proposed model, the magnetic field distribution characteristics, diamagnetic levitation force characteristics (i.e., levitation height and stiffness), and optimized theoretical conditions for realizing stable levitation are determined. Experiments are conducted to verify the feasibility of the proposed mathematical model. Theoretical predictions and experimental results indicate that increasing the levitation height enlarges the stable region. Moreover, with a further increase in the rotor radius, the stable regions of the rotor gradually diminish and even vanish. Thus, when the levitation height is fixed, a moderate rotor radius permits stable levitation. This study proposes a mathematical modeling method for a diamagnetic levitation system that has potential applications in miniaturized mechanical systems.
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- 2024
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10. Neoadjuvant therapy of sequential TACE, camrelizumab, and apatinib for single huge hepatocellular carcinoma (NEO-START): study protocol for a randomized controlled trial
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Yun Hao, Fei Xie, Yongjie Zhou, Chuan Li, Xiaoyun Zhang, Junyi Shen, Minghong Yao, Xin Sun, Jin Zhou, Tianfu Wen, and Wei Peng
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Hepatocellular carcinoma ,Neoadjuvant therapy ,Camrelizumab ,Apatinib ,Transarterial chemoembolization ,Medicine (General) ,R5-920 - Abstract
Abstract Background The high recurrence rate after liver resection emphasizes the urgent need for neoadjuvant therapy in hepatocellular carcinoma (HCC) to enhance the overall prognosis for patients. Immune checkpoint inhibitors, camrelizumab combined with an anti-angiogenic tyrosine kinase inhibitor (TKI) apatinib, have emerged as a first-line treatment option for patients with unresectable HCC, yet its neoadjuvant application in combination with transarterial chemoembolization (TACE) in HCC remains unexplored. Therefore, this study aims to investigate the efficacy and safety of sequential TACE, camrelizumab, and apatinib as a neoadjuvant therapy for single, huge HCC. Methods This multi-center, open-label randomized phase 3 trial will be conducted at 7 tertiary hospitals. Patients with single huge (≥ 10 cm in diameter), resectable HCC will be randomly assigned in a 1:1 ratio to arm of surgery alone or arm of neoadjuvant therapy followed by surgery. In the neoadjuvant therapy group, patients will receive TACE within 1 week after randomization, followed by camrelizumab (200 mg q2w, 4 cycles), along with apatinib (250 mg qd, 2 months). Patients will receive liver resection after neoadjuvant therapy unless the disease is assessed as progressive. The primary outcome is recurrence-free survival (RFS) at 1 year. The planned sample size of 60 patients will be calculated to permit the accumulation of sufficient RFS events in 1 year to achieve 80% power for the RFS primary endpoint. Discussion Synergistic effects provided by multimodality therapy of locoregional treatment, TKI, and anti-programmed cell death 1 inhibitor significantly improved overall survival for patients with unresectable HCC. Our trial will investigate the efficacy and safety of the triple combination of TACE, camrelizumab, and apatinib as a neoadjuvant strategy for huge, resectable HCC. Trial registration www.chitr.org.cn ChiCTR2300078086. Registered on November 28, 2023. Start recruitment: 1st January 2024. Expected completion of recruitment: 15th June 2025.
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- 2024
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11. Strain-tuned incompatible magnetic exchange-interaction in La2NiO4
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Izabela Biało, Leonardo Martinelli, Gabriele De Luca, Paul Worm, Annabella Drewanowski, Simon Jöhr, Jaewon Choi, Mirian Garcia-Fernandez, Stefano Agrestini, Ke-Jin Zhou, Kurt Kummer, Nicholas B. Brookes, Luo Guo, Anthony Edgeton, Chang B. Eom, Jan M. Tomczak, Karsten Held, Marta Gibert, Qisi Wang, and Johan Chang
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Astrophysics ,QB460-466 ,Physics ,QC1-999 - Abstract
Abstract Magnetic frustration is a route for novel ground states, including spin liquids and spin ices. Such frustration can be introduced through either lattice geometry or incompatible exchange interactions. Here, we find that epitaxial strain is an effective tool for tuning antiferromagnetic exchange interactions in a square-lattice system. By studying the magnon excitations in La2NiO4 films using resonant inelastic x-ray scattering, we show that the magnon displays substantial dispersion along the antiferromagnetic zone boundary, at energies that depend on the lattice of the film’s substrate. Using first principles simulations and an effective spin model, we demonstrate that the antiferromagnetic next-nearest neighbour coupling is a consequence of the two-orbital nature of La2NiO4. Altogether, we illustrate that compressive epitaxial strain enhances this coupling and, as a result, increases the level of incompatibility between exchange interactions within a model square-lattice system.
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- 2024
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12. Magnetic excitations in strained infinite-layer nickelate PrNiO2 films
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Qiang Gao, Shiyu Fan, Qisi Wang, Jiarui Li, Xiaolin Ren, Izabela Biało, Annabella Drewanowski, Pascal Rothenbühler, Jaewon Choi, Ronny Sutarto, Yao Wang, Tao Xiang, Jiangping Hu, Ke-Jin Zhou, Valentina Bisogni, Riccardo Comin, J. Chang, Jonathan Pelliciari, X. J. Zhou, and Zhihai Zhu
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Science - Abstract
Abstract Strongly correlated materials respond sensitively to external perturbations such as strain, pressure, and doping. In the recently discovered superconducting infinite-layer nickelates, the superconducting transition temperature can be enhanced via only ~ 1% compressive strain-tuning with the root of such enhancement still being elusive. Using resonant inelastic x-ray scattering (RIXS), we investigate the magnetic excitations in infinite-layer PrNiO2 thin films grown on two different substrates, namely SrTiO3 (STO) and (LaAlO3)0.3(Sr2TaAlO6)0.7 (LSAT) enforcing different strain on the nickelates films. The magnon bandwidth of PrNiO2 shows only marginal response to strain-tuning, in sharp contrast to the enhancement of the superconducting transition temperature T c in the doped superconducting samples. These results suggest the bandwidth of spin excitations of the parent compounds is similar under strain while T c in the doped ones is not, and thus provide important empirics for the understanding of superconductivity in infinite-layer nickelates.
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- 2024
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13. Expert Consensus on the Diagnosis and Treatment of FGFR Gene-Altered Solid Tumors
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Chunwei Xu, Bin Lian, Juanjuan Ou, Qian Wang, Wenxian Wang, Ke Wang, Dong Wang, Zhengbo Song, Aijun Liu, Jinpu Yu, Wenzhao Zhong, Zhijie Wang, Yongchang Zhang, Jingjing Liu, Shirong Zhang, Xiuyu Cai, Anwen Liu, Wen Li, Lili Mao, Ping Zhan, Hongbing Liu, Tangfeng Lv, Liyun Miao, Lingfeng Min, Yu Chen, Jingping Yuan, Feng Wang, Zhansheng Jiang, Gen Lin, Long Huang, Xingxiang Pu, Rongbo Lin, Weifeng Liu, Chuangzhou Rao, Dongqing Lv, Zongyang Yu, Xiaoyan Li, Chuanhao Tang, Chengzhi Zhou, Junping Zhang, Junli Xue, Hui Guo, Qian Chu, Rui Meng, Jingxun Wu, Rui Zhang, Jin Zhou, Zhengfei Zhu, Yongheng Li, Hong Qiu, Fan Xia, Yuanyuan Lu, Xiaofeng Chen, Rui Ge, Enyong Dai, Yu Han, Weiwei Pan, Fei Pang, Jintao Huang, Kai Wang, Fan Wu, Bingwei Xu, Liping Wang, Youcai Zhu, Li Lin, Yanru Xie, Xinqing Lin, Jing Cai, Ling Xu, Jisheng Li, Xiaodong Jiao, Kainan Li, Jia Wei, Huijing Feng, Lin Wang, Yingying Du, Wang Yao, Xuefei Shi, Xiaomin Niu, Dongmei Yuan, Yanwen Yao, Jianhui Huang, Yue Feng, Yinbin Zhang, Pingli Sun, Hong Wang, Mingxiang Ye, Zhaofeng Wang, Yue Hao, Zhen Wang, Bin Wan, Donglai Lv, Zhanqiang Zhai, Shengjie Yang, Jing Kang, Jiatao Zhang, Chao Zhang, Lin Shi, Yina Wang, Bihui Li, Zhang Zhang, Zhongwu Li, Zhefeng Liu, Nong Yang, Lin Wu, Huijuan Wang, Gu Jin, Guansong Wang, Jiandong Wang, Meiyu Fang, Yong Fang, Yuan Li, Xiaojia Wang, Jing Chen, Yiping Zhang, Xixu Zhu, Yi Shen, Shenglin Ma, Biyun Wang, Lu Si, Yuanzhi Lu, Ziming Li, Wenfeng Fang, and Yong Song
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solid tumors ,tyrosine receptor kinase ,precision medicine ,targeted therapy ,Genetics ,QH426-470 ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
The fibroblast growth factor receptor (FGFR) is a crucial receptor tyrosine kinase involved in essential biological processes, including growth, development, and tissue repair. However, FGFR gene mutations, including amplification, fusion, and mutation, can disrupt epigenetics, transcriptional regulation, and tumor microenvironment interactions, leading to cancer development. Targeting these kinase mutations with small molecule drugs or antibodies has shown clinical benefits. For example, erdafitinib is approved for treating locally advanced or metastatic urothelial cancer patients with FGFR2/FGFR3 mutations, and pemigatinib is approved for treating cholangiocarcinoma with FGFR2 fusion/rearrangement. Effective screening of FGFR variant patients is crucial for the clinical application of FGFR inhibitors. Various detection methods, such as polymerase chain reaction, next-generation sequencing, fluorescence in situ hybridization, and immunohistochemistry, are available, and their selection should be based on diagnostic and treatment decision-making needs. Our developed expert consensus aims to standardize the diagnosis and treatment process for FGFR gene mutations and facilitate the practical application of FGFR inhibitors in clinical practice.
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- 2024
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14. Biotic interactions and environmental modifications determine symbiotic microbial diversity and stability
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Zhidong Liu, Zeguang Guo, Jin Zhou, Xuecheng Guo, and Youhua Chen
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Microbial diversity-area relationship (MDAR) ,Microbial stability-area relationship (MSAR) ,Environmental modification ,Empirical networks ,Biotechnology ,TP248.13-248.65 - Abstract
Taking amphibians as island models, we examined the effects of interspecific interaction on the diversity and stability of microbial ecological. As skin area increased, the diversity and stability of skin microbes decreased, but the strength of negative interactions increased significantly. In contrast, as gut area increased, the diversity and stability of gut microbes increased, but the strength of interactions remained constant. These results indicate that microbial interactions are affected by habitat properties. When living in fluctuating environments without strong filtering, microorganisms can enhance their negative interactions with other taxa by changing the pH of their surroundings. In contrast, the pH of the gut is relatively stable, and colonized microorganisms cannot alter the gut pH and inhibit other colonizers. This study demonstrates that in the field of microbiology, diversity and stability are predominantly influenced by the intensity of interspecies interactions. The findings in this study deepen our understanding of microbial diversity and stability and provide a mechanistic link between species interactions, biodiversity, and stability in microbial ecosystems.
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- 2024
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15. Graph Embedding-Based Deep Multi-view Clustering.
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Cong Chen, Jin Zhou 0003, Shiyuan Han, Yingxu Wang 0002, Tao Du 0002, Cheng Yang, and Bowen Liu
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- 2024
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16. Visible-Hidden Multi-view Collaborative Fuzzy Clustering Based on Graph Constraints.
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Jiahao Mei, Chen Zhang, Jin Zhou 0003, Shiyuan Han, Yingxu Wang 0002, Tao Du 0002, Cheng Yang, and Bowen Liu
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- 2024
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17. Many Objectives Autonomous Robot Path Planning with Improved MOEA/D.
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Jin Zhou, David Chieng, Boon-Giin Lee, Junkai Ji, and Jianqiang Li 0001
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- 2024
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18. Speak From Heart: An Emotion-Guided LLM-Based Multimodal Method for Emotional Dialogue Generation.
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Chenxiao Liu, Zheyong Xie, Sirui Zhao, Jin Zhou, Tong Xu 0001, Minglei Li 0001, and Enhong Chen
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- 2024
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19. HardenVR: Harassment Detection in Social Virtual Reality.
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Na Wang, Jin Zhou, Jie Li, Bo Han 0001, Fei Li 0001, and Songqing Chen
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- 2024
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20. Accelerating Large-Scale Sparse LU Factorization for RF Circuit Simulation
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Feng, Guofeng, Wang, Hongyu, Guo, Zhuoqiang, Li, Mingzhen, Zhao, Tong, Jin, Zhou, Jia, Weile, Tan, Guangming, Sun, Ninghui, Goos, Gerhard, Series Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Carretero, Jesus, editor, Shende, Sameer, editor, Garcia-Blas, Javier, editor, Brandic, Ivona, editor, Olcoz, Katzalin, editor, and Schreiber, Martin, editor
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- 2024
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21. The Microscopic Mechanism of Asphaltene Deposition and Prevention of Deposition During Oil Extraction
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Wang, Cheng-jie, Liu, Ping-li, Zhao, Jin-zhou, Song, Xian-yu, Du, Juan, Chen, Xiang, Liu, Jin-ming, Wang, Guan, Wu, Wei, Series Editor, and Lin, Jia'en, editor
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- 2024
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22. Serum beta2-microglobulin acts as a biomarker for severity and prognosis in glioma patients: a preliminary clinical study
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Liu, Zhen-Yuan, Tang, Feng, Wang, Jing, Yang, Jin-Zhou, Chen, Xi, Wang, Ze-Fen, and Li, Zhi-Qiang
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- 2024
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23. The Role of Beta2-Microglobulin in Central Nervous System Disease
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Liu, Zhen-Yuan, Tang, Feng, Yang, Jin-Zhou, Chen, Xi, Wang, Ze-Fen, and Li, Zhi-Qiang
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- 2024
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24. Enhanced cellular therapy: revolutionizing adoptive cellular therapy
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Xu, Meng-Yao, Zeng, Na, Liu, Chen-Qian, Sun, Jian-Xuan, An, Ye, Zhang, Si-Han, Xu, Jin-Zhou, Zhong, Xing-Yu, Ma, Si-Yang, He, Hao-Dong, Hu, Jia, Xia, Qi-Dong, and Wang, Shao-Gang
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- 2024
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25. Photodynamic therapy upregulates expression of HIF-1α and PD-L1 in related pathways and its clinical relevance in non-small-cell lung cancer
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Sun, Wen, Cheng, Yuan, Ma, Xiaoyu, Jin, Zhou, Zhang, Qi, and Wang, Guangfa
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- 2024
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26. The moderated-mediation role of risk perception and intolerance of uncertainty in the association between residual symptoms and psychological distress: a cross-sectional study after COVID-19 policy lifted in China
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Sun, Zhiyu, Jin, Zhou, Zhao, Kejie, Wen, Xin, Lu, Hui, Hu, Nuonuo, Zhu, Qinxin, Zhang, Yi, Ye, Minjie, Huang, Yili, Song, Weihong, Wang, Deborah Baofeng, and Wu, Yili
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- 2024
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27. Perceived risk of COVID-19 hurts mental health: the mediating role of fear of COVID-19 and the moderating role of resilience
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Lu, Hui, Yang, Jialin, Zhao, Kejie, Jin, Zhou, Wen, Xin, Hu, Nuonuo, Yang, Hongshen, Sun, Zhiyu, Chen, Haitao, Huang, Yili, Wang, Deborah Baofeng, and Wu, Yili
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- 2024
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28. Late gadolinium enhanced cardiac MR derived radiomics approach for predicting all-cause mortality in cardiac amyloidosis: a multicenter study
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Zhou, Xi Yang, Tang, Chun Xiang, Guo, Ying Kun, Chen, Wen Cui, Guo, Jin Zhou, Ren, Gui Sheng, Li, Xiao, Li, Jun Hao, Lu, Guang Ming, Huang, Xiang Hua, Wang, Yi Ning, Zhang, Long Jiang, and Yang, Gui Fen
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- 2024
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29. Insight-HXMT and GECAM-C observations of the brightest-of-all-time GRB 221009A
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An, Zheng-Hua, Antier, S., Bi, Xing-Zi, Bu, Qing-Cui, Cai, Ce, Cao, Xue-Lei, Camisasca, Anna-Elisa, Chang, Zhi, Chen, Gang, Chen, Li, Chen, Tian-Xiang, Chen, Wen, Chen, Yi-Bao, Chen, Yong, Chen, Yu-Peng, Coughlin, Michael W., Cui, Wei-Wei, Dai, Zi-Gao, Hussenot-Desenonges, T., Du, Yan-Qi, Du, Yuan-Yuan, Du, Yun-Fei, Fan, Cheng-Cheng, Frontera, Filippo, Gao, He, Gao, Min, Ge, Ming-Yu, Gong, Ke, Gu, Yu-Dong, Guan, Ju, Guo, Dong-Ya, Guo, Zhi-Wei, Guidorzi, Cristiano, Han, Da-Wei, He, Jian-Jian, He, Jun-Wang, Hou, Dong-Jie, Huang, Yue, Huo, Jia, Ji, Zhen, Jia, Shu-Mei, Jiang, Wei-Chun, Kann, David Alexander, Klotz, A., Kong, Ling-Da, Lan, Lin, Li, An, Li, Bing, Li, Chao-Yang, Li, Cheng-Kui, Li, Gang, Li, Mao-Shun, Li, Ti-Pei, Li, Wei, Li, Xiao-Bo, Li, Xin-Qiao, Li, Xu-Fang, Li, Yan-Guo, Li, Zheng-Wei, Liang, Jing, Liang, Xiao-Hua, Liao, Jin-Yuan, Lin, Lin, Liu, Cong-Zhan, Liu, He-Xin, Liu, Hong-Wei, Liu, Jia-Cong, Liu, Xiao-Jing, Liu, Ya-Qing, Liu, Yu-Rong, Lu, Fang-Jun, Lu, Hong, Lu, Xue-Feng, Luo, Qi, Luo, Tao, Ma, Bin-Yuan, Ma, Fu-Li, Ma, Rui-Can, Ma, Xiang, Maccary, Romain, Mao, Ji-Rong, Meng, Bin, Nie, Jian-Yin, Orlandini, Mauro, Ou, Ge, Peng, Jing-Qiang, Peng, Wen-Xi, Qiao, Rui, Qu, Jin-Lu, Ren, Xiao-Qin, Shi, Jing-Yan, Shi, Qi, Song, Li-Ming, Song, Xin-Ying, Su, Ju, Sun, Gong-Xing, Sun, Liang, Sun, Xi-Lei, Tan, Wen-Jun, Tan, Ying, Tao, Lian, Tuo, You-Li, Turpin, Damien, Wang, Jin-Zhou, Wang, Chen, Wang, Chen-Wei, Wang, Hong-Jun, Wang, Hui, Wang, Jin, Wang, Ling-Jun, Wang, Peng-Ju, Wang, Ping, Wang, Wen-Shuai, Wang, Xiang-Yu, Wang, Xi-Lu, Wang, Yu-Sa, Wang, Yue, Wen, Xiang-Yang, Wu, Bo-Bing, Wu, Bai-Yang, Wu, Hong, Xiao, Sheng-Hui, Xiao, Shuo, Xiao, Yun-Xiang, Xie, Sheng-Lun, Xiong, Shao-Lin, Xiong, Sen-Lin, Xu, Dong, Xu, He, Xu, Yan-Jun, Xu, Yan-Bing, Xu, Ying-Chen, Xu, Yu-Peng, Xue, Wang-Chen, Yang, Sheng, Yang, Yan-Ji, Yang, Zi-Xu, Ye, Wen-Tao, Yi, Qi-Bin, Yi, Shu-Xu, Yin, Qian-Qing, You, Yuan, Yu, Yun-Wei, Yu, Wei, Yu, Wen-Hui, Zeng, Ming, Zhang, Bing, Zhang, Bin-Bin, Zhang, Da-Li, Zhang, Fan, Zhang, Hong-Mei, Zhang, Juan, Zhang, Liang, Zhang, Peng, Zhang, Shu, Zhang, Shuang-Nan, Zhang, Wan-Chang, Zhang, Xiao-Feng, Zhang, Xiao-Lu, Zhang, Yan-Qiu, Zhang, Yan-Ting, Zhang, Yi-Fei, Zhang, Yuan-Hang, Zhang, Zhen, Zhao, Guo-Ying, Zhao, Hai-Sheng, Zhao, Hong-Yu, Zhao, Qing-Xia, Zhao, Shu-Jie, Zhao, Xiao-Yun, Zhao, Xiao-Fan, Zhao, Yi, Zheng, Chao, Zheng, Shi-Jie, Zhou, Deng-Ke, Zhou, Xing, and Zhu, Xiao-Cheng
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Astrophysics - High Energy Astrophysical Phenomena - Abstract
GRB 221009A is the brightest gamma-ray burst ever detected since the discovery of this kind of energetic explosions. However, an accurate measurement of the prompt emission properties of this burst is very challenging due to its exceptional brightness. With joint observations of \textit{Insight}-HXMT and GECAM-C, we made an unprecedentedly accurate measurement of the emission during the first $\sim$1800 s of GRB 221009A, including its precursor, main emission (ME, which dominates the burst in flux), flaring emission and early afterglow, in the hard X-ray to soft gamma-ray band from $\sim$ 10 keV to $\sim$ 6 MeV. Based on the GECAM-C unsaturated data of the ME, we measure a record-breaking isotropic equivalent energy ($E_{\rm iso}$) of $\bf \sim 1.5 \times 10^{55}$ erg, which is about eight times the total rest-mass energy of the Sun. The early afterglow data require a significant jet break between 650 s and 1100 s, most likely at $\sim950$ s from the afterglow starting time $T_{AG}$, which corresponds to a jet opening angle of $\sim {0.7^\circ} \ (\eta_\gamma n)^{1/8}$, where $n$ is the ambient medium density in units of $\rm cm^{-3}$ and $\eta_\gamma$ is the ratio between $\gamma$-ray energy and afterglow kinetic energy. The beaming-corrected total $\gamma$-ray energy $E_{\gamma}$ is $\sim 1.15 \times10^{51} \ (\eta_\gamma n)^{1/4}$ erg, which is typical for long GRBs. These results suggest that this GRB may have a special central engine, which could launch and collimate a very narrowly beamed jet with an ordinary energy budget, leading to exceptionally luminous gamma-ray radiation per unit solid angle. Alternatively, more GRBs might have such a narrow and bright beam, which are missed by an unfavorable viewing angle or have been detected without distance measurement., Comment: Submitted to National Science Review. This paper is under press embargo, contact the corresponding author for details
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- 2023
30. Cross calibration of gamma-ray detectors (GRD) of GECAM-C
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Zhang, Yan-Qiu, Xiong, Shao-Lin, Qiao, Rui, Guo, Dong-Ya, Peng, Wen-Xi, Li, Xin-Qiao, Xue, Wang-Chen, Zheng, Chao, Liu, Jia-Cong, Tan, Wen-Jun, Wang, Chen-Wei, Zhang, Peng, Wang, Ping, Cai, Ce, Xiao, Shuo, Huang, Yue, Feng, Pei-Yi, Li, Xiao-Bo, Song, Li-Ming, Yi, Qi-Bin, Zhao, Yi, Guo, Zhi-Wei, He, Jian-Jian, Li, Chao-Yang, Liu, Ya-Qing, Gong, Ke, Du, Yan-Qi, Liu, Xiao-Jing, Xie, Sheng-Lun, Zhao, Guo-Ying, Zhao, Xiao-Yun, Zhang, Xiao-Lu, Zhang, Zhen, Zheng, Shi-Jie, Wang, Jin, Wen, Xiang-Yang, An, Zheng-Hua, Zhang, Da-Li, Gao, Min, Sun, Xi-Lei, Liang, Xiao-Hua, Yang, Sheng, Wang, Jin-Zhou, Chen, Gang, and Zhang, Fan
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Astrophysics - Instrumentation and Methods for Astrophysics ,Astrophysics - High Energy Astrophysical Phenomena - Abstract
The gamma-ray detectors (GRDs) of GECAM-C onborad SATech-01 satellite is designed to monitor gamma-ray transients all over the sky from 6 keV to 6 MeV. The energy response matrix is the key to do spectral measurements of bursts, which is usually generated from GEANT4 simulation and partially verified by the ground calibration. In this work, energy response matrix of GECAM-C GRD is cross-calibrated with Fermi/GBM and Swift/BAT using a sample of Gamma-Ray Bursts (GRBs) and Soft Gamma-Ray Repeaters (SGRs). The calibration results show there is a good agreement between GECAM-C and other reasonably well calibrated instrument (i.e. Fermi/GBM and Swift/BAT). We also find that different GRD detectors of GECAM-C also show consistency with each other. All these results indicate that GECAM-C GRD can provide reliable spectral measurements., Comment: preliminary version, will be updated soon
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- 2023
31. Ground calibration of Gamma-Ray Detectors of GECAM-C
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Zheng, Chao, An, Zheng-Hua, Peng, Wen-Xi, Zhang, Da-Li, Xiong, Shao-Lin, Qiao, Rui., Zhang, Yan-Qiu, Xue, Wang-Chen, Liu, Jia-Cong, Feng, Pei-Yi, Cai, Ce., Gao, Min, Gong, Ke, Guo, Dong-Ya, Hou, Dong-Jie, Li, Gang, Li, Xin-Qiao, Li, Yan-Guo, Li, Mao-Shun, Liang, Xiao-Hua, Liu, Ya-Qing, Liu, Xiao-Jing, Song, Li-Ming, Sun, Xi-Lei, Tan, Wen-Jun, Wang, Chen-Wei, Wang, Hui, Wang, Jin-Zhou, Wen, Xiang-Yang, Xiao, Shuo, Xu, Yan-Bing, Yang, Sheng, Yi, Qi-Bing, Zhang, Fan, Zhang, Peng, Zhang, Zhen, Zhao, Yi, and Zhou, Xing
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Astrophysics - Instrumentation and Methods for Astrophysics ,Physics - Instrumentation and Detectors - Abstract
As a new member of GECAM mission, GECAM-C (also named High Energy Burst Searcher, HEBS) was launched onboard the SATech-01 satellite on July 27th, 2022, which is capable to monitor gamma-ray transients from $\sim$ 6 keV to 6 MeV. As the main detector, there are 12 gamma-ray detectors (GRDs) equipped for GECAM-C. In order to verify the GECAM-C GRD detector performance and to validate the Monte Carlo simulations of detector response, comprehensive on-ground calibration experiments have been performed using X-ray beam and radioactive sources, including Energy-Channel relation, energy resolution, detection efficiency, SiPM voltage-gain relation and the non-uniformity of positional response. In this paper, the detailed calibration campaigns and data analysis results for GECAM-C GRDs are presented, demonstrating the excellent performance of GECAM-C GRD detectors., Comment: third version
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- 2023
32. 0.75% ropivacaine may be a suitable drug in pregnant women undergoing urgent cesarean delivery during labor analgesia period
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Xin Men, Qian Wang, Jia-fu Dong, Pei Chen, Xiao-xiao Qiu, Yin-qiu Han, Wei-long Wang, Jin Zhou, Hong-yan Shou, and Zhen-feng Zhou
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Ropivacaine ,Chloroprocaine ,Urgent cesarean delivery ,Epidural ,Anesthesiology ,RD78.3-87.3 - Abstract
Abstract Background 3% chloroprocaine (CP) has been reported as the common local anesthetic used in pregnant women undergoing urgent cesarean delivery during labor analgesia period. However, 0.75% ropivacaine is considered a promising and effective alternative. Therefore, we conducted a randomized controlled trial to compare the effectiveness and safety of 0.75% ropivacaine with 3% chloroprocaine for extended epidural anesthesia in pregnant women. Methods We conducted a double-blind, randomized, controlled, single-center study from November 1, 2022, to April 30, 2023. We selected forty-five pregnant women undergoing urgent cesarean delivery during labor analgesia period and randomized them to receive either 0.75% ropivacaine or 3% chloroprocaine in a 1:1 ratio. The primary outcome was the time to loss of cold sensation at the T4 level. Results There was a significant difference between the two groups in the time to achieve loss of cold sensation (303, 95%CI 255 to 402 S vs. 372, 95%CI 297 to 630 S, p = 0.024). There was no significant difference the degree of motor block (p = 0.185) at the Th4 level. Fewer pregnant women required additional local anesthetics in the ropivacaine group compared to the chloroprocaine group (4.5% VS. 34.8%, p = 0.011). The ropivacaine group had lower intraoperative VAS scores (p = 0.023) and higher patient satisfaction scores (p = 0.040) than the chloroprocaine group. The incidence of intraoperative complications was similar between the two groups, and no serious complications were observed. Conclusions Our study found that 0.75% ropivacaine was associated with less intraoperative pain treatment, higher patient satisfaction and reduced the onset time compared to 3% chloroprocaine in pregnant women undergoing urgent cesarean delivery during labor analgesia period. Therefore, 0.75% ropivacaine may be a suitable drug in pregnant women undergoing urgent cesarean delivery during labor analgesia period. Clinical trial number and registry URL The registration number: ChiCTR2200065201; http://www.chictr.org.cn , Principal investigator: MEN, Date of registration: 31/10/2022.
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- 2024
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33. Heterogeneous associations of multiplexed environmental factors and multidimensional aging metrics
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Fan Pu, Weiran Chen, Chenxi Li, Jingqiao Fu, Weijing Gao, Chao Ma, Xingqi Cao, Lingzhi Zhang, Meng Hao, Jin Zhou, Rong Huang, Yanan Ma, Kejia Hu, and Zuyun Liu
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Science - Abstract
Abstract Complicated associations between multiplexed environmental factors and aging are poorly understood. We manipulated aging using multidimensional metrics such as phenotypic age, brain age, and brain volumes in the UK Biobank. Weighted quantile sum regression was used to examine the relative individual contributions of multiplexed environmental factors to aging, and self-organizing maps (SOMs) were used to examine joint effects. Air pollution presented a relatively large contribution in most cases. We also found fair heterogeneities in which the same environmental factor contributed inconsistently to different aging metrics. Particulate matter contributed the most to variance in aging, while noise and green space showed considerable contribution to brain volumes. SOM identified five subpopulations with distinct environmental exposure patterns and the air pollution subpopulation had the worst aging status. This study reveals the heterogeneous associations of multiplexed environmental factors with multidimensional aging metrics and serves as a proof of concept when analyzing multifactors and multiple outcomes.
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- 2024
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34. Serum beta2-microglobulin acts as a biomarker for severity and prognosis in glioma patients: a preliminary clinical study
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Zhen-Yuan Liu, Feng Tang, Jing Wang, Jin-Zhou Yang, Xi Chen, Ze-Fen Wang, and Zhi-Qiang Li
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Glioma ,Glioblastoma ,Beta2-microglobulin ,Prognosis ,Biomarker ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Abstract Background Gliomas are the deadliest malignant tumors of the adult central nervous system. We previously discovered that beta2-microglobulin (B2M) is abnormally upregulated in glioma tissues and that it exerts a range of oncogenic effects. Besides its tissue presence, serum B2M levels serve as biomarkers for various diseases. This study aimed to explore whether serum B2M levels can be used in the diagnosis and prognosis of gliomas. Methods Medical records from 246 glioma patients were retrospectively analyzed. The relationship between preoperative serum B2M levels and clinicopathological features was examined. Kaplan-Meier analysis, alongside uni- and multivariate Cox regression, assessed the association between B2M levels, systemic inflammatory markers, and glioma patient prognosis. Receiver operating characteristic (ROC) curve analysis evaluated the diagnostic significance of these biomarkers specifically for glioblastoma (GBM). Results Patients with malignant gliomas exhibited elevated preoperative serum B2M levels. Glioma patients with high serum B2M levels experienced shorter survival times. Multivariate Cox analysis determined the relationship between B2M levels (hazard ratio = 1.92, 95% confidence interval: 1.05–3.50, P = 0.034) and the overall survival of glioma patients. B2M demonstrated superior discriminatory power in distinguishing between GBM and non-GBM compared to inflammation indicators. Moreover, postoperative serum B2M levels were lower than preoperative levels in the majority of glioma patients. Conclusions High preoperative serum B2M levels correlated with malignant glioma and a poor prognosis. Serum B2M shows promise as a novel biomarker for predicting patient prognosis and reflecting the therapeutic response.
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- 2024
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35. Enhanced cellular therapy: revolutionizing adoptive cellular therapy
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Meng-Yao Xu, Na Zeng, Chen-Qian Liu, Jian-Xuan Sun, Ye An, Si-Han Zhang, Jin-Zhou Xu, Xing-Yu Zhong, Si-Yang Ma, Hao-Dong He, Jia Hu, Qi-Dong Xia, and Shao-Gang Wang
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Enhanced cellular therapy ,Adoptive cellular therapy ,Immunotherapy ,Immune checkpoint inhibitor ,PROTAC ,Oncolytic virus ,Diseases of the blood and blood-forming organs ,RC633-647.5 ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Abstract Enhanced cellular therapy has emerged as a novel concept following the basis of cellular therapy. This treatment modality applied drugs or biotechnology to directly enhance or genetically modify cells to enhance the efficacy of adoptive cellular therapy (ACT). Drugs or biotechnology that enhance the killing ability of immune cells include immune checkpoint inhibitors (ICIs) / antibody drugs, small molecule inhibitors, immunomodulatory factors, proteolysis targeting chimera (PROTAC), oncolytic virus (OV), etc. Firstly, overcoming the inhibitory tumor microenvironment (TME) can enhance the efficacy of ACT, which can be achieved by blocking the immune checkpoint. Secondly, cytokines or cytokine receptors can be expressed by genetic engineering or added directly to adoptive cells to enhance the migration and infiltration of adoptive cells to tumor cells. Moreover, multi-antigen chimeric antigen receptors (CARs) can be designed to enhance the specific recognition of tumor cell-related antigens, and OVs can also stimulate antigen release. In addition to inserting suicide genes into adoptive cells, PROTAC technology can be used as a safety switch or degradation agent of immunosuppressive factors to enhance the safety and efficacy of adoptive cells. This article comprehensively summarizes the mechanism, current situation, and clinical application of enhanced cellular therapy, describing potential improvements to adoptive cellular therapy.
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- 2024
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36. Structure and Properties of Epoxy Resin/Graphene Oxide Composites Prepared from Silicon Dioxide-Modified Graphene Oxide
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Jin An, Yue Zhang, Xiaojun Zhang, Mingpeng He, Jiang Zhou, Jin Zhou, Yan Liu, Xuebing Chen, Yiwen Hu, Xiuduo Song, Jinyao Chen, Tong Wu, Jian Kang, and Zhihui Xie
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Chemistry ,QD1-999 - Published
- 2024
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37. CDK4/6 inhibition sensitizes MEK inhibition by inhibiting cell cycle and proliferation in pancreatic ductal adenocarcinoma
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Ke Cheng, Zijian Zhou, Qiangxing Chen, Zixin Chen, Yu Cai, He Cai, Shangdi Wu, Pan Gao, Yunqiang Cai, Jin Zhou, Xin Wang, Zhong Wu, and Bing Peng
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PDAC ,Trametinib ,Palbociclib ,Drug resistance ,Medicine ,Science - Abstract
Abstract Pancreatic ductal adenocarcinoma (PDAC) is not sensitive to most chemotherapy drugs, leading to poor chemotherapy efficacy. Recently, Trametinib and Palbociclib have promising prospects in the treatment of pancreatic cancer. This article aims to explore the effects of Trametinib on pancreatic cancer and address the underlying mechanism of resistance as well as its reversal strategies. The GDSC (Genomics of Drug Sensitivity in Cancer) and CTD2 (Cancer Target Discovery and Development) were utilized to screen the potential drug candidate in PDAC cell lines. The dose-increase method combined with the high-dose shock method was applied to induce the Trametinib-resistant PANC-1 and MIA PaCa-2 cell lines. The CCK8 proliferation assay, colony formation assay, flow cytometry, and western blot were conducted to verify the inhibitory effect of Trametinib and Palbociclib. RNA-seq was performed in resistant PDAC cell lines to find the differential expression genes related to drug resistance and predict pathways leading to the reversal of Trametinib resistance. The GDSC and CTD2 database screening revealed that Trametinib demonstrates a significant inhibitory effect on PDAC. We found that Trametinib has a lower IC50 than Gemcitabine in PDAC cell lines. Both Trametinib and Gemcitabine can decrease the proliferation capacity of pancreatic cells, induce cell cycle arrest, and increase apoptosis. Simultaneously, the phosphorylation of the AKT and ERK pathways were inhibited by the treatment of Trametinib. In addition, the RNA-seq of Trametinib-induced resistance PDAC cell lines reveals that the cyclin-dependent kinase (CDK)-RB-E2F regulatory axis and G2/M DNA damage checkpoint might lead the drug resistance. Besides, the combination of Trametinib with Palbociclib could inhibit the proliferation and cell cycle of both resistant cells lines and also restore the sensitivity of drug-resistant cells to Trametinib. Last but not least, the interferon-α and interferon-γ expression were upregulated in resistance cell lines, which might lead to the reversal of drug resistance. The study shows Trametinib has a critical inhibitory effect on PDAC. Besides, the combination of Trametinib with Palbociclib can inhibit the proliferation of PDAC-resistant cells.
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- 2024
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38. Associations between corneal curvature and other anterior segment biometrics in young myopic adults
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Li Jiang, Zijing Du, Wei Sun, Shanqing Zhu, Lu Xiong, Xuejun Fang, Jin Zhou, Qingsong Zhang, Xiaohua Lei, Qingyan Zeng, Zheng Wang, and Yijun Hu
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Ocular biometrics ,Anterior segment biometrics ,Corneal biometrics ,Corneal curvature (CC) ,Myopia ,Refractive surgery ,Medicine ,Science - Abstract
Abstract To investigate the associations between corneal curvature (CC) and other anterior segment biometrics in young myopic adults. In this retrospective multi-center study, 7893 young myopic adults were included. CC and other anterior segment biometrics were measured by Scheimpflug imaging (Pentacam). CC was defined as SimK at central 3 mm area, and other anterior segment biometrics included white-to-white corneal diameter (WTW), central corneal thickness (CCT), corneal volume (CV) at 3 mm, 5 mm, and 7 mm area, anterior corneal astigmatism (ACA), posterior corneal astigmatism (PCA), anterior corneal eccentricity (ACE) and asphericity (ACAP), posterior corneal eccentricity (PCE) and asphericity (PCAP), anterior chamber depth (ACD), and anterior chamber volume (ACV). Univariate regression analyses were used to assess the associations between CC and other anterior segment biometrics, and multivariate regression analyses were further performed to adjusted for age, gender and spherical equivalent. CC was higher in patients of female gender and higher myopia (all P
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- 2024
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39. Limit Cycles Appearing from a Generalized Heteroclinic Loop with an Elementary Saddle and a Nilpotent Saddle by Perturbing Piecewise Hamiltonian Systems
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Jin, Zhou, Wei, Zhouchao, and Muni, Sishu Shankar
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Mathematics - Dynamical Systems - Abstract
In this paper, we study limit cycle bifurcations for a class of general near-Hamiltonian systems near a heteroclinic loop with an elementary saddle and a nilpotent saddle. Firstly, we consider the behaviors of the unperturbed system, providing the phase portraits of the system and the necessary conditions for the appearance of a heteroclinic loop with an elementary saddle and a nilpotent saddle by using the relevant qualitative theory. Then, with consideration of the expression of the first-order Melnikov function, we derive its expansion near the heteroclinic loop by employing some techniques and properties of the Abelian integral. Finally, we investigate the coefficients of the expansion and show that there can exist at least $4[\frac{n+1}{2}]+1$ limit cycles under disturbance., Comment: 21 pages, 1 figure
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- 2022
40. GECAM Localization of High Energy Transients and the Systematic Error
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Zhao, Yi, Xue, Wang-Chen, Xiong, Shao-Lin, Wang, Yuan-Hao, Liu, Jia-Cong, Liuo, Qi, Zhang, Yan-Qiu, Sun, Jian-Chao, Zhao, Xiao-Yun, Cai, Ce, Xiao, Shuo, Huang, Yue, Li, Xiao-Bo, Zhang, Zhen, Liao, Jin-Yuan, Yang, Sheng, Qiao, Rui, Guo, Dong-Ya, Zheng, Chao, Yi, Qi-Bin, Xie, Sheng-Lun, Guo, Zhi-Wei, Li, Chao-Yang, Wang, Chen-Wei, Tan, Wen-Jun, Wang, Yue, Peng, Wen-Xi, Zheng, Shi-Jie, He, Jian-Jian, Wang, Ping, Wang, Jin, Ma, Xiang, Song, Xin-Ying, Zhang, Hong-Mei, Li, Bing, Zhang, Peng, Wu, Hong, Du, Yan-Qi, Liang, Jing, Zhao, Guo-Ying, Li, Xin-Qiao, Wen, Xiang-Yang, An, Zheng-Hua, Sun, Xi-Lei, Xu, Yan-Bing, Zhang, Fan, Zhang, Da-Li, Gong, Ke, Liu, Ya-Qing, Liang, Xiao-Hua, Liu, Xiao-Jing, Gao, Min, Wang, Jin-Zhou, Song, Li-Ming, Chen, Gang, Zhang, Ke-Ke, Han, Xing-Bo, Wu, Hai-Yan, Hu, Tai, Geng, Hao, Lu, Fang-Jun, Zhang, Shu, Zhang, Shuang-Nan, Lu, Gao-Peng, Zeng, Ming, and Yu, Heng
- Subjects
Astrophysics - Instrumentation and Methods for Astrophysics ,Astrophysics - High Energy Astrophysical Phenomena - Abstract
Gravitational wave high-energy Electromagnetic Counterpart All-sky Monitor (GECAM) is a pair of microsatellites (i.e. GECAM-A and GECAM-B) dedicated to monitoring gamma-ray transients including gravitational waves high-energy electromagnetic counterparts, Gamma-ray Bursts, Soft Gamma-ray Repeaters, Solar Flares and Terrestrial Gamma-ray Flashes. Since launch in December 2020, GECAM-B has detected hundreds of astronomical and terrestrial events. For these bursts, localization is the key for burst identification and classification as well as follow-up observations in multi-wavelength. Here, we propose a Bayesian localization method with Poisson data with Gaussian background profile likelihood to localize GECAM bursts based on the burst counts distribution in detectors with different orientations. We demonstrate that this method can work well for all kinds of bursts, especially for extremely short ones. In addition, we propose a new method to estimate the systematic error of localization based on a confidence level test, which can overcome some problems of the existing method in literature. We validate this method by Monte Carlo simulations, and then apply it to a burst sample with accurate location and find that the mean value of the systematic error of GECAM-B localization is $\sim 2.5^{\circ}$. By considering this systematic error, we can obtain a reliable localization probability map for GECAM bursts. Our methods can be applied to other gamma-ray monitors., Comment: The paper has been accepted by Astrophysical Journal Supplement Series
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- 2022
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41. Silencing GDI2 inhibits proliferation, migration and invasion of colorectal cancer through activation of p53 signaling pathway
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Wen-Ting Ou, Rong-Jian Tan, Jia-Wei Zhai, Li-Jun Sun, Fei-Peng Xu, Xian-Jin Huang, Zhen-Hao Quan, and Cai-Jin Zhou
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Colorectal cancer ,GDI2 ,Transcriptomics ,p53 signaling pathway ,Science (General) ,Q1-390 ,Social sciences (General) ,H1-99 - Abstract
Objective: To investigate the effect of silencing GDP dissociation inhibitor 2 (GDI2) on colorectal cancer development and possible mechanisms based on transcriptomic analysis. Methods: The differences in the expression levels of GDI2 in normal colorectal tissues and tumor tissues of colorectal cancer (CRC) patients were detected. The correlation of GDI2 expression levels with survival and clinical characteristics of CRC patients was analyzed. The effects of GDI2 expression levels on the biological functions of CRC cells were examined by CCK-8 assay, plate clone formation assay, wound healing assay, and Transwell assay. The effect of GDI2 on the proliferation and growth of xenograft tumors was investigated by a xenograft tumor model of CRC in nude mice. Based on transcriptomics, we explored the possible mechanisms and associated pathways of the effect of silencing GDI2 on CRC cells. Cellular experiments and Western blot assays were performed to verify the potential mechanisms and related pathway of GDI2 action on CRC. Results: The expression levels of GDI2 in CRC tissues and cells were higher than those in normal tissues and cells. The expression level of GDI2 correlated with clinical characteristics such as lymphatic metastasis, tumor stage, tumor volume, and lymphocyte count. Silencing of GDI2 reduced the proliferative activity and migration and invasion ability of CRC cells, as well as inhibited the proliferation of CRC xenograft tumors. The differentially expressed genes were significantly enriched in biological processes such as cell cycle arrest and the p53 signaling pathway after GDI2 silencing. The percentage of G0/G1 phase cells in CRC cells was increased after silencing GDI2 as verified by flow cytometry. RAB5A was highly associated with the p53 pathway and could interact with TP53 via the ZFYVE20 protein. The mutual binding between GDI2 protein and RAB5A protein was verified by immunoprecipitation assay. Silencing GDI2 while overexpressing RAB5A reversed the reduced proliferation, migration, and invasion ability as well as cell cycle arrest of CRC cells. Meanwhile, the addition of p53 signaling pathway inhibitor Pifithrin-α (PFT-α) also reversed the biological effects of silencing GDI2 on CRC cells. The p-p21 and p-p53 protein expression levels were significantly greater in the sh-GDI2 group than in the sh-NC group. However, the p-p21 and p-p53 protein expression levels were reduced after silencing GDI2 while overexpressing RAB5A. Conclusion: Silencing GDI2 activates the p53 signaling pathway by regulating RAB5A expression levels, which in turn induces cell cycle arrest and ultimately affects the proliferative activity, migration, and invasive ability of CRC cells.
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- 2024
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42. Esrra regulates Rplp1-mediated translation of lysosome proteins suppressed in metabolic dysfunction-associated steatohepatitis and reversed by alternate day fasting
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Madhulika Tripathi, Karine Gauthier, Reddemma Sandireddy, Jin Zhou, Priyanka Guptta, Suganya Sakthivel, Wei Wen Teo, Yadanar Than Naing, Kabilesh Arul, Keziah Tikno, Sung-Hee Park, Yajun Wu, Lijin Wang, Boon-Huat Bay, Lei Sun, Vincent Giguere, Pierce K.H. Chow, Sujoy Ghosh, Donald P. McDonnell, Paul M. Yen, and Brijesh K. Singh
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Metabolic dysfunction-associated steatohepatitis (MASH) ,Lysosome ,Estrogen related receptor alpha (ERRα/Esrra) ,Ribosome ,Protein translation ,Internal medicine ,RC31-1245 - Abstract
Objective: Currently, little is known about the mechanism(s) regulating global and specific protein translation during metabolic dysfunction-associated steatohepatitis (MASH; previously known as non-alcoholic steatohepatitis, NASH). Methods: Unbiased label-free quantitative proteome, puromycin-labelling and polysome profiling were used to understand protein translation activity in vitro and in vivo. Results: We observed a global decrease in protein translation during lipotoxicity in human primary hepatocytes, mouse hepatic AML12 cells, and livers from a dietary mouse model of MASH. Interestingly, proteomic analysis showed that Rplp1, which regulates ribosome and translation pathways, was one of the most downregulated proteins. Moreover, decreased Esrra expression and binding to the Rplp1 promoter, diminished Rplp1 gene expression during lipotoxicity. This, in turn, reduced global protein translation and Esrra/Rplp1-dependent translation of lysosome (Lamp2, Ctsd) and autophagy (sqstm1, Map1lc3b) proteins. Of note, Esrra did not increase its binding to these gene promoters or their gene transcription, confirming its regulation of their translation during lipotoxicity. Notably, hepatic Esrra-Rplp1-dependent translation of lysosomal and autophagy proteins also was impaired in MASH patients and liver-specific Esrra knockout mice. Remarkably, alternate day fasting induced Esrra-Rplp1-dependent expression of lysosomal proteins, restored autophagy, and reduced lipotoxicity, inflammation, and fibrosis in hepatic cell culture and in vivo models of MASH. Conclusions: Esrra regulation of Rplp1-mediated translation of lysosome/autolysosome proteins was downregulated during MASH. Alternate day fasting activated this novel pathway and improved MASH, suggesting that Esrra and Rplp1 may serve as therapeutic targets for MASH. Our findings also provided the first example of a nuclear hormone receptor, Esrra, to not only regulate transcription but also protein translation, via induction of Rplp1.
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- 2024
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43. Acupuncture, an effective treatment for post-stroke neurologic dysfunction
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You Zhang, Yi-Wen Tang, Yu-Ting Peng, Zi Yan, Jin Zhou, and Zeng-Hui Yue
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Stroke ,Acupuncture ,Neurologic recovery ,Rehabilitation ,Neurologic dysfunction ,Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 - Abstract
Stroke episodes represent a significant subset of cerebrovascular diseases globally, often resulting in diverse neurological impairments such as hemiparesis, spasticity, dysphagia, sensory dysfunction, cognitive impairment, depression, aphasia, and other sequelae. These dysfunctions markedly diminish patients' quality of life and impose substantial burdens on their families and society. Consequently, the restoration of neurological function post-stroke remains a primary objective of clinical treatment. Acupuncture, a traditional Chinese medicine technique, is endorsed by the World Health Organization (WHO) for stroke treatment due to its distinct advantages in managing cerebrovascular diseases, including ischemic stroke. Numerous clinical studies have substantiated the efficacy of acupuncture in ameliorating neurological dysfunctions following stroke. This review systematically examines the improvements in post-stroke neurological dysfunction attributable to acupuncture treatment and elucidates potential mechanisms of action proposed in recent years. Additionally, this article aims to present novel therapeutic concepts and strategies for the clinical management of post-stroke neurological dysfunction.
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- 2024
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44. From mitochondria to tumor suppression: ACAT1's crucial role in gastric cancer
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Wei He, Yanfang Li, Song-Bai Liu, Ying Chang, Shiyuan Han, Xingyu Han, Zixin Ma, Hesham M. Amin, Yao-Hua Song, and Jin Zhou
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gastric cancer ,ACAT1 ,tumor stem cells ,EMT ,mitochondrial enzyme ,Immunologic diseases. Allergy ,RC581-607 - Abstract
Acetyl CoA acetyltransferase 1 (ACAT1), a mitochondrial enzyme, is mainly involved in the formation and decomposition of ketones, isoleucine, and fatty acids. Previous clinical studies showed that mutations in the ACAT1 gene lead to ketoacidosis, Notably the role of ACAT1 in human cancer’ pathogenesis varies depending on cancer type, and its specific role in gastric cancer remains largely unknown. In the current study, we found that the expression of ACAT1 in primary late-stage gastric cancer tumor tissues was significantly lower than in early-stage tumors. This observation was further confirmed in high-grade gastric cancer cell line MKN45. The expression of CD44 and OCT4 was decreased, while CD24 expression was increased by overexpressing ACAT1 in MKN45 gastric cancer cells. Moreover, the ability of gastric cancer cells to form colonies on soft agar was also reduced by ACAT1 overexpression. Likewise, overexpression of ACAT1 inhibited epithelial mesenchymal transition (EMT) in gastric cancer cells evidenced by increased expression of the epithelial marker E-Cadherin, decreased expression of mesenchymal marker vimentin, and decreased expression levels of SNAI 1/3. In addition, ACAT1 overexpression inhibited cell migration and invasion, improved the response to 5-Fluorouracil (5-FU) and etoposide. In contrast, inhibition of ACAT1 activity promoted the proliferation of gastric cancer cells. The xenotransplantation results in nude mice showed that overexpression of ACAT1 in gastric cancer cells inhibited tumor growth in vivo. In addition, the low expression of ACAT1 in gastric cancer was further validated by searching public databases and conducting bioinformatic analyses. Mechanistically, bioinformatic analysis found that the inhibitory effect of ACAT1 in gastric cancer may be related to the Adipocytokine Signaling Pathway, Ppar Signaling Pathway, Propanoate Metabolism and P53 Signaling Pathway. Correlation analysis indicated ACAT1 mRNA expression was correlated with immune infiltrates. Collectively, our data show that ACAT1 induces pronounced inhibitory effects on gastric cancer initiation and development, which may impact future strategies to treat this aggressive cancer.
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- 2024
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45. Enhanced recovery after surgery in elective cesarean section patients with gestational diabetes mellitus does not lead to glucose-related maternal and neonatal complications
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Jin Zhou, Peizhen Zhang, Zhangmin Tan, Chuo Li, Lin Yao, Tiantian He, Hongyin Hou, and Yuzhu Yin
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enhanced recovery after surgery ,gestational diabetes mellitus ,cesarean section ,hypoglycemia ,carbohydrate ,Diseases of the endocrine glands. Clinical endocrinology ,RC648-665 - Abstract
ObjectiveFor elective cesarean section patients with gestational diabetes mellitus (GDM), there is a lack of evidence-based research on the use of enhanced recovery after surgery (ERAS). This study aims to compare the ERAS after-surgery protocol and traditional perioperative management.Research design and methodsIn this retrospective cohort study, singleton pregnancies with good glucose control GDM, delivered by elective cesarean sections under intravertebral anesthesia at least 37 weeks from January 1 to December 31, 2022, were collected at the Third Affiliated Hospital of Sun Yat-sen University. We divided all enrolled pregnant women and newborns into an ERAS group and a control group (the traditional perioperative management group) based on their adherence to the ERAS protocol. The primary outcome was the preoperative blood glucose level, with an increase of more than 1 mmol/L indicating clinical significance when compared to the control group. The secondary outcome was centered around an adverse composite outcome that affected both mothers and newborns.ResultsWe collected a total of 161 cases, with 82 in the ERAS group and 79 in the control group. Although the mean preoperative blood glucose level in the ERAS group was significantly higher than in the control group (5.01 ± 1.06 mmol/L vs. 4.45 ± 0.90 mmol/L, p
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- 2024
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46. Pretreatment pulmonary tumor necrosis is a promising prognostic imaging biomarker for first-line anti-PD-1/PD-L1 therapy in advanced lung squamous cell carcinoma: a multi-institutional, propensity score-matching cohort analysis
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Qiaofeng Zhong, Longfeng Zhang, Lin Wu, Jun Zhao, Jianguo Sun, Yong Fang, Jin Zhou, Qian Chu, Yihong Shen, Zhenzhou Yang, Lijin Chen, Meijuan Huang, Xiaoyan Lin, Zhenhua Liu, Peng Shen, Zhijie Wang, Xin Wang, Huijuan Wang, Chengbo Han, Anwen Liu, Hongmei Zhang, Feng Ye, Wen Gao, Fang Wu, Zhengbo Song, Shengchi Chen, Chengzhi Zhou, Dingzhi Huang, Qiuyu Zhang, Xinlong Zheng, Xiaobin Zheng, Qian Miao, Kan Jiang, Zihua Zou, Yiquan Xu, Shiwen Wu, Haibo Wang, Yaping Hong, Tao Lu, Chao Li, Cheng Huang, Chuanben Chen, and Gen Lin
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Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Background: Tumor necrosis (TN) is a common feature in lung squamous cell carcinoma (LSCC), which could provide useful predictive and prognostic information. Objectives: This study aimed to investigate the effect of pretreatment pulmonary TN (PTN) on the prognosis of first-line anti-programmed cell death 1 (PD-1)/PD ligand 1 (PD-L1) inhibitor in advanced LSCC. Design: We conducted a retrospective study to analyze the association between the presence of PTN and clinical outcomes in advanced LSCC patients treated with anti-PD-1/PD-L1 inhibitors. Methods: Data from 240 eligible patients were collected from 27 hospitals across China between 2016 and 2020. The presence of PTN was assessed using contrast-enhanced chest computed tomography (CT) imaging at baseline. We utilized the Cox proportional-hazards regression model to analyze the association between PTN and clinical outcomes. In addition, to account for potential confounding factors and ensure comparability between groups, we employed propensity score-matching (PSM) analysis. Results: In the overall patient cohort, the presence of PTN was 39.6%. The median follow-up duration was 20.3 months. The positive PTN group exhibited a notably inferior median progression-free survival (PFS; 6.5 months vs 8.6 months, p = 0.012) compared to the negative PTN group. Within the Cox proportional-hazards regression model, PTN emerged as an independent predictor of unfavorable PFS (hazard ratio (HR) = 1.354, 95% confidence interval (CI): 1.002–1.830, p = 0.049). After PSM, the median PFS for the positive PTN group (6.5 months vs 8.0 months, p = 0.027) remained worse than that of the negative PTN group. Multivariate analyses also further underscored that the presence of PTN independently posed a risk for shorter PFS (HR = 1.494, 95% CI: 1.056–2.112, p = 0.023). However, no statistically significant difference in overall survival was observed between the two groups. Conclusion: Our study suggests that the presence of PTN on baseline contrast-enhanced chest CT is a potential negative prognostic imaging biomarker for the outcome of anti-PD-1/PD-L1 inhibitor therapy in advanced LSCC. Further studies are warranted to validate these findings and explore the underlying mechanisms.
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- 2024
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47. Two colistin resistance-producing Aeromonas strains, isolated from coastal waters in Zhejiang, China: characteristics, multi-drug resistance and pathogenicity
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Hong-Xian Chen, Fang-Jie Chen, Qian-Jin Zhou, Shi-Lin Shang, Biao Tang, Zhong-Jie Xu, Li-Jun Duan, Jing-Lei Jin, Gui-Zong Xu, Mao-Cang Yan, and Jiong Chen
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Aeromonas ,antibiotic resistance genes ,mobile genetic elements ,mcr-3 ,pathogenicity ,coastal water ,Microbiology ,QR1-502 - Abstract
IntroductionAeromonas spp. are ubiquitous inhabitants of ecosystems, and many species are opportunistically pathogenic to humans and animals. Multidrug-resistant (MDR) Aeromonas species have been widely detected in hospitals, urban rivers, livestock, and aquatic animals.ResultsIn this study, we identified two Aeromonas isolates, namely Aeromonas veronii 0728Q8Av and Aeromonas caviae 1029Y16Ac, from coastal waters in Zhejiang, China. Both isolates exhibited typical biochemical characteristics and conferred MDR to 11 kinds of antibiotics, remaining susceptible to ceftazidime. Whole-genome sequencing revealed that both isolates harbored multiple antibiotic resistance genes (ARGs) and several mobile genetic elements (MGEs) on the chromosomes, each containing a resistance genomic island (GI), a typical class 1 integron, a transposon, and various insertion sequences (ISs). Most ARGs were situated within the multiple resistance GI, which contained a class 1 integron and a transposon in both Aeromonas isolates. Furthermore, a chromosomal mcr-3.16 gene was identified in A. veronii 0728Q8Av, while a chromosomal mcr-3.3 was found in A. caviae 1029Y16Ac. Both mcr-3 variants were not located within but were distanced from the multidrug resistance GI on the chromosome, flanking by multiple ISs. In addition, a mcr-3-like was found adjacent to mcr-3.16 to form a tandem mcr-3.16-mcr-3-like-dgkA structure; yet, Escherichia coli carrying the recombinants of mcr-3-like did not exhibit resistance to colistin. And an incomplete mcr-3-like was found adjacent to mcr-3.3 in A. caviae 1029Y16Ac, suggesting the possibility that mcr-3 variants originated from Aeromonas species. In vivo bacterial pathogenicity test indicated that A. veronii 0728Q8Av exhibited moderate pathogenicity towards infected ayu, while A. caviae 1029Y16Ac was non-virulent.DiscussionThus, both Aeromonas species deserve further attention regarding their antimicrobial resistance and pathogenicity.
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- 2024
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48. Knowledge, attitude, and practice of Chinese parents with infants (aged 0–3 years) toward immunity, gut microbiota and biotics: a comprehensive study
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Jiongnan Wang, Nan Liu, Yufan Chen, Jialu You, Yunqing Yang, Yi Jin, Guiju Sun, and Jin Zhou
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infants ,KAP ,immunity ,gut microbiota ,biotics ,Immunologic diseases. Allergy ,RC581-607 - Abstract
In the wake of the COVID-19 pandemic, there has been an increasing focus towards infant immunity. The development and maintenance of the immune system are significantly influenced from birth, and is shaped by early-life infant feeding behavior. Hence, the knowledge, attitude, and practice (KAP) of parents play a crucial role in shaping the immune system of infants. A total of 2369 parents across 19 cities in China were surveyed using a self-designed online questionnaire. The KAP questionnaire assessed three domains: immunity, gut microbiota, and biotics (prebiotics, probiotics, and synbiotics). The questionnaire also included questions on infant health. An overwhelming majority of parents (97.90%) placed high value on their children’s immunity, and 40.40% of them reported an increased level of concern following the COVID-19 pandemic. Diarrhea (78.80%), colds (75.70%), nighttime crying (73.80%), regurgitation (71.70%) and food retention (66.50%) were the major health issues reported. Knowledge scores toward immunity and gut microbiota were positively correlated to attitude and practice scores, respectively. Attitude scores toward immunity, gut microbiota and biotics were positively correlated to their respective practice scores. Parental knowledge score on immunity was negatively correlated with diarrhea, colds, regurgitation and food retention. On the other hand, parental practice scores toward immunity were negatively correlated with food retention. In regards to gut microbiota, parental knowledge score was negatively correlated with diarrhea, regurgitation and food retention; parental attitude score was negatively correlated with nighttime crying whereas practice score was negatively correlated with diarrhea, regurgitation, food retention and nighttime crying. Attitude score toward biotics was negatively correlated with nighttime crying and practice scores toward biotics was negatively correlated with colds, food retention and nighttime crying. This study demonstrated that significant gaps and misunderstandings exist among parents regarding immunity, gut microbiota health, and biotics. Both public education and interventions are crucial to enhance parental knowledge and practices, thereby improving infant immunity.
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- 2024
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49. Unraveling the signaling network between dysregulated microRNA and mRNA expression in sevoflurane-induced developmental neurotoxicity in rat
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Yuanyuan Wang, Xin Men, Xiaodong Huang, Xiaoxiao Qiu, Weilong Wang, Jin Zhou, and Zhenfeng Zhou
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Sevoflurane ,Neurotoxicity ,miRNA-mRNA network ,Neuroapoptosis ,Science (General) ,Q1-390 ,Social sciences (General) ,H1-99 - Abstract
Research has indicated that general anesthesia may cause neuroapoptosis and long-term cognitive dysfunction in developing animals, however, the precise mechanisms orchestrating these outcomes remain inadequately elucidated within scholarly discourse. The purpose of this study was to investigate the impact of sevoflurane on the hippocampus of developing rats by analyzing the changes in microRNA and mRNA and their interactions. Rats were exposed to sevoflurane for 4 h on their seventh day after birth, and the hippocampus was collected for analysis of neuroapoptosis by Western blot and immunohistochemistry. High-throughput sequencing was conducted to analyze the variances in miRNA and mRNA expression levels, and the Morris water maze was employed to assess long-term memory in rats exposed to sevoflurane after 8 weeks. The results showed that sevoflurane exposure led to dysregulation of 5 miRNAs and 306 mRNAs in the hippocampus. Bioinformatic analysis revealed that these dysregulated miRNA-mRNA target pairs were associated with pathological neurodevelopment and developmental disorders, such as regulation of axonogenesis, regulation of neuron projection development, regulation of neuron differentiation, transmission of nerve impulse, and neuronal cell body. Further analysis showed that these miRNAs formed potential network interactions with 44 mRNAs, and two important nodes were identified, miR-130b-5p and miR-449c-5p. Overall, this study suggests that the dysregulation of the miRNA-mRNA signaling network induced by sevoflurane may contribute to neurodevelopmental toxicity in the hippocampus of rats and be associated with long-term cognitive dysfunction.
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- 2024
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50. A Miniaturized Filtering Power Divider With High Selectivity and Wide Stopband Based on 3-D Heterogeneous Integration Technology.
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Zhi-Hao Liu, Yu-Jin Zhou, and Chong-Hu Cheng
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- 2024
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