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Your search keyword '"Jin, Yin-Chuan"' showing total 14 results
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14 results on '"Jin, Yin-Chuan"'

2. Commentary: Targeting the MRI-mapped psychopathology of major psychiatric disorders with neurostimulation

Author

Xie, Jia-Xin, primary, Cui, Jin-Jin, additional, Cao, Yang, additional, Gu, Yue-Wen, additional, Fan, Jing-Wen, additional, Ren, Lei, additional, Liu, Xiao-Fan, additional, Zhao, Shu-Wan, additional, Shi, Wang-Hong, additional, Yang, Qun, additional, Jin, Yin-Chuan, additional, Li, Feng-Zhan, additional, Song, Lei, additional, Yin, Hong, additional, Cao, Feng, additional, Li, Baojuan, additional, and Cui, Long-Biao, additional

Published
2022
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6. Shaping the Trans-Scale Properties of Schizophrenia via Cerebral Alterations on Magnetic Resonance Imaging and Single-Nucleotide Polymorphisms of Coding and Non-Coding Regions

Author

Zhao, Shu-Wan, primary, Xu, Xian, additional, Wang, Xian-Yang, additional, Yan, Tian-Cai, additional, Cao, Yang, additional, Yan, Qing-Hong, additional, Chen, Kun, additional, Jin, Yin-Chuan, additional, Zhang, Ya-Hong, additional, Yin, Hong, additional, and Cui, Long-Biao, additional

Published
2021
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9. Combination of stromal vascular fraction and Ad-COMP-Ang1 gene therapy improves long-term therapeutic efficacy for diabetes-induced erectile dysfunction

Author

Wang, Xiong, primary, Jin, Hai-Rong, primary, Yin, Guo-Nan, additional, Wang, Lin, additional, Lin, Xiang-Nan, additional, Shi, Lei, additional, Gao, Zhen-Lin, additional, Han, Feng-Chan, additional, Li, Ping, additional, Jin, Yin-Chuan, additional, Suh, Jun-Kyu, additional, and Ryu, Ji-Kan, additional

Published
2018
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14. Combination of stromal vascular fraction and Ad-COMP-Ang1 gene therapy improves long-term therapeutic efficacy for diabetes-induced erectile dysfunction.

Author

Yin GN, Wang L, Lin XN, Shi L, Gao ZL, Han FC, Li P, Jin YC, Suh JK, Ryu JK, Wang X, and Jin HR

Subjects
Animals, Diabetes Mellitus, Experimental metabolism, Endothelium, Vascular metabolism, Erectile Dysfunction etiology, Erectile Dysfunction metabolism, Intercellular Junctions metabolism, Male, Mice, Permeability, Angiopoietin-1 genetics, Diabetes Mellitus, Experimental complications, Erectile Dysfunction therapy, Genetic Therapy methods, Mesenchymal Stem Cell Transplantation, Penile Erection physiology
Abstract

Men with diabetic erectile dysfunction (ED) respond poorly to the currently available oral phosphodiesterase-5 inhibitors. Therefore, functional therapies for diabetic ED are needed. Stromal vascular fraction (SVF) and the adenovirus-mediated cartilage oligomeric matrix angiopoietin-1 (Ad-COMP-Ang1) gene are known to play critical roles in penile erection. We previously reported that SVF and Ad-COMP-Ang1 have only a short-term effect in restoring erectile function. Further improvements to ED therapy are needed for long-lasting effects. In the present study, we aimed to test if the combination of SVF and Ad-COMP-Ang1 could extend the erection effect in diabetic ED. We found that the combination therapy showed a long-term effect in restoring erectile function through enhanced penile endothelial and neural cell regeneration. Combination therapy with SVF and Ad-COMP-Ang1 notably restored cavernous endothelial cell numbers, pericyte numbers, endothelial cell-cell junctions, decreased cavernous endothelial cell permeability, and promoted neural regeneration for at least 4 weeks in diabetic mice. In summary, this is an initial description of the long-term effect of combination therapy with SVF and Ad-COMP-Ang1 in restoring erectile function through a dual effect on endothelial and neural cell regeneration. Such combination therapy may have therapeutic potential for the treatment of diabetic ED., Competing Interests: All authors declared no competing interests

Published
2018
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