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25 results on '"Jin, Shuyu"'

4. Automatically Generate Steganographic Text Based on Markov Model and Huffman Coding

Author

Yang, Zhongliang, Jin, Shuyu, Huang, Yongfeng, Zhang, Yujin, and Li, Hui

Subjects
Computer Science - Cryptography and Security
Abstract

Steganography, as one of the three basic information security systems, has long played an important role in safeguarding the privacy and confidentiality of data in cyberspace. The text is the most widely used information carrier in people's daily life, using text as a carrier for information hiding has broad research prospects. However, due to the high coding degree and less information redundancy in the text, it has been an extremely challenging problem to hide information in it for a long time. In this paper, we propose a steganography method which can automatically generate steganographic text based on the Markov chain model and Huffman coding. It can automatically generate fluent text carrier in terms of secret information which need to be embedded. The proposed model can learn from a large number of samples written by people and obtain a good estimate of the statistical language model. We evaluated the proposed model from several perspectives. Experimental results show that the performance of the proposed model is superior to all the previous related methods in terms of information imperceptibility and information hidden capacity., Comment: Submitted to IETE Technical Review

Published
2018

10. Identification of a Self-Assembling Small-Molecule Cancer Vaccine Adjuvant with an Improved Toxicity Profile

Author

Zhuo, Shao-Hua, primary, Noda, Naotaka, additional, Hioki, Kou, additional, Jin, Shuyu, additional, Hayashi, Tomoya, additional, Hiraga, Kou, additional, Momose, Haruka, additional, Li, Wen-Hao, additional, Zhao, Lang, additional, Mizukami, Takuo, additional, Ishii, Ken J., additional, Li, Yan-Mei, additional, and Uesugi, Motonari, additional

Published
2023
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14. High-Power, Short-Duration Ablation under the Guidance of Relatively Low Ablation Index Values for Paroxysmal Atrial Fibrillation: Long-Term Outcomes and Characteristics of Recurrent Atrial Arrhythmias

Author

Jin, Shuyu, primary, Lin, Weidong, additional, Fang, Xianhong, additional, Liao, Hongtao, additional, Zhan, Xianzhang, additional, Fu, Lu, additional, Jiang, Junrong, additional, Ye, Xingdong, additional, Liu, Huiyi, additional, Chen, Yanlin, additional, Pu, Sijia, additional, Wu, Shulin, additional, Deng, Hai, additional, and Xue, Yumei, additional

Published
2023
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15. A normative model of brain responses to social scenarios reflects the maturity of children and adolescents’ social–emotional abilities

Author

Xie, Shuqi, primary, Liu, Jingjing, additional, Hu, Yang, additional, Liu, Wenjing, additional, Ma, Changminghao, additional, Jin, Shuyu, additional, Zhang, Lei, additional, Kang, Yinzhi, additional, Ding, Yue, additional, Zhang, Xiaochen, additional, Hu, Zhishan, additional, Cheng, Wenhong, additional, and Yang, Zhi, additional

Published
2023
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16. Age-dependent alterations in the coordinated development of subcortical regions in adolescents with social anxiety disorder

Author

Liu, Jingjing, primary, Xie, Shuqi, additional, Hu, Yang, additional, Ding, Yue, additional, Zhang, Xiaochen, additional, Liu, Wenjing, additional, Zhang, Lei, additional, Ma, Changminghao, additional, Kang, Yinzhi, additional, Jin, Shuyu, additional, Xia, Yufeng, additional, Hu, Zhishan, additional, Liu, Zhen, additional, Cheng, Wenhong, additional, and Yang, Zhi, additional

Published
2022
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18. Discovery of Self‐Assembling Small Molecules as Vaccine Adjuvants

Author

Motonari Uesugi, Hiroki Yoshida, Hue Thi Vu, Yoshiyuki Mizuhata, Naoya Nishimura, Hiroki Kurata, Daniel M. Packwood, Ken Ishii, Shigenari Ishizuka, Shimane Toru, Norihiro Tokitoh, Tetsuya Ogawa, Jin Shuyu, Ippei Takashima, Sho Yamasaki, Hioki Kou, Kathleen Beverly Pe, and Naotaka Noda

Subjects
Influenza vaccine, medicine.medical_treatment, Chemical biology, Drug Evaluation, Preclinical, Biology, 010402 general chemistry, Antibodies, Viral, 01 natural sciences, Catalysis, Mice, Structure-Activity Relationship, Immune system, Adjuvants, Immunologic, Toll-like receptor, medicine, Animals, Fluorescent Dyes, Mice, Knockout, Innate immune system, 010405 organic chemistry, Interleukin-6, Macrophages, self-assembly, General Chemistry, TLR7, Dendritic Cells, General Medicine, Potentiator, Amides, Immunity, Innate, 0104 chemical sciences, Cell biology, Nanostructures, Mice, Inbred C57BL, RAW 264.7 Cells, Toll-Like Receptor 7, Influenza Vaccines, Immunoglobulin G, Adjuvant, Deoxycholic Acid
Abstract

Immune potentiators, termed adjuvant, trigger early innate immune responses to ensure the generation of robust and long‐lasting adaptive immune responses of vaccines. Here we present study that takes advantage of a self‐assembling small molecule library for the development of a novel vaccine adjuvant. Cell‐based screening of the library and subsequent structural optimization led to the discovery of a simple, chemically tractable deoxycholate derivative (molecule 6 , also named cholicamide) whose well‐defined nano‐assembly potently elicits innate immune responses in macrophages and dendritic cells. Functional and mechanistic analyses indicate that the virus‐like assembly is engulfed inside cells and stimulates the innate immune response through toll‐like receptor 7 (TLR7), an endosomal TLR that detects single‐stranded viral RNA. As an influenza vaccine adjuvant in mice, molecule 6 was as potent as Alum, a clinically used adjuvant. The studies described here paves the way for a new approach to discovering and designing self‐assembling small‐molecule adjuvants against pathogens, including emerging viruses., 自己集合性ワクチンアジュバントの発見. 京都大学プレスリリース. 2020-10-07., Vaccine ingredients could be hiding in small molecule libraries. 京都大学プレスリリース. 2020-10-07.

Published
2020

22. Discovery of Self‐Assembling Small Molecules as Vaccine Adjuvants

Author

Jin, Shuyu, primary, Vu, Hue Thi, additional, Hioki, Kou, additional, Noda, Naotaka, additional, Yoshida, Hiroki, additional, Shimane, Toru, additional, Ishizuka, Shigenari, additional, Takashima, Ippei, additional, Mizuhata, Yoshiyuki, additional, Beverly Pe, Kathleen, additional, Ogawa, Tetsuya, additional, Nishimura, Naoya, additional, Packwood, Daniel, additional, Tokitoh, Norihiro, additional, Kurata, Hiroki, additional, Yamasaki, Sho, additional, Ishii, Ken J., additional, and Uesugi, Motonari, additional

Published
2020
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25. Discovery of Self‐Assembling Small Molecules as Vaccine Adjuvants.

Author

Jin, Shuyu, Vu, Hue Thi, Hioki, Kou, Noda, Naotaka, Yoshida, Hiroki, Shimane, Toru, Ishizuka, Shigenari, Takashima, Ippei, Mizuhata, Yoshiyuki, Beverly Pe, Kathleen, Ogawa, Tetsuya, Nishimura, Naoya, Packwood, Daniel, Tokitoh, Norihiro, Kurata, Hiroki, Yamasaki, Sho, Ishii, Ken J., and Uesugi, Motonari

Subjects
*SMALL molecules, *VACCINE effectiveness, *STRUCTURAL optimization, *TOLL-like receptors, *IMMUNE response
Abstract

Immune potentiators, termed adjuvants, trigger early innate immune responses to ensure the generation of robust and long‐lasting adaptive immune responses of vaccines. Presented here is a study that takes advantage of a self‐assembling small‐molecule library for the development of a novel vaccine adjuvant. Cell‐based screening of the library and subsequent structural optimization led to the discovery of a simple, chemically tractable deoxycholate derivative (molecule 6, also named cholicamide) whose well‐defined nanoassembly potently elicits innate immune responses in macrophages and dendritic cells. Functional and mechanistic analyses indicate that the virus‐like assembly enters the cells and stimulates the innate immune response through Toll‐like receptor 7 (TLR7), an endosomal TLR that detects single‐stranded viral RNA. As an influenza vaccine adjuvant in mice, molecule 6 was as potent as Alum, a clinically used adjuvant. The studies described here pave the way for a new approach to discovering and designing self‐assembling small‐molecule adjuvants against pathogens, including emerging viruses. [ABSTRACT FROM AUTHOR]

Published
2021
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