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4. Electro-acupuncture regulates glucose metabolism in chronic stress model rats

Author

Jia-cheng Shen, Jun-Jie Wei, Jin-Jian Chang, Fu-qiang Ma, Wang Yadong, and Chan-Juan Sun

Subjects
Blood Glucose, Male, Pain Threshold, 0301 basic medicine, medicine.medical_specialty, Magnetic Resonance Spectroscopy, Molecular biology, Physiology, Electroacupuncture, medicine.medical_treatment, lcsh:Medicine, Carbohydrate metabolism, Article, Rats, Sprague-Dawley, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Stress, Physiological, Corticosterone, Internal medicine, Adrenal Glands, Threshold of pain, Acupuncture, medicine, Animals, Chronic stress, lcsh:Science, Alanine, Multidisciplinary, Behavior, Animal, business.industry, Adrenal cortex, lcsh:R, Body Weight, Valine, Rats, 030104 developmental biology, Endocrinology, medicine.anatomical_structure, chemistry, Adrenal Cortex, lcsh:Q, sense organs, business, 030217 neurology & neurosurgery, Neuroscience, Hormone
Abstract

Studies have shown that acupuncture is very effective in treating chronic stress depression. However, little is known about the therapeutic mechanism of electro-acupuncture. Metabolomics, on the other hand, is a technology that determines the metabolic changes of organisms caused by various interventions as a whole and is related to the overall effect of electro-acupuncture (EA). 1HNMR, serum sample analysis, and histopathology and molecular biology analysis were used to evaluate the effects of EA. The results show that electro-acupuncture points can regulate the heat pain threshold of chronic stress model rats and change the morphology of adrenal cortex cells Structure, and regulate the contents of corticotropin-releasing hormone, Corticosterone (CORT), glucose, alanine and valine in the samples. These findings help to clarify the therapeutic mechanism of electro-acupuncture on heterologous chronic stress model rats. The effect of electro-acupuncture on improving chronic stress is likely to be achieved by regulating glucose metabolism, which can provide a reference for clinical acupuncture treatment of chronic stress depression.

Published
2020

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