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12 results on '"Jimenez‐Agüero, Raúl"'

1. Liquid biopsy-based protein biomarkers for risk prediction, early diagnosis and prognostication of cholangiocarcinoma

Author

Lapitz, Ainhoa, Azkargorta, Mikel, Milkiewicz, Piotr, Olaizola, Paula, Zhuravleva, Ekaterina, Grimsrud, Marit M., Schramm, Christoph, Arbelaiz, Ander, O'Rourke, Colm J., La Casta, Adelaida, Milkiewicz, Malgorzata, Pastor, Tania, Vesterhus, Mette, Jimenez-Agüero, Raul, Dill, Michael T., Lamarca, Angela, Valle, Juan W., Macias, Rocio I.R., Izquierdo-Sanchez, Laura, Castaño, Ylenia Pérez, Caballero-Camino, Francisco Javier, Riaño, Ioana, Krawczyk, Marcin, Ibarra, Cesar, Bustamante, Javier, Nova-Camacho, Luiz M., Falcon-Perez, Juan M., Elortza, Felix, Perugorria, Maria J., Andersen, Jesper B., Bujanda, Luis, Karlsen, Tom H., Folseraas, Trine, Rodrigues, Pedro M., and Banales, Jesus M.

Published
2023
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2. Metabolomic‐based noninvasive serum test to diagnose nonalcoholic steatohepatitis: Results from discovery and validation cohorts

Author

Mayo, Rebeca, Crespo, Javier, Martínez‐Arranz, Ibon, Banales, Jesus M, Arias, Mayte, Mincholé, Itziar, de la Fuente, Rocío Aller, Jimenez‐Agüero, Raúl, Alonso, Cristina, de Luis, Daniel A, Vitek, Libor, Stritesky, Jan, Caballería, Joan, Romero‐Gómez, Manuel, Martín‐Duce, Antonio, Huguet, Jose Maria Mugüerza, Busteros‐Moraza, José Ignacio, Idowu, Michael O, Castro, Azucena, Martínez‐Chantar, M Luz, Ortiz, Pablo, Bruha, Radan, Lu, Shelly C, Bedossa, Pierre, Noureddin, Mazen, Sanyal, Arun J, and Mato, José M

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Chronic Liver Disease and Cirrhosis, Clinical Research, Liver Disease, Digestive Diseases, Hepatitis, Oral and gastrointestinal, Clinical sciences
Abstract

Nonalcoholic fatty liver disease (NAFLD) is the most common type of chronic liver disease worldwide and includes a broad spectrum of histologic phenotypes, ranging from simple hepatic steatosis or nonalcoholic fatty liver (NAFL) to nonalcoholic steatohepatitis (NASH). While liver biopsy is the reference gold standard for NAFLD diagnosis and staging, it has limitations due to its sampling variability, invasive nature, and high cost. Thus, there is a need for noninvasive biomarkers that are robust, reliable, and cost effective. In this study, we measured 540 lipids and amino acids in serum samples from biopsy-proven subjects with normal liver (NL), NAFL, and NASH. Using logistic regression analysis, we identified two panels of triglycerides that could first discriminate between NAFLD and NL and second between NASH and NAFL. These noninvasive tests were compared to blinded histology as a reference standard. We performed these tests in an original cohort of 467 patients with NAFLD (90 NL, 246 NAFL, and 131 NASH) that was subsequently validated in a separate cohort of 192 patients (7 NL, 109 NAFL, 76 NASH). The diagnostic performances of the validated tests showed an area under the receiver operating characteristic curve, sensitivity, and specificity of 0.88 ± 0.05, 0.94, and 0.57, respectively, for the discrimination between NAFLD and NL and 0.79 ± 0.04, 0.70, and 0.81, respectively, for the discrimination between NASH and NAFL. When the analysis was performed excluding patients with glucose levels >136 mg/dL, the area under the receiver operating characteristic curve for the discrimination between NASH and NAFL increased to 0.81 ± 0.04 with sensitivity and specificity of 0.73 and 0.80, respectively. Conclusion: The assessed noninvasive lipidomic serum tests distinguish between NAFLD and NL and between NASH and NAFL with high accuracy. (Hepatology Communications 2018;2:807-820).

Published
2018

3. miR‐21‐5p promotes NASH‐related hepatocarcinogenesis

Author

Rodrigues, Pedro M., primary, Afonso, Marta B., additional, Simão, André L., additional, Islam, Tawhidul, additional, Gaspar, Maria M., additional, O'Rourke, Colm J., additional, Lewinska, Monika, additional, Andersen, Jesper B., additional, Arretxe, Enara, additional, Alonso, Cristina, additional, Santos‐Laso, Álvaro, additional, Izquierdo‐Sanchez, Laura, additional, Jimenez‐Agüero, Raúl, additional, Eizaguirre, Emma, additional, Bujanda, Luis, additional, Pareja, Maria J., additional, Prip‐Buus, Carina, additional, Banales, Jesus M., additional, Rodrigues, Cecília M. P., additional, and Castro, Rui E., additional

Published
2023
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4. Ursodeoxycholic acid inhibits hepatic cystogenesis in experimental models of polycystic liver disease

Author

Munoz-Garrido, Patricia, Marin, José J.G., Perugorria, María J., Urribarri, Aura D., Erice, Oihane, Sáez, Elena, Úriz, Miriam, Sarvide, Sarai, Portu, Ainhoa, Concepcion, Axel R., Romero, Marta R., Monte, María J., Santos-Laso, Álvaro, Hijona, Elizabeth, Jimenez-Agüero, Raúl, Marzioni, Marco, Beuers, Ulrich, Masyuk, Tatyana V., LaRusso, Nicholas F., Prieto, Jesús, Bujanda, Luis, Drenth, Joost P.H., and Banales, Jesús M.

Published
2015
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5. LIQUID BIOPSY PROTEINS AS PSC-SPECIFIC AND PAN-CCA BIOMARKERS OF CANCER RISK, EARLY DIAGNOSIS AND SURVIVAL MIRRORING TUMOR CELLS

Author

Lapitz, Ainhoa, Azkargorta, Mikel, Milkiewicz, Piotr, Olaizola, Paula, Zhuravleva, Ekaterina, Grimsrud, Marit M., Schramm, Christoph, Arbelaiz, Ander, O’Rourke, Colm J., Casta, Adelaida La, Milkiewicz, Malgorzata, Pastor, Tania, Vesterhus, Mette, Jiménez-Agüero, Raul, Dill, Michael T., Lamarca, Angela, Valle, Juan W., Macias, Rocio I.R., Izquierdo-Sánchez, Laura, Castaño, Ylenia Pérez, Camino, Francisco Javier Caballero, Riano, Ioana, Krawczyk, Marcin, Ibarra, Cesar, Bustamante, Javier, Camacho, Luiz Miguel Nova, Falcon-Pérez, Juan M., Elortza, Felix, Perugorria, Maria J., Andersen, Jesper B., Bujanda, Luis, Karlsen, Tom H., Folseraas, Trine, Rodrigues, Pedro M., and Banales, Jesus M.

Published
2023
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9. PS-179 - Hepamet Score: a new non-invasive method for NAFLD-related fibrosis screening in clinical practice

Author

Ampuero, J., Aller, Rocío, Gallego-Durán, Rocío, Banales, Jesús, Crespo, J., Vilar-Gomez, E., Petta, S., Garcia-Monzon, C., Mora-Cuadrado, N., Castellanos-Fernandez, M., Craxi, A., Pareja, María Jesús, Jiménez-Agüero, Raúl, Caballería, J., Loste, María T.A., Escudero-García, D., Gómez-Camarero, J., Panero, José L.C., De Luis Román, D.A., Fabian, L.G., Di Marco, V., Gónzalez-Rodriguez, Águeda, Latorre, M., Albillos, A., Aguilar-Urbano, Victor, Salmerón, J., Olcoz-Goñi, José L., Aspichueta, P., Santos-Laso, Álvaro, Lo Iacono, O., Iruzubieta, P., Graupera, I., García-Torres, M., Badia-Aranda, E., Guerra, J.A., Francés, Rubén, Pastor, H., Del Pozo-Maroto, E., Diago, M., Martin-Mateos, R., Benlloch, S., Fernández-Rodríguez, C., Rey, F.J.G.-S., Estevez, P., Andrade, R.J., Turnés, J., and Gomez, M.R.

Published
2018
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