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Objective: To evaluate psychopathological status and stress level from a sample with SLE; compare mental functioning and stress levels between women with SLE and healthy women; determine whether disease duration, disease activity, cumulative organ damage and stress have an influence on psychopathological symptoms in SLE patients; and evaluate whether perception of stress is related to SLE severity. Methods: We conducted a cross-sectional study of 425 participants; 202 women with SLE, with an average age (SD) of 36.61 (10.15), and 223 healthy women, with age-matched controls. The assessment included the clinical characteristics (disease duration, SLE activity, cumulative organ damage, pharmacotherapy), the Symptom Checklist-90-Revised (SCL-90-R) and the Perceived Stress Scale. Descriptive, comparative, univariate and multivariate analysis were performed. Results: SLE patients showed psychopathological alterations in the somatisation, obsessive-compulsive and positive discomfort subscales of SCL-90-R. Women with SLE reported significantly higher scores on the psychopathological dimensions and perceived stress compared to healthy women, except for paranoid ideation. Disease duration, SLE activity, cumulative organ damage, and perceived stress were shown to be significant predictors of psychopathological manifestations, explaining a range, between 20 and 43%, of variance across SCL-90-R dimensions. Moreover, perceived stress was related to SLE activity, after controlling for psychopathological dimensions. Conclusion: The psychopathological manifestations in SLE appeared to be influenced by perceived stress, disease duration, disease activity and cumulative organ damage. In turn, perceived stress was associated with disease severity. This knowledge may contribute to a more comprehensive perspective of these manifestations in the SLE population in the clinical setting. This research was developed in the framework of the I+D Project “SEJ2007-61857” and the I+D Project ‘‘PSI2010- 15780’’, funded by the Spanish Ministry of Education and Science. In addition, this study was supported by the Andalusian Health Service (grant no. PI-0059/2007).

La aterosclerosis es la principal causa de muerte en los paises desarrollado, por las complicaciones a nivel cardiaco, accidentes vasculocerebrales y enfermedad vascular periférica. Aunque su etiología es desconocida si se ha producido en los últimos años un importante progreso en un mejor conocimiento de los llamados factores de riesgo: Las dislipoproteinemias, hipertensión arterial y tabaquismo son los mas destacados, pero se han implicado otras muchas condiciones y enfermedades, como edad, sexo masculino, factores genéticos, historia personal o familiar de aterosclerosis, niveles bajos de HDL-colesterol, niveles elevados de lipoproteina (a), diabetes, hiperinsulinemia,hipertrofia ventricular izquierda, obesidad, sedentarismo, alcoholismo, estrés-personalidad tipo A, niveles elevados de fibrinógeno, mujer postrnenopaúsica, uso de anticonceptivos orales o microalburninuria. Numerosos estudios han probado recientemente que la aterosclerosis es una enfermedad reversible cuando se hace un control adecuado de los diversos factores de riesgo cardiovascular., Atherosclerosis is responsible for the majority of deaths in the developped countries. This disorder is the underlying cause of heart attacks, strokes and peripheral vascular disease. Although the etioloy is unknown, progress has been made in identifying the risk factors that predispose to it. Thus, a number of conditions are more frequent in the atherosclerotic patients: Hypercholesterolemia, hypertension and cigarette smoking are the most potent, but another conditions has been lmplicated, such as age, male gender, farnily or personal history of cardiovascular disease, low HDL-Cholesterol, high lipoprotein (a), diabetes, hyperinsulinemia, left ventricular hypertrophia, abdominal obesity,physical inactivity, alcoholism, stress-type of personality, high fibrinogen levels , postrnenopausic woman, use of oral contraceptiv or microalburninuria. The regression or interruption of progression of atherosclerotic lesions can be acomplished in humans, as has been demonstrated in an important number of studies.

Tesis Univ. Granada. Departamento de Medicina

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