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We present the case of a patient with an infection by Nocardia which manifested itself with monocular endophthalmitis. Nocardia infection is not common and ocular involvement is one of the most uncommon presentations. In these cases it is very important to make an early diagnosis and intensive treatment to prevent the visual prognosis.

Although the scientific community had knowledge of the human induced vibration problems in structures since the end of the 19th century, it was not until the occurrence of the vibration phenomenon happened in the Millennium Bridge (London, 2000) that the importance of the problem revealed and a higher level of attention devoted. Despite the large advances achieved in the determination of the human-structure interaction force, one of the main deficiencies of the existing models is the exclusion of the effect of changes in the footbridge dynamic properties due to the presence of pedestrians. In this paper, the formulation of a human-structure interaction model, addresses these limitations, is carried out and its reliability is verified from previously published experimental results.Aunque la comunidad científica tenía conocimiento de los problemas vibratorios inducidos por peatones en estructuras desde finales del siglo xix, no fue hasta la ocurrencia de los eventos vibratorios acontecidos en la pasarela del Milenio (Londres, 2000), cuando la importancia del problema se puso de manifiesto y se le comenzó a dedicar un mayor nivel de atención. A pesar de los grandes avances alcanzados en la caracterización de la fuerza de interacción peatón-estructura una de las principales deficiencias de los modelos existentes es la exclusión del cambio en las propiedades dinámicas de la pasarela por la presencia de peatones. En este artículo, se presenta la formulación de un modelo de interacción peatón-estructura que intenta dar respuesta a dichas limitaciones, y su validación a partir de resultados experimentales previamente publicados por otros autores.

Item does not contain fulltext OBJECTIVES: The TRAF1-C5 locus has recently been identified as a genetic risk factor for rheumatoid arthritis (RA). Since genetic risk factors tend to overlap with several autoimmune diseases, a study was undertaken to investigate whether this region is associated with type 1 diabetes (TID), celiac disease (CD), systemic sclerosis (SSc) and systemic lupus erythematosus (SLE). METHODS: The most consistently associated SNP, rs10818488, was genotyped in a total of 735 patients with T1D, 1049 with CD, 367 with SSc, 746 with SLE and 3494 ethnically- and geographically-matched healthy individuals. The replication sample set consisted of 99 patients with T1D, 272 with SLE and 482 healthy individuals from Crete. RESULTS: A significant association was detected between the rs10818488 A allele and T1D (OR 1.14, p=0.027) and SLE (OR 1.16, p=0.016), which was replicated in 99 patients with T1D, 272 with SLE and 482 controls from Crete (OR 1.64, p=0.002; OR 1.43, p=0.002, respectively). Joint analysis of all patients with T1D (N=961) and all patients with SLE (N=1018) compared with 3976 healthy individuals yielded an allelic common OR of 1.19 (p=0.002) and 1.22 (p=2.6 x 10(-4)), respectively. However, combining our dataset with the T1D sample set from the WTCCC resulted in a non-significant association (OR 1.06, p=0.087). In contrast, previously unpublished results from the SLEGEN study showed a significant association of the same allele (OR 1.19, p=0.0038) with an overall effect of 1.22 (p=1.02 x 10(-6)) in a total of 1577 patients with SLE and 4215 healthy individuals. CONCLUSION: A significant association was found for the TRAF1-C5 locus in SLE, implying that this region lies in a pathway relevant to multiple autoimmune diseases. 01 april 2010

Sanchez, E., Callejas-Rubio, J.L., Sabio, J.M., Gonzalez-Gay, M.A., Jimenez-Alonso, J., Micó, L., Ramón, E.D., Camps, M., Suarez, A., Gutierrez, C., Garcia-Portales, R., Tolosa, C., Ortego-Centeno, N., Sánchez-Román, J., Garcia-Hernández, F.J., Gónzalez-Escribano, M.F., Martin, I., López-Nevot, M.A.

En pacientes hipertensos además de reducir la presión arterial, debemos plantearnos el patrón circadiano que presenta el paciente, dado que los pacientes no depresores (no descenso de presión arterial durante la noche con respecto al día) (non-dipper) se asocian a un peor pronóstico cardiovascular. El propósito de este estudio fue determinar el patrón circadiano de presión arterial en pacientes hipertensos tratados y no tratados y su relación con la afectación orgánica. Se incluyeron en el estudio a 702 pacientes con indicación clínica para monitorización ambulatoria de la presión arterial de 24 horas. El 39% fue dipper, 2% dipper extremo, 49,6% non-dipper y 9,4% riser. Los pacientes non dipper tenían mayores niveles de presión arterial sistólica de 24 horas, nocturna y mayor repercusión orgánica. Los factores principales asociados a este patrón fue la presión arterial sistólica clínica, obesidad y sobretodo un filtrado glomerular menor a 60 ml/min. In arterial hypertension besides reducing blood pressure, we should think about the circadian pressure profile that the patient presents, since the patients non depressors (not descent of arterial pressure during the night with regard to the day) (non-dipper) they associate to a worse cardiovascular prognosis. The purpose of the present study was to determine the circadian pressure profile in patient treated arterial hypertension and never previously treated with antihypertensive medication; and its relationship with the organic damage. They were included in the study to 702 patients with clinical indication for 24 hour ambulatory blood pressure monitoring. The 39% was dipper, 2% extreme dipper, 49.6% non-dipper and 9.4% riser. The patient non dipper had bigger levels of 24 hours systolic blood pressure, night blood pressure and bigger organic damage. The main factors associated to this pattern were the clinic systolic blood pressure, obesity and overalls a filtrate smaller glomerular to 60 ml/min.