Search

Variable Common Immunodeficiency (VCI) can course with non necrotizing epithelioid granulomatosis of sarcoid type. Although this entity is frequently referred, it is rare and its significance is not clear. The immunological study and response to treatment with corticoids and i.v. immunoglobulins of a patient is who suffered VIC with sarcoid granulomas on lymph node, liver and skin biopsies is here presented. The association between VCI and granulomatosis is discussed.

Endocarditis produced by E. rhusiopathiae is a uncommon disease. Most of the infected persons (90%) work in environments with frequent exposure to E. rhusiopathiae (butchers, fisherman). Although the clinical picture of endocarditis produced by E. rhusiopathiae is indistinguishable from other forms of subacute endocarditis, this infection has a mortality rate of 40% and a high morbidity. Microbiological diagnosis should consider the possibility of making a mistake considering that isolation of a gram-positive bacillus may represent contamination by an agent without clinical relevance. Treatment with penicillin G during 4 weeks is commonly sufficient to cure the disease.

Bone sarcoidosis preferentially localizes in skull bones with long lasting skin lesions, (its manifestation in skull are rare and there are only 12 or 13 published cases) and the bone involvement of the cranial basis has been referred, until now, as extensive lesions of granulomas localized in neighbouring structures. We present a case of cranial basis granulomatosis, in a patient diagnosed of multiple sarcoidosis by repetitive biopsies of lymph nodes, liver, and skin with chronic skin lesions, the rare localization of which in the orbital vertex with an original bone procedence, is discussed in the neuroradiologic findings. Such rareness has been found in a carrier of a form of common variable immunodeficiency, a disease which is also rare.

A case of gastroenteritis due to Giardia lamblia with severe dehydration and complicated with arterial thrombosis, accompanied by eosinophilia and increased serum IgE levels, is presented. The relationship between Giardia and eosinophilia and allergic manifestations is discussed as well as its pathogenesis.