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1. Differences in Metabolomic Profiles Between Black and White Women and Risk of Coronary Heart Disease: an Observational Study of Women From Four US Cohorts

Author

Hu, Jie, Yao, Jie, Deng, Shuliang, Balasubramanian, Raji, Jiménez, Monik C, Li, Jun, Guo, Xiuqing, Cruz, Daniel E, Gao, Yan, Huang, Tianyi, Zeleznik, Oana A, Ngo, Debby, Liu, Simin, Rosal, Milagros C, Nassir, Rami, Paynter, Nina P, Albert, Christine M, Tracy, Russell P, Durda, Peter, Liu, Yongmei, Taylor, Kent D, Johnson, W Craig, Sun, Qi, Rimm, Eric B, Eliassen, A Heather, Rich, Stephen S, Rotter, Jerome I, Gerszten, Robert E, Clish, Clary B, and Rexrode, Kathryn M

Subjects
Biomedical and Clinical Sciences, Cardiovascular Medicine and Haematology, Clinical Sciences, Heart Disease - Coronary Heart Disease, Atherosclerosis, Aging, Cardiovascular, Prevention, Clinical Research, Heart Disease, Good Health and Well Being, Amino Acids, Coronary Disease, Female, Hormones, Humans, Lipids, Risk Factors, United States, heart diseases, health status disparities, metabolomics, plasma, race, women, Cardiorespiratory Medicine and Haematology, Cardiovascular System & Hematology, Cardiovascular medicine and haematology, Clinical sciences
Abstract

BackgroundRacial differences in metabolomic profiles may reflect underlying differences in social determinants of health by self-reported race and may be related to racial disparities in coronary heart disease (CHD) among women in the United States. However, the magnitude of differences in metabolomic profiles between Black and White women in the United States has not been well-described. It also remains unknown whether such differences are related to differences in CHD risk.MethodsPlasma metabolomic profiles were analyzed using liquid chromatography-tandem mass spectrometry in the WHI-OS (Women's Health Initiative-Observational Study; 138 Black and 696 White women), WHI-HT trials (WHI-Hormone Therapy; 156 Black and 1138 White women), MESA (Multi-Ethnic Study of Atherosclerosis; 114 Black and 219 White women), JHS (Jackson Heart Study; 1465 Black women with 107 incident CHD cases), and NHS (Nurses' Health Study; 2506 White women with 136 incident CHD cases). First, linear regression models were used to estimate associations between self-reported race and 472 metabolites in WHI-OS (discovery); findings were replicated in WHI-HT and validated in MESA. Second, we used elastic net regression to construct a racial difference metabolomic pattern (RDMP) representing differences in the metabolomic patterns between Black and White women in the WHI-OS; the RDMP was validated in the WHI-HT and MESA. Third, using conditional logistic regressions in the WHI (717 CHD cases and 719 matched controls), we examined associations of metabolites with large differences in levels by race and the RDMP with risk of CHD, and the results were replicated in Black women from the JHS and White women from the NHS.ResultsOf the 472 tested metabolites, levels of 259 (54.9%) metabolites, mostly lipid metabolites and amino acids, significantly differed between Black and White women in both WHI-OS and WHI-HT after adjusting for baseline characteristics, socioeconomic status, lifestyle factors, baseline health conditions, and medication use (false discovery rate

Published
2022

3. Cardiovascular risk factors and dehydroepiandrosterone sulfate among Latinos in the Boston Puerto Rican Health Study

Author

Jiménez, Monik C, Tucker, Katherine L, Rodriguez, Fátima, Porneala, Bianca C, Meigs, James B, and López, Lenny

Subjects
Biomedical and Clinical Sciences, Cardiovascular Medicine and Haematology, Clinical Research, Heart Disease, Cardiovascular, Prevention, Aging, 3.1 Primary prevention interventions to modify behaviours or promote wellbeing, Prevention of disease and conditions, and promotion of well-being, Good Health and Well Being, Latino, cardiovascular risk factors, dehydroepiandrosterone sulfate, Cardiovascular medicine and haematology
Abstract

Low blood dehydroepiandrosterone sulfate (DHEAS) levels have strong positive associations with stroke and coronary heart disease. However, it is unclear whether DHEAS is independently associated with cardiovascular risk factors. Therefore, we examined the association between cardiovascular risk factors and DHEAS concentration among a high-risk population of Latinos (Puerto Ricans aged 45 to 75 years at baseline) in a cross-sectional analysis of the Boston Puerto Rican Health Study. Of eligible participants, 72% completed baseline interviews and provided blood samples. Complete data were available for 1355 participants. Associations between cardiovascular risk factors (age, sex, total cholesterol, high-density lipid cholesterol, triglycerides, and glucose) and log-transformed DHEAS (μg/dL) were assessed. In robust multivariable regression analyses, DHEAS was significantly inversely associated with age (β = -12.4; 95% CI: -15.2, -9.7; per 5 years), being female (vs. male) (β = -46; 95% CI: -55.3, -36.6), and plasma triglyceride concentration (β = -0.2; 95% CI: -0.3, -0.1; per 10 mg/dL) and was positively associated with total cholesterol and plasma glucose levels (β = 1.8; 95% CI: 0.6, 3 and β = 0.2; 95% CI: 0.04, 0.3, respectively, per 10 mg/dL) after adjustment for smoking, alcohol, and physical activity and for postmenopausal hormone use in women. Estimates were unchanged after adjustment for measures of chronic disease and inflammation. Women exhibited a stronger age-related decline in DHEAS and a positive association with glucose in contrast to findings among men (P interaction < 0.05). In conclusion, in this large study of Latinos with a heavy cardiovascular risk factor burden, we observed significant associations between cardiovascular disease (CVD) risk factors and DHEAS, with variations by sex. These findings improve our understanding of the role DHEAS may play in CVD etiology.

Published
2019

4. The PhenX Toolkit: Recommended Measurement Protocols for Social Determinants of Health Research

Author

Ives, Cataia L., primary, Krzyzanowski, Michelle C., additional, Marshall, Vanessa J., additional, Norris, Keith, additional, Cockburn, Myles, additional, Bentley‐Edwards, Keisha, additional, Mohottige, Dinushika, additional, Pollack Porter, Keshia M., additional, Dillard, Denise, additional, Eisenberg, Yochai, additional, Jiménez, Monik C., additional, Pérez‐Stable, Eliseo J., additional, Jones, Nancy L., additional, Dayal, Jyoti, additional, Maiese, Deborah R., additional, Williams, David, additional, Hendershot, Tabitha P., additional, and Hamilton, Carol M., additional

Published
2024
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7. Heart Disease and Stroke Statistics—2016 Update

Author

Mozaffarian, Dariush, Benjamin, Emelia J, Go, Alan S, Arnett, Donna K, Blaha, Michael J, Cushman, Mary, Das, Sandeep R, de Ferranti, Sarah, Després, Jean-Pierre, Fullerton, Heather J, Howard, Virginia J, Huffman, Mark D, Isasi, Carmen R, Jiménez, Monik C, Judd, Suzanne E, Kissela, Brett M, Lichtman, Judith H, Lisabeth, Lynda D, Liu, Simin, Mackey, Rachel H, Magid, David J, McGuire, Darren K, Mohler, Emile R, Moy, Claudia S, Muntner, Paul, Mussolino, Michael E, Nasir, Khurram, Neumar, Robert W, Nichol, Graham, Palaniappan, Latha, Pandey, Dilip K, Reeves, Mathew J, Rodriguez, Carlos J, Rosamond, Wayne, Sorlie, Paul D, Stein, Joel, Towfighi, Amytis, Turan, Tanya N, Virani, Salim S, Woo, Daniel, Yeh, Robert W, and Turner, Melanie B

Subjects
Biomedical and Clinical Sciences, Cardiovascular Medicine and Haematology, Health Sciences, Clinical Sciences, Sports Science and Exercise, American Heart Association, Data Interpretation, Statistical, Heart Diseases, Humans, Life Style, Research Report, Stroke, United States, AHA Scientific Statements, cardiovascular diseases, epidemiology, risk factors, statistics, stroke, Writing Group Members, American Heart Association Statistics Committee, Stroke Statistics Subcommittee, Cardiorespiratory Medicine and Haematology, Public Health and Health Services, Cardiovascular System & Hematology, Cardiovascular medicine and haematology, Clinical sciences, Sports science and exercise
Published
2016

8. Executive Summary

Author

Mozaffarian, Dariush, Benjamin, Emelia J, Go, Alan S, Arnett, Donna K, Blaha, Michael J, Cushman, Mary, Das, Sandeep R, de Ferranti, Sarah, Després, Jean-Pierre, Fullerton, Heather J, Howard, Virginia J, Huffman, Mark D, Isasi, Carmen R, Jiménez, Monik C, Judd, Suzanne E, Kissela, Brett M, Lichtman, Judith H, Lisabeth, Lynda D, Liu, Simin, Mackey, Rachel H, Magid, David J, McGuire, Darren K, Mohler, Emile R, Moy, Claudia S, Muntner, Paul, Mussolino, Michael E, Nasir, Khurram, Neumar, Robert W, Nichol, Graham, Palaniappan, Latha, Pandey, Dilip K, Reeves, Mathew J, Rodriguez, Carlos J, Rosamond, Wayne, Sorlie, Paul D, Stein, Joel, Towfighi, Amytis, Turan, Tanya N, Virani, Salim S, Woo, Daniel, Yeh, Robert W, and Turner, Melanie B

Subjects
Biomedical and Clinical Sciences, Cardiovascular Medicine and Haematology, Health Sciences, Clinical Sciences, Sports Science and Exercise, American Heart Association, Data Interpretation, Statistical, Health Behavior, Heart Diseases, Humans, Research Report, Stroke, United States, AHA Scientific Statements, cardiovascular diseases, epidemiology, risk factors, statistics, stroke, Writing Group Members, American Heart Association Statistics Committee, Stroke Statistics Subcommittee, Cardiorespiratory Medicine and Haematology, Public Health and Health Services, Cardiovascular System & Hematology, Cardiovascular medicine and haematology, Clinical sciences, Sports science and exercise
Published
2016

9. Executive Summary: Heart Disease and Stroke Statistics--2016 Update: A Report From the American Heart Association.

Author

Writing Group Members, Mozaffarian, Dariush, Benjamin, Emelia J, Go, Alan S, Arnett, Donna K, Blaha, Michael J, Cushman, Mary, Das, Sandeep R, de Ferranti, Sarah, Després, Jean-Pierre, Fullerton, Heather J, Howard, Virginia J, Huffman, Mark D, Isasi, Carmen R, Jiménez, Monik C, Judd, Suzanne E, Kissela, Brett M, Lichtman, Judith H, Lisabeth, Lynda D, Liu, Simin, Mackey, Rachel H, Magid, David J, McGuire, Darren K, Mohler, Emile R, Moy, Claudia S, Muntner, Paul, Mussolino, Michael E, Nasir, Khurram, Neumar, Robert W, Nichol, Graham, Palaniappan, Latha, Pandey, Dilip K, Reeves, Mathew J, Rodriguez, Carlos J, Rosamond, Wayne, Sorlie, Paul D, Stein, Joel, Towfighi, Amytis, Turan, Tanya N, Virani, Salim S, Woo, Daniel, Yeh, Robert W, Turner, Melanie B, American Heart Association Statistics Committee, and Stroke Statistics Subcommittee

Subjects
Writing Group Members, American Heart Association Statistics Committee, Stroke Statistics Subcommittee, Humans, Heart Diseases, Data Interpretation, Statistical, Health Behavior, American Heart Association, United States, Stroke, Research Report, AHA Scientific Statements, cardiovascular diseases, epidemiology, risk factors, statistics, stroke, Data Interpretation, Statistical, Clinical Sciences, Cardiorespiratory Medicine and Haematology, Public Health and Health Services, Cardiovascular System & Hematology
Published
2016

10. Heart Disease and Stroke Statistics-2016 Update: A Report From the American Heart Association.

Author

Writing Group Members, Mozaffarian, Dariush, Benjamin, Emelia J, Go, Alan S, Arnett, Donna K, Blaha, Michael J, Cushman, Mary, Das, Sandeep R, de Ferranti, Sarah, Després, Jean-Pierre, Fullerton, Heather J, Howard, Virginia J, Huffman, Mark D, Isasi, Carmen R, Jiménez, Monik C, Judd, Suzanne E, Kissela, Brett M, Lichtman, Judith H, Lisabeth, Lynda D, Liu, Simin, Mackey, Rachel H, Magid, David J, McGuire, Darren K, Mohler, Emile R, Moy, Claudia S, Muntner, Paul, Mussolino, Michael E, Nasir, Khurram, Neumar, Robert W, Nichol, Graham, Palaniappan, Latha, Pandey, Dilip K, Reeves, Mathew J, Rodriguez, Carlos J, Rosamond, Wayne, Sorlie, Paul D, Stein, Joel, Towfighi, Amytis, Turan, Tanya N, Virani, Salim S, Woo, Daniel, Yeh, Robert W, Turner, Melanie B, American Heart Association Statistics Committee, and Stroke Statistics Subcommittee

Subjects
Writing Group Members, American Heart Association Statistics Committee, Stroke Statistics Subcommittee, Humans, Heart Diseases, Data Interpretation, Statistical, Life Style, American Heart Association, United States, Stroke, Research Report, AHA Scientific Statements, cardiovascular diseases, epidemiology, risk factors, statistics, stroke, Data Interpretation, Statistical, Clinical Sciences, Cardiorespiratory Medicine and Haematology, Public Health and Health Services, Cardiovascular System & Hematology
Published
2016

18. Heart Disease and Stroke Statistics—2018 Update: A Report From the American Heart Association

Author

Benjamin, Emelia J., Virani, Salim S., Callaway, Clifton W., Chamberlain, Alanna M., Chang, Alexander R., Cheng, Susan, Chiuve, Stephanie E., Cushman, Mary, Delling, Francesca N., Deo, Rajat, de Ferranti, Sarah D., Ferguson, Jane F., Fornage, Myriam, Gillespie, Cathleen, Isasi, Carmen R., Jiménez, Monik C., Jordan, Lori Chaffin, Judd, Suzanne E., Lackland, Daniel, Lichtman, Judith H., Lisabeth, Lynda, Liu, Simin, Longenecker, Chris T., Lutsey, Pamela L., Mackey, Jason S., Matchar, David B., Matsushita, Kunihiro, Mussolino, Michael E., Nasir, Khurram, O’Flaherty, Martin, Palaniappan, Latha P., Pandey, Ambarish, Pandey, Dilip K., Reeves, Mathew J., Ritchey, Matthew D., Rodriguez, Carlos J., Roth, Gregory A., Rosamond, Wayne D., Sampson, Uchechukwu K.A., Satou, Gary M., Shah, Svati H., Spartano, Nicole L., Tirschwell, David L., Tsao, Connie W., Voeks, Jenifer H., Willey, Joshua Z., Wilkins, John T., Wu, Jason HY., Alger, Heather M., Wong, Sally S., and Muntner, Paul

Published
2018
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19. Heart Disease and Stroke Statistics—2017 Update: A Report From the American Heart Association

Author

Benjamin, Emelia J., Blaha, Michael J., Chiuve, Stephanie E., Cushman, Mary, Das, Sandeep R., Deo, Rajat, de Ferranti, Sarah D., Floyd, James, Fornage, Myriam, Gillespie, Cathleen, Isasi, Carmen R., Jiménez, Monik C., Jordan, Lori Chaffin, Judd, Suzanne E., Lackland, Daniel, Lichtman, Judith H., Lisabeth, Lynda, Liu, Simin, Longenecker, Chris T., Mackey, Rachel H., Matsushita, Kunihiro, Mozaffarian, Dariush, Mussolino, Michael E., Nasir, Khurram, Neumar, Robert W., Palaniappan, Latha, Pandey, Dilip K., Thiagarajan, Ravi R., Reeves, Mathew J., Ritchey, Matthew, Rodriguez, Carlos J., Roth, Gregory A., Rosamond, Wayne D., Sasson, Comilla, Towfighi, Amytis, Tsao, Connie W., Turner, Melanie B., Virani, Salim S., Voeks, Jenifer H., Willey, Joshua Z., Wilkins, John T., Wu, Jason HY., Alger, Heather M., Wong, Sally S., and Muntner, Paul

Published
2017
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30. Prevalence of periodontitis by Hispanic/Latino background among study participants of the Hispanic Community Cohort Study/Study of Latinos

Author

Jiménez, Monik C., Sanders, Anne E., Mauriello, Sally M., Kaste, Linda M., and Beck, James D.

Subjects
Adult, Male, Adolescent, Hispanic or Latino, Middle Aged, Article, United States, Young Adult, Risk Factors, Prevalence, Humans, Female, Longitudinal Studies, Periodontitis, Aged
Abstract

Hispanics and Latinos are an ethnically heterogeneous population with distinct oral health risk profiles. Few study investigators have examined potential variation in the burden of periodontitis according to Hispanic or Latino background.The authors used a multicenter longitudinal population-based cohort study to examine the periodontal health status at screening (2008-2011) of 14,006 Hispanic and Latino adults, aged 18 to 74 years, from four U.S. communities who self-identified as Cuban, Dominican, Mexican, Puerto Rican, Central American or South American. The authors present weighted, age-standardized prevalence estimates and corrected standard errors of probing depth (PD), attachment loss (AL) and periodontitis classified according to the case definition established by the Centers for Disease Control and Prevention and the American Academy of Periodontology (CDC-AAP). The authors used a Wald χ(2) test to compare prevalence estimates across Hispanic or Latino background, age and sex.Fifty-one percent of all participants had exhibited total periodontitis (mild, moderate or severe) per the CDC-AAP classification. Cubans and Central Americans exhibited the highest prevalence of moderate periodontitis (39.9 percent and 37.2 percent, respectively). Across all ages, Mexicans had the highest prevalence of PD across severity thresholds. Among those aged 18 through 44 years, Dominicans consistently had the lowest prevalence of AL at all severity thresholds.Measures of periodontitis varied significantly by age, sex and Hispanic or Latino background among the four sampled Hispanic Community Health Study/Study of Latinos communities. Further analyses are needed to account for lifestyle, behavioral, demographic and social factors, including those related to acculturation.Aggregating Hispanics and Latinos or using estimates from Mexicans may lead to substantial underestimation or overestimation of the burden of disease, thus leading to errors in the estimation of needed clinical and public health resources. This information will be useful in informing decisions from public health planning to patient-centered risk assessment.

Published
2014

34. Executive Summary: Heart Disease and Stroke Statistics—2016 Update

Author

Mozaffarian, Dariush, primary, Benjamin, Emelia J., additional, Go, Alan S., additional, Arnett, Donna K., additional, Blaha, Michael J., additional, Cushman, Mary, additional, Das, Sandeep R., additional, de Ferranti, Sarah, additional, Després, Jean-Pierre, additional, Fullerton, Heather J., additional, Howard, Virginia J., additional, Huffman, Mark D., additional, Isasi, Carmen R., additional, Jiménez, Monik C., additional, Judd, Suzanne E., additional, Kissela, Brett M., additional, Lichtman, Judith H., additional, Lisabeth, Lynda D., additional, Liu, Simin, additional, Mackey, Rachel H., additional, Magid, David J., additional, McGuire, Darren K., additional, Mohler, Emile R., additional, Moy, Claudia S., additional, Muntner, Paul, additional, Mussolino, Michael E., additional, Nasir, Khurram, additional, Neumar, Robert W., additional, Nichol, Graham, additional, Palaniappan, Latha, additional, Pandey, Dilip K., additional, Reeves, Mathew J., additional, Rodriguez, Carlos J., additional, Rosamond, Wayne, additional, Sorlie, Paul D., additional, Stein, Joel, additional, Towfighi, Amytis, additional, Turan, Tanya N., additional, Virani, Salim S., additional, Woo, Daniel, additional, Yeh, Robert W., additional, and Turner, Melanie B., additional

Published
2016
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35. Low dehydroepiandrosterone sulphate is associated with increased risk of ischemic stroke among women: DHEAS and Risk of Ischemic Stroke in Women

Author

Jiménez, Monik C., Sun, Qi, Schürks, Markus, Chiuve, Stephanie, Hu, Frank B., Manson, JoAnn E., and Rexrode, Kathryn M.

Subjects
Adult, Risk, Dehydroepiandrosterone Sulfate, Down-Regulation, Middle Aged, Health Surveys, Article, Brain Ischemia, Stroke, Sex Factors, Case-Control Studies, Humans, Female, Aged
Abstract

Previous research suggests greater risk of coronary heart disease with lower levels of the adrenal steroid dehydroepiandrosterone sulfate (DHEAS). No studies have examined the association between DHEAS and risk of ischemic stroke. DHEAS may influence ischemic stroke risk through atherosclerotic-related mechanisms (endothelial function and smooth muscle cell proliferation) or insulin resistance.Between 1989 and 1990, 32 826 women without prior stroke in the Nurses' Health Study, an observational cohort, provided blood samples and were followed up for cardiovascular events. Among this sample, using a nested case-control design, 461 ischemic strokes were confirmed by medical records by 2006. Cases were matched to controls free of stroke at the time of the index case and by age, race, menopausal status, postmenopausal hormone use, smoking status, and date of sample collection. Multivariable conditional logistic regression was used.Median DHEAS levels did not differ between cases (median=58.7) and controls (median=66.0; P=0.10). Conditional on matching factors, the lowest DHEAS quartile exhibited a relative risk of 1.30 for ischemic stroke (95% confidence interval, 0.88-1.94), compared with the highest quartile and marginally unchanged when adjusted for confounders (relative risk=1.33; 95% confidence interval, 0.87-2.02). When modeled as a binary variable dichotomized at the lowest quartile, women with low DHEAS (≤the lowest quartile) had a significantly increased multivariable adjusted risk of ischemic stroke compared with those with higher levels (relative risk=1.41; 95% confidence interval, 1.03-1.92).Lower DHEAS levels were associated with a greater risk of ischemic stroke, even after adjustment for potential confounders. These novel observations warrant confirmation in other populations.

Published
2013

45. Conditions of Confinement in U.S. Carceral Facilities During COVID-19: Individuals Speak-Incarcerated During the COVID-19 Epidemic.

Author

Cassarino N, Dabbara H, Monteiro CB, Bembury A, Credle L, Grandhi U, Patil A, White S, and Jiménez MC

Abstract

Objectives: We aimed to describe conditions of confinement among people incarcerated in the United States during the coronavirus disease 2019 (COVID-19) pandemic using a community-science data collection approach., Methods: We developed a web-based survey with community partners to collect information on confinement conditions (COVID-19 safety, basic needs, support). Formerly incarcerated adults released after March 1, 2020, or nonincarcerated adults in communication with an incarcerated person (proxy) were recruited through social media from July 25, 2020 to March 27, 2021. Descriptive statistics were estimated in aggregate and separately by proxy or formerly incarcerated status. Responses between proxy and formerly incarcerated respondents were compared using Chi-square or Fisher's exact tests based on α=0.05., Results: Of 378 responses, 94% were by proxy, and 76% reflected state prison conditions. Participants reported inability to physically distance (≥6 ft at all times; 92%), inadequate access to soap (89%), water (46%), toilet paper (49%), and showers (68%) for incarcerated people. Among those receiving prepandemic mental health care, 75% reported reduced care for incarcerated people. Responses were consistent between formerly incarcerated and proxy respondents, although responses by formerly incarcerated people were limited., Conclusions: Our findings suggest that a web-based community-science data collection approach through nonincarcerated community members is feasible; however, recruitment of recently released individuals may require additional resources. Our data obtained primarily through individuals in communication with an incarcerated person suggest COVID-19 safety and basic needs were not sufficiently addressed within some carceral settings in 2020-2021. The perspectives of incarcerated individuals should be leveraged in assessing crisis-response strategies., Competing Interests: No competing financial interests exist., (© Nicole Cassarino et al., 2023; Published by Mary Ann Liebert, Inc.)

Published
2023
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46. Prospective association between β 2 -microglobulin levels and ischemic stroke risk among women.

Author

Rist PM, Jiménez MC, and Rexrode KM

Subjects
Biomarkers blood, Brain Ischemia epidemiology, Case-Control Studies, Female, Follow-Up Studies, Humans, Logistic Models, Longitudinal Studies, Middle Aged, Multivariate Analysis, Nurses, Odds Ratio, Prospective Studies, Risk Factors, Stroke epidemiology, Brain Ischemia blood, Stroke blood, beta 2-Microglobulin blood
Abstract

Objective: To determine whether elevated β 2 -microglobulin (B2M) levels were associated with an increased risk of incident ischemic stroke events among women., Methods: We performed a nested case-control study among women enrolled in the Nurses' Health Study who provided blood samples between 1989 and 1990 and were free of prior stroke and cancer. We measured B2M levels in 473 ischemic strokes cases confirmed by medical record review and in 473 controls matched 1:1 to the cases on age, race, date of blood collection, menopausal status, postmenopausal hormone use, and smoking status. We analyzed the association between B2M and ischemic stroke using multivariable conditional logistic regression to adjust for traditional stroke risk factors., Results: Median levels of B2M were higher among cases (1.86 mg/L) than controls (1.80 mg/L, p = 0.009, Wilcoxon rank-sum test). Women in the highest B2M quartile had a multivariable-adjusted increased risk of ischemic stroke compared to those in the lowest quartile (odds ratio [OR] 1.56, 95% confidence interval [CI] 1.02-2.39). Results were similar when restricted to those without evidence of chronic kidney disease (estimated glomerular filtration rate ≥60 mL·min -1 ·1.73 m -2 ) (OR 1.49, 95% CI 1.08-2.06). In an exploratory analysis, the association between B2M and thrombotic stroke was similar to the overall ischemic stroke results, but no association was observed for embolic stroke risk., Conclusion: High levels of B2M were associated with an increased risk of ischemic stroke among women., (© 2017 American Academy of Neurology.)

Published
2017
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