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There is significant interest and importance to develop robust machine learning models to assist organic chemistry synthesis. Typically, task-specific machine learning models for distinct reaction prediction tasks have been developed. In this work, we develop a unified deep learning model, T5Chem, for a variety of chemical reaction predictions tasks by adapting the "Text-to-Text Transfer Transformer" (T5) framework in natural language processing (NLP). On the basis of self-supervised pretraining with PubChem molecules, the T5Chem model can achieve state-of-the-art performances for four distinct types of task-specific reaction prediction tasks using four different open-source data sets, including reaction type classification on USPTO_TPL, forward reaction prediction on USPTO_MIT, single-step retrosynthesis on USPTO_50k, and reaction yield prediction on high-throughput C-N coupling reactions. Meanwhile, we introduced a new unified multitask reaction prediction data set USPTO_500_MT, which can be used to train and test five different types of reaction tasks, including the above four as well as a new reagent suggestion task. Our results showed that models trained with multiple tasks are more robust and can benefit from mutual learning on related tasks. Furthermore, we demonstrated the use of SHAP (SHapley Additive exPlanations) to explain T5Chem predictions at the functional group level, which provides a way to demystify sequence-based deep learning models in chemistry. T5Chem is accessible through https://yzhang.hpc.nyu.edu/T5Chem.

With the GPS mobile devices were widely used and the rapid development of wireless network communication technology. A large number of Moving-Object data that contains spatiotemporal attributes has appeared in our worldwide. However, it is always a hot research issue about how to efficiently store, manage, query, and analyze these massive but valuable spatiotemporal data.This paper proposes a distributed NoSQL index, DWPMIndex (Distributed Weighted Phase-point Moving Object Index) which is based on the Hadoop platform, a distributed infrastructure developed by Apache. DWPMIndex mainly provides data partitioning technology, global index, and local index. We adopted a data partition algorithm for moving objects based on the sampled road segment data which satisfied "balanced partition" and "local dispersion". Furthermore, we creatively design two indexing data structures, i.e., QMS-tree (Quad-tree based on Median point to Split) and WPM-tree (Weighted Phase-point Moving Object Tree), which accelerates global and local indexing tremendously. DWPMIndex can support plentiful queries efficiently, including Spatio-temporal range query, spatial range query, and trajectory query. Experimental results show the powerful query efficiency and scalability of DWPMIndex.

A dataset is the basis of deep learning model development, and the success of deep learning models heavily relies on the quality and size of the dataset. In this work, we present a new data preparation protocol and build a large fragment-based dataset Frag20, which consists of optimized 3D geometries and calculated molecular properties from Merck molecular force field (MMFF) and DFT at the B3LYP/6-31G* level of theory for more than half a million molecules composed of H, B, C, O, N, F, P, S, Cl, and Br with no larger than 20 heavy atoms. Based on the new dataset, we develop robust molecular energy prediction models using a simplified PhysNet architecture for both DFT-optimized and MMFF-optimized geometries, which achieve better than or close to chemical accuracy (1 kcal/mol) on multiple test sets, including CSD20 and Plati20 based on experimental crystal structures.

Background: Currently, standard medical therapies have limited effects on heart failure with preserved ejection fraction (HFpEF), which impacts on the life quality and survival of patients. This study aimed to evaluate the safety and efficacy of the percutaneous radiofrequency ablation–based interatrial shunting for HFpEF with a novel atrial septostomy device. Methods: A preclinical study in 11 normal domestic pigs and the first-in-man study in 10 patients with HFpEF were performed. The major safety events and interatrial shunt performance were evaluated at baseline, 1 month, 3 months, and 6 months post-procedure in both animals and human patients. The clinical functional status was also assessed in the first-in-man study. Results: Percutaneous radiofrequency ablation–based interatrial shunting therapy was performed successfully both in animals and patients. In the animal study, a left-to-right interatrial shunt was created with a mean defect size of 5.5±2.2 mm without procedure-related safety events. Seven pigs showed the continuous shunting with a mean defect size of 4.1±1.5 mm at 6 months. In the first-in-man study, a median interatrial defect diameter of 5.0 (4.0–6.0) mm was measured immediately. No major safety events including death and thromboembolism were observed. The continuous shunting with the defect size of 4.0 (3.0–4.0) mm could still be observed in 7 patients at 6 months. The clinical status was significantly improved with NT-proBNP (N-terminal pro-B-type natriuretic peptide) reduced by 2149 pg/mL ([95% CI, 204–3301] P =0.028), with 6-minute walk distance increased by 88 m ([95% CI, 50–249] P =0.008) and with New York Heart Association class improved in 8 patients at 6 months. Conclusions: The present results showed that percutaneous radiofrequency ablation–based interatrial shunting was a safe and potentially effective therapy for HFpEF, providing a nonpharmacological and nonimplanted option for HFpEF management. Registration: URL: https://www.chictr.org.cn ; Unique identifier: ChiCTR1900027664.

Objectives COVID-19 has become a global epidemic, and effective therapies have not been discovered up to now. We conducted this study to explore the effectiveness and safety of tocilizumab recently used for treating COVID-19. Method A comprehensive search was conducted (up to September 27, 2020), and 19 eligible records were identified according to the inclusion and exclusion criteria. The data of the studies were extracted by 2 independent reviewers and were analyzed to evaluate the safety and availability of tocilizumab for treating COVID-19. Results Thirteen retrospective case-control studies (n = 2285 patients) and 6 retrospective single-armed studies (n = 208) were retrieved in this study. In the comparison of tocilizumab treatment group (TCZ) and standard treatment group (ST), significant associations with a lower risk of admission to ICU, use of ventilation, and mortality (OR, 95% CI: 0.53, 0.26~1.09; 0.66, 0.46~0.94; 0.44, 0.36~0.55) were found in the tocilizumab treatment group. What is more, patients treated with tocilizumab had better clinical improvement compared with the patients treated with ST (OR, 1.24; 95% CI, 0.96~1.62). After taking tocilizumab, the patients had lower C-reactive protein (CRP), white blood cell count (WBC), aspartate aminotransferase (AST) (WMD, 95% CI: − 99.66, − 156.24~− 43.09; − 0.95, − 1.8~− 0.11; − 12.58, − 18.88~−6.29) but higher troponin (WMD, 7.61; 95% CI, 3.06~12.15) than before. In addition, tocilizumab did not have significant influence on patients’ neutrophil count (Neut), lymphocyte count (Lymp), platelet count (Plt), alanine aminotransferase (ALT), and creatine (WMD, 95% CI: − 0.29, − 2.91~2.33; 0.42, − 0.23~1.07; 5.2, − 2.85~13.25; 22.49, − 2.73~47.7; − 44.78, − 93.37~3.81). Conclusion Tocilizumab may have potential effectiveness to treat COVID-19 according to the results of this study. However, more large-scale studies are needed for more accurate conclusions. Electronic supplementary material The online version of this article (10.1007/s00228-020-03017-5) contains supplementary material, which is available to authorized users.

Isoflurane, an anesthetic, can aggravate the progression of Alzheimer's disease (AD). Long non-coding RNA β-secretase 1 (BACE1)-antisense transcript (BACE1-AS) and miR-214-3p are related to AD progression. Nevertheless, it is unclear whether BACE1-AS is involved in the development of isoflurane-mediated AD via miR-214-3p. Amyloid beta peptide (Aβ) was employed to construct the AD cell model. The expression of BACE1-AS and miR-214-3p in the plasma of AD patients and SK-N-SH and SK-N-AS cells treated with Aβ and isoflurane was assessed through quantitative reverse transcription polymerase chain reaction (qRT-PCR). The proliferation and apoptosis of Aβ-treated SK-N-SH and SK-N-AS cells were determined via 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2-H-tetrazolium bromide (MTT) or flow cytometry assays, respectively. Protein levels of B cell lymphoma 2 (Bcl-2), Bcl-2-associated X (Bax), CyclinD1, microtubule-associated protein A1/1B-light chain3 (LC3 I/LC3 II), p62 and Beclin1 were detected via western blot analysis. The relationship between BACE1-AS and miR-214-3p was verified by dual-luciferase reporter assay. We found that BACE1-AS was upregulated and miR-214-3p was downregulated in the plasma of AD patients and SK-N-SH and SK-N-AS cells treated with Aβ and isoflurane. Both BACE1-AS depletion and miR-214-3p augmentation restored the suppression of proliferation and the facilitation of apoptosis and autophagy of Aβ-treated SK-N-SH and SK-N-AS cells induced by isoflurane. Importantly, BACE1-AS acted as a sponge for miR-214-3p. Additionally, miR-214-3p silencing reversed the influence of BACE1-AS knockdown on isoflurane-mediated proliferation, apoptosis and autophagy in Aβ-induced SK-N-SH and SK-N-AS cells. In conclusion, BACE1-AS aggravated isoflurane-induced neurotoxicity to AD via sponging miR-214-3p.

The High Mountain Asia (HMA) region, ranging from the Hindu Kush and Tien Shan in the west to the Himalaya in the south with an altitude between 2000 and 8844 m, holds the largest reservoir of glaciers and snow outside Earth Polar Regions. In the last decades, numerous glaciers and lake areas there have undergone tremendous changes with water redistribution. In order to increase understanding of the pattern of distribution of water resources, and their dynamic changes at the basin scale, a watershed classification based on the water replenishment patterns dataset was constructed. The input dataset are from the Randolph Glacier Inventory V.6.0 and the vector data of rivers and streams. Four datasets were thus obtained: Glacier-fed and Runoff-fed Drainage Area (GRDA), Glacier-fed and Runoff-free Drainage Area (GDA), Glacier-free and Runoff-fed Drainage Area (RDA), and the Glacier-free and Runoff-free Drainage Area (NGRDA), and the numbers of these four types of basins are 87, 107, 32, and 448 separately. The statistical results show GRDA has the largest surface area, accounting for 82.2% of the total basin area in HMA, mainly in the region of the basin with outflow rivers or streams. Dominated by small basins, the GDA area accounts for the smallest area, only 3.86% and the RDA accounts for 5.62%. For NGRDA, most are with small areas, accounting for 8.32%, and mainly distributes in the closed basin of the Qiangtang Plateau. This dataset provides a fundamental classified data source for research on water resources, climate, ecology, and environment in HMA. The published data are available at https://data.4tu.nl/download/uuid:d07d748f-d10b-4308-9626-199ef05cc9af/ and http://www.dx.doi.org/10.11922/sciencedb.923.

This study aimed to determine the extent to which nurses report assessing evidence-based falls risk factors and implementing targeted prevention for medical and surgical patients in China.This study was a national online survey.The respondents were registered nurses working in medical and surgical units in 662 Chinese hospitals. The data concerning the falls risk factor assessments and targeted interventions implemented by nurses were collected online by the Nursing Management Committee of the Chinese Nursing Association in China in 2019.In total, 68 527 valid questionnaires were returned (95.0%). In medical and surgical units, nurses were most likely to report assessing balance, mobility and strength (81.6%) and orthostatic hypotension (76.4%) in falls patients and least likely to report assessing continence (61.3%) and feet and footwear (55.8%). Ensuring the use of appropriate footwear (79.3%) and managing syncope, dizziness and vertigo (73.8%) were the most common multiple interventions, while managing postural hypotension (48.8%) and cognitive impairment (48.4%) was the least common. Nine falls risk factors with clearly matched multifactorial interventions were identified in medical and surgical units (68.2%-97.1%).The implementation of multifactorial interventions in medical and surgical wards is inconsistent as reported by nurses in medical and surgical wards. Throughout China, nurses are generally concerned about falls risk factors and prevention for their patients; however, limited attention has been focused on continence, feet and footwear assessment and the management of cognitive impairment. Evidence-based falls prevention should be further tailored to the specific risk factors of each patient.Best practice guidelines for falls prevention in hospitals have been developed and published, and it is important for nurses to use these guidelines to guide practice. Our findings identify that in routine care, healthcare providers and hospitals can prevent falls.

Rationale, Aims, and Objectives: To determine the extent to which nurses reportedly assess evidence-based falls risk factors and identify targeted prevention implemented for medical and surgical patients in China. Method: This was a multicenter retrospective observational study. Respondents were nurses working in medical and surgical units of Chinese 662 hospitals. Fall-risk factors assessments and targeted interventions by health professionals were collected online by the Nursing Management Committee of Chinese Nursing Association in China, in 2019. Results: A total of 68527 valid questionnaires were recovered (95.0%). In medical and surgical units, nurses were most likely to report assessing balance, mobility and strength (81.6%) and orthostatic hypotension (76.4%) for falls and least likely to continence (61.3%) and feet and footwear (55.8%). Appropriate footwear (79.3%) and managing syncope, dizziness and vertigo (73.8%) were the most frequently falls multiple interventions, while managing postural hypotension (48.8%) and cognitive imparement (48.4%) were the least. Nine fall-risk factors with clearly matched multifactorial interventions were determined in medical and surgical units (68.2%~ 97.5%). On comparative analysis, Cognitive therapy, Toileting-assistance, Indwelling catheter, Monitor postural blood pressure, Dizziness and vertigo interventions, Minimise asthma triggers, Educating medication use, Keeping floor surface clean and dry were more common in medical ward, while With the head of the bed raised, Assessments and referrals and Bed brakes locked in surgical ward. Conclusion: Health professionals are generally concerned about risk factors and prevention for falls with their patients in much of China, however limited attention was directed at the continence, feet and footwears assessment and managing cognitive imparement. Evidence-based prevention should be further tailored to the individual, based on an individual risk factors.

Summary Objectives To explore the characteristics of functional dysphonia (FD) using multimodal methods. Methods A total of 47 FD patients and a group of 22 normal controls were enrolled. Subjective auditory-perceptual assessment of the voice, Voice Handicap Index (VHI) 30, acoustic analysis, psychological scales assessment, surface electromyography (sEMG), nasal airflow and thoracoabdominal studies were performed. Results FD was mostly triggered by mood changes. Patient self-evaluation was more serious than auditory-perceptual evaluation and objective acoustic analysis. There was no obvious organic disorder observed under laryngoscope in patients with FD, but there were cases of glottic insufficiency and supraglottic compensation. With regards to sEMG, nasal airflow, chest, and abdomen examination results: (1) sEMG in the normal control group was symmetrical and stable on both sides during rest and phonation, and nasal airflow as well as the chest and abdomen were symmetrical and regular; (2) sEMG in the FD group showed increased recruitment of the sternocleidomastoid muscles, the infra- and suprahyoid muscles, and the cricothyroid muscle, accompanied by prephonation recruitment and postphonation persistence, mainly involving the infra- and suprahyoid muscles; (3) In the FD group, there was shortened inspiratory time, increased chest breathing amplitude, and reduced abdominal breathing, with predominantly chest breathing, and a “breath-holding” phenomenon was observed in some patients, with a significant increase in the number of breaths during the short text task. Conclusions FD occurs mainly in middle-aged women, and there are many triggers. The Hamilton Anxiety/Depression Rating Scale scores were higher, and subjective symptoms were more serious than objective evaluation. No obvious organic changes were seen under laryngoscope, and features such as supraglottic compensation and glottic insufficiency were observed; muscle tension was significantly higher than that of the normal control group, and prephonation recruitment and postphonatory persistence were seen in some patients; the breathing pattern was mainly chest breathing, and the times of breaths during the short text task significantly increased. With identification of the characteristics of FD, the therapy could be focused them.

The high prevalence of hypertension contributes to an increased global burden of cardiovascular diseases. Calcium channel blockers (CCBs) and angiotensin type 1 receptor blockers (ARBs) are the most widely used antihypertensive drugs, and the effects of these drugs on serum metabolites remain unknown. Untargeted metabolomics has been proved to be a powerful approach for the detection of biomarkers and new compounds. In this study, we aimed to determine the changes in metabolites after single-drug therapy with a CCB or ARB in patients newly diagnosed with mild to moderate primary hypertension. We enrolled 33 patients and used an untargeted metabolomics approach to measure 625 metabolites associated with the response to a 4-week treatment of antihypertensive drugs. After screening based on P0.05, fold change1.2 or fold change0.83, and variable importance in projection1, 63 differential metabolites were collected. Four metabolic pathways-cysteine and methionine metabolism, phenylalanine metabolism, taurine and hypotaurine metabolism, and tyrosine metabolism-were identified in participants treated with ARBs. Only taurine and hypotaurine metabolism were identified in participants treated with CCBs. Furthermore, homocitrulline and glucosamine-6-phosphate were relevant to whether the blood pressure reduction achieved the target blood pressure (P0.05). Our study provides some evidence that changes in certain metabolites may be a potential marker for the dynamic monitoring of the protective effects and side effects of antihypertensive drugs.

Reduced prolactin (PRL) has been shown to delay wound healing with a limited understanding of the underlying mechanisms. Here, we aim to explore the role of PRL in the repair of vocal fold (VF) injury. A microarray was used to detect the expressed levels of PRL in rat VF tissue at 1, 4, and 8 weeks after VF injury compared with normal uninjured rats. Then, a systematic bioinformatics analysis has been conducted to explore the literature-based biology network and signaling pathways involved in the repair of VF injury. The expression of PRL was significantly decreased in all VF injury groups (week 1, 4, and 8) compared with the control group (F stats = 280.34; P=4.88e-14), with no significant difference among the three VF injury groups (F stats = 1.97; P=0.18). Wounding has been shown to interfere with both PRL-promoting and inhibiting pathways that were involved in wound healing, including 11 PRL inhibitors and 6 PRL promoters. Our results reveal decreased PRL expression levels in VF injury, which is not in favor of the wound healing. The pathways identified may help in understanding the role of PRL as a treatment target for VF wound healing.

Background: Long noncoding RNA (lncRNA) H19 is emerging as a vital regulatory molecule in the progression of different types of cancer and miR-675 is reported to be embedded in H19's first exon. However, their function and specific mechanisms of action have not been fully elucidated. The aim of this study was to identify a novel lncRNA-microRNA-mRNA functional network in gastric cancer. Methods: Quantitative real-time polymerase chain reaction (qRT-PCR) was used to assess the relative expression of H19 and miR-675 in normal (GES-1) and gastric cancer cell lines (SGC-7901, SGC-7901/DDP) as well as in tumor tissues. Gain and loss of function approaches were carried out to investigate the potential roles of H19/miR-675 in cell proliferation and apoptosis. Moreover, Fas associated via death domain (FADD) was validated to be the target of miR-675 via luciferase reporter assay. Western blotting was used to evaluate the protein expression of related signaling pathway. Results: In our study H19 and miR-675 were increased in gastric cancer cell lines and tissues. Overexpression of H19 and miR-675 promoted cell proliferation and inhibited cell apoptosis, whereas knockdown of H19 and miR-675 inhibited these effects. By further examining the underlying mechanism, we showed that H19/miR-675 axis inhibited expression of FADD. FADD downregulation subsequently inhibited the caspase cleavage cascades including caspase 8 and caspase 3. Conclusion: Taken together, our results point to a novel regulatory pathway H19/miR-675/ FADD/caspase 8/caspase 3 in gastric cancer which may be potential target for cancer therapy.

In the process of China’s going global, building a positive Chinese image is of great significance to the development of our country. It is important to promote Chinese culture when teaching Chinese as a foreign language. This article aims at analyzing the influence of Chinese culture teaching on building Chinese image when we teach Chinese as a foreign language, so as to improve the popularity and understanding of Chinese image within a wider range internationally.

A highly concise, enantioselective synthesis of (–)-colchicine, the first syntheses of (+)-demecolcinone and metacolchicine, was reported., Here, we describe a concise, enantioselective, and scalable synthesis of (–)-colchicine (9.2% overall yield, >99% ee). Moreover, we have also achieved the first syntheses of (+)-demecolcinone and metacolchicine, and determined their absolute configurations. The challenging tricyclic 6-7-7 core of colchicinoids was efficiently introduced using an intramolecular oxidopyrylium-mediated [5 + 2] cycloaddition reaction. Notably, the synthesized colchicinoid 23 exhibited potent inhibitory activity toward the cell growth of human cancer cell lines (IC50 = ∼3.0 nM), and greater inhibitory activity towards microtubule assembly than colchicine, making it a promising lead in the search for novel anticancer agents.

Correction for ‘Enantioselective total synthesis of (−)-colchicine, (+)-demecolcinone and metacolchicine: determination of the absolute configurations of the latter two alkaloids’ by Chuang-Chuang Li et al., Chem. Sci., 2017, 8, 4961–4966.

It was practicable to remove hemangiomas at the labyrinth region and distal internal auditory canal with complete or serviceable hearing preservation by the transmastoid approach. The majority of cases where the nerve integrity was preserved achieved acceptable recovery of facial nerve function during the first few years according to our study. Long-term outcomes of nerve graft were acceptable, while short-term outcomes were unsatisfactory based on the literature.This study aimed to present our surgical experience of nine intratemporal facial nerve hemangiomas and provide a brief literature review.Clinical data for the cases were retrospectively analyzed. They were followed up for 5-59 months and related literature was reviewed.All of the hemangiomas were removed by the transmastoid approach, and only three cases developed mild conductive hearing loss. Nerve integrity was preserved for all cases. In all, 66.7% of patients maintained or recovered to grade III or better, and one patient with grade VI recovered to grade V during the average follow-up period of 2 years. In the literature the majority of grafted patients recovered to an acceptable level 5 years later, although recovery was usually poor during the first year.

The sustainable development of grain production is a necessary condition for Chinese rapid economic development, which is directly related to people's livelihood and national security. This paper analyzed the frequent occurrence causes of regional drought in China, emphatically enumerated the North-South imbalance of precipitation distribution in time and space, the excessive tillage and grazing and vegetation damage, the hydro-agricultural infrastructure aging and the rapid urbanization diverted for agricultural water resources, which impact the sustainable development of grain production, then proposed some countermeasures coping with frequently regional drought crisis: strengthen the protection of forest vegetation, the scientific planning of planting structure, and the balance regulation of urban industrial water and grain irrigation water, surface water and ground water and of the water allocation between the administrative region, and solve the discharge of sewage purification and desalination technologies, thus establish an integrated balance system of total supply and regional control of grain irrigation water, so as to continuously perfect the durable and stable supply of grain in China.

Conclusions: A lateral hump anomaly of the pyramid segment of the facial nerve deserves special attention during otologic surgery. Coronary high-resolution CT (HRCT) reconstruction of temporal bone was highly valuable in preoperative detection of the anomaly. Objective: This study aimed to investigate lateral hump anomaly of the pyramid segment of the facial nerve in adult patients and assess the value of coronary HRCT reconstruction of the temporal bone in preoperative detection of the anomaly. Methods: We carried out a prospective study in 439 Han Chinese adults who underwent unilateral facial nerve decompression due to Bell's palsy in our department between April 2005 and October 2012, focusing on lateral hump anomaly of the pyramid segment of the facial nerve, detection sensitivity, and accuracy of coronary HRCT reconstruction of the temporal bone. Results: Lateral hump anomaly of the pyramid segment was observed in 21 cases (4.83%) undergoing surgery. The detection sensitivity and accuracy o...

Subtotal facial nerve decompression seems effective to prevent further episodes of facial palsy and promote facial nerve recovery for recurrent facial palsy in Melkersson Rosenthal syndrome (MRS). The main inflammatory sites of recurrent facial palsy in MRS may be the mastoid segment, tympanic segment, geniculate ganglion, and labyrinthine segment.To present our surgical experience in preventing further episodes of facial palsy and improving facial nerve recovery of patients with recurrent facial palsy in MRS.We performed transmastoid subtotal facial nerve decompression on eight patients with recurrent facial palsy in MRS. They were followed up for 3.3 years on average (range 2-5 years).There were no further attacks of facial palsy in any of the cases. Seven cases (87.5%) recovered to grade I or grade II, and three of eight cases (37.5%) recovered completely. We found obvious edema of the facial nerve at the mastoid segment in all cases, at the tympanic segment and geniculate ganglion in five cases (62.5%), and at the labyrinthine segment in only one case (12.5%).

The successive approximation register analog to digital converter (SAR ADC) technique is not yet mature in China mainly because of the imperfect analog module of the SAR ADC. The purpose of this design was to optimize the analog module by designing and making a 8-bit 1MHz SAR ADC and testing a 12-bit SAR ADC theoretically and by simulation. The design of the 1MHz SAR DAC, which consists of analog circuit and digital circuit, was designed according to the positive design method and the specific standard. And the ADC circuit was designed according to the sub-module layout. By the time the project design was finished, its hardware which was made of discrete components by welding printed circuit board (PCB) was debugged. The hardware’s physical properties were analyzed by using a SAR DAC test platform created in LabVIEW8.6 interfaced with data acquisition cards. This designed SAR ADC can be applied to sensor interface, data acquisition system, portable test instrument, low power control system and some aspects of communication. Its absolute average error is about 1% in the laboratory tests which meet the expectations of high accuracy requirement. When it was used in the ropeway project of agriculture engineering project, it reached a good accuracy of 91.5%. It is recommended that PCB automatic routing function be used to reduce the error and interference in the further study from the tests result.