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5 results on '"Jieh-Hen Tsung"'

1. Pharmacogenomics study on cadherin 2 network with regard to HIV infection and methadone treatment outcome.

Author

Hsiang-Wei Kuo, Chia-Lung Shih, Jieh-Hen Tsung, Sheng-Wen Liu, Shih-Kai Chu, Hsin-Chou Yang, Hsiao-Hui Tsou, Zih-Hsiang Wang, Andrew C H Chen, and Yu-Li Liu

Subjects
Medicine, Science
Abstract

Heroin dependent patients have a high incidence of HIV infection. In contrast to the gene expression method, we developed a systemic correlation analysis method built upon the results of pharmacogenomics study in a methadone maintenance treatment (MMT) cohort consisting of 344 Taiwanese heroin dependent patients. We identified genetic variants and their encoding proteins that may be involved with HIV infection and MMT treatment outcome. Cadherin 2 (CDH2) genetic determinants were identified through the genome-wide pharmacogenomic study. We found significant correlations among HIV infection status, plasma levels of CDH2, cytokine IL-7, ADAM10, and the treatment responses to methadone. Two single nucleotide polymorphisms located within CDH2 gene showed associations with blood pressure and plasma CDH2 concentration. Plasma concentration of CDH2 showed correlations with the level of cytokine IL-7, status of HIV infection, and urine morphine test result. Plasma level of IL-7 was correlated with corrected QT interval (QTc) and gooseflesh skin withdrawal symptom score, while level of ADAM10 was correlated with plasma concentrations of vitamin D metabolite, nicotine metabolite, and R-methadone. The results suggest a novel network involving HIV infection and methadone treatment outcome.

Published
2017
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2. Adhesion Molecules as Potential Novel Biomarkers for Opioid Dependence

Author

Hsiang-Wei Kuo, Jieh-Hen Tsung, Chiu-Ping Fang, Andrew C.H. Chen, and Yu-Li Liu

Subjects
Methadone maintenance, CDH2, Bioinformatics, 01 natural sciences, 03 medical and health sciences, Nectin, Drug Discovery, Humans, Medicine, Neural Cell Adhesion Molecules, 030304 developmental biology, Pharmacology, 0303 health sciences, business.industry, Cell adhesion molecule, Adhesion, Cadherins, Opioid-Related Disorders, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Opioid, Neural cell adhesion molecule, business, Biomarkers, Methadone, medicine.drug
Abstract

Background: Cell-cell adhesion is essential in maintaining the structure and function of an organ. Several adhesion molecules have recently been identified as associated with heroin dependence in both genetic and peripheral plasma studies. Methods and Results: We reviewed literature concerning studies on adhesion molecules in opioid addictions in rodents and human, including human genetic associations in different ethnic groups, and treatment responses to methadone maintenance treatment in heroin-dependent patients. Conclusion: Some important and novel findings were summarized and discussed. Adhesion molecules in the peripheral plasma, e.g., cadherin-2 (CDH2), may be biomarkers for both methadone treatment outcome and nectin 4 may be an indicator for continued opioid use. Neural cell adhesion molecule (NCAM) in the central nervous system may regulate opioid withdrawal and analgesic responses. Future studies to uncover the mechanisms underlying the involvement of adhesion molecules in the pathological process of addictions will be an important research direction in the field.

Published
2020

3. Pharmacogenomics study on cadherin 2 network with regard to HIV infection and methadone treatment outcome

Author

Shih-Kai Chu, Jieh-Hen Tsung, Hsiao-Hui Tsou, Chia-Lung Shih, Zih-Hsiang Wang, Sheng-Wen Liu, Hsiang-Wei Kuo, Andy Chun Hang Chen, Hsin-Chou Yang, and Yu-Li Liu

Subjects
0301 basic medicine, RNA viruses, Male, Physiology, lcsh:Medicine, Blood Pressure, HIV Infections, Urine, Pathology and Laboratory Medicine, Vascular Medicine, Heroin, ADAM10 Protein, Immunodeficiency Viruses, Immune Physiology, Medicine and Health Sciences, Vitamin D, lcsh:Science, Analgesics, Innate Immune System, Multidisciplinary, Morphine, Heroin Dependence, Drugs, Cadherins, Body Fluids, Blood, Treatment Outcome, Medical Microbiology, Viral Pathogens, Physical Sciences, Viruses, Infectious diseases, Cytokines, Female, Anatomy, Pathogens, medicine.drug, Research Article, Adult, Methadone maintenance, Permutation, Immunology, Single-nucleotide polymorphism, Viral diseases, QT interval, Microbiology, Polymorphism, Single Nucleotide, Blood Plasma, 03 medical and health sciences, Antigens, CD, Retroviruses, medicine, Vitamin D and neurology, Pain Management, Humans, Microbial Pathogens, Pharmacology, business.industry, Discrete Mathematics, Interleukin-7, lcsh:R, Lentivirus, Organisms, Biology and Life Sciences, HIV, Membrane Proteins, Molecular Development, Opioids, 030104 developmental biology, Combinatorics, Pharmacogenetics, Pharmacogenomics, Immune System, lcsh:Q, Amyloid Precursor Protein Secretases, business, Mathematics, Methadone, Developmental Biology
Abstract

Heroin dependent patients have a high incidence of HIV infection. In contrast to the gene expression method, we developed a systemic correlation analysis method built upon the results of pharmacogenomics study in a methadone maintenance treatment (MMT) cohort consisting of 344 Taiwanese heroin dependent patients. We identified genetic variants and their encoding proteins that may be involved with HIV infection and MMT treatment outcome. Cadherin 2 (CDH2) genetic determinants were identified through the genome-wide pharmacogenomic study. We found significant correlations among HIV infection status, plasma levels of CDH2, cytokine IL-7, ADAM10, and the treatment responses to methadone. Two single nucleotide polymorphisms located within CDH2 gene showed associations with blood pressure and plasma CDH2 concentration. Plasma concentration of CDH2 showed correlations with the level of cytokine IL-7, status of HIV infection, and urine morphine test result. Plasma level of IL-7 was correlated with corrected QT interval (QTc) and gooseflesh skin withdrawal symptom score, while level of ADAM10 was correlated with plasma concentrations of vitamin D metabolite, nicotine metabolite, and R-methadone. The results suggest a novel network involving HIV infection and methadone treatment outcome.

Published
2017

4. List of Contributors

Author

Ghulam Abbas, Piotr Adamowicz, Ana Adan, Nirit Agay, S. Al-Halabí, Hatice Altun, Maryam Amini, Monica L. Andersen, Cecilie Schou Andreassen, James C. Anthony, Yalda Hosseinzadeh Ardakani, Mariarosaria Aromatario, Priti Arun, Anzari Atik, Anna Rita Atti, Alison L. Baird, Michela Balconi, Anna Lukačišinová Ballóková, M.T. Bascarán, Gemma Battagliese, Irina Benaiges, Dessa Bergen-Cico, Wade H. Berrettini, Laís F. Berro, Elisabetta Bertol, Jin-Song Bian, M.T. Bobes-Bascarán, J. Bobes, Miriam E. Bocarsly, Marie-Laure Bocca, Roberta Bonafede, Dasiel O. Borroto-Escuela, Edoardo Bottoni, M. Bousoño, Michael T. Bowen, Placido Bramanti, Kari J. Buck, Femke T.A. Buisman-Pijlman, Andreas Büttner, Rocco S. Calabrò, Ulaş M. Çamsari, Simone Cappelletti, María Carbo-Gas, Paola Casadio, Verònica Casadó-Anguera, Vicent Casadó, Mauro Ceccanti, Yong-Yuan Chang, Young-Tae Chang, Meng-Chun Chiu, Nan-Ying Chiu, Zang-Hee Cho, Yemina Chung, Costantino Ciallella, Eduardo Cinosi, Katherine M. Conigrave, Andrew N. Coogan, Maurizio Coppola, Antoni Cortés, Giulia Costa, Stephen Cox, Nachum Dafny, Subhash Das, Jonathan M. Davis, Robert De Matteo, Zsolt Demetrovics, Apo Demirkol, Eileen M. Denovan-Wright, Massimo di Giannantonio, Tuba Edgunlu, Simon Elliott, Nicole M. Enman, Ali A. Ensafi, Marco Faccini, Brian A. Falls, Chiu-Ping Fang, Lir-Wan Fan, Ahsana Dar Farooq, Daniel Feingold, Luca Ferraro, Daniela Fialová, Malgorzata Filip, Ebru Findikli, Roberta Finocchiaro, Paola A. Fiore, Sílvia Font-Mayolas, Jonah Fox, Domniki Fragou, Qiang Fu, Kjell Fuxe, Maximilian Gahr, M.P. García-Portilla, Preeta George, Isis Gil-Miravet, Philip Gorwood, Maria Eugènia Gras, María Clara Gravielle, Mark D. Griffiths, Paul S. Haber, Natalie A. Hadad, F. Scott Hall, Doug Hyun Han, Richard Harding, Rida Hashmi, Hossein Hassanian-Moghaddam, Olga Hernández-Serrano, Evan S. Herrmann, Thaddeus A. Herzog, Esmaeil Heydari-Bafrooei, Kiichi Hirota, Ming-Chou Ho, Leonard L. Howell, Wen-Yu Hsu, Chieh-Liang Huang, Robert N. Hughes, Kristen A. Hymel, Gi Jung Hyun, Koichi Inoue, M. Mofizul Islam, Bardia Jamali, Grażyna Jerzemowska, Martin O. Job, Jan Olav Johannessen, Helen J. Johansen, Matthew W. Johnson, Patrick S. Johnson, Chang-Ki Kang, Sevim Karakaş-Çelik, Natasha Kharas, Young-Bo Kim, Lori A. Knackstedt, Hannu Kokki, Merja Kokki, Anna Konopka, Kathleen Kopcza, Dimitrios Kouvelas, Leda Kovatsi, Lauren C. Kruse, Chien-Wen Lai, Maryse Lapeyre-Mestre, Edward C. Lauterbach, Yann Le Strat, Chen-Yi Lee, Michel Lejoyeux, Roberto Leone, Shaul Lev-Ran, Ren-Hau Li, Willmann Liang, Jiajun Liu, Ling-Jun Liu, Liwei Liu, Sheng-Wen Liu, Yu-Li Liu, Zia Li, Daniela S.S. Lobo, Jingsheng Lou, Rocco Luigi Picci, Matteo Lupi, Brianna M. Lutz, Kendra MacClurg, Lara Magro, Mirko Manchia, Aniko Maraz, Rémi Martin-Fardon, Giovanni Martinotti, Alessandra Matzeu, Jay P. McLaughlin, Ian S. McRae, Dieter J. Meyerhoff, Marta Miquel, Raffaella Mondola, Robert Moore, Micaela Morelli, Estefanía Moreno, Tomohisa Mori, Bridin Murnion, Kelle L. Murphy, Bhushan Vijay Nagpure, Antonino Naro, C. Ineke Neutel, Suzanne Nielsen, Motoo Nomura, Francesco Oliva, M. Foster Olive, Deanna Olivoni, Qin Ouyang, Ståle Pallesen, Aurore Palmaro, Georgios Papazisis, Jason J. Paris, Chan-A Park, Jeong Ha Park, Justyna Pełka Wysiecka, Verity Pearson-Dennett, Daniel E. Phillips, Martina Pinna, Paul L. Plener, Nicolas Ramoz, Perry F. Renshaw, Beverly A.S. Reyes, Alicia Rivera, Susan E. Robinson, Francesco S. Romolo, Ali Roohbakhsh, Mohammadreza Rouini, Anne Roussin, Florence F. Roussotte, P.A. Saiz, J. Samochowiec, Carla Sanchis-Segura, Rita Santacroce, Carmen Sato-Bigbee, H. Umit Sayin, Veronica B. Searles Quick, Ömer Şenormanci, Emmanuel Seseña, Ali Shamsizadeh, Behjat Sheikholeslami, Bin Shen, Masahiro Shibasaki, Samuel D. Shillcutt, Nicola Simola, Rachana Singh, Amuchou Singh Soraisham, Enrique Soto, Michael Soyka, Ainars Stepens, Mark J.M. Sullman, Linlin Sun, Tsutomu Suzuki, Attila Szabo, Pille Taba, Hong Chai Tang, Tze-Chun Tang, Yuan-Xiang Tao, Wenche ten Velden Hegelstad, Johannes Thome, Paul M. Thompson, Lu-Tai Tien, Elizabeth I. Tietz, Gabrielle Todd, Mary Tolcos, Meshkat Torkamanian, Jieh-Hen Tsung, Sergio Tufik, Mafaz Ullah, Fabio Vaiano, Elisabeth J. Van Bockstaele, Ryan Vandrey, Dolores Vazquez-Sanroman, Rosario Vega, Mario Vitali, Maria S.M. Wai, Junmei Wang, Lirong Wang, Sheng-Chang Wang, Melissa A. Weibell, Aviv Weinstein, Jason M. White, Robert A. Wilcox, Hester Wilson, Trecia A. Wouldes, Karolina Wydra, Xiang-Qun Xie, Zhaojun Xie, Zheng-Xiong Xi, Wang Xu, Hai-Yu Yang, Peng Yang, Eldad Yechiam, David T. Yew, Andrew W.S. Yong, Nasim Zamani, Hans Zoellner, and Dariusz Zuba

Published
2016

5. Genetic Polymorphisms on OPRM1 Involved in Multiple Responses of a Methadone Maintenance Population

Author

Yu-Li Liu, Sheng-Chang Wang, Sheng-Wen Liu, Chiu-Ping Fang, Chieh-Liang Huang, Chien-Wen Lai, and Jieh-Hen Tsung

Subjects
Libido, education.field_of_study, Methadone maintenance, business.industry, medicine.drug_class, Population, Pharmacology, Bioinformatics, chemistry.chemical_compound, chemistry, Opioid receptor, mental disorders, Medicine, Animal studies, μ-opioid receptor, education, business, Cotinine, Methadone, medicine.drug
Abstract

The opioid receptor, mu 1 (OPRM1) is a gene that encodes for the mu opioid receptor (MOR). The role of the MOR has been well characterized in both physiological and pharmacological animal studies. Its role in heroin-dependent patients under treatment with the synthetic opioid methadone, however, is unclear. Using a Taiwan methadone maintenance treatment cohort, we have discovered that the genetic polymorphisms on the OPRM1 genetic regions were significantly associated with the severity of smoking. We did this by using the plasma nicotine metabolite cotinine concentrations as indicator, self-reports of methadone-induced insomnia, and change-in-libido side effects, as rated by the treatment emergent symptom scale and the plasma concentrations of macrophage-derived chemokine (MDC). Our results suggest that the OPRM1 genetic variants may be indicators for the severity of smoking, the severity of methadone-induced insomnia and change-in-libido side effects, and the plasma levels of MDC-related immune responses.

Published
2016

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