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2 results on '"Jiebei Xian"'

1. Structural characterization and protective effects of polysaccharide from Gracilaria lemaneiformis on LPS-induced injury in IEC-6 cells

Author

Xiong Li, Yufeng Gong, Wanzi Yao, Xiaoyong Chen, Jiebei Xian, Lijun You, and Pedro Fardim

Subjects
Gracilaria lemaneiformis, Sulfated polysaccharide, Anti-inflammatory activity, Tight junction, Nutrition. Foods and food supply, TX341-641, Food processing and manufacture, TP368-456
Abstract

This study was aimed to characterize Gracilaria lemaneiformis polysaccharides and evaluate their protective effects on Lipopolysaccharide-induced injury in IEC-6 cells. The G. lemaneiformis polysaccharide was degraded by UV/H2O2 treatment and purified to three fractions named GLP-1.0 M, GLP-1.4 M and GLP-1.6 M. The purified fractions were mainly composed of galactose, glucose and xylose. The structural analysis showed that GLP-1.6 M was a typical sulfated red alga polysaccharide containing the linear backbone of β-(1 → 3)- and α-(1 → 4)-linked galactosyl residues, anhydro-galactose units. In the Lipopolysaccharide-induced IEC-6 cells model, GLP-1.6 M exerted the strongest in vitro anti-inflammatory activity by inhibiting the release and expressions of tumor necrosis factor-α, interleukin-6 and interleukin-1β by 89.93%, 67.82% and 38.06%, respectively. Meanwhile, GLP-1.6 M enhanced the intestinal barrier function via up-regulating the expressions of tight junctions and mucin. Therefore, the purified polysaccharide from G. lemaneiformis could be a promising candidate for maintaining intestinal health in the food and pharmaceutical industries.

Published
2021
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2. Structural characterization and protective effects of polysaccharide from Gracilaria lemaneiformis on LPS-induced injury in IEC-6 cells

Author

Wanzi Yao, Xiong Li, Jiebei Xian, Lijun You, Pedro Fardim, Yufeng Gong, and Xiaoyong Chen

Subjects
Gracilaria lemaneiformis, STRESS, Xylose, Polysaccharide, Food processing and manufacture, Analytical Chemistry, SULFATED POLYSACCHARIDES, chemistry.chemical_compound, Anti-inflammatory activity, Sulfation, INFLAMMATION, ANTIOXIDANT, TX341-641, FRUITS, Barrier function, Tight junction, chemistry.chemical_classification, Science & Technology, Nutrition. Foods and food supply, Mucin, TP368-456, GALACTANS, In vitro, Chemistry, Applied, Chemistry, chemistry, Biochemistry, ANTIINFLAMMATORY ACTIVITY, Galactose, Food Science & Technology, Sulfated polysaccharide, Physical Sciences, Life Sciences & Biomedicine, Food Science
Abstract

This study was aimed to characterize Gracilaria lemaneiformis polysaccharides and evaluate their protective effects on Lipopolysaccharide-induced injury in IEC-6 cells. The G. lemaneiformis polysaccharide was degraded by UV/H2O2 treatment and purified to three fractions named GLP-1.0 M, GLP-1.4 M and GLP-1.6 M. The purified fractions were mainly composed of galactose, glucose and xylose. The structural analysis showed that GLP-1.6 M was a typical sulfated red alga polysaccharide containing the linear backbone of β-(1 → 3)- and α-(1 → 4)-linked galactosyl residues, anhydro-galactose units. In the Lipopolysaccharide-induced IEC-6 cells model, GLP-1.6 M exerted the strongest in vitro anti-inflammatory activity by inhibiting the release and expressions of tumor necrosis factor-α, interleukin-6 and interleukin-1β by 89.93%, 67.82% and 38.06%, respectively. Meanwhile, GLP-1.6 M enhanced the intestinal barrier function via up-regulating the expressions of tight junctions and mucin. Therefore, the purified polysaccharide from G. lemaneiformis could be a promising candidate for maintaining intestinal health in the food and pharmaceutical industries. ispartof: FOOD CHEMISTRY-X vol:12 ispartof: location:Netherlands status: published

Published
2021

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