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Breast neuroendocrine neoplasms (NENs) constitute a rare histologic subtype that includes both neuroendocrine tumors (NETs) and neuroendocrine carcinomas (NECs). In this study, we aimed to gain insight into the clinical and molecular characteristics of NENs of the breast. NEN and paired distant normal fresh tissues and clinicopathological data were obtained from 17 patients with NENs, and clinicopathological data were collected from 755 patients with invasive breast carcinomas of no special type (IBCs-NST). We compared the clinicopathological characteristics of NENs and IBCs-NST and performed whole-exome sequencing (WES) of both NEN and paired normal tissues. Compared with the IBC-NST patients, the NEN patients had a higher mean age, lower clinical stage, and lower pathological nodal (pN) stage (P

The first isolable Ge5-spiropentadiene 1 was synthesized via the reduction of (iPr3Si)2NGeCl (3) with potassium. The crystal structure of 1 reveals a spirocyclic Ge5 skeleton containing two Ge-Ge double bonds (avg. 2.34 A), which are fettered in two Ge3 rings with a dihedral angle of 70.193°. The DFT calculations and orbital analysis show that the σ-delocalization of the Ge5 skeleton and the 2π-delocalized aromatic Ge3 rings enhance the stability of molecule 1.

A new stable six-membered cyclic germylene radical C (•L3Ge:; •L3 = •[CH3C(PhCN–Dip)2]2–, where Dip = 2,6-iPr2C6H3) has been synthesized and structurally characterized. Unlike the germanium-centere...

A new digermylene has been synthesized through the reaction of a six-membered cyclic radical germylene precursor with a mixture of CoBr2 and a seven-membered N-heterocyclic carbene. The density functional theory simulation on the geometry of the digermylene agrees well with the experimental X-ray diffraction result. The digermylene possesses the shortest GeI–GeI bond [2.4853(6) A] compared to the known singly bonded analogues, which can be attributed to σ → π* conjugation. In addition, it is revealed that a stable dative bond cannot form for the reductive radical germylene with the oxidative metal centers.

A new digermylene has been synthesized through the reaction of a six-membered cyclic radical germylene precursor with a mixture of CoBr