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2 results on '"Jianzhuang Miao"'

1. Development of 3-alkyl-6-methoxy-7-hydroxy-chromones (AMHCs) from natural isoflavones, a new class of fluorescent scaffolds for biological imaging

Author

Hui Wen, Dali Yin, Huaqing Cui, Gian Filippo Ruda, Xiang Zhang, Jianzhuang Miao, Xiaoguang Chen, Fangfang Lai, and Jing Jin

Subjects
Stereochemistry, Catalysis, Mice, chemistry.chemical_compound, Materials Chemistry, Fluorescence microscope, Animals, Humans, Moiety, Solubility, Alkyl, Fluorescent Dyes, chemistry.chemical_classification, Biological Products, Optical Imaging, Metals and Alloys, Hep G2 Cells, General Chemistry, Isoflavones, Combinatorial chemistry, Fluorescence, Surfaces, Coatings and Films, Electronic, Optical and Magnetic Materials, chemistry, Chromones, Ceramics and Composites, Pharmacophore, Biological imaging
Abstract

Starting from 7-hydroxyisoflavones, we developed a new class of fluorescent scaffolds, 3-alkyl-6-methoxy-7-hydroxy-chromones (AMHCs, MW ∼ 205.19, λab ∼ 350 nm, λem ∼ 450 nm) via a trial and error process. AMHCs have the advantages of being a small molecular moiety, having strong fluorescence in basic buffers, reasonable solubility and stability, non-toxicity, and are conveniently linked to pharmacophores. AMHCs were successfully used in fluorescence microscopy imaging of cells and tissues.

Published
2015

2. Development of 3-alkyl-6-methoxy-7-hydroxy-chromones (AMHCs) from natural isoflavones, a new class of fluorescent scaffolds for biological imaging.

Author

Jianzhuang Miao, Huaqing Cui, Jing Jin, Fangfang Lai, Hui Wen, Xiang Zhang, Filippo Ruda, Gian, Xiaoguang Chen, and Dali Yin

Subjects
*BIOLOGICAL research, *STABILITY theory, *FLUORESCENT dyes, *CHROMONES, *METHOXY compounds, *BENZOPYRANS
Abstract

Starting from 7-hydroxyisoflavones, we developed a new class of fluorescent scaffolds, 3-alkyl-6-methoxy-7-hydroxy-chromones (AMHCs, MW ~ 205.19, λab ~ 350 nm, λem ~ 450 nm) via a trial and error process. AMHCs have the advantages of being a small molecular moiety, having strong fluorescence in basic buffers, reasonable solubility and stability, non-toxicity, and are conveniently linked to pharmacophores. AMHCs were successfully used in fluorescence microscopy imaging of cells and tissues. [ABSTRACT FROM AUTHOR]

Published
2015
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