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We show that new types of rogue wave patterns exist in integrable systems, and these rogue patterns are described by root structures of Okamoto polynomial hierarchies. These rogue patterns arise when the $\tau$ functions of rogue wave solutions are determinants of Schur polynomials with index jumps of three, and an internal free parameter in these rogue waves gets large. We demonstrate these new rogue patterns in the Manakov system and the three-wave resonant interaction system. For each system, we derive asymptotic predictions of its rogue patterns under a large internal parameter through Okamoto polynomial hierarchies. Unlike the previously reported rogue patterns associated with the Yablonskii-Vorob'ev hierarchy, a new feature in the present rogue patterns is that, the mapping from the root structure of Okamoto-hierarchy polynomials to the shape of the rogue pattern is linear only to the leading order, but becomes nonlinear to the next order. As a consequence, the current rogue patterns are often deformed, sometimes strongly deformed, from Okamoto root structures, unless the underlying free parameter is very large. Our analytical predictions of rogue patterns are compared to true solutions, and excellent agreement is observed, even when rogue patterns are strongly deformed from Okamoto root structures., Comment: 37 pages, 12 figures

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As the largest family within the order Saxifragales, Crassulaceae contains about 34 genera with 1400 species. Mitochondria play a critical role in cellular energy production. Since the first land plant mitogenome was reported in

Partial-rogue waves, i.e., waves that ``come from nowhere but leave with a trace", are analytically predicted and numerically confirmed in the Sasa-Satsuma equation. We show that, among a class of rational solutions in this equation that can be expressed through determinants of 3-reduced Schur polynomials, partial-rogue waves would arise if these rational solutions are of certain orders, where the associated generalized Okamoto polynomials have real but not imaginary roots, or imaginary but not real roots. We further show that, at large negative time, these partial-rogue waves approach the constant-amplitude background, but at large positive time, they split into several fundamental rational solitons, whose numbers are determined by the number of real or imaginary roots in the underlying generalized Okamoto polynomial. Our asymptotic predictions are compared to true solutions, and excellent agreement is observed., 11 pages, 6 figures

Inflammasomes are related to tumorigenesis and immune-regulation. Here, we investigated the prognostic value of the NLR family pyrin domain containing (NLRP) 1/NLRP3 inflammasome and its potential mechanisms in immune-regulation in gastric cancer (GC).We analyzed the differential expression of NLRP1/NLRP3 between tumor and normal tissues using the Oncomine and Tumor Immune Estimate Resource (TIMER) databases. Immunohistochemistry and western blotting were used to detect NLRP1/NLRP3 protein expression in GC tissues. Correlations between NLRP1/NLRP3 expression levels and patient survival were analyzed using Kaplan-Meier survival curves. The relationships of NLRP1/NLRP3 expression and tumor-infiltrating immune cells/marker genes were assessed using the TIMER database. NLRP1/NLRP3 and immune checkpoint gene correlations were verified by single-gene co-expression analyses, and tumor immune-related pathways involving NLRP1/NLRP3 were analyzed using gene set enrichment analysis (GSEA).Elevated NLRP1/NLRP3 expression was significantly correlated with lymph node metastasis, poor survival, immune-infiltrating cell abundances, and immune cell markers. NLRP3 showed stronger correlations with immune infiltration and the prognosis of gastric cancer. NLRP1 and NLRP3 might be involved in the same tumor immune-related pathways. Thus, high NLRP1/NLRP3 expression promotes immune cell infiltration and poor prognosis in GC. NLRP1/NLRP3, particularly NLRP3, may have important roles in immune infiltration and may serve as a prognostic biomarker for GC.NLRP1/NLRP3, particularly NLRP3, may have important roles in immune infiltration and may serve as a prognostic biomarker for GC.

General rogue waves in (1+1)-dimensional three-wave resonant interaction systems are derived by the bilinear method. These solutions are divided into three families, which correspond to a simple root, two simple roots and a double root of a certain quartic equation arising from the dimension reduction respectively. It is shown that while the first family of solutions associated with a simple root exist for all signs of the nonlinear coefficients in the three-wave interaction equations, the other two families of solutions associated with two simple roots and a double root can only exist in the so-called soliton-exchange case, where the nonlinear coefficients have certain signs. Many of these rogue wave solutions, such as those associated with two simple roots, and higher-order solutions associated with a simple root, are new solutions which have not been reported before. Technically, our bilinear derivation of rogue waves for the double-root case is achieved by a generalization to the previous dimension reduction procedure in the bilinear method, and this generalized procedure allows us to treat roots of arbitrary multiplicities. Dynamics of the derived rogue waves is also examined, and new rogue-wave patterns are presented. Connection between these bilinear rogue waves and those derived earlier by Darboux transformation is also explained., A revised version, where Theorem 3 is further generalized, so that additional new rogue waves are obtained. In addition, boundary conditions for rational solutions in Theorem 2 are also proved

Purpose Recent clinical trials with agents targeting immune checkpoint pathway have emerged as an important therapeutic approach for a broad range of cancer types. Resveratrol has been shown to possess cancer preventive and therapeutic effects and has potential to be chemotherapeutic agent/adjuvant. Here, we assessed the effect of resveratrol on immune checkpoint pathways. Methods The expression patterns of Wnt components and PD-L1 were examined by Western blot, Chromatin immunoprecipitation (ChIP) was used for analysis of DNA–protein interaction, the promoter activity was determined by luciferase reporter assay, apoptosis was analyzed by flow cytometry and the ability of the resveratrol to modulate T cell function was assessed in a co-culture system. Results Although the dose-, and cell-type dependent effects of resveratrol on PD-L1 expression have been reported, we show here that resveratrol dose-dependently upregulates PD-L1 expression at the range of pharmacologic-achievable concentrations in lung cancer cells and that is essential for suppression of T-cell-mediated immune response. We also found that Wnt pathway is critical for mediating resveratrol-induced PD-L1 upregulation. Mechanistically, resveratrol activates SirT1 deacetylase to deacetylate and stabilize transcriptional factor Snail. Snail in turn inhibits transcription of Axin2, which leads in disassembly of destruction complex and enhanced binding of β-catenin/TCF to PD-L1 promoter. Conclusion We conclude that resveratrol is capable to suppress anti-tumor immunity by controlling mainly PD-L1 expression. This finding will extend the understanding of resveratrol in regulation of tumor immunity and is relevant to the debate on resveratrol supplements for lung cancer patients.

Pattern formation in higher-order lumps of the Kadomtsev-Petviashvili I equation at large time is analytically studied. For a broad class of these higher-order lumps, we show that two types of solution patterns appear at large time. The first type of patterns comprise fundamental lumps arranged in triangular shapes, which are described analytically by root structures of the Yablonskii-Vorob'ev polynomials. As time evolves from large negative to large positive, this triangular pattern reverses itself along the x-direction. The second type of patterns comprise fundamental lumps arranged in non-triangular shapes in the outer region, which are described analytically by nonzero-root structures of the Wronskian-Hermit polynomials, together with possible fundamental lumps arranged in triangular shapes in the inner region, which are described analytically by root structures of the Yablonskii-Vorob'ev polynomials. When time evolves from large negative to large positive, the non-triangular pattern in the outer region switches its x and y directions, while the triangular pattern in the inner region, if it arises, reverses its direction along the x-axis. Our predicted patterns at large time are compared to true solutions, and excellent agreement is observed., Comment: 25 pages, 8 figures

Background Metabolic reprogramming contributes significantly to tumor development and is tightly linked to drug resistance. The chemotherapeutic agent etoposide (VP-16) has been used clinically in the treatment of lung cancer but possess different sensitivity and efficacy towards SCLC and NSCLC. Here, we assessed the impact of etoposide on glycolytic metabolism in SCLC and NSCLC cell lines and investigated the role of metabolic rewiring in mediating etoposide resistance. Methods glycolytic differences of drug-treated cancer cells were determined by extracellular acidification rate (ECAR), glucose consumption, lactate production and western blot. DNA damage was evaluated by the comet assay and western blot. Chemoresistant cancer cells were analyzed by viability, apoptosis and western blot. Chromatin immunoprecipitation (ChIP) was used for analysis of DNA-protein interaction. Results Here we showed that exposure to chemotherapeutic drug etoposide induces an exacerbation of ROS production which activates HIF-1α-mediated the metabolic reprogramming toward increased glycolysis and lactate production in non-small cell lung cancer (NSCLC). We identified lactic acidosis as the key that confers multidrug resistance through upregulation of multidrug resistance-associated protein 1 (MRP1, encoded by ABCC1), a member of ATP-binding cassette (ABC) transporter family. Mechanistically, lactic acid coordinates TGF-β1/Snail and TAZ/AP-1 pathway to induce formation of Snail/TAZ/AP-1 complex at the MRP1/ABCC1 promoter. Induction of MRP1 expression inhibits genotoxic and apoptotic effects of chemotherapeutic drugs by increasing drug efflux. Furthermore, titration of lactic acid with NaHCO3 was sufficient to overcome resistance. Conclusions The chemotherapeutic drug etoposide induces the shift toward aerobic glycolysis in the NSCLC rather than SCLC cell lines. The increased lactic acid in extracellular environment plays important role in etoposide resistance through upregulation of MRP expression. These data provide first evidence for the increased lactate production, upon drug treatment, contributes to adaptive resistance in NSCLC and reveal potential vulnerabilities of lactate metabolism and/or pathway suitable for therapeutic targeting. Graphical abstract

Heat shock protein 60 (HSP60) is a well-recognized multifunctional protein, playing a substantial role in protecting organisms from environmental stress. The domestic pigeon (Columba livia) is a promising model organism, with important economic and ecological value, and its health is susceptible to temperature stress. To explore the molecular characteristics, tissue expression profile, and response to temperature stress for HSP60 of Columba livia (ClHSP60), we firstly cloned and characterized the complete cDNA sequence and investigated its expression profile under optimal conditions and acute temperature stress. The cDNA of ClHSP60 contained 2257 nucleotides, consisting of 12 exons with length ranging from 65 to 590 bp. The open reading frame (ORF) encoded 573 amino acids with calculated molecular weight of 60.97 kDa that contained a number of structurally prominent domains or motifs. Under optimal temperature conditions, levels of ClHSP60 expression differed between all the tested tissues (the highest was noted in liver and the lowest in pectoralis major muscle). Under acute temperature stress, five patterns of change were detected in the tested tissues, suggesting that different tissues in domestic pigeons differentially responded to various temperature stress conditions. Upregulation of ClHSP60 expression was highest in the lung and pectoralis major muscle, reflecting the crucial role of these two tissues in temperature regulation. However, the crop, cerebrum, and heart showed little change or decreased ClHSP60 expression. The results indicate that ClHSP60 may be sensitive to and play pivotal roles in responding to acute temperature stress. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s12192-020-01160-7) contains supplementary material, which is available to authorized users.

General rogue waves are derived for the generalized derivative nonlinear Schrodinger (GDNLS) equations by a bilinear Kadomtsev-Petviashvili (KP) reduction method. These GDNLS equations contain the Kaup-Newell equation, the Chen-Lee-Liu equation and the Gerdjikov-Ivanov equation as special cases. In this bilinear framework, it is shown that rogue waves to all members of these equations are expressed by the same bilinear solution. Compared to previous bilinear KP reduction methods for rogue waves in other integrable equations, an important improvement in our current KP reduction procedure is a new parameterization of internal parameters in rogue waves. Under this new parameterization, the rogue wave expressions through elementary Schur polynomials are much simpler. In addition, the rogue wave with the highest peak amplitude at each order can be obtained by setting all those internal parameters to zero, and this maximum peak amplitude at order $N$ turns out to be $2N+1$ times the background amplitude, independent of the individual GDNLS equation and the background wavenumber. It is also reported that these GDNLS equations can be decomposed into two different bilinear systems which require different KP reductions, but the resulting rogue waves remain the same. Dynamics of rogue waves in the GDNLS equations is also analyzed. It is shown that the wavenumber of the constant background strongly affects the orientation and duration of the rogue wave. In addition, some new rogue patterns are presented., 19 pages, 3 figures

Gryllodes sigillatus is a cricket widely distributed throughout the world. In this study, we reported the first complete mitogenome sequence of Genus Gryllodes and inferred its phylogeny. The mitog...

Rogue waves in (2+1)-dimensional three-wave resonant interactions are studied. General rogue waves arising from a constant background, from a lump-soliton background and from a dark-soliton background have been derived, and their dynamics illustrated. For rogue waves arising from a constant background, fundamental rogue waves are line-shaped, and multi-rogue waves exhibit multiple intersecting lines. Higher-order rogue waves could also be line-shaped, but they exhibit multiple parallel lines. For rogue waves arising from a lump-soliton background, they could exhibit distinctive patterns due to their interaction with the lump soliton. For rogue waves arising from a dark-soliton background, their intensity pattern could feature half-line shapes or lump shapes, which are very novel., 19 pages,7 figures

General N-solitons in three recently-proposed nonlocal nonlinear Schrodinger equations are presented. These nonlocal equations include the reverse-space, reverse-time, and reverse-space–time nonlinear Schrodinger equations, which are nonlocal reductions of the Ablowitz–Kaup–Newell–Segur (AKNS) hierarchy. It is shown that general N-solitons in these different equations can be derived from the same Riemann–Hilbert solutions of the AKNS hierarchy, except that symmetry relations on the scattering data are different for these equations. This Riemann–Hilbert framework allows us to identify new types of solitons with novel eigenvalue configurations in the spectral plane. Dynamics of N-solitons in these equations is also explored. In all the three nonlocal equations, their solutions often collapse repeatedly, but can remain bounded or nonsingular for wide ranges of soliton parameters as well. In addition, it is found that multi-solitons can behave very differently from fundamental solitons and may not correspond to a nonlinear superposition of fundamental solitons.

Many scholars focus on China’s booming economy and its social impacts, while there is little attention regarding subjective well-being, especially after considering income and social capital. Therefore, the purpose of this paper was to examine the correlations between income, social capital and subjective well-being of western Chinese residents, basing on a representative comprehensive social survey. Several meaningful conclusions are shown below: (1) Western residents in China retain a relatively high degree of subjective well-being on average, and the mean value of subjective well-being for urban residents is slightly higher than that for rural residents; (2) there are regional and group differences in the influence of income and social capital on residents’ subjective well-being; and (3), although economic factors play a primary role in subjective well-being, the potential influence of non-economic factors cannot be ignored. This paper attempts to fill the gap in perspective regarding potential correlations between income, social capital, and subjective well-being.

Recent studies have shown that mitochondria play a crucial role in cellular energy production through the oxidative phosphorylation (OXPHOS) system. Complex I (NADH:ubiquinone oxidoreductase), the first and largest enzyme complex of the OXPHOS system, includes both nuclear- and mitochondrial-encoded proteins. However, the patterns of natural selection and phylogenetic implications of complex I in birds still remain unclear. In this study, we combined transcriptomic and phylogenetic analyses to comprehensively determine the evolution of avian complex I. The transcriptomes of three Passerida species (Leiothrix lutea, Spodiopsar sericeus, and Passer montanus) were obtained using the Illumina HiSeq™ 2500 system. More than 192,000,000 clean reads were assembled in a total of 828,267 transcripts. Evolutionary selection analysis suggested that six genes of the core subunits in avian complex I may have undergone putative positive selection. Notably, we found that the mean dN/dS (ω) ratio for mitochondrial genes of core subunits was significantly lower than that for nuclear genes of non-core subunits within complex I. The constructed maximum-parsimony, maximum-likelihood, and Bayesian inference phylogenetic trees were based on 44 complex I genes. We verified that the family Paridae (represented by Parus major and Pseudopodoces humilis) was clustered with Musicicapoidea. Our results provide new insights into the evolution of avian mitochondrial complex I.

Heat shock protein 60 (HSP60) is highly conserved from prokaryotic to eukaryotic organisms, acting as molecular chaperone and other vital biological functions. In spite of increasing knowledge of HSP60, its evolutionary mechanism on functional adaption is still far from completely understood. Moreover, analysis of codon usage bias (CUB) is a powerful tool to understand evolutionary association studies. However, so far, as we know, no scientific work on CUB of HSP60 in birds has been reported. In this study, we provide a comprehensive analysis on the codon usage and molecular evolution of HSP60 across birds. The results indicated that HSP60 had a weak codon usage bias with high ENC values (range from 52.66 to 61), low RSCU, and A/T-ending codons were mostly preferred. Meanwhile, it was considered that mutation, natural selection, and genetic drift combined to shape codon usage patterns with different strength proportions among various birds for HSP60. Then, the LRT tests suggested that different lineages of birds might be under similar selective pressures. Besides, the two positive selection sites (151 and 131) were detected and might undergo radical changes. These findings would contribute to understand function diversity and molecular evolution of HSP60 in birds.

We report on hollow beam generation in an otherwise uniform low-power infrared beam co-propagating with a green beam in plasmonic nanosuspensions. Experimentally observed beam dynamics are numerically corroborated based on nonlinear cross-phase modulation.

Effects of nonlinearity on topologically protected linear modes in photonic SSH lattices are studied theoretically and experimentally. Nonlinearity turns these linear modes into weakly nonlinear topological gap solitons that cannot sustain high powers.

We study both theoretically and experimentally the effect of nonlinearity on topologically protected linear interface modes in a photonic Su-Schrieffer-Heeger (SSH) lattice. It is shown that under either focusing or defocusing nonlinearity, this linear topological mode of the SSH lattice turns into a family of topological gap solitons. These solitons are stable. However, they exhibit only a low amplitude and power and are thus weakly nonlinear, even when the bandgap of the SSH lattice is wide. As a consequence, if the initial beam has modest or high power, it will either delocalize, or evolve into a soliton not belonging to the family of topological gap solitons. These theoretical predictions are observed in our experiments with optically induced SSH-type photorefractive lattices., Comment: 6 pages, 5 figures. To appear in Opt. Lett

The damage identification method based on macro-strain modality has shown good results for large-span flexible bridges. However, medium- and small-span bridges have a high stiffness, and the axle system is embodied. The strong time-varying vibration characteristics, coupled with the non-stationary characteristics of vehicle loads, make it difficult to accurately determine the stable strain modes of such bridges. To solve this problem, a damage localization index in the form of an amplitude vector matrix of the mutual energy density spectrum based on macro-strain was constructed using wavelet transform de-noising and reconstruction technology and cross-correlation function. The macro-static strain and macro-dynamic strain data obtained from a vehicle–bridge coupling experiment were reconstructed through wavelet transform, and the factors influencing the damage indices were analyzed. The results showed that the proposed indicators could help realize an accurate damage localization for medium- and small-span bridge systems with different damage degrees under the action of vehicle–bridge coupling.

Rogue waves in the nonlocal $${\mathcal {PT}}$$ -symmetric nonlinear Schrodinger (NLS) equation are studied by Darboux transformation. Three types of rogue waves are derived, and their explicit expressions in terms of Schur polynomials are presented. These rogue waves show a much wider variety than those in the local NLS equation. For instance, the polynomial degrees of their denominators can be not only $$n(n+1)$$ , but also $$n(n-1)+1$$ and $$n^2$$ , where n is an arbitrary positive integer. Dynamics of these rogue waves is also examined. It is shown that these rogue waves can be bounded for all space and time or develop collapsing singularities, depending on their types as well as values of their free parameters. In addition, the solution dynamics exhibits rich patterns, most of which have no counterparts in the local NLS equation.

We show that universal rogue wave patterns exist in integrable systems. These rogue patterns comprise fundamental rogue waves arranged in shapes such as triangle, pentagon and heptagon, with a possible lower-order rogue wave at the center. These patterns appear when one of the internal parameters in bilinear expressions of rogue waves gets large. Analytically, these patterns are determined by the root structures of the Yablonskii-Vorob'ev polynomial hierarchy through a linear transformation. Thus, the induced rogue patterns in the space-time plane are simply the root structures of Yablonskii-Vorob'ev polynomials under actions such as dilation, rotation, stretch, shear and translation. As examples, these universal rogue patterns are explicitly determined and graphically illustrated for the generalized derivative nonlinear Schr\"odinger equations, the Boussinesq equation, and the Manakov system. Similarities and differences between these rogue patterns and those reported earlier in the nonlinear Schr\"odinger equation are discussed., Comment: 30 pages,8 figures,2 tables

Recently, a number of nonlocal integrable equations, such as the PT-symmetric nonlinear Schrodinger (NLS) equation and PT-symmetric Davey-Stewartson equations, were proposed and studied. Here we show that many of such nonlocal integrable equations can be converted to local integrable equations through simple variable transformations. Examples include these nonlocal NLS and Davey-Stewartson equations, a nonlocal derivative NLS equation, the reverse space-time complex modified Korteweg-de Vries (CMKdV) equation, and many others. These transformations not only establish immediately the integrability of these nonlocal equations, but also allow us to construct their analytical solutions from solutions of the local equations. These transformations can also be used to derive new nonlocal integrable equations. As applications of these transformations, we use them to derive rogue wave solutions for the partially PT-symmetric Davey-Stewartson equations and the nonlocal derivative NLS equation. In addition, we use them to derive multi-soliton and quasi-periodic solutions in the reverse space-time CMKdV equation. Furthermore, we use them to construct many new nonlocal integrable equations such as nonlocal short pulse equations, nonlocal nonlinear diffusion equations, and nonlocal Sasa-Satsuma equations., 15 pages, 4 figures

It is known that standard multiple-scale perturbation techniques fail to pinpoint the soliton solution branches that bifurcate at edges of bandgaps in periodic media, owing to the appearance of exponentially small growing wave tails when the soliton's envelope is not properly positioned. When the bifurcation is from a single wave mode of a band edge, this difficulty has been handled in recent work by computing these tails via an exponential asymptotics technique in the wave number domain. However, the same approach is not directly applicable to the bifurcation of solitons near the opening of a bandgap, where wave modes from two nearby band edges interact with each other. Here, we discuss two nontrivial extensions of the exponential asymptotics technique that enable resolving this issue. For simplicity, the analysis focuses on two model problems, namely, a steady-state forced Korteweg–de Vries equation and a steady-state forced nonlinear Schrodinger equation, with the precise form of forcing and balance between nonlinear and dispersive terms chosen so as to mimic the situation encountered in the bifurcation of solitons near a bandgap opening. Our analysis exhibits a number of new features that are significantly different from previous exponential asymptotics procedures, such as the treatments when the nonlinearity dominates dispersion and when the decay rates of the Fourier-transformed solution are asymmetric. In addition, the analysis reveals new, and in some cases rather unexpected, functional forms for exponentially small wave tails, which are also confirmed by numerical results.

// Fang Liu 1, 2, * , Yuan Zhang 1, * , Tingting Men 1 , Xingyue Jiang 2 , Chunhua Yang 1 , He Li 4 , Xiaodan Wei 1 , Dong Yan 1 , Gangming Feng 5 , Jianke Yang 1 , Jonas Bergquist 3 , Bin Wang 2 , Wenguo Jiang 1 , Jia Mi 1, 3 , Geng Tian 1 1 Medicine and Pharmacy Research Center, Binzhou Medical University, Yantai, Shandong Province, 264003 China 2 Department of Radiology, Affiliated Hospital of Binzhou Medical University, Binzhou, Shandong Province, 256603 China 3 Department of Chemistry – BMC, Uppsala University, Uppsala, 75124, Sweden 4 Department of Gastric and Intestine, Yantai Affiliated Hospital of Binzhou Medical University, Yantai, Shandong Province, 264003 China 5 Yantai Institute, China Agriculture University, Yantai, Shandong Province, 264670 China * Shared first author Correspondence to: Geng Tian, email: Tiangeng@live.se Wenguo Jiang, email: jiangwg@foxmail.com Jia Mi, email: jia.mi@kemi.uu.se Keywords: proteomic, PDGF-B, gastric cancer, PRDX5, pathway Received: December 02, 2016 Accepted: February 07, 2017 Published: March 06, 2017 ABSTRACT Gastric cancer is one of the most common cancers in Asian countries. Searching for reliable biomarkers involving the development of gastric cancer is important for clinical practice. Quantitative proteomics has become an important method contributed to the discovery of novel diagnostic or therapeutic targets for the management of cancer. Here, we identified differently expressed proteins in gastric cancer and normal gastric tissues by using the high resolution mass spectrometer. Among the total of 2280 identified proteins, 87 were differentially expressed between gastric cancer and normal gastric tissues. Notably, several significant proteins are in the PDGF-B signaling pathway, including peroxiredoxin5 (PRDX5), S100A6, calreticulin (CALR) and cathepsin D (CTSD), which were validated by western blot. Furthermore, upstream regulators including PDGF-B, PDGFR-β, Akt, eIF4E and p70s6K were found significantly increased in the gastric cancer tissues. In addition, silencing of PRDX5 and PDGF-B suppressed the proliferation of gastric cancer cells in vitro . The administration of exogenous PDGF-BB recovered the reduced expression of PDGF-B signaling pathway in PDGF-B knockdown cells. Taken together, our findings suggested that PDGF-B signaling pathway plays an important role in the regulation of gastric cancer proliferation and the inhibition of this pathway may be a potential approach for treatment of gastric cancer.

We report a new type of symmetry-breaking bifurcation of solitons in optical systems with parity-time-symmetric potentials. In this bifurcation, the two bifurcated branches of asymmetric solitons exhibit opposite stability, which contrasts all previous symmetry-breaking bifurcations in conservative and non-conservative systems. We show that this novel symmetry-breaking bifurcation can be exploited to achieve unidirectional propagation of high-intensity light beams in parity-time-symmetric potentials., 5 pages, 5 figures