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Systemic lupus erythematosus (SLE) is a complex autoimmune disorder. In patients with childhood SLE (cSLE), the onset of the disease occurs before 18 years of age and accounts for a high proportion of childhood autoimmune diseases. Adult SLE and cSLE differ in terms of clinical manifestations, gene expression profiles, and treatment. Because current diagnostic methods do not meet clinical requirements, researchers currently use transcriptome analysis to investigate the characteristics of the cSLE genome. In the present study, we used bioinformatics methods to genotype cSLE and identify potential therapeutic targets.The transcriptomes of 952 patients with cSLE and 94 normal controls were obtained from the Gene Expression Omnibus using unsupervised class learning to determine the genotypes in the microarray dataset, and the clinical characteristics, differentially expressed genes, and biological characteristics of the subtypes were analyzed.Patients with cSLE were accordingly classified into three subgroups. Subgroup I was associated with lupus nephritis, female patients, and a high SLE disease activity index, and the disease in this subgroup was more severe than that in other subgroups. The SLE disease activity index in subgroup II was low; this subgroup may be related to lupus vasculitis. Subgroup III mostly included male patients and was associated with neuropsychiatric manifestations of lupus.We divided patients with cSLE into three subgroups with different characteristics based on transcriptome data. Our findings provide molecular evidence for future diagnosis and individualized treatment of cSLE.

Background It remains no clear conclusion about which is better between robot-assisted thoracic surgery (RATS) and video-assisted thoracic surgery (VATS) for the treatment of patients with non-small cell lung cancer (NSCLC). Therefore, this meta-analysis aimed to compare the short-term and long-term efficacy between RATS and VATS for NSCLC. Methods Pubmed, Cochrane Library, Embase, China National Knowledge Infrastructure (CNKI), Medline, and Web of Science databases were comprehensively searched for studies published before December 2020. The quality of the articles was evaluated using the Newcastle-Ottawa Scale (NOS) and the data analyzed using the Review Manager 5.3 software. Fixed or random effect models were applied according to heterogeneity. Subgroup analysis and sensitivity analysis were conducted. Results A total of 18 studies including 11,247 patients were included in the meta-analyses, of which 5114 patients were in the RATS group and 6133 in the VATS group. Compared with VATS, RATS was associated with less blood loss (WMD = − 50.40, 95% CI -90.32 ~ − 10.48, P = 0.010), lower conversion rate (OR = 0.50, 95% CI 0.43 ~ 0.60, P P = 0.002) and stations (WMD = 0.51, 95% CI 0.15 ~ 0.86, P = 0.005), shorter duration of postoperative chest tube drainage (WMD = − 0.61, 95% CI -0.78 ~ − 0.44, P P P = 0.020), lower recurrence rate (OR = 0.51, 95% CI 0.36 ~ 0.72, P P < 0.001). There was no significant difference between RATS and VATS in operative time, mortality, overall survival (OS), and disease-free survival (DFS). Sensitivity analysis showed that no significant differences were found between the two techniques in conversion rate, number of harvested lymph nodes and stations, and overall complication. Conclusions The results revealed that RATS is a feasible and safe technique compared with VATS in terms of short-term and long-term outcomes. Moreover, more randomized controlled trials comparing the two techniques with rigorous study designs are still essential to evaluate the value of robotic surgery for NSCLC.

Additional file 2: Figure S2. Sensitivity analysis result of length of hospital stay.

Additional file 6: Figure S6. Subgroup analysis result of operation time. Figure S7. Subgroup analysis result of conversion. Figure S8. Subgroup analysis result of dissected lymph node stations. Figure S9. Subgroup analysis result of dissected lymph nodes. Figure S10. Subgroup analysis result of time of chest tube drainage. Figure S11. Subgroup analysis result of length of hospital stay. Figure S12. Subgroup analysis result of overall complications. Figure S13. Subgroup analysis result of recurrence rate.

Additional file 5: Figure S5. Sensitivity analysis result of postoperative duration of drainage.

Additional file 4: Figure S4. Sensitivity analysis result of operative time.

Additional file 3: Figure S3. Sensitivity analysis result of mortality.

Additional file 1: Figure S1. Sensitivity analysis result of estimated blood loss.

Background To date, robotic surgery has been widely used worldwide. We conducted a systematic review and meta-analysis to evaluate short-term and long-term outcomes of robotic gastrectomy (RG) in gastric cancer patients to determine whether RG can replace laparoscopic gastrectomy (LG). Methods The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement was applied to perform the study. Pubmed, Cochrane Library, WanFang, China National Knowledge Infrastructure (CNKI), and VIP databases were comprehensively searched for studies published before May 2020 that compared RG with LG. Next, two independent reviewers conducted literature screening and data extraction. The quality of the literature was assessed using the Newcastle-Ottawa Scale (NOS), and the data analyzed using the Review Manager 5.3 software. Random effects or fixed effects models were applied according to heterogeneity. Results A total of 19 studies including 7275 patients were included in the meta-analyses, of which 4598 patients were in the LG group and 2677 in the RG group. Compared with LG, RG was associated with longer operative time (WMD = −32.96, 95% CI −42.08 ~ −23.84, P < 0.001), less blood loss (WMD = 28.66, 95% CI 18.59 ~ 38.73, P < 0.001), and shorter time to first flatus (WMD = 0.16 95% CI 0.06 ~ 0.27, P = 0.003). There was no significant difference between RG and LG in terms of the hospital stay (WMD = 0.23, 95% CI −0.53 ~ 0.98, P = 0.560), overall postoperative complication (OR = 1.07, 95% CI 0.91 ~ 1.25, P = 0.430), mortality (OR = 0.67, 95% CI 0.24 ~ 1.90, P = 0.450), the number of harvested lymph nodes (WMD = −0.96, 95% CI −2.12 ~ 0.20, P = 0.100), proximal resection margin (WMD = −0.10, 95% CI −0.29 ~ 0.09, P = 0.300), and distal resection margin (WMD = 0.15, 95% CI −0.21 ~ 0.52, P = 0.410). No significant differences were found between the two treatments in overall survival (OS) (HR = 0.95, 95% CI 0.76 ~ 1.18, P = 0.640), recurrence-free survival (RFS) (HR = 0.91, 95% CI 0.69 ~ 1.21, P = 0.530), and recurrence rate (OR = 0.90, 95% CI 0.67 ~ 1.21, P = 0.500). Conclusions The results of this study suggested that RG is as acceptable as LG in terms of short-term and long-term outcomes. RG can be performed as effectively and safely as LG. Moreover, more randomized controlled trials comparing the two techniques with rigorous study designs are still essential to evaluate the value of the robotic surgery for gastric cancer.

Additional file 1.

In this chapter, the grant-free multiple access scheme is introduced for a transmission without dynamic scheduling. A few key technical components have been addressed, including the grant-free resource configuration, user equipment activity identification with contention transmission, HARQ procedure and soft-combining, contention resolutions. Numerical and simulation evaluation results have also been provided to demonstrate the performance of the grant-free scheme operating with OFDMA and NOMA. The grant-free multiple access scheme is able to achieve transmission latency and control signaling reduction, and the device energy saving; thus, it provides a promising solution to small data transmissions, massive connectivity, and low-latency applications such as mMTC and URLLC services.

On the basis of our previous work, the eigenvalues of the characteristic equations corresponding to higher-order modes are solved and the mode characteristic in circular groove guide is investigated.

The underlying waveform has always been a shaping factor for each generation of the cellular networks, such as orthogonal frequency division multiplexing (OFDM) for the 4th generation cellular networks (4G). To meet the diversified and pronounced expectations upon the upcoming 5G cellular networks, here we present an enabler for flexible waveform configuration, named as filtered-OFDM (f-OFDM). With the conventional OFDM, a unified numerology is applied across the bandwidth provided, balancing among the channel characteristics and the service requirements, and the spectrum efficiency is limited by the compromise we made. In contrast, with f-OFDM, the assigned bandwidth is split up into several subbands, and different types of services are accommodated in different subbands with the most suitable waveform and numerology, leading to an improved spectrum utilization. After outlining the general framework of f-OFDM, several important design aspects are also discussed, including filter design and guard tone arrangement. In addition, an extensive comparison among the existing 5G waveform candidates is also included to illustrate the advantages of f-OFDM. Our simulations indicate that, in a specific scenario with four distinct types of services, f-OFDM provides up to 46% of throughput gains over the conventional OFDM scheme., Comment: Accepted to IEEE Globecom, San Diego, CA, Dec. 2015