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134 results on '"Jiang, Yubao"'

10. Case report: Anti-GAD65 antibody-associated autoimmune encephalitis following HPV vaccination

Author

Li, Aonan, Hu, Ying, Li, Jialu, Chen, Xingui, Jiang, Yubao, and Xie, Chengjuan

Subjects
Neurology, Neurology (clinical)
Abstract

Human papillomavirus (HPV) infection is a sexually transmitted disease that may lead to cervical cancer. HPV vaccines have been implemented widely to prevent this. While generally few complications of vaccination are reported, there have been occasional reports of adverse reactions post-vaccination. The safety profile of the HPV vaccine is reassuring. However, since its introduction, several serious post-vaccination central nervous system complications have been reported; however, causality has not been established. Herein, we describe a 39-year-old woman who developed seizures and experienced a rapid decline in memory shortly after her first dose of the HPV vaccine. Cranial magnetic resonance imaging and cerebrospinal fluid analysis were performed, and the patient was diagnosed with anti-glutamic acid decarboxylase 65 (anti-GAD65) antibody-associated autoimmune encephalitis. She responded well to high-dose glucocorticoids. Four-month follow-up revealed full recovery and absence of recurrence. Since the HPV vaccine is administered worldwide, this case should raise clinicians' awareness regarding the possible CNS complications related to vaccinations, such as anti-GAD65 antibody-associated AE.

Published
2022

16. The Effect of Chronic Disease Management on the Treat-to-Target of Gout: A Cross-Sectional Study

Author

Jia, Ertao, primary, Hu, Shasha, additional, Zhan, Zhiying, additional, Ma, Wukai, additional, Geng, Hongling, additional, Zhu, Haiqiong, additional, Zhong, Li, additional, Yao, Xueming, additional, Wei, Jiaxin, additional, Xie, Jingjing, additional, Xiao, Yuya, additional, Jiang, Yubao, additional, Qiu, Xia, additional, Xiao, Min, additional, Zhang, Yanying, additional, Tang, Dabin, additional, and Zhang, Jianyong, additional

Published
2021
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19. Initiation of febuxostat for acute gout flare does not prolong the current episode: a randomized clinical trial

Author

Jia, Ertao, primary, Zhang, Yanying, additional, Ma, Wukai, additional, Li, Bo, additional, Geng, Hongling, additional, Zhong, Li, additional, Yao, Xueming, additional, Xie, Jingjing, additional, Xiao, Yuya, additional, Jiang, Yubao, additional, Qiu, Xia, additional, Xiao, Min, additional, Cui, Xiang, additional, Wei, Jiaxin, additional, and Zhang, Jianyong, additional

Published
2021
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25. Serum Metabolic Profiling Analysis of Gout Patients Treated with Traditional Chinese Medicine Tongfengtai Granules Based on Gas Chromatography-Mass Spectrometry

Author

Zhang, Jianyong, primary, Pan, Hong, additional, Xie, Jingjing, additional, Wang, Jing, additional, Wang, Ruyi, additional, Qiu, Xia, additional, Zhong, Li, additional, Li, Tengyan, additional, Xiao, Yuya, additional, Xiao, Min, additional, Zhang, Yanying, additional, Jia, Ertao, additional, Jiang, Yubao, additional, and Wang, Binbin, additional

Published
2020
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30. Impaired Executive Function by Interictal Epileptiform Discharges in Patients with Idiopathic Generalized Epilepsy

Author

Wu Jiaonan, Wang Yu, Wang Kai, and Jiang Yubao

Subjects
medicine.medical_specialty, medicine.diagnostic_test, Cognition, Audiology, Electroencephalography, medicine.disease, Idiopathic generalized epilepsy, Epilepsy, medicine, Memory span, Verbal fluency test, Ictal, Psychiatry, Psychology, Stroop effect
Abstract

Objective: Many patients with Idiopathic Generalized Epilepsy (IGE) exhibit cognitive deficits. Interictal Epileptiform Discharges (IEDs) may contribute to cognitive impairment in epilepsy; however, the relationship between IEDs and cognitive impairment is unclear. Methods: In this study, we analysed executive function in three groups: IGE patients with IEDs, IGE patients without IEDs and healthy controls. Executive function was assessed using the Stroop Test, the Verbal Fluency Test, the Digit Span Test and Wisconsin Card-Sorting Test. Results: The IGE patients with IEDs performed worse on executive function tests compared with patients without IEDs. Furthermore, the IGE patients without IEDs performed worse compared with healthy controls. There were significant differences between the three groups in performance on the Stroop Test, the Digit Span Test (forward and backward), Verbal Fluency Test (animals, fruits) and the subscales of WCST (Categories Completed, Correct Response, Total Errors and Preservative Errors). Conclusion: These results suggest that executive function in patients with IGE is impaired and is further impaired by IEDs. Future studies should determine whether well-controlled patients with IGE could benefit from antiepileptic treatment.

Published
2017

33. MicroRNA dysregulation and esophageal cancer development depend on the extent of zinc dietary deficiency.

Author

Fong, Louise, Taccioli, Cristian, Jing, Ruiyan, Smalley, Karl, Alder, Hansjuerg, Jiang, Yubao, Fadda, Paolo, Farber, John, Croce, Carlo M, Fong, Louise, Taccioli, Cristian, Jing, Ruiyan, Smalley, Karl, Alder, Hansjuerg, Jiang, Yubao, Fadda, Paolo, Farber, John, and Croce, Carlo M

Abstract

Zinc deficiency (ZD) increases the risk of esophageal squamous cell carcinoma (ESCC), and marginal ZD is prevalent in humans. In rats, marked-ZD (3 mg Zn/kg diet) induces a proliferative esophagus with a 5-microRNA signature (miR-31, -223, -21, -146b, -146a) and promotes ESCC. Here we report that moderate and mild-ZD (6 and 12 mg Zn/kg diet) also induced esophageal hyperplasia, albeit less pronounced than induced by marked-ZD, with a 2-microRNA signature (miR-31, -146a). On exposure to an environmental carcinogen, ~16% of moderate/mild-ZD rats developed ESCC, a cancer incidence significantly greater than for Zn-sufficient rats (0%) (P ≤ 0.05), but lower than marked-ZD rats (68%) (P < 0.001). Importantly, the high ESCC, marked-ZD esophagus had a 15-microRNA signature, resembling the human ESCC miRNAome, with miR-223, miR-21, and miR-31 as the top-up-regulated species. This signature discriminated it from the low ESCC, moderate/mild-ZD esophagus, with a 2-microRNA signature (miR-31, miR-223). Additionally, Fbxw7, Pdcd4, and Stk40 (tumor-suppressor targets of miR-223, -21, and -31) were downregulated in marked-ZD cohort. Bioinformatics analysis predicted functional relationships of the 3 tumor-suppressors with other cancer-related genes. Thus, microRNA dysregulation and ESCC progression depend on the extent of dietary Zn deficiency. Our findings suggest that even moderate ZD may promote esophageal cancer and dietary Zn has preventive properties against ESCC. Additionally, the deficiency-associated miR-223, miR-21, and miR-31 may be useful therapeutic targets in ESCC.

Published
2016

39. Genome-wide association analyses in Han Chinese identify two new susceptibility loci for amyotrophic lateral sclerosis

Author

Deng, Min, Wei, Ling, Zuo, Xianbo, Tian, Yanghua, Xie, Fei, Hu, Panpan, Zhu, Chunyan, Yu, Fengqiong, Meng, Yu, Wang, Honghao, Zhang, Fangfang, Ma, Huijuan, Ye, Rong, Cheng, Huaidong, Du, Jing, Dong, Wenwen, Zhou, Shanshan, Wang, Changqing, Wang, Yu, Wang, Jingye, Chen, Xianwen, Sun, Zhongwu, Zhou, Nong, Jiang, Yubao, Liu, Xiuxiu, Li, Xiaogang, Zhang, Nan, Liu, Na, Guan, Yingjun, Han, Yongsheng, Han, Yongzhu, Lv, Xinyi, Fu, Yu, Yu, Hui, Xi, Chunhua, Xie, Dandan, Zhao, Qiyuan, Xie, Peng, Wang, Xin, Zhang, Zhijun, Shen, Lu, Cui, Yong, Yin, Xianyong, Cheng, Hui, Liang, Bo, Zheng, Xiaodong, Lee, Tatia M. C., Chen, Gang, Zhou, Fusheng, Veldink, Jan H., Robberecht, Wim, Landers, John E., Andersen, Peter M., Al-Chalabi, Ammar, Shaw, Chris, Liu, Chunfeng, Tang, Beisha, Xiao, Shangxi, Robertson, Janice, Zhang, Fengyu, van den Berg, Leonard H., Sun, Liangdan, Liu, Jianjun, Yang, Sen, Ju, Xiaodong, Wang, Kai, Zhang, Xuejun, Deng, Min, Wei, Ling, Zuo, Xianbo, Tian, Yanghua, Xie, Fei, Hu, Panpan, Zhu, Chunyan, Yu, Fengqiong, Meng, Yu, Wang, Honghao, Zhang, Fangfang, Ma, Huijuan, Ye, Rong, Cheng, Huaidong, Du, Jing, Dong, Wenwen, Zhou, Shanshan, Wang, Changqing, Wang, Yu, Wang, Jingye, Chen, Xianwen, Sun, Zhongwu, Zhou, Nong, Jiang, Yubao, Liu, Xiuxiu, Li, Xiaogang, Zhang, Nan, Liu, Na, Guan, Yingjun, Han, Yongsheng, Han, Yongzhu, Lv, Xinyi, Fu, Yu, Yu, Hui, Xi, Chunhua, Xie, Dandan, Zhao, Qiyuan, Xie, Peng, Wang, Xin, Zhang, Zhijun, Shen, Lu, Cui, Yong, Yin, Xianyong, Cheng, Hui, Liang, Bo, Zheng, Xiaodong, Lee, Tatia M. C., Chen, Gang, Zhou, Fusheng, Veldink, Jan H., Robberecht, Wim, Landers, John E., Andersen, Peter M., Al-Chalabi, Ammar, Shaw, Chris, Liu, Chunfeng, Tang, Beisha, Xiao, Shangxi, Robertson, Janice, Zhang, Fengyu, van den Berg, Leonard H., Sun, Liangdan, Liu, Jianjun, Yang, Sen, Ju, Xiaodong, Wang, Kai, and Zhang, Xuejun

Abstract

To identify susceptibility genes for amyotrophic lateral sclerosis (ALS), we conducted a genome-wide association study (GWAS) in 506 individuals with sporadic ALS and 1,859 controls of Han Chinese ancestry. Ninety top SNPs suggested by the current GWAS and 6 SNPs identified by previous GWAS were analyzed in an independent cohort of 706 individuals with ALS and 1,777 controls of Han Chinese ancestry. We discovered two new susceptibility loci for ALS at 1q32 (CAMK1G, rs6703183, P-combined = 2.92 x 10(-8), odds ratio (OR) = 1.31) and 22p11 (CABIN1 and SUSD2, rs8141797, P-combined = 2.35 x 10(-9), OR = 1.52). These two loci explain 12.48% of the overall variance in disease risk in the Han Chinese population. We found no association evidence for the previously reported loci in the Han Chinese population, suggesting genetic heterogeneity of disease susceptibility for ALS between ancestry groups. Our study identifies two new susceptibility loci and suggests new pathogenic mechanisms of ALS.

Published
2013
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41. Erratum: Genome-wide association analyses in Han Chinese identify two new susceptibility loci for amyotrophic lateral sclerosis

Author

Deng, Min, primary, Wei, Ling, additional, Zuo, Xianbo, additional, Tian, Yanghua, additional, Xie, Fei, additional, Hu, Panpan, additional, Zhu, Chunyan, additional, Yu, Fengqiong, additional, Meng, Yu, additional, Wang, Honghao, additional, Zhang, Fangfang, additional, Ma, Huijuan, additional, Ye, Rong, additional, Cheng, Huaidong, additional, Du, Jing, additional, Dong, Wenwen, additional, Zhou, Shanshan, additional, Wang, Changqing, additional, Wang, Yu, additional, Wang, Jingye, additional, Chen, Xianwen, additional, Sun, Zhongwu, additional, Zhou, Nong, additional, Jiang, Yubao, additional, Liu, Xiuxiu, additional, Li, Xiaogang, additional, Zhang, Nan, additional, Liu, Na, additional, Guan, Yingjun, additional, Han, Yongsheng, additional, Han, Yongzhu, additional, Lv, Xinyi, additional, Fu, Yu, additional, Yu, Hui, additional, Xi, Chunhua, additional, Xie, Dandan, additional, Zhao, Qiyuan, additional, Xie, Peng, additional, Wang, Xin, additional, Zhang, Zhijun, additional, Shen, Lu, additional, Cui, Yong, additional, Yin, Xianyong, additional, Cheng, Hui, additional, Liang, Bo, additional, Zheng, Xiaodong, additional, Lee, Tatia M C, additional, Chen, Gang, additional, Zhou, Fusheng, additional, Veldink, Jan H, additional, Robberecht, Wim, additional, Landers, John E, additional, Andersen, Peter M, additional, Al-Chalabi, Ammar, additional, Shaw, Chris, additional, Liu, Chunfeng, additional, Tang, Beisha, additional, Xiao, Shangxi, additional, Robertson, Janice, additional, Zhang, Fengyu, additional, van den Berg, Leonard H, additional, Sun, Liangdan, additional, Liu, Jianjun, additional, Yang, Sen, additional, Ju, Xiaodong, additional, Wang, Kai, additional, and Zhang, Xuejun, additional

Published
2013
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42. Genome-wide association analyses in Han Chinese identify two new susceptibility loci for amyotrophic lateral sclerosis

Author

Deng, Min, primary, Wei, Ling, additional, Zuo, Xianbo, additional, Tian, Yanghua, additional, Xie, Fei, additional, Hu, Panpan, additional, Zhu, Chunyan, additional, Yu, Fengqiong, additional, Meng, Yu, additional, Wang, Honghao, additional, Zhang, Fangfang, additional, Ma, Huijuan, additional, Ye, Rong, additional, Cheng, Huaidong, additional, Du, Jing, additional, Dong, Wenwen, additional, Zhou, Shanshan, additional, Wang, Changqing, additional, Wang, Yu, additional, Wang, Jingye, additional, Chen, Xianwen, additional, Sun, Zhongwu, additional, Zhou, Nong, additional, Jiang, Yubao, additional, Liu, Xiuxiu, additional, Li, Xiaogang, additional, Zhang, Nan, additional, Liu, Na, additional, Guan, Yingjun, additional, Han, Yongsheng, additional, Han, Yongzhu, additional, Lv, Xinyi, additional, Fu, Yu, additional, Yu, Hui, additional, Xi, Chunhua, additional, Xie, Dandan, additional, Zhao, Qiyuan, additional, Xie, Peng, additional, Wang, Xin, additional, Zhang, Zhijun, additional, Shen, Lu, additional, Cui, Yong, additional, Yin, Xianyong, additional, Cheng, Hui, additional, Liang, Bo, additional, Zheng, Xiaodong, additional, Lee, Tatia M C, additional, Chen, Gang, additional, Zhou, Fusheng, additional, Veldink, Jan H, additional, Robberecht, Wim, additional, Landers, John E, additional, Andersen, Peter M, additional, Al-Chalabi, Ammar, additional, Shaw, Chris, additional, Liu, Chunfeng, additional, Tang, Beisha, additional, Xiao, Shangxi, additional, Robertson, Janice, additional, Zhang, Fengyu, additional, van den Berg, Leonard H, additional, Sun, Liangdan, additional, Liu, Jianjun, additional, Yang, Sen, additional, Ju, Xiaodong, additional, Wang, Kai, additional, and Zhang, Xuejun, additional

Published
2013
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43. Abstract LB-241: Silencing of microRNA-31 prevents esophageal neoplasia in zinc deficient rats.

Author

Taccioli, Cristian, primary, Chen, Hongping, additional, Garofalo, Michela, additional, Jiang, Yubao, additional, Di Leva, Gianpiero, additional, Alder, Hansjuerg, additional, Middleton, Justin, additional, Smalley, Karl J., additional, Bottoni, Arianna, additional, Costinean, Stefan, additional, Farber, John L., additional, Croce, Carlo M., additional, and Fong, Louise Y Y, additional

Published
2013
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