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4. Click chemistry extracellular vesicle/peptide/chemokine nanocarriers for treating central nervous system injuries

Author

Ruan, Huitong, primary, Li, Yongfang, additional, Wang, Cheng, additional, Jiang, Yixu, additional, Han, Yulong, additional, Li, Yiwei, additional, Zheng, Dandan, additional, Ye, Jing, additional, Chen, Gang, additional, Yang, Guo-yuan, additional, Deng, Lianfu, additional, Guo, Ming, additional, Zhang, Xingcai, additional, Tang, Yaohui, additional, and Cui, Wenguo, additional

Published
2023
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5. Click chemistry extracellular vesicle/peptide/chemokine nanocarriers for treating central nervous system injuries

Author

Massachusetts Institute of Technology. School of Engineering, Ruan, Huitong, Li, Yongfang, Wang, Cheng, Jiang, Yixu, Han, Yulong, Li, Yiwei, Zheng, Dandan, Ye, Jing, Chen, Gang, Yang, Guo-yuan, Deng, Lianfu, Guo, Ming, Zhang, Xingcai, Tang, Yaohui, Cui, Wenguo, Massachusetts Institute of Technology. School of Engineering, Ruan, Huitong, Li, Yongfang, Wang, Cheng, Jiang, Yixu, Han, Yulong, Li, Yiwei, Zheng, Dandan, Ye, Jing, Chen, Gang, Yang, Guo-yuan, Deng, Lianfu, Guo, Ming, Zhang, Xingcai, Tang, Yaohui, and Cui, Wenguo

Abstract

Central nervous system (CNS) injuries, including stroke, traumatic brain injury, and spinal cord injury, are essential causes of death and long-term disability and are difficult to cure, mainly due to the limited neuron regeneration and the glial scar formation. Herein, we apply extracellular vesicles (EVs) secreted by M2 microglia to improve the differentiation of neural stem cells (NSCs) at the injured site, and simultaneously modify them with the injured vascular targeting peptide (DA7R) and the stem cell recruiting factor (SDF-1) on their surface via copper-free click chemistry to recruit NSCs, inducing their neuronal differentiation, and serving as the nanocarriers at the injured site (Dual-EV). Results prove that the Dual-EV could target human umbilical vascular endothelial cells (HUVECs), recruit NSCs, and promote the neuronal differentiation of NSCs in vitro. Furthermore, 10 miRNAs are found to be upregulated in Dual-M2-EVs compared to Dual-M0-EVs via bioinformatic analysis, and further NSC differentiation experiment by flow cytometry reveals that among these miRNAs, miR30b-3p, miR-222-3p, miR-129-5p, and miR-155-5p may exert effect of inducing NSC to differentiate into neurons. In vivo experiments show that Dual-EV nanocarriers achieve improved accumulation in the ischemic area of stroke model mice, potentiate NSCs recruitment, and increase neurogenesis. This work provides new insights for the treatment of neuronal regeneration after CNS injuries as well as endogenous stem cells, and the click chemistry EV/peptide/chemokine and related nanocarriers for improving human health.

Published
2023

9. Additional file 1 of Targeted delivery of fat extract by platelet membrane-cloaked nanocarriers for the treatment of ischemic stroke

Author

Wang, Cheng, Yang, Xuewei, Jiang, Yixu, Qi, Lin, Zhuge, Deli, Xu, Tongtong, Guo, Yiyan, Deng, Mingwu, Zhang, Wenjie, Tian, Dongyan, Yin, Qingqing, Li, Li, Zhang, Zhijun, Wang, Yongting, Yang, Guo-Yuan, Chen, Yijie, and Tang, Yaohui

Abstract

Additional file 1: Figure S1. The encapsulation efficiency and loading efficiency of FE. Table S1. Death rate of each group after tMCAO. Figure S2. The death and survival rate of mice after tMCAO in each group. Figure S3. Characterization of the insertion of RGD onto PLT membrane. Figure S4. The total fluorescence intensity in liver and spleen (RES). Figure S5. Cell proliferation and cytotoxicity assay. Figure S6. The protein compositions before and after the process of encapsulation. Figure S7. The stability of nanoparticles in solution. Figure S8. TTC staining assay.

Published
2022
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10. Additional file 1 of Extracellular vesicles from adipose-derived stem cells promote microglia M2 polarization and neurological recovery in a mouse model of transient middle cerebral artery occlusion

Author

Hu, Xiaowen, Pan, Jiaji, Li, Yongfang, Jiang, Yixu, Zheng, Haoran, Shi, Rubing, Zhang, Qi, Liu, Chang, Tian, Hengli, Zhang, Zhijun, Tang, Yaohui, Yang, Guo-Yuan, and Wang, Yongting

Abstract

Additional file 1: Figure S1. Cell morphology and differentiation of ADSCs. Figure S2. Laser speckle images of tMCAO mice brain. Figure S3. Very few polarized microglia were detected in the contralateral hemisphere of tMCAO mice. Figure S4. ADSC-EVs administration did not decrease the population of Iba1+ cells in the ipsilateral hemisphere of tMCAO mice.

Published
2022
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11. M2 microglia-derived extracellular vesicles promote white matter repair and functional recovery via miR-23a-5p after cerebral ischemia in mice

Author

Li, Yongfang, primary, Liu, Ze, additional, Song, Yaying, additional, Pan, Jia-ji, additional, Jiang, Yixu, additional, Shi, Xiaojing, additional, Liu, Chang, additional, Ma, Yuanyuan, additional, Luo, Longlong, additional, Mamtilahun, Muyassar, additional, Shi, Zhiyu, additional, Khan, Haroon, additional, Xie, Qing, additional, Wang, Yongting, additional, Tang, Yaohui, additional, Zhang, Zhijun, additional, and Yang, Guo-Yuan, additional

Published
2022
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13. Extracellular Vesicles from Adipose-derived Stem Cells Promote Microglia M2 Polarization and Neurological Recovery after Ischemic Stroke

Author

Hu, Xiaowen, primary, Pan, Jiaji, additional, Li, Yongfang, additional, Jiang, Yixu, additional, Zheng, Haoran, additional, Shi, Rubing, additional, Zhang, Qi, additional, Liu, Chang, additional, Tian, Hengli, additional, Zhang, Zhijun, additional, Tang, Yaohui, additional, Yang, Guo-Yuan, additional, and Wang, Yongting, additional

Published
2021
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14. Plasma from healthy donors protects blood–brain barrier integrity via FGF21 and improves the recovery in a mouse model of cerebral ischaemia

Author

Mamtilahun, Muyassar, primary, Jiang, Lu, additional, Song, Yaying, additional, Shi, Xiaojing, additional, Liu, Chang, additional, Jiang, Yixu, additional, Deng, Lidong, additional, Zheng, Haoran, additional, Shen, Hui, additional, Li, Yongfang, additional, Zhang, Zhijun, additional, Wang, Yongting, additional, Tang, Yaohui, additional, and Yang, Guo-Yuan, additional

Published
2021
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16. Epidermal Growth Factor Induces Proliferation of Hair Follicle-Derived Mesenchymal Stem Cells Through Epidermal Growth Factor Receptor-Mediated Activation of ERK and AKT Signaling Pathways Associated with Upregulation of Cyclin D1 and Downregulation of p16

Author

Bai, Tingting, primary, Liu, Feilin, additional, Zou, Fei, additional, Zhao, Guifang, additional, Jiang, Yixu, additional, Liu, Li, additional, Shi, Jiahong, additional, Hao, Deshun, additional, Zhang, Qi, additional, Zheng, Tong, additional, Zhang, Yingyao, additional, Liu, Mingsheng, additional, Li, Shilun, additional, Qi, Liangchen, additional, and Liu, Jin Yu, additional

Published
2017
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