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Your search keyword '"Jiang, Xu-dong"' showing total 37 results
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37 results on '"Jiang, Xu-dong"'

12. Animal models of heart failure with preserved ejection fraction (HFpEF): from metabolic pathobiology to drug discovery

Author

Gao, Si, Liu, Xue-ping, Li, Ting-ting, Chen, Li, Feng, Yi-ping, Wang, Yu-kun, Yin, Yan-jun, Little, Peter J., Wu, Xiao-qian, Xu, Suo-wen, and Jiang, Xu-dong

Abstract

Heart failure (HF) with preserved ejection fraction (HFpEF) is currently a preeminent challenge for cardiovascular medicine. It has a poor prognosis, increasing mortality, and is escalating in prevalence worldwide. Despite accounting for over 50% of all HF patients, the mechanistic underpinnings driving HFpEF are poorly understood, thus impeding the discovery and development of mechanism-based therapies. HFpEF is a disease syndrome driven by diverse comorbidities, including hypertension, diabetes and obesity, pulmonary hypertension, aging, and atrial fibrillation. There is a lack of high-fidelity animal models that faithfully recapitulate the HFpEF phenotype, owing primarily to the disease heterogeneity, which has hampered our understanding of the complex pathophysiology of HFpEF. This review provides an updated overview of the currently available animal models of HFpEF and discusses their characteristics from the perspective of energy metabolism. Interventional strategies for efficiently utilizing energy substrates in preclinical HFpEF models are also discussed.

Published
2024
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20. Efficient On-Chip Training of Optical Neural Networks Using Genetic Algorithm

Author

Zhang, Hui, primary, Thompson, Jayne, additional, Gu, Mile, additional, Jiang, Xu Dong, additional, Cai, Hong, additional, Liu, Patricia Yang, additional, Shi, Yuzhi, additional, Zhang, Yi, additional, Karim, Muhammad Faeyz, additional, Lo, Guo Qiang, additional, Luo, Xianshu, additional, Dong, Bin, additional, Kwek, Leong Chuan, additional, and Liu, Ai Qun, additional

Published
2021
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37. In Situ Preparation of TiO2 Composite Layer upon Ti Alloy Substrate Using Micro-Arc Oxidation and its Photocatalytic Property

Author

Wang, Yong Qian, Jiang, Xu Dong, and Pan, Chun Xu

Abstract

In this paper, a micro-arc oxidation (MAO) approach is introduced for “in-situ” preparing TiO2 composite layer upon the surface of titanium alloy (Ti-6Al-4V) substrate. The surface morphologies, chemical compositions, crystal microstructure and photocatalytic properties of the layers were investigated by using a field emission scanning electron microscope (FE-SEM), energy dispersive spectrometer (EDS), X-ray photoelectron spectroscopy (XPS), X-ray diffraction (XRD), electro-chemical workstation and UV-Vis spectrophotometer. The experimental results revealed that photocatalytic performance of the TiO2 composite layers was much higher than that of the pure TiO2 layer and also exhibited absorption under the visible light irradiation.

Published
2010
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