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28 results on '"Jiang, Xiaoshuang"'

5. Choroidal Changes After Anti-VEGF Therapy in AMD Eyes With Different Types of Macular Neovascularization Using Swept-Source OCT Angiography

Author

Shen, Mengxi, primary, Zhou, Hao, additional, Lu, Jie, additional, Li, Jianqing, additional, Jiang, Xiaoshuang, additional, Trivizki, Omer, additional, Laiginhas, Rita, additional, Liu, Jeremy, additional, Zhang, Qinqin, additional, de Sisternes, Luis, additional, Feuer, William J., additional, O'Brien, Robert, additional, Gregori, Giovanni, additional, Wang, Ruikang K., additional, and Rosenfeld, Philip J., additional

Published
2023
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8. Hierarchical-Instance Contrastive Learning for Minority Detection on Imbalanced Medical Datasets

Author

Li, Yiyue, Qian, Guangwu, Jiang, Xiaoshuang, Jiang, Zekun, Wen, Wen, Zhang, Shaoting, Li, Kang, and Lao, Qicheng

Abstract

Deep learning methods are often hampered by issues such as data imbalance and data-hungry. In medical imaging, malignant or rare diseases are frequently of minority classes in the dataset, featured by diversified distribution. Besides that, insufficient labels and unseen cases also present conundrums for training on the minority classes. To confront the stated problems, we propose a novel Hierarchical-instance Contrastive Learning (HCLe) method for minority detection by only involving data from the majority class in the training stage. To tackle inconsistent intra-class distribution in majority classes, our method introduces two branches, where the first branch employs an auto-encoder network augmented with three constraint functions to effectively extract image-level features, and the second branch designs a novel contrastive learning network by taking into account the consistency of features among hierarchical samples from majority classes. The proposed method is further refined with a diverse mini-batch strategy, enabling the identification of minority classes under multiple conditions. Extensive experiments have been conducted to evaluate the proposed method on three datasets of different diseases and modalities. The experimental results show that the proposed method outperforms the state-of-the-art methods.

Published
2024
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12. Choroidal Changes in Eyes With Polypoidal Choroidal Vasculopathy After Anti-VEGF Therapy Imaged With Swept-Source OCT Angiography

Author

Shen, Mengxi, primary, Zhou, Hao, additional, Kim, Kiyoung, additional, Bo, Qiyu, additional, Lu, Jie, additional, Laiginhas, Rita, additional, Jiang, Xiaoshuang, additional, Yan, Quan, additional, Iyer, Prashanth, additional, Trivizki, Omer, additional, Shi, Yingying, additional, de Sisternes, Luis, additional, Durbin, Mary K., additional, Feuer, William, additional, Gregori, Giovanni, additional, Wang, Ruikang K., additional, Sun, Xiaodong, additional, Wang, Fenghua, additional, Yu, Seung-Young, additional, and Rosenfeld, Philip J., additional

Published
2021
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17. Swept-Source OCT Angiographic Characteristics of Treatment-Naïve Nonexudative Macular Neovascularization in AMD Prior to Exudation

Author

Shen, Mengxi, primary, Zhang, Qinqin, additional, Yang, Jin, additional, Zhou, Hao, additional, Chu, Zhongdi, additional, Zhou, Xiao, additional, Feuer, William, additional, Jiang, Xiaoshuang, additional, Shi, Yingying, additional, de Sisternes, Luis, additional, Durbin, Mary K., additional, Wang, Ruikang K., additional, Gregori, Giovanni, additional, and Rosenfeld, Philip J., additional

Published
2021
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19. Correlations Between Choriocapillaris and Choroidal Measurements and the Growth of Geographic Atrophy Using Swept Source OCT Imaging

Author

Shi, Yingying, primary, Zhang, Qinqin, additional, Zhou, Hao, additional, Wang, Liang, additional, Chu, Zhongdi, additional, Jiang, Xiaoshuang, additional, Shen, Mengxi, additional, Thulliez, Marie, additional, Lyu, Cancan, additional, Feuer, William, additional, de Sisternes, Luis, additional, Durbin, Mary K., additional, Gregori, Giovanni, additional, Wang, Ruikang K., additional, and Rosenfeld, Philip J., additional

Published
2021
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23. Changes of Subfoveal Choroidal Thickness after Cataract Surgery: A Meta-Analysis

Author

Zeng, Shaoxue, Liang, Chen, He, Yueqing, Chen, Yingying, Zhao, Qing, Dai, Shuiping, Cheng, Fengrui, Zhang, Junjun, and Jiang, Xiaoshuang

Subjects
Article Subject, sense organs
Abstract

Purpose. To investigate the effect of cataract surgery on subfoveal choroid thickness (SFCT) using enhanced-depth imaging optical coherence tomography (EDI-OCT). Materials and Methods. Relevant publications were searched systematically through various databases from inception to March 2018. The unit of choroidal thickness measurements is micrometers. Studies comparing SFCT before and after cataract surgery were retrieved. All qualified articles were analyzed using RevMan 5.3. Results. A total of 13 studies with 802 eyes from 646 patients were identified for inclusion. There was a significant increase of SFCT at 1 week (MD = 6.62, 95% CI: 1.20–12.05, P=0.02, I2 = 0%), 1 month (MD = 8.30, 95% CI: 3.20–13.39, P=0.001, I2 = 0%), and 3 months (MD = 8.28, 95% CI: 1.84–14.73, P=0.01, I2 = 0%) after cataract surgery. In subgroup analysis, SFCT in Asians and patients without nonsteroidal anti-inflammatory drugs (NSAIDs) in postoperative medication was significantly thicker (P

Published
2018
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25. Dose-Response Relationship between Intravitreal Injections and Retinal Nerve Fiber Layer Thinning in Age-Related Macular Degeneration

Author

Wang, Liang, Swaminathan, Swarup S., Yang, Jin, Barikian, Anita, Shi, Yingying, Shen, Mengxi, Jiang, Xiaoshuang, Feuer, William, Gregori, Giovanni, and Rosenfeld, Philip J.

Abstract

To determine if multiple intravitreal injections of vascular endothelial growth factor (VEGF) inhibitors for unilateral exudative age-related macular degeneration (eAMD) are associated with thinning of the retinal nerve fiber layer (RNFL), we compared RNFL thickness measurements from the injected eye with that of the fellow eye with nonexudative age-related macular degeneration (neAMD).

Published
2021
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28. Identification of the CDH18 gene associated with age-related macular degeneration using weighted gene co-expression network analysis.

Author

Liu G, Tan M, Liu R, Lu X, Jiang X, Bai Y, Guo Z, and Lu F

Abstract

Purpose: Age-related macular degeneration (AMD) is a chronic and progressive macular degenerative disease that culminates in a gradual deterioration of central vision. Despite its prevalence, the key biomarkers for AMD have not yet been fully elucidated. In this study, we aimed to efficiently identify biomarkers crucial for diagnosing AMD. Methods: Three datasets pertaining to retinal pigment epithelium (RPE)/choroid tissues associated with AMD were selected from the GEO database. The GSE50195 dataset was utilized to conduct weighted gene co-expression network analysis (WGCNA) for identifying module genes linked to AMD. KEGG and GO enrichment analyses were subsequently conducted on these module genes. GSE29801 and GSE135092 datasets were subjected to differential expression analysis to pinpoint the DEGs intersecting with the module genes. Subsequently, wet AMD (wAMD) and dry AMD (dAMD) mouse models were developed, from which RPE/choroid tissues were harvested to validate the hub genes via RT-qPCR and Western blot. Results: Using the WGCNA, we selected the "antiquewhite4" module ( r = 0.91 and p = 7e-07), which contains a total of 325 genes. Through the intersection of module genes with DEGs, nine hub genes were identified. Pathways involved in complement and coagulation cascades, ECM-receptor interactions, unsaturated fatty acid biosynthesis, and fatty acid elongation play important roles in AMD. Notably, CDH18 demonstrated notable variance across all three datasets. Post validation using RT-qPCR experiments revealed a significant downregulation of CDH18 in both dAMD and wAMD. EGLN3 was expressed at low levels in wAMD. In dAMD, EYA2, LTB, and PODXL were significantly downregulated, whereas APOC1 was notably upregulated. Western blot confirmed that CDH18 was lowly expressed in dAMD and wAMD mouse models. Conclusion: CDH18 was identified as the key gene involved in the pathogenesis of AMD. An imbalance of the complement and coagulation cascades is a potential mechanism of AMD. This study provides a novel idea for diagnosing and treating AMD in the future., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2024 Liu, Tan, Liu, Lu, Jiang, Bai, Guo and Lu.)

Published
2024
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