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638 results on '"Jiang, Wenlong"'

8. A wearable platform for closed-loop stimulation and recording of single-neuron and local field potential activity in freely moving humans.

Author

Topalovic, Uros, Barclay, Sam, Ling, Chenkai, Alzuhair, Ahmed, Yu, Wenhao, Hokhikyan, Vahagn, Chandrakumar, Hariprasad, Rozgic, Dejan, Jiang, Wenlong, Basir-Kazeruni, Sina, Maoz, Sabrina L, Inman, Cory S, Stangl, Matthias, Gill, Jay, Bari, Ausaf, Fallah, Aria, Eliashiv, Dawn, Pouratian, Nader, Fried, Itzhak, Suthana, Nanthia, and Markovic, Dejan

Subjects
Humans, Deep Brain Stimulation, Mental Disorders, Wearable Electronic Devices, Brain Disorders, Bioengineering, Neurosciences, Behavioral and Social Science, Assistive Technology, Mental health, Neurological, Psychology, Cognitive Sciences, Neurology & Neurosurgery
Abstract

Advances in technologies that can record and stimulate deep brain activity in humans have led to impactful discoveries within the field of neuroscience and contributed to the development of novel therapies for neurological and psychiatric disorders. Further progress, however, has been hindered by device limitations in that recording of single-neuron activity during freely moving behaviors in humans has not been possible. Additionally, implantable neurostimulation devices, currently approved for human use, have limited stimulation programmability and restricted full-duplex bidirectional capability. In this study, we developed a wearable bidirectional closed-loop neuromodulation system (Neuro-stack) and used it to record single-neuron and local field potential activity during stationary and ambulatory behavior in humans. Together with a highly flexible and customizable stimulation capability, the Neuro-stack provides an opportunity to investigate the neurophysiological basis of disease, develop improved responsive neuromodulation therapies, explore brain function during naturalistic behaviors in humans and, consequently, bridge decades of neuroscientific findings across species.

Published
2023

28. Effect of Childhood Trauma on Aggressive Behavior in Stable Schizophrenia Patients: the Chain Mediating Effect of Self-esteem and Resilience

Author

SUN Yujing, ZHANG Jing, YU Hong, ZHOU Yuqiu, JIANG Wenlong, JIA Yannan

Subjects
schizophrenia, stable phase schizophrenia, childhood trauma, self-esteem, resilience, aggressive behavior, mediation analysis, chain mediating effect, Medicine
Abstract

Background Among people with various mental illnesses, those with schizophrenia have the highest incidence of aggressive behavior, which not only disturbs the medical environment, but also poses a great threat to family stability and social harmony. Previous regression analysis studies have shown that childhood trauma, self-esteem and resilience are influencing factors of aggressive behavior in schizophrenia patients, but few studies have explored the internal relationship between these four variables. Objective To explore the relationship between childhood trauma, self-esteem, resilience and aggressive behavior in schizophrenic patients using a self-constructed chain mediation model, and to clarify its internal mechanism. Methods A convenience sample of stable schizophrenia inpatients were selected from Daqing Third Hospital and Chifeng Anding Hospital from March 2021 to July 2022. A survey was conducted with them using a questionnaire consisting of general information questionnaire, Positive and Negative Symptom Scale (PANSS) , Childhood Trauma Questionnaire-Short Form (CTQ-SF) , Connor-Davidson Resilience Scale (CD-RISC) , Self-esteem Scale (SES) , and Aggressive Questionnaire (AQ) . Pearson correlation analysis was used to explore the correlation of AQ score with CTQ-SF, CD-RISC and SES scores. Multiple linear regression analysis was used to explore the influencing factors of aggressive behavior. AMOS 24.0 was used to construct the chain mediation model. The mediation effect of the chain mediation model was tested using Bootstrap method. Results Three hundred and ten cases attended the survey, and 300 of them (96.8%) who responded effectively were finally included for analysis. The average scores of PANSS, CTQ-SF, SES, CD-RISC and AQ were (18.4±3.7) , (49.7±13.5) , (26.9±6.9) , (55.2±15.5) and (84.3±19.8) , respectively. Multiple linear regression analysis showed that childhood trauma〔B=0.551, 95%CI (0.421, 0.681) , P

Published
2023
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