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Your search keyword '"Jiang, Si-Tse"' showing total 176 results
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176 results on '"Jiang, Si-Tse"'

1. A resource of targeted mutant mouse lines for 5,061 genes

Author

Birling, Marie-Christine, Yoshiki, Atsushi, Adams, David J, Ayabe, Shinya, Beaudet, Arthur L, Bottomley, Joanna, Bradley, Allan, Brown, Steve DM, Bürger, Antje, Bushell, Wendy, Chiani, Francesco, Chin, Hsian-Jean Genie, Christou, Skevoulla, Codner, Gemma F, DeMayo, Francesco J, Dickinson, Mary E, Doe, Brendan, Donahue, Leah Rae, Fray, Martin D, Gambadoro, Alessia, Gao, Xiang, Gertsenstein, Marina, Gomez-Segura, Alba, Goodwin, Leslie O, Heaney, Jason D, Hérault, Yann, de Angelis, Martin Hrabe, Jiang, Si-Tse, Justice, Monica J, Kasparek, Petr, King, Ruairidh E, Kühn, Ralf, Lee, Ho, Lee, Young Jae, Liu, Zhiwei, Lloyd, KC Kent, Lorenzo, Isabel, Mallon, Ann-Marie, McKerlie, Colin, Meehan, Terrence F, Fuentes, Violeta Munoz, Newman, Stuart, Nutter, Lauryl MJ, Oh, Goo Taeg, Pavlovic, Guillaume, Ramirez-Solis, Ramiro, Rosen, Barry, Ryder, Edward J, Santos, Luis A, Schick, Joel, Seavitt, John R, Sedlacek, Radislav, Seisenberger, Claudia, Seong, Je Kyung, Skarnes, William C, Sorg, Tania, Steel, Karen P, Tamura, Masaru, Tocchini-Valentini, Glauco P, Wang, Chi-Kuang Leo, Wardle-Jones, Hannah, Wattenhofer-Donzé, Marie, Wells, Sara, Wiles, Michael V, Willis, Brandon J, Wood, Joshua A, Wurst, Wolfgang, Xu, Ying, Teboul, Lydia, and Murray, Stephen A

Subjects
Biological Sciences, Genetics, Infectious Diseases, Biotechnology, 2.1 Biological and endogenous factors, Animals, Gene Deletion, Genetic Association Studies, Genome, Genotype, Information Dissemination, International Cooperation, Internet, Mice, Mice, Knockout, Mouse Embryonic Stem Cells, Mutagenesis, Phenotype, International Mouse Phenotyping Consortium, Medical and Health Sciences, Developmental Biology, Agricultural biotechnology, Bioinformatics and computational biology
Abstract

The International Mouse Phenotyping Consortium reports the generation of new mouse mutant strains for over 5,000 genes, including 2,850 novel null, 2,987 novel conditional- ready, and 4,433 novel reporter alleles.

Published
2021

2. Negative Regulation of the Differentiation of Flk2− CD34− LSK Hematopoietic Stem Cells by EKLF/KLF1

Author

Hung, Chun-Hao, Wang, Keh-Yang, Liou, Yae-Huei, Wang, Jing-Ping, Huang, Anna Yu-Szu, Lee, Tung-Liang, Jiang, Si-Tse, Liao, Nah-Shih, Shyu, Yu-Chiau, and Shen, Che-Kun James

Subjects
Hematology, Stem Cell Research, Stem Cell Research - Nonembryonic - Non-Human, Stem Cell Research - Nonembryonic - Human, Regenerative Medicine, Blood, Animals, Antigens, CD34, Cell Differentiation, Cell Lineage, Cells, Cultured, Cytokine Receptor Common beta Subunit, Hematopoiesis, Hematopoietic Stem Cell Transplantation, Hematopoietic Stem Cells, Homeostasis, Kruppel-Like Transcription Factors, Liver, Mice, Mice, Inbred C57BL, Mice, Knockout, RNA, Messenger, fms-Like Tyrosine Kinase 3, EKLF/KLF1, Flk2-CD34-HSC, differentiation, hematopoiesis, Other Chemical Sciences, Genetics, Other Biological Sciences, Chemical Physics
Abstract

Erythroid Krüppel-like factor (EKLF/KLF1) was identified initially as a critical erythroid-specific transcription factor and was later found to be also expressed in other types of hematopoietic cells, including megakaryocytes and several progenitors. In this study, we have examined the regulatory effects of EKLF on hematopoiesis by comparative analysis of E14.5 fetal livers from wild-type and Eklf gene knockout (KO) mouse embryos. Depletion of EKLF expression greatly changes the populations of different types of hematopoietic cells, including, unexpectedly, the long-term hematopoietic stem cells Flk2- CD34- Lin- Sca1+ c-Kit+ (LSK)-HSC. In an interesting correlation, Eklf is expressed at a relatively high level in multipotent progenitor (MPP). Furthermore, EKLF appears to repress the expression of the colony-stimulating factor 2 receptor β subunit (CSF2RB). As a result, Flk2- CD34- LSK-HSC gains increased differentiation capability upon depletion of EKLF, as demonstrated by the methylcellulose colony formation assay and by serial transplantation experiments in vivo. Together, these data demonstrate the regulation of hematopoiesis in vertebrates by EKLF through its negative regulatory effects on the differentiation of the hematopoietic stem and progenitor cells, including Flk2- CD34- LSK-HSCs.

Published
2020

12. Genetic Disruption of KLF1 K74 SUMOylation in Hematopoietic System Promotes Healthy Longevity in Mice

Author

Shyu, Yu‐Chiau, primary, Liao, Po‐Cheng, additional, Huang, Ting‐Shou, additional, Yang, Chun‐Ju, additional, Lu, Mu‐Jie, additional, Huang, Shih‐Ming, additional, Lin, Xin‐Yu, additional, Liou, Cai‐Cin, additional, Kao, Yu‐Hsiang, additional, Lu, Chi‐Huan, additional, Peng, Hui‐Ling, additional, Chen, Jim‐Ray, additional, Cherng, Wen‐Jin, additional, Yang, Ning‐I, additional, Chen, Yung‐Chang, additional, Pan, Heng‐Chih, additional, Jiang, Si‐Tse, additional, Hsu, Chih‐Chin, additional, Lin, Gigin, additional, Yuan, Shin‐Sheng, additional, Hsu, Paul Wei‐Che, additional, Wu, Kou‐Juey, additional, Lee, Tung‐Liang, additional, and Shen, Che‐Kun James, additional

Published
2022
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26. Collagen gel overlay induces apoptosis of polarized cells in cultures: disoriented cell death

Author

Tang, Ming-Jer, Hu, Jeng-Jay, Lin, Hsi-Hui, Chiu, Wen-Tai, and Jiang, Si-Tse

Subjects
Cell death -- Physiological aspects, Epithelium -- Physiological aspects, Extracellular matrix -- Physiological aspects, Biological sciences
Abstract

The response of cell lines of epithelial Madin-Darby canine kidney (MDCK) and endothelial cells to inappropriate interaction with the extracellular matrix (ECM) in a collagen gel overlay was investigated. The epithelial and endothelial cells developed apoptosis after interacting with the collagen overlay. However, the findings showed that the apoptosis was limited only to the polarized cells and was reversed by anti-alpha2--integrin antibodies. The data confirmed that inappropriate ECM interaction can lead to disoriented cell death.

Published
1998

27. Inducible expression of bcl-2 by the lac operator/repressor system in MDCK cells

Author

Lin, Hsi-Hui, Yang, Tzi-Peng, Jiang, Si-Tse, Liu, Hsiao-Sheng, and Tang, Ming-Jer

Subjects
Cell death -- Research, Kidneys -- Research, Dogs -- Research, Biological sciences
Abstract

An analysis of the inducible expression of B cell lymphoma-2 by the lac operator/repressor system in Madin-Darby canine kidney (MDCK) was conducted. Results of the analysis revealed that the expression of the bcl-2 gene could be repressed to basal level by binding the lac repressor to the lac operator sequence. Furthermore, functional assays revealed that isopropyl-beta-D-thiogalactoside-induced expression of bcl-2 gene exhibits partial resistance to homeless cell death.

Published
1997

33. MST3 is involved in ENaC-mediated hypertension

Author

Lu, Te-Jung, primary, Kan, Wei-Chih, additional, Yang, Sung-Sen, additional, Jiang, Si-Tse, additional, Wu, Sheng-Nan, additional, Ling, Pin, additional, Bao, Bo-Ying, additional, Lin, Chia-Yu, additional, Yang, Zin-Ya, additional, Weng, Yui-Ping, additional, Chan, Chee-Hong, additional, and Lu, Te Ling, additional

Published
2019
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