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PNB organic flame retardant was synthesized using 4‐formylphenylboronic acid, 4‐aminophenylthiophenol, 9,10‐dihydro‐9‐oxa‐10‐phos‐phaphenanthrene‐10‐oxide (DOPO), and then introduced into the hydroxyl‐terminated polybutadiene acrylonitrile (HTBN) molecular chain to successfully prepare a macromolecular flame retardant, which was used to prepare flame retardant waterborne polyurethane. The mechanical properties, thermal properties, and flame retardancy of waterborne polyurethane (FR‐WPU) were studied using thermogravimetic analysis (TGA), limiting oxygen index (LOI), scanning electron microscope (SEM), cone calorimeter, and universal testing machine, respectively, and the flame retardant mechanism of macromolecular flame retardants was explored. An LOI value of 29.76% and a UL‐94 V‐0 rating could be realized when the APFBH conjugation is 7.5 wt%, showing a significant improvement of melt dripping behavior and flame retardancy. It indicated that the fire resistance of FR‐WPU remarkably improved and displayed both gas and condensed phase mechanism. As the content of APBDH increased, the tensile strength and the elongation at break of FR‐WPU increased firstly and then decreased. [ABSTRACT FROM AUTHOR]

Background: This study aimed to explore the current situation of anxiety and depression on day of transfer in couples receiving in vitro fertilization and embryo transfer (IVF-ET) with donor sperm and analyze its influencing factors. Methods: This study selected 187 IVF-ET administered couples who received donor sperm from our Hospital from August 2021 to July 2022. On the day of IVF-ET with donor sperm transplantation, patients were investigated with general data questionnaire, self-rating anxiety scale (SAS) and self-rating depression scale (SDS) to analyze their anxiety and depression scores and their influencing factors. Results: Scores of anxiety and depression on the day of transplantation in patients receiving IVF-ET with donor sperm were 43.98± 6.80 and 46.03± 10.61 respectively, which were higher compared to levels of Chinese health norm (P< 0.05). The anxiety score of patients' spouses was 41.23± 6.69 and depression score was 44.23± 11.65, which were higher compared to levels of Chinese health norm (P< 0.05). Score of anxiety and depression of women was significantly higher compared to those of their spouse (P< 0.05). Anxiety and depression scores of women in non-pregnant group were significantly higher compared to those in pregnant group (P< 0.05). Regression analysis showed that education level and annual family income were influencing factors of anxiety and depression scores of IVF-ET with donor sperm couples on the day of transfer, and number of eggs taken and transfer times were influencing factors of depression scores of IVF-ET with donor sperm patients on the day of transfer. Conclusion: Psychological state of couples receiving IVF-ET with donor sperm was significantly affected, especially in female side. Medical staff should focus on patients with low education level, low family income, and more times of transfer and egg retrieval, and take targeted intervention measures to keep them in good psychological state, which is conducive to improving pregnancy outcome. [ABSTRACT FROM AUTHOR]

MicroRNAs(miRNAs) are emerging as important regulators in tumorigenesis. Increasing evidences have indicated microRNA-7(miR-7) to be a potential tumor suppressor in several human cancers. However, only a limited number of target genes have been identified so far and its biological function in Non-Small Cell Lung Cancer (NSCLC) remains to be further elucidated. In the present study, we observed a reduction of miR-7 level in NSCLC cell lines. Overexpression of miR-7 not only suppressed NSCLC A549 cells proliferation, induced cell apoptosis and inhibited cell migration in vitro, but also reduced tumorigenicity in vivo. Bioinformatics predictions revealed a potential binding site of miR-7 on 3'UTR of BCL-2 and it was further confirmed by luciferase assay. Moreover, subsequent experiments showed that BCL-2 was downregulated by miR-7 at both transcriptional and translational levels. These results suggest that miR-7 regulates the expression of BCL-2 through direct 3'UTR interactions. Therefore, we postulate BCL-2 to be a novel target possibly involved in miR-7-mediated growth suppression and apoptosis of A549 cells. These findings may provide a basic rationale for the use of miR-7 in the treatment of NSCLC.

2D MXene‐based catalysts, such as Ti3C2Tx have unique, excellent properties and show extraordinary advantages in many catalytic reactions. However, as cocatalysts for photocatalytic hydrogen evolution reaction (HER), MXene has insufficient catalytic activity because the active metal sites of H+ binding are hidden by passivation −F/−O termination, which hinders postreaction desorption of H2. A simple ultrasonic treatment method is used to expose more active sites and adjust the surface work function of Ti3C2Tx, and additionally inactive −F/−O terminal groups are replaced with diaminoethanethiol, denoted as Ti3C2‐Ax, as the surface terminal group through covalent bonds (Ti−S). The optimized photocatalyst (Cd0.4Zn0.6S/Ti3C2‐A40) demonstrates excellent catalytic activity (HER: 13.44 mmol h−1 g−1), which is about 5.8 and 1.9 times higher than that of pristine Cd0.4Zn0.6S and Cd0.4Zn0.6S/Ti3C2 with stability (24 h of cycle experiments), outperforming most of the reported MXene‐based photocatalysts. The results of relevant experiments and density functional theory calculations reveal that the excellent conductivity of Ti3C2‐A40, well‐structured Cd0.4Zn0.6S/Ti3C2‐A40 Schottky junction, and the efficient interfacial charge transfer are major factors that contribute to the improved photocatalytic mechanism. This promotes application of surface‐modified MXene as an efficient cocatalyst and provides a new idea for design and synthesis of heterojunction materials. [ABSTRACT FROM AUTHOR]