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183 results on '"Jiang, Kehua"'

3. Tip bendable suction ureteral access sheath versus traditional sheath in retrograde intrarenal stone surgery: an international multicentre, randomized, parallel group, superiority study

Author

Zhu, Wei, Liu, Shusheng, Cao, Jianwei, Wang, Hao, Liang, Hui, Jiang, Kehua, Cui, Yu, Chai, Chu Ann, Sahinler, Emre Burak, Aquino, Albert, Mazzon, Giorgio, Zhong, Wen, Zhao, Zhijian, Zhang, Lin, Ding, Jie, Wang, Qing, Wang, Yizhou, Chen, Kelven Weijing, Liu, Yongda, Choong, Simon, Sarica, Kemal, and Zeng, Guohua

Published
2024
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14. Nanoparticles targeting the adenosine pathway for cancer immunotherapy.

Author

Jiang, Kehua, Wu, Jian, Wang, Qing, Chen, Xiaolong, Zhang, Yanlong, Gu, Xiaoya, and Tang, Kun

Abstract

Cancer immunotherapy, as an emerging approach to cancer treatment, has tremendous potential for application. Compared to traditional methods such as surgery, chemotherapy, and radiation therapy, it has the ability to restore the patient's immune system, leading to long-term immune memory with less damage to normal tissues. However, immunotherapy has its limitations, including limited therapeutic efficacy, restricted patient populations, and inconsistent treatment responses. Finding effective immunotherapeutic approaches has become a key focus of its clinical application. The adenosine pathway is a recently discovered tumor immune regulatory signaling pathway. It can influence the metabolism and growth of tumor cells by acting through key enzymes in the adenosine pathway, thereby affecting the development of tumors. Therefore, inhibiting the adenosine pathway is an effective cancer immunotherapy. Common adenosine pathway inhibitors include small molecules and antibody proteins, and extensive preclinical trials have demonstrated their effectiveness in inhibiting tumor growth. The short half-life, low bioavailability, and single administration route of adenosine pathway inhibitors limit their clinical application. With the advent of nanotechnology, nano-delivery of adenosine pathway inhibitors has addressed these issues. Compared to traditional drugs, nano-drugs extend the drug's circulation time and improve its distribution within the body. They also offer targeting capabilities and have low toxic side effects, making them very promising for future applications. In this review, we discuss the mechanism of the adenosine pathway in tumor immune suppression, the clinical applications of adenosine pathway inhibitors, and nano-delivery based on adenosine pathway inhibitors. In the final part of this article, we also briefly discuss the technical issues and challenges currently present in nano-delivery of adenosine pathway inhibitors, with the hope of advancing the progress of adenosine inhibitor nano-drugs in clinical treatment. [ABSTRACT FROM AUTHOR]

Published
2024
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18. Prevalence of urolithiasis in China: a systematic review and meta‐analysis.

Author

Tan, Songsong, Yuan, Dongbo, Su, Hao, Chen, Weihong, Zhu, Siqi, Yan, Bo, Sun, Fa, Jiang, Kehua, and Zhu, Jianguo

Subjects
URINARY calculi, BLADDER stones, KIDNEY stones, REGIONAL disparities, CHINESE people
Abstract

Objective: To estimate the pooled prevalence, as well as the spatial and temporal distribution, of urolithiasis among subjects in China. Materials and Methods: We conducted a comprehensive search of both Chinese and English databases to retrieve literature pertaining to the prevalence of urolithiasis in the indigenous Chinese population. A random‐effects meta‐analysis model was employed to calculate the pooled prevalence of urolithiasis. Subgroup analyses were conducted based on factors such as time, region, gender, and sample size. Prevalence and spatial distribution maps were created based on provinces and latitude/longitude coordinates. Results: A total of 46 studies conducted in 22 provinces across China were included in this meta‐analysis and the pooled prevalence of urolithiasis, kidney stones, ureteric calculi, urethral and bladder stones were 8.1% (95% confidence interval [CI] 5.6–11.1%), 7.8% (95% CI 5.8–10.0%), 3.2% (95% CI 0.6–5.7%), 0.5% (95% CI 0.1–0.9%). Most of the urolithiasis prevalence screening in China was concentrated between 100° E and 120° E, with higher rates observed in low latitude areas. Subgroup analysis of kidney stones revealed that Guangdong (12.7%) and Guangxi (10.3%) had the highest prevalence, with the eastern developed area exhibiting higher rates compared to the west. The prevalence in males was higher than in females (odds ratio 1.67, 95% CI 1.46–1.92), although the gender gap has significantly reduced since 2006. Moreover, a greater sample size is associated with a decreased prevalence of urolithiasis. Conclusions: The prevalence of urolithiasis is increasing in China, and there are noteworthy regional or provincial disparities in occurrence. It is worth noting that the current number of screening studies in some areas is insufficient. Additional investigations with appropriate sample sizes should be supplemented in time. [ABSTRACT FROM AUTHOR]

Published
2024
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21. Root extract of Hemsleya amabilis Diels suppresses renal cell carcinoma cell growth through inducing apoptosis and G2/M phase arrest via PI3K/AKT signaling pathway activation

Author

Li, Kai, primary, You, Ganhua, additional, Jiang, Kehua, additional, Wang, Rongpin, additional, Li, Wuchao, additional, Meng, Yonglu, additional, Fang, Yinyi, additional, Chen, Weiming, additional, Zhu, Guohua, additional, Song, Jukun, additional, Wang, Wei, additional, Su, Hao, additional, Hu, Bin, additional, Sun, Fa, additional, Jia, Zhenyu, additional, Li, Can, additional, and Zhu, Jianguo, additional

Published
2023
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24. Exposure to Heavy Metal Elements May Significantly Increase Serum Prostate-Specific Antigen Levels with Overdosed Dietary Zinc

Author

Fang, Yinyi, primary, Yuan, Dongbo, additional, Chen, Weiming, additional, Chen, Chi, additional, Chen, Xiaoyue, additional, Song, Jukun, additional, Feng, Shuangshuang, additional, Li, Zhuang, additional, Li, Zhengnan, additional, Xiong, Yuliang, additional, Zhang, Qinyi, additional, Liu, Heng, additional, Zhu, Guohua, additional, Hu, Bin, additional, Wang, Wei, additional, Liu, Zhangcheng, additional, Jiao, Ke, additional, Su, Hao, additional, Zhang, Chang, additional, Zhang, Fan, additional, Jiang, Kehua, additional, He, Jun, additional, Sun, Zhaolin, additional, and Zhu, Jianguo, additional

Published
2023
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42. Incaspitolide A extracted from Carpesium cernuum induces apoptosis in vitro via the PI3K/AKT pathway in benign prostatic hyperplasia

Author

Dongbo Yuan, Shuhui Feng, Zhu Guohua, Yanmei Li, Song Jingrui, Chen Xiaoyue, Jiang Kehua, Yan Chen, Jianguo Zhu, and Qing Rao

Subjects
Male, 0301 basic medicine, Cell cycle checkpoint, Prostatic Hyperplasia, Biophysics, Apoptosis, Cell Cycle Proteins, Asteraceae, urologic and male genital diseases, Incaspitolide A, Biochemistry, Cell Line, 03 medical and health sciences, 0302 clinical medicine, Carpesium cernuum, Humans, PTEN, Molecular Biology, Protein kinase B, Research Articles, PI3K/AKT/mTOR pathway, Cancer, Cell Proliferation, benign prostatic hyperplasia, Cyclin-dependent kinase 1, biology, Plant Extracts, Cell growth, Chemistry, PTEN Phosphohydrolase, Prostate, Cell Biology, Cell cycle, Signaling, Mitochondria, PI3K/AKT pathway, G2 Phase Cell Cycle Checkpoints, 030104 developmental biology, 030220 oncology & carcinogenesis, Cell Cycle, Growth & Proliferation, biology.protein, Cancer research, cell cycle, Phosphatidylinositol 3-Kinase, Apoptosis Regulatory Proteins, Proto-Oncogene Proteins c-akt, Sesquiterpenes, Signal Transduction
Abstract

Benign prostatic hyperplasia (BPH) is a common disease that occurs mainly in older men. The pathogenesis of BPH is complex and patients face a prolonged treatment course, and novel drugs with better selectivity and lower toxicity are required. Incaspitolide A (compound TMJ-12) is a germacrane-type sesquiterpenoid compound extracted from the plant Carpesium carnuum. Extracts of C. carnuum are known to exert suppressive effects on BPH-1 cells. In the present study, we investigated the molecular mechanisms underlying the suppressive effect of TMJ-12 specifically on BPH-1 cells. A cytotoxicity assay indicated that TMJ-12 inhibited BPH-1 cell proliferation, while flow cytometry assays showed that TMJ-12 induced G2/M phase cell cycle arrest and the apoptosis of BPH-1 cells. TMJ-12 was also shown to regulate the expression of several apoptosis- and cell cycle-related proteins, namely Bcl-2, Bax, Bad, Caspase-9, Caspase-3, cyclin-dependent kinase 1 (CDK1), Cyclin B1, CDC25C, and c-Myc, among others. Collapse of the mitochondrial membrane potential (ΔΨm) following exposure to TMJ-12 was detected with the JC-1 staining assay. Further investigation revealed that treatment with TMJ-12 inhibited the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT) pathway by increasing the expression of phosphatase and tensin homolog deleted on chromosome 10 (PTEN). Taken together, the results suggest that TMJ-12 prevents BPH-1 cell proliferation via the PI3K/AKT pathway by inducing apoptosis and cell cycle arrest.

Published
2021

43. Exposure to Heavy Metal Elements May Significantly Increase Serum Prostate-Specific Antigen Levels With Overdosed Dietary Zinc

Author

Jiao Ke, Zhu Guohua, Jiang Kehua, Chen Weiming, Fa Sun, Liu Heng, Yuan Dongbo, Song Jukun, Zhang Fan, Zhu Jianguo, Lingyue An, Bohao Zheng, Hu Bin, Wei Wang, Chi Chen, Luo Fu, Zhaolin Sun, Liu Zhangcheng, Chen Xiaoyue, Zhang Chang, Su Hao, and Zongjian Tan

Subjects
Metal, medicine.medical_specialty, Endocrinology, Chemistry, Internal medicine, visual_art, medicine, visual_art.visual_art_medium, urologic and male genital diseases, Dietary zinc, Serum prostate specific antigen
Abstract

Background: Serum prostate-specific antigen (PSA) is a primary metric for diagnosis and prognosis of prostate cancer (PCa). Exposure to heavy metals, such as lead, cadmium, mercury, and zinc can impact PSA levels in PCa patients. However, it is unclear whether this effect also occurs in men without PCa, which may lead to the overdiagnosis of PCa.Method: Data on a total of 5,089 American men who had never been diagnosed with PCa were obtained from the National Health and Nutrition Examination Survey performed from 2003–2010. The relationship between serum PSA levels (dependent variable) and concentrations of lead (μmol/L), cadmium (nmol/L), and mercury (μmol/L) were investigated with dietary zinc intake being used as a potential modifier or covariate in a weighted linear regression model and a generalized additive model. A series of bootstrapping analyses were performed to evaluate sensitivity and specificity using these models. Results: Regression analyses suggested that, in general, lead, cadmium, or mercury did not show an association with PSA levels, which was consistent with the results of the bootstrapping analyses. However, in a subgroup of participants with a high level of dietary zinc intake (≥14.12 mg/day), a significant positive association between cadmium and serum PSA was identified (1.06, 95% CI, P=0.0268, P for interaction=0.0249).Conclusions: With high-level zinc intake, serum PSA levels may rise in PCa-free men as the exposure to cadmium increases, leading to a potential risk of an overdiagnosis of PCa and unnecessary treatment. Therefore, environmental variables should be factored in the current diagnostic model for PCa that is solely based on PSA measurements. Different criteria for PSA screening are necessary based on geographical variables. Further investigations are needed to uncover the biological and biochemical relationship between zinc, cadmium, and serum PSA levels to more precisely diagnose PCa.

Published
2021

48. Exposure to Heavy Metal Elements May Significantly Increase Serum Prostate-Specific Antigen Levels With Overdosed Dietary Zinc

Author

Chen, Xiaoyue, primary, Chen, Chi, additional, Song, Jukun, additional, Liu, Heng, additional, An, Lingyue, additional, Yuan, Dongbo, additional, Zhu, Guohua, additional, Hu, Bin, additional, Wang, Wei, additional, Liu, Zhangcheng, additional, Jiao, Ke, additional, Su, Hao, additional, Zhang, Chang, additional, Zhang, Fan, additional, Jiang, Kehua, additional, Luo, Fu, additional, Tan, Zongjian, additional, Zheng, Bohao, additional, Sun, Zhaolin, additional, Chen, Weiming, additional, Sun, Fa, additional, and zhu, jianguo, additional

Published
2021
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