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278 results on '"Jiang, Guanyu"'

38. Unlocking the NIR-II AIEgen for High Brightness through Intramolecular Electrostatic Locking

Author

Wang, Xinyuan, Yang, Xueqin, Jiang, Guanyu, Hu, Zhubin, Liao, Tao, Wang, Guoxin, Zhang, Xun, He, Xinyuan, Zhang, Jianyu, Zhang, Jianquan, Cao, Wuke, Zhang, Kaizhen, Lam, Wing Yip, Sun, Jianwei, Sun, Haitao, Liang, Yongye, Tang, Benzhong, Wang, Xinyuan, Yang, Xueqin, Jiang, Guanyu, Hu, Zhubin, Liao, Tao, Wang, Guoxin, Zhang, Xun, He, Xinyuan, Zhang, Jianyu, Zhang, Jianquan, Cao, Wuke, Zhang, Kaizhen, Lam, Wing Yip, Sun, Jianwei, Sun, Haitao, Liang, Yongye, and Tang, Benzhong

Abstract

Fluorescent imaging and biosensing in the near-infrared-II (NIR-II) window holds great promise for non-invasive, radiation-free, and rapid-response clinical diagnosis. However, it’s still challenging to develop bright NIR-II fluorophores. In this study, we report a new strategy to enhance the brightness of NIR-II aggregation-induced emission (AIE) fluorophores through intramolecular electrostatic locking. By introducing sulfur atoms into the side chains of the thiophene bridge in TSEH molecule, the molecular motion of the conjugated backbone can be locked through intramolecular interactions between the sulfur and nitrogen atoms. This leads to enhanced NIR-II fluorescent emission of TSEH in both solution and aggregation states. Notably, the encapsulated nanoparticles (NPs) of TSEH show enhanced brightness, which is 2.6-fold higher than TEH NPs with alkyl side chains. The in vivo experiments reveal the feasibility of TSEH NPs in vascular and tumor imaging with a high signal-to-background ratio and precise resection for tiny tumors. In addition, polystyrene nanospheres encapsulated with TSEH are utilized for antigen detection in lateral flow assays, showing a signal-to-noise ratio 1.9-fold higher than the TEH counterpart in detecting low-concentration antigens. This work highlights the potential for developing bright NIR-II fluorophores through intramolecular electrostatic locking and their potential applications in clinical diagnosis and biomedical research.

Published
2024

42. Synergistic Inter‐ and Intramolecular Aggregation of Dimeric Cyanine Dyes Affords Highly Efficient In Vivo Self‐Delivery and Photothermal Therapy.

Author

Hou, Yanxian, Li, Jianwei, Jiang, Guanyu, Xia, Tianping, Li, Zipeng, Gu, Hua, Liu, Xiaogang, Yao, Qichao, Zhang, Changyu, Liu, Wenkai, Du, Jianjun, Sun, Wen, Fan, Jiangli, and Peng, Xiaojun

Subjects
PHOTOTHERMAL conversion, ANTINEOPLASTIC agents, NANOPARTICLES, TREATMENT effectiveness, PHARMACOKINETICS
Abstract

Advancing photothermal therapy hinges on developing PTAs with robust in vivo delivery and therapeutic efficacy. However, effective molecular design approaches for high‐performance PTAs remain lacking. Herein a strategic design of dimeric heptamethine cyanine (Cy7) molecules is presented, covalently linked via ortho/meta/para‐phenyldithiol. These designs facilitate spontaneous nanoparticle assembly in water, attributed to efficient intermolecular aggregation, enhancing in vivo delivery. Additionally, aggregation between intramolecular Cy7 units promotes superior photothermal conversion efficiency (PCE) up to 74.1% for meta‐dimer. Remarkably, the para‐dimer variant not only achieves a high PCE of 61.1% but also exhibits the most effective pharmacokinetic profile, leading to unparalleled anticancer efficacy in vivo. This dual aggregation strategy, leveraging both inter‐ and intramolecular dynamics, equips dimeric Cy7 with superior self‐delivery and photothermal efficacy, offering a promising approach for the next generation of photothermal therapeutics. [ABSTRACT FROM AUTHOR]

Published
2024
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