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Your search keyword '"Jiang, Elisabeth"' showing total 24 results
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24 results on '"Jiang, Elisabeth"'

1. Acute Isolated Thenar Compartment Syndrome in a Patient with Evans Syndrome: A Case Report

Author

Jiang, Elisabeth, Kim, Kevin H., and Babigian, Alan

Subjects
case report, atraumatic compartment syndrome, Evans syndrome, hand compartment syndrome.
Abstract

Introduction: Acute compartment syndrome of the hand is a rare medical emergency, most often associated with trauma or fracture.Case Report: Here, we describe a rare case of isolated thenar compartment syndrome of the hand in the absence of major trauma as the presenting symptom of pancytopenia due to Evans syndrome, an uncommon autoimmune hematologic disorder.Conclusion: In cases of atraumatic compartment syndrome, it is critical to evaluate for underlying coagulopathy in patients presenting to the emergency department.

Published
2022

8. Mesenchymal condensation-dependent accumulation of collagen VI stabilizes organ-specific cell fates during embryonic tooth formation

Author

Mammoto, Tadanori, Mammoto, Akiko, Jiang, Amanda, Jiang, Elisabeth, Hashmi, Basma, and Ingber, Donald E.

Subjects
Extracellular Matrix Proteins, Transcription, Genetic, MAP Kinase Signaling System, Sp1 Transcription Factor, Gene Expression Profiling, Gene Expression Regulation, Developmental, Collagen Type VI, Plicamycin, Microarray Analysis, Molar, p38 Mitogen-Activated Protein Kinases, Article, Mesoderm, Protein-Lysine 6-Oxidase, Mice, Organ Specificity, Animals, Odontogenesis, Paired Box Transcription Factors, Cell Lineage, PAX9 Transcription Factor, Cell Shape, Protein Kinase Inhibitors
Abstract

Mechanical compression of cells during mesenchymal condensation triggers cells to undergo odontogenic differentiation during tooth organ formation in the embryo. However, the mechanism by which cell compaction is stabilized over time to ensure correct organ-specific cell fate switching remains unknown.Here, we show that mesenchymal cell compaction induces accumulation of collagen VI in the extracellular matrix (ECM), which physically stabilizes compressed mesenchymal cell shapes and ensures efficient organ-specific cell fate switching during tooth organ development. Mechanical induction of collagen VI deposition is mediated by signaling through the actin-p38MAPK-SP1 pathway, and the ECM scaffold is stabilized by lysyl oxidase in the condensing mesenchyme. Moreover, perturbation of synthesis or cross-linking of collagen VI alters the size of the condensation in vivo.These findings suggest that the odontogenic differentiation process that is induced by cell compaction during mesenchymal condensation is stabilized and sustained through mechanically regulated production of collagen VI within the mesenchymal ECM.

Published
2015

24. Assessing Resistance Costs of Antiretroviral Therapies via Measures of Future Drug Options.

Author

Hongyu Jiang, Elisabeth E., Deeks, Steven G., Kuritzkes, Daniel R., Lallemant, Marc, Katzenstein, David, Albrecht, Mary, and DeGruttola, Victor

Subjects
*ANTIRETROVIRAL agents, *DRUG resistance
Abstract

Assesses resistance costs of antiretroviral therapies via measures of future drug options. Indication tha tthe regimen with the highest virologic failure rate preserved greater future drug options; Outcome of antiretroviral therapy trials which may complement traditional clinical, virologic and immunologic end points.

Published
2003
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