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Abstract Temperature is one of the seven fundamental physical quantities. The ability to measure temperatures approaching absolute zero has driven numerous advances in low-temperature physics and quantum physics. Currently, millikelvin temperatures and below are measured through the characterization of a certain thermal state of the system as there is no traditional thermometer capable of measuring temperatures at such low levels. In this study, we develop a kind of diamond with sp 2-sp 3 composite phase to tackle this problem. The synthesized composite phase diamond (CPD) exhibits a negative temperature coefficient, providing an excellent fit across a broad temperature range, and reaching a temperature measurement limit of 1 mK. Additionally, the CPD demonstrates low magnetic field sensitivity and excellent thermal stability, and can be fabricated into probes down to 1 micron in diameter, making it a promising candidate for the manufacture of next-generation cryogenic temperature sensors. This development is significant for the low-temperature physics researches, and can help facilitate the transition of quantum computing, quantum simulation, and other related technologies from research to practical applications.

In response to the intricate interplay of uncertain factors within the airport system, which leads to challenges in predicting and optimizing departure operations in the airport, this study investigates a probabilistic prediction of operation times for departure flights, as well as an integrated stochastic optimized scheduling method considering multiple resources on the airport surface under the impact of these uncertain operation times. A probabilistic predictive model for departure operations is formulated, employing a combination of random forest regression and kernel density estimation. This model was used to obtain the prediction results of the probabilistic distribution of various departure operation times under uncertainty. Chance constraints are introduced to control the stability of the scheduling strategies including the push back time and takeoff time scheduling. Taking minimizing operational delays and maximizing the probability of satisfying the chance constraints as the optimization objectives, a comprehensive integrated stochastic scheduling model is developed for airport departure operations under uncertainty. Lastly, the method is validated and analyzed using Kunming Changshui International Airport as a case study. Experimental results firstly demonstrate that the proposed method is capable of effectively predict the probability distributions of estimated push back times and taxi times for departure flights. The continuous ranked probability scores of the estimated push back times and taxi times are 9.25 and 1.21 respectively, indicating that the estimated push back times of the departure flights is more uncertain than the taxi times. Then, results of the integrated airport surface departure scheduling model show that the model can comprehensively consider the minimization of flight delays and the satisfaction of the two chance constraints, and obtain the Pareto optimal solutions achieving balance between strategy efficiency and strategy stability.

The clinical manifestations of ischemic cardiomyopathy (ICM) bear resemblance to dilated cardiomyopathy (DCM), yet their treatments and prognoses are quite different. Early differentiation between these conditions yields positive outcomes, but the gold standard (coronary angiography) is invasive. The potential use of ECG signals based on variational mode decomposition (VMD) as an alternative remains underexplored. An ECG dataset containing 87 subjects (44 DCM, 43 ICM) is pre-processed for denoising and heartbeat division. Firstly, the ECG signal is processed by empirical mode decomposition (EMD) and VMD. And then, five modes are determined by correlation analysis. Secondly, bispectral analysis is conducted on these modes, extracting corresponding bispectral and nonlinear features. Finally, the features are processed using five machine learning classification models, and a comparative assessment of their classification efficacy is facilitated. The results show that the technique proposed provides a better categorization for DCM and ICM using ECG signals compared to previous approaches, with a highest classification accuracy of 98.30%. Moreover, VMD consistently outperforms EMD under diverse conditions such as different modes, leads, and classifiers. The superiority of VMD on ECG analysis is verified.

In this paper, a data-driven framework aimed at investigating how weather factors affect the spatio-temporal patterns of air traffic flow in the terminal maneuvering area (TMA) is presented. The framework mainly consists of three core modules, namely, trajectory structure characterization, flow pattern recognition, and association rule mining. To fully characterize trajectory structure, abnormal trajectories and typical operations are sequentially extracted based on a deep autoencoder network with two specially designed loss functions. Then, using these extracted elements as basic components to further construct and cluster per-hour-level descriptions of airspace structure, the spatio-temporal patterns of air traffic flow can be recognized. Finally, the association rule mining technique is applied to find sets of weather factors that often appear together with each flow pattern. Experimental analysis is demonstrated on two months of arrival flight trajectories at Hong Kong International Airport (HKIA). The results clearly show that the proposed framework effectively captures spatial anomalies, fine-grained trajectory structures, and representative flow patterns. More importantly, it also reveals that those flow patterns with non-conforming behaviors result from complex interactions of various weather factors. The findings provide valuable insights into the causal relationships between weather factors and changes in flow patterns, greatly enhancing the situational awareness of TMA.

Accurate prediction of taxiing time is important in ensuring efficient and safe operations on the airport surface. It helps improve ground operation efficiency, reduce fuel waste, and improve carbon emissions at the airport. In actual operations, taxiing time is influenced by various factors, including a large number of categorical features. However, few previous studies have focused on selecting such features. Additionally, traditional taxiing time prediction methods are often black-box models that only provide a single prediction result; they fail to provide effective practical references for controllers. Therefore, this paper analyses the features that affect taxiing time from different data types and forms a taxi feature set consisting of nine key features. We also propose a taxiing time prediction method based on adaptive scenario matching rules. This process classifies the scenarios into multiple typical historical scenario sets and adaptively matches the current target scenario to a typical scenario set based on quantified rules. Then, based on the matching results, a pre-trained model obtained from the corresponding scenario set is used to predict the taxiing time of an aircraft in the target scenario, aiming to mitigate the impact of data heterogeneity on prediction results. Experimental results show that compared to baseline methods, the mean absolute error and root mean square error of the proposed method decreased by 4.8% and 12.6%, respectively. This method significantly reduces the fluctuations in results caused by sample heterogeneity and enhances controllers’ acceptance of prediction results from the model. It can be used to further improve auxiliary decision making systems and enhance the precise control capabilities of airport surface operations.

Since the surface operation of hub airports was facing severe congestion and aircraft delay under the de-icing mode, some practical problems of improving aircraft operation and support efficiency are put forward. A two-phase model is constructed to coordinate the scheduling of aircraft surface operation (ASO) and de-icing support resources operation (DSRO). An optimized method is used to schedule the aircraft surface operation. On the basis of the scheduling results of surface operation, an aircraft and de-icing resource collaborative scheduling (ADCS) mechanism is established to optimize the assignment of aircraft and de-icing resources. The algorithm combining receding horizon control strategy and CPLEX solver (RHC-CPLEX) is designed to solve the model. Computational experiments performed on case studies of Beijing DaXing airport show some potential improvements: Firstly, for the ASO model, the RHC-CPLEX algorithm can reduce the objective function value by more than 20% compared with the FCFS algorithm. And the results shows that not only the delay distributions under different snow conditions are reasonable, but the spatial distributions of the de-icing zones of aircraft are closer to the location of their apron and allocated runway. Secondly, for the DSRO model, the RHC-CPLEX algorithm can reduce the objective function value by more than 6% compared with the algorithm based on the principle of proximity and availability. The de-icing vehicles are used efficiently and the number of refilling de-icing fluid and the free time of the de-icing vehicles can be significantly reduced.

BackgroundObservational studies have suggested U-shaped relationships between sleep duration and systolic blood pressure (SBP) with risks of many cardiovascular diseases (CVDs), but the cut-points that separate high-risk and low-risk groups have not been confirmed. We aimed to examine the U-shaped relationships between sleep duration, SBP, and risks of CVDs and confirm the optimal cut-points for sleep duration and SBP.MethodsA retrospective analysis was conducted on NHANES 2007–2016 data, which included a nationally representative sample of participants. The maximum equal-odds ratio (OR) method was implemented to obtain optimal cut-points for each continuous independent variable. Then, a novel “recursive gradient scanning method” was introduced for discretizing multiple non-monotonic U-shaped independent variables. Finally, a multivariable logistic regression model was constructed to predict critical risk factors associated with CVDs after adjusting for potential confounders.ResultsA total of 26,691 participants (48.66% were male) were eligible for the current study with an average age of 49.43 ± 17.69 years. After adjusting for covariates, compared with an intermediate range of sleep duration (6.5–8.0 h per day) and SBP (95–120 mmHg), upper or lower values were associated with a higher risk of CVDs [adjusted OR (95% confidence interval) was 1.20 (1.04–1.40) for sleep duration and 1.17 (1.01–1.36) for SBP].ConclusionsThis study indicates U-shaped relationships between SBP, sleep duration, and risks of CVDs. Both short and long duration of sleep/higher and lower BP are predictors of cardiovascular outcomes. Estimated total sleep duration of 6.5–8.0 h per day/SBP of 95–120 mmHg is associated with lower risk of CVDs.

The complex layout of the airport surface, coupled with interrelated vehicle behaviors and densely mixed traffic flows, frequently leads to operational conflict risks. To address this issue, research was conducted on the recognition of characteristics and risk assessment for airport surface operations in mixed traffic flows. Firstly, a surface topological network model was established based on the analysis of the physical structure features of the airport surface. Based on the Monte Carlo simulation method, the simulation framework for airport surface traffic operations was proposed, enabling the simulation of mixed traffic flows involving aircraft and vehicles. Secondly, from various perspectives, including topological structural characteristics, network vulnerabilities, and traffic complexity, a comprehensive system for feature indices and their measurement methods was developed to identify risk hotspots in mixed traffic flows on the airport surface, which facilitated the extraction of comprehensive risk elements for any node’s operation. Finally, a weighting rule for risk hotspot feature indices based on the CRITIC–entropy method was designed, and a risk assessment method for surface operations based on TOPSIS–gray relational analysis was proposed. This method accurately measured risk indices for airport surface operations hotspots. Simulations conducted at Shenzhen Bao’an International Airport demonstrate that the proposed methods achieve high simulation accuracy. The identified surface risk hotspots closely matched actual conflict areas, resulting in a 20% improvement in the accuracy of direct risk hotspot identification compared to simulation experiments. Additionally, 10.9% of nodes in the airport surface network were identified as risk hotspots, including 3 nodes with potential conflicts between aircraft and ground vehicles and 21 nodes with potential conflicts between aircraft. The proposed methods can effectively provide guidance for identifying potential “aircraft–vehicle” conflicts in complex airport surface layouts and scientifically support informed decisions in airport surface operation safety management.

Airport arrival and departure movements are characterized by high dynamism, stochasticity, and uncertainty. Therefore, it is of paramount importance to predict and analyze surface taxi time accurately and scientifically. This paper conducts a comprehensive review of existing studies on surface taxi time prediction and analysis. Firstly, the overall research framework of surface taxi time prediction and analysis is categorized from three perspectives: taxi time type, movement type, and modeling method. Then, focusing on the two means of taxi time analytical modeling and simulation modeling, the existing mainstream models and methods are categorized, and the main ideas and scope of application of the various methods are analyzed. Finally, the paper presents the future development direction of surface taxi time prediction prospects. The research results are aimed at providing basic support and methodological guidance for reducing the uncertainty in airport surface operation and enhancing the level of control and decision-making ability of airport surface operation.

Metabolic interactions within gut microbiota play a vital role in human health and disease. Targeting metabolically interacting bacteria could provide effective treatments; however, obtaining functional bacteria remains a significant challenge due to the complexity of gut microbiota. Here, we developed a facile droplet-based approach to isolate and enrich functional gut bacteria that could utilize metabolites from an engineered butyrate-producing bacteria (EBPB) of anti-obesity potential. This involves the high throughput formation of single-bacteria droplets, followed by culturing “droplets” on agar plates to form discrete single-cell colonies. This approach eliminates the need for sophisticated s instruments to sort droplets and thus allows the operation hosted in a traditional anaerobic chamber. In comparison to the traditional culture, the droplet-based approach obtained a community of substantially higher diversity and evenness. Using the conditioned plates containing metabolites from the EBPB supernatant, we obtained gut bacteria closely associated or interacting with the EBPB. These include anaerobic Lactobacillus and Bifidobacterium, which are often used as probiotics. The study illustrates the potential of our approach in the search for the associated bacteria within the gut microbiota and retrieving those yet-to-be cultured.

Congestion in airports and metroplexes is increasingly becoming a key bottleneck in the global air transport system. It is largely due to inefficient utilization of runway resources and its consequences of imbalance between demand and capacity. Existing studies mainly focus on runway configuration in a single airport system, and little consideration is given to the impact of demand management on runway configuration in metroplexes. Therefore, this paper proposes a methodology and assessment framework for runway configuration with a focus on the exploitation of multiple active runways in metroplex airports. The primary innovation is an integrated runway configuration management formulation with air traffic demand management options. The first is static and dynamic runway configuration management models featuring three optimization objectives, four cases of demand-capacity imbalance, three air traffic demand management options and three assessment scenarios, for eleven priority settings. The second is an efficient multi-objective evolutionary algorithm with a mechanism of objective-guided individual selection, which can obtain close-to optimal solutions with a very low computational cost within 6 seconds. Computational experiments for the real-world case of the Shanghai metroplex airports show that, the inducing strategy of minimizing the total number of adjusted flights is the best mechanism for making satisfactory tradeoffs among multiple objectives in dynamic runway configuration. The proposed model reduces the total number of adjusted flights by an average of 36% compared with the baseline static runway configuration management. Furthermore, unlike the conventional approach of giving priority to arriving aircraft, a higher priority for departures is more effective in enhancing the performance of runway systems and reducing the number of adjusted flights. The proposed framework can be applied at pre-tactical (e.g., one-day planning) as well as tactical (e.g., several-hours rolling horizon) levels.

Airspace sectorization is a powerful means to balance the increasing air traffic flow and limited airspace resources, which is related to the efficiency and safety of operations. In order to divide sectors reasonably, a multi-objective optimization framework for 3D airspace sectorization is proposed in this paper, including four core modules: Flight clustering, sector generation, workload evaluation, and sector optimization. Specifically, it clusters flights and generates initial sectors using a Voronoi diagram. To further optimize sector shape, the concept of dynamic density is introduced to evaluate the controller workload, based on which a sector optimization model is constructed. The model not only considers intra-sector and inter-sector workloads as objective functions but also sets hard constraints to meet operation and safety requirements. To solve it, a Non-dominated Sorting Genetic Algorithm II (NSGA-II) with prior knowledge and an external archive is designed. By analyzing the optimization results of actual operational data in the Singapore regional airspace, our approach obtains diverse optimal sectorization schemes for decision makers to choose from. Qualitative and quantitative experimental results confirm that the initial population strategy with prior knowledge significantly accelerates the convergence process. At the same time, the mechanism of the external archive effectively enriches the diversity of solutions.

In view of the common U-shaped apron structure of large- and medium-sized airports at home and abroad, this study considered the optimization design and performance evaluation of the U-shaped apron operation procedure. First, by analyzing the physical structure characteristics and traffic operation characteristics of the U-shaped area, exclusive, partition-shared, and global-shared operation procedures of the U-shaped area were designed, and differentiated apron-operation rules and traffic models were constructed for different types of operation procedures. Then, from the perspectives of safety, efficiency, and environmental protection, a multi-dimensional evaluation index system of U-shaped area operation performance is established, and a classification measurement and comprehensive evaluation method based on critique is proposed. Finally, a traffic simulation model was established based on airport network topology modeling. We used Monte Carlo methods for the simulation in Python 3.6, and the experimental results show that, in the scenario of high-density traffic operation, compared with exclusive and partition-shared procedures, the implementation effect of the global shared procedure is very significant, and the apron operation capacity increased by 14.8% and 5.0%, respectively. The probability of aircraft conflict decreased by 32.2% and 11.8%, respectively, and the time of single conflict relief decreased by 16.1 s and 10.6 s, respectively. The average resource utilization in each U-shaped area increased by 66% and 25%, respectively, while the average daily carbon emissions of a single aircraft were reduced by 16.7 kg and 11.0 kg and the average daily fuel consumption of a single aircraft were reduced by 3.6 kg and 2.4 kg, respectively. The proposed method is scientific and effective and can provide theoretical and methodological support for optimizing the configuration of the scene operation mode of complex airports and for improving flight operation efficiency.

The runway system is more likely to be a bottleneck area for airport operations because it serves as a link between the air routes and airport ground traffic. As a key problem of air traffic flow management, the aircraft runway scheduling problem (ARSP) is of great significance to improve the utilization of runways and reduce aircraft delays. This paper proposes a large neighborhood search algorithm combined with simulated annealing and the receding horizon control strategy (RHC-SALNS) which is used to solve the ARSP. In the framework of simulated annealing, the large neighborhood search process is embedded, including the breaking, reorganization and local search processes. The large neighborhood search process could expand the range of the neighborhood building in the solution space. A receding horizon control strategy is used to divide the original problem into several subproblems to further improve the solving efficiency. The proposed RHC-SALNS algorithm solves the ARSP instances taken from the actual operation data of Wuhan Tianhe Airport. The key parameters of the algorithm were determined by parametric sensitivity analysis. Moreover, the proposed RHC-SALNS is compared with existing algorithms with excellent performance in solving large-scale ARSP, showing that the proposed model and algorithm are correct and efficient. The algorithm achieves better optimization results in solving large-scale problems.

Air transportation is a huge, complex system with emergence and self-organization, which makes it important for it to be modelled. In this paper, to model the air transportation system with more accuracy, from physical facilities to traffic applications, three-layer networks, including the air route network, the city-pair airline network, and flight operation network, are built, where the air route network is regarded as the physical layer, and city-pair airline network and flight operation network are the application layers. Furthermore, a powerful tool, complex network theory, is applied to discuss the topology characteristics of the three-layer networks. Moreover, considering the path diversity of city-pair airlines, a simulated annealing-based framework is proposed to optimize the routing paths on an air route network for each city-pair airline, such that the traffic congestion of the air route network can be alleviated, where an elaborated method for perturbing solutions, named Selection after Remove (SAR), is adopted. Experimental results show that, compared with the default routing paths, the shortest routing paths, and the random routing paths, the proposed routing-path optimization strategy can reduce the maximum traffic flows of the air route network by 2.4%, 4.6%, and 4.8%, respectively, which shows that the proposed optimization method performs well in alleviating the traffic congestion of the air route network.

Gate allocation has always been a fundamental but critical issue in the daily operation of airports, which is related to service quality and schedule efficiency. In order to obtain reasonable and efficient gate allocation results, in this paper, a multi-commodity network flow model is proposed to describe the gate allocation process in flight flow, based on which a multi-objective optimization model is constructed. It not only comprehensively considers the flight information of aircraft arrivals and departures, but also integrates the broader interests of passengers, airlines, and airports. To solve it, a linear weighting technique is applied. In addition, K-means cluster analysis is used to explore different weight combinations, and on this basis, the idle time of the gate is introduced as a performance evaluation index to guide the selection of the final weight. By analyzing the optimization results of actual operation data, the proposed model significantly balances the interests of multiple parties and the number of flights at each gate and has a relatively high gate-utilization rate. It can provide rich decision support and a reasonable allocation scheme for airport management to a certain extent.