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Hand, foot and mouth disease (HFMD) is a widespread infectious disease that causes a significant disease burden on society. To achieve early intervention and to prevent outbreaks of disease, we propose a novel warning model that can accurately predict the incidence of HFMD.We propose a spatial-temporal graph convolutional network (STGCN) that combines spatial factors for surrounding cities with historical incidence over a certain time period to predict the future occurrence of HFMD in Guangdong and Shandong between 2011 and 2019. The 2011-2018 data served as the training and verification set, while data from 2019 served as the prediction set. Six important parameters were selected and verified in this model and the deviation was displayed by the root mean square error and the mean absolute error.As the first application using a STGCN for disease forecasting, we succeeded in accurately predicting the incidence of HFMD over a 12-week period at the prefecture level, especially for cities of significant concern.This model provides a novel approach for infectious disease prediction and may help health administrative departments implement effective control measures up to 3 months in advance, which may significantly reduce the morbidity associated with HFMD in the future.

This paper presents a layered and integrated approach to the SCC system in TT&C area. The SCC system is developed to encapsulate this approach. A four-layer hierarchy is proposed for the SCC system among the following layers: user agent layer, application process layer, lower layer services and support, and hardware. The SCC system includes nine functional components: monitoring and control, data display, command operation, data processing, data storage and management, orbit calculation and analysis, interface computer software, duplex management and time service. The SCC system is implemented as five functional subsystems: data processing system, database management system, operation and control system, and interface computer system. Details of the overall system architecture and the integration of the above components and subsystems are included in the paper.

Three novel cyclometalated ligands 1-benzyl-2-phenyl-1H-benzoimidazole(BPBM), 1-(4-methoxy-benzyl)-2-(4-methoxy-phenyl)-1H-benzoimidazole(MBMPB) and 4-[2-(4-dimethylamino-phenyl)-benzoinidazol-1-ylmethyl]-phenyl-dimethyl-amine(DBPA) were designed and synthesized, and the corresponding highly efficiency green-emitting phosphorescent iridium complexes Ir(BPBM)(2)(acac)(1), Ir(MBMPB)(2)(acac)(2) and Ir(DPBA)(2)(acac) (3) with acetylacetone(acac) as auxiliary ligand were also synthesized. The ligands are functionalized by bulky non-planarity substituents, thus the phosphorescent concentration quenching is substantially suppressed, and all the complexes exhibit bright photoluminescence(PL) in solid state. The photo-physical properties of the three iridium complexes were researched in detail. The results indicate that they have potential application in fabricating non-doped electrophosphorescence device.

According to the production process of grade 45 steel(120tBOF→slag refining→ CC), some system analysis are introduced to research on the type composition and quantity of micro-inclusions, and the effect of slag washing production process on the cleanliness of casting slab is evaluated. The results of the study show that: The content of T[O] is 48.75ppm in normal slab, The content of T[O] is 56.2ppm in head slab, The content of T[O] is 49.2ppm in compound casting slab.The main types of micro-inclusion in slab are MnS inclusion and Al2O3 inclusion. The quality of micro-inclusions is 14.32/mm2 in the normal slab, the quality of micro-inclusions is 17.68 /mm2 in the head slab, the quality of micro-inclusions is 27.94 /mm2 in the compound casting. In the normal slab, the average total volume ratio of micro-inclusions is 0.0458%. The particle size of micro-inclusions is smaller. The particle size of less than 10μm in micro-inclusions is the largest and is about 80%.

The research about the macro-inclusions of three processes: BOF→ LF→ CC, BOF→ RH→ CC and BOF→ LF→ RH→ CC, shows that: The types of inclusion are SiO2-Al2O3-CaO-TiO2-MnO, SiO2 and SiO2-Al2O3. The content of SiO2-Al2O3- CaO-TiO2-MnO in the three processes are 34.2%、23.5% and 27%; The content of SiO2 are 24.4%、47% and 27%; The content of SiO2-Al2O3 are 26.8%、17.6% and 9%. Large inclusion>300μm takes up 69.8%~85% of the total inclusion in billet in three technological processes, and the inclusion, containing K and Na, is the most; slag entrapment in mould is really serious. Considering the cleanliness and cost, the better technological process of MRT3-BA stamping steel is BOF→ RH→ CC.

Using first-principles density-functional theory investigate (5, 5) capped single-walled carbon nanotubes adsorbed at one end by hydrogen molecule with and without an applied electric field. It is found that the structure of carbon nanotubes with hydrogen molecules is stable under field-emission conditions. The induced dipole moments is the direction of the applied electric field，and the LUMO-HOMO energy gaps decrease. These results elucidate that the field-emission properties of carbon nanotubes can be enhanced by the adsorption of hydrogen molecules, and are consistent with the experimental results.

To understand the clinical features of death from hand, foot and mouth disease (HFMD) and to explore the early warning index of HFMD death.A total of 41 HFMD death cases were collected as case group in Shandong province between 2009 and 2011, and another 123 serious HFMD cases were selected as control group according to the similar gender, place of origin and hospital level, with the ratio at 1:3. We investigated the general situation, clinical treatment, past medical history, clinical symptoms and signs of the ill children, and applied the conditional logistic regression to explore early warning index of HFMD death.The rate of patients who had symptoms in nervous system, digestive system, circulatory system and respiratory system were separately 90.2% (37/41), 58.5% (24/41), 53.7% (22/41) and 90.2% (37/41) in case group; and the proportions were 44.7% (55/123), 13.8% (17/123), 10.6% (13/123) and 12.2% (15/123) respectively in control group. The difference between the two groups showed statistical significance (χ(2) = 25.881, 32.791, 34.011, 86.505, P0.05). In case group, 37 patients had neurogenic pulmonary edema, 26 patients got encephalitis, 15 patients had respiratory and circulatory failure, 7 patients got pulmonary hemorrhage, 4 patients had multiple organ failure, 4 patients got myocarditis and 1 patient had cerebral hernia. According to multi-factor logistic regression analysis, the early warning indicators of HFMD death included neck resistance (case group: 34.1% (14/41), control group: 4.1% (5/123); OR = 7.145, 95%CI: 1.748 - 29.204), vomiting (case group: 58.5% (24/41), control group: 13.8% (17/123); OR = 5.632, 95%CI: 1.793 - 17.685) and increase of heart rate (case group: 53.7% (22/41), control group: 10.6% (14/123), OR = 6.370, 95%CI: 1.517 - 26.743).In the process of clinical treatment and care, we should interfere the serious HFMD patients with neck resistance, vomiting and increase of heart rate, and thereby reduce the death from HFMD.

Objective Severe fever with thrombocytopenia syndrome (SFTS) is an emerging hemorrhagic fever caused by a tick-borne bunyavirus (SFTSV) in East Asian countries. The role of human leukocyte antigen (HLA) in resistance and susceptibility to SFTSV is not known. We investigated the correlation of HLA locus A, B and DRB1 alleles with the occurrence of SFTS. Methods A total of 84 confirmed SFTS patients (patient group) and 501 unrelated non-SFTS patients (healthy individuals as control group) from Shandong Province were genotyped by PCR-sequence specific oligonucleotide probe (PCR-SSOP) for HLA-A, B and DRB1 loci.Allele frequency was calculated and compared using χ2 test or the Fisher's exact test. A corrected P value was calculated with a bonferronis correction. Odds Ratio (OR) and 95% confidence intervals (CI) were calculated by Woolf’s method. Results A total of 11 HLA-A, 23 HLA-B and 12 HLA-DRB1 alleles were identified in the patient group, whereas 15 HLA-A, 30 HLA-B and 13 HLA-DRB1 alleles were detected in the control group. The frequencies of A*30 and B*13 in the SFTS patient group were lower than that in the control group (P = 0.0341 and 0.0085, Pc = 0.5115 and 0.252). The ORs of A*30 and B*13 in the SFTS patient group were 0.54 and 0.49, respectively. The frequency of two-locus haplotype A*30-B*13 was lower in the patient group than in the control group(5.59% versus 12.27%, P = 0.037,OR = 0.41, 95%CI = 0.18–0.96) without significance(Pc>0.05). A*30-B*13-DRB1*07 and A*02-B*15-DRB1*04 had strong associations with SFTS resistance and susceptibility respectively (Pc = 0.0412 and 0.0001,OR = 0.43 and 5.07). Conclusion The host HLA class I polymorphism might play an important role with the occurrence of SFTS. Negative associations were observed with HLA-A*30, HLA-B*13 and Haplotype A*30-B*13, although the associations were not statistically significant. A*30-B*13-DRB1*07 had negative correlation with the occurrence of SFTS; in contrast, haplotype A*02-B*15-DRB1*04 was positively correlated with SFTS., Author Summary Severe fever with thrombocytopenia syndrome (SFTS) is an emerging hemorrhagic fever caused by a tick-borne bunyavirus (SFTSV) in East Asian countries. The role of human leukocyte antigen (HLA) in resistance and susceptibility to SFTSV is not known. In this study, we investigated the correlation of HLA locus A, B and DRB1 alleles with the occurrence of SFTS. Our results have expanded the knowledge of the association of HLA genes with SFTS. Our study may be helpful to state the relationship between the occurrence of SFTS with HLA alleles or haplotypes and provide scientific basis for study on pathogenesis and vaccine development.

Stationary and transient spectroscopic studies on the eosin bis(diphenyliodonium) salt/triethylamine (Eo(IPh 2 ) 2 /TEA) system were carried out in comparison with Eo(IPh 2 ) 2 alone. In non-polar solvents where Eo(IPh 2 ) 2 forms contact ion pairs. TEA molecules insert themselves between the anions and cations, resulting in the formation of amine-separated ion pairs. When exposed to visible light, Eo(IPh 2 ) 2 / TEA undergoes oxidative electron transfer firstly. Synergetic effects of amines on Eo(IPh 2 ) 2 were found for which a cyclic regenerative mechanism was proposed. Eo(IPh 2 ) 2 /TEA was applicable for various monomers and unsaturated oligomers, especially of the acrylate type, even in the presence of oxygen. Concentration effects of Eo(IPh 2 ) 2 , amine and monomer were also investigated.

The calorific value of coal is an important factor for the economic operation of coal fired power plant. However calorific value is tremendous difference between the different coal, and even if coal is from the same mine. Restricted by the coal market, most of coal fired power plants can not burn the designed-coal by now in China. The properties of coal as received are changing so frequently that pulverized coal firing is always with the unexpected condition. Therefore, the researches on the on-line prediction of calorific value of coal has a profound significance for the economic operation of power plants. Aiming at the problem of uncertainty of calorific value of coal, a soft measurement model for calorific value of coal is proposed based on the BP neural network with appropriate optimization. It is shown by an example that the optimized model, which could be established at a high rate of speed, was at the higher training accuracy and with generalization ability. The model could provide a good guidance for the calculation of the calorific value of coal and optimization operation of coal fired power plants.

A sensitive method has been developed for the simultaneous determination of 10 benzimidazole residues and some of their metabolites in egg, milk, chicken, and pork. This method is based on the combination of polymer monolith microextraction (PMME) technique with liquid chromatography and electrospray ionization mass spectrometry (LC-ESI/MS). The extraction was performed with a poly(methacrylic acid-co-ethylene glycol dimethacrylate) (MAA-co-EGDMA) monolithic capillary column. Under the optimized extraction conditions, good extraction efficiencies for the targets were obtained with no matrix interference in the subsequent detection. The LODs (S/N=3) for 10 benzimidazoles were found to be 0.56-2.76 ng g(-1) in egg, 0.50-1.41 ng mL(-1) in milk, 0.09-0.28 ng g(-1) in chicken, and 0.08-0.15 ng g(-1) in pork. The recoveries in egg, milk, chicken, and pork matrices ranged from 75.2 to 116.8% spiked at different levels with analytes, with RSDs of

To construct the bait vector pGBKT7-TACEc (cytoplasmic tail of tumor necrosis factor-alpha converting enzyme) of Macthmaker GAL4 Two-hybrid System 3, and to test whether it has self-activation and toxic action.TACEc gene was amplified by RT-PCR from the mouse testis, and the EcoRI and BamHI sites were introduced into it. The TACEc gene, after sequenced, was cloned into pGBKT7. Self-activation and toxic action of the recombination vector pGBKT7-TACEc was tested.The pGBKT7-TACEc vector was successfully constructed and proved of no self-activation and toxic action.The pGBKT7-TACEc can be applied to the screening of the mouse testis cDNA library in the yeast two-hybrid system.