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Observing the structure and regeneration of the myelin sheath in peripheral nerves following injury and during repair would help in understanding the pathogenesis and treatment of neurological diseases caused by an abnormal myelin sheath. In the present study, transmission electron microscopy, immunofluorescence staining, and transcriptome analyses were used to investigate the structure and regeneration of the myelin sheath after end-to-end anastomosis, autologous nerve transplantation, and nerve tube transplantation in a rat model of sciatic nerve injury, with normal optic nerve, oculomotor nerve, sciatic nerve, and Schwann cells used as controls. The results suggested that the double-bilayer was the structural unit that constituted the myelin sheath. The major feature during regeneration was the compaction of the myelin sheath, wherein the distance between the 2 layers of cell membrane in the double-bilayer became shorter and the adjacent double-bilayers tightly closed together and formed the major dense line. The expression level of myelin basic protein was positively correlated with the formation of the major dense line, and the compacted myelin sheath could not be formed without the anchoring of the lipophilin particles to the myelin sheath. [ABSTRACT FROM AUTHOR]

The disassembly line is the best choice for automated disassembly of disposal products. Therefore, disassembly line should be designed and balanced so that it can work as efficiently as possible. In this paper, a mathematical model for the multi-objective disassembly line balancing problem is formalized firstly. Then, a novel multi-objective ant colony optimization (MOACO) algorithm is proposed for solving this multi-objective optimization problem. Taking into account the problem constraints, a solution construction mechanism based on the method of tasks assignment is utilized in the algorithm. Additionally, niche technology is used to embed in the updating operation to search the Pareto optimal solutions. Moreover, in order to find the Pareto optimal set, the MOACO algorithm uses the concept of Pareto dominance to dynamically filter the obtained non-dominated solution set. To validate the performance of algorithm, the proposed algorithm is measured over published results obtained from single-objective optimization approaches and compared with multi-objective ACO algorithm based on uniform design. The experimental results show that the proposed MOACO is well suited to multi-objective optimization in disassembly line balancing. [ABSTRACT FROM AUTHOR]

In order to solve the complex multi-objective optimal performance design of large-scale injection molding machines, NSGA-II is used to find a much better spread of design solutions and better convergence near the true Pareto-optimal front. The combination of the design method and the injection molding machine is discussed. Screw diameter performance, stick inside distance performance, mold moving route performance and mold-locked force performance are chosen as the four main performance evaluation indexes. Some related parameters are associated to get a performance indication. And performance optimization design parameter constraints are listed to make the design solutions to have practical significance. The mathematical models of two objectives and the mathematical models of three objectives are analyzed. Finally, the instance of HTF180X1N large-scale injection molding machine is taken as an example to demonstrated that such method is effective and practical. [ABSTRACT FROM AUTHOR]