609 results on '"Jian-Hua, Zhu"'
Search Results
2. Protective effect of N-acetylcysteine on acute lung injury in septic rats by inhibiting inflammation, oxidation, and apoptosis
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Jian-wei Le, Min Sun, Jian-hua Zhu, and Heng Fan
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acute lung injury ,apoptosis ,inflammation ,n-acetylcysteine ,oxidative stress ,sepsis ,Medicine - Abstract
Objective(s): Acute lung injury (ALI) is a common comorbidity in patients with sepsis, and finding drugs that can effectively reduce its mortality is a hot spot in current research. The purpose of this study is to explore the protective mechanism of N-acetylcysteine (NAC) on ALI in septic rats.Materials and Methods: We used NAC to intervene in septic rats to evaluate the plasma inflammatory factors and lung tissue pathological damage. Biochemical methods were used to determine the levels of oxidases in lung tissue, the expression of inducible nitric oxide synthase (iNOS) and endothelial nitric oxide synthase (eNOS) proteins, and observed lung tissue cell apoptosis.Results: NAC pretreatment decreased the mortality of septic rats, improved lung tissue pathological damage, reduced the levels of tumor necrosis factor-α, interleukin-1β, interleukin-6, interleukin-8, and malondialdehyde, and increased activity of superoxide dismutase, glutathione peroxidase, and catalase. Moreover, NAC pretreatment significantly decreased iNOS protein expression and increased eNOS protein expression in lung tissue. Meanwhile, NAC significantly decreased the number of apoptosis and the levels of Bax and Caspase-3 mRNA and increased the level of Bcl-2 mRNA in the lung tissue of septic rats. Conclusion: NAC protects ALI in septic rats by inhibiting inflammation, oxidative stress, and apoptosis.
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- 2022
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3. Tumor-induced osteomalacia characterized by 'painful knee joint with difficulty in moving': a case report
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Lan Jiang, Qing-Qing Tan, Chen-Lin Gao, Ling Xu, Jian-Hua Zhu, Pi-Jun Yan, Ying Miao, Qin Wan, and Yong Xu
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Tumor-induced osteomalacia ,Fibroblast growth factor-23 ,Hypophosphatemia ,68Ga DOTATATE PET/CT ,Case report ,Diseases of the endocrine glands. Clinical endocrinology ,RC648-665 - Abstract
Abstract Background Tumor-related osteomalacia (TIO) is a rare paraneoplastic syndrome characterized by severe hypophosphatemia and osteomalacia. The diagnosis of TIO can be very difficult because of its nonspecific nature of clinical manifestations. Here we reported a case of young TIO patient with “painful knee joint with difficulty in moving” to improve the clinical diagnosis and treatment levels. Case presentation The patient’s clinical features were consistent with TIO. A tumor was successfully located in left tibial by 68Ga-DOTATATE PET/CT, and then was surgically resected. Upon pathologic assessment, the tumor was diagnosed as phosphaturia stromal tumor (PMT) with positive Vim staining. After the surgery, serum phosphate level rapidly recovered and symptoms significantly improved. Conclusion TIO should be considered in patients with chronically hypophosphorus osteomalacia in the setting of no family history. Early removal of the responsible tumors is clinically essential for the treatment, and imaging examination is of great significance for tumor localization.
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- 2022
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4. Molecular and clinical features of papillary thyroid cancer in adult patients with a non-classical phenotype
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Jie Zhou, Wei-Ran Wang, Hui-Fang Zhang, Qi-Qi Gao, Wei-Bin Wang, Jian-Hua Zhu, Yu-Shuai Han, Jing Chen, Tong-Hui Ma, Xiao-Yan Zhang, and Xiao-Dong Teng
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papillary thyroid carcinoma ,phenotype ,gene fusion ,ETV6-NTRK3 ,NCOA4-RET ,Diseases of the endocrine glands. Clinical endocrinology ,RC648-665 - Abstract
PurposeGenotyping is fundamental in papillary thyroid cancer (PTC) and helps to enhance diagnosis and prognosis and determine appropriate treatments. The phenotype-genotype association in PTC was previously studied, with BRAF V600E characterizing classic PTC and tall-cell PTC and RAS mutations characterizing follicular-variant PTC. In clinic, some non-classical histological subtypes of PTC were also identified, however, their genotype remains unclear. In this study, we collected samples of these non-classical PTC after the exclusion of classic phenotypes and examined their phenotypes, genotype and the relationship between phenotype and genotype.MethodsWe screened out non-classical PTC by excluding classical PTC from 1,059 different thyroid samples, and a total of 24 cases was obtained and described from the morphological features, which is rare in differentiated PTC. DNA/RNA sequencing was performed using 18 available samples to describe the genetic features.ResultsPTC with the non-classical phenotype were characterized cuboidal to low columnar tumor cells with subtle nuclear features of PTC and without discernible nuclear elongation, concurrently with dense microfollicles, delicate papillae or solid nodules with delicate fibrovascular cores. They were associated with lymphatic vessel invasion (P
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- 2023
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5. N-acetylcysteine protects septic acute kidney injury by inhibiting SIRT3-mediated mitochondrial dysfunction and apoptosis.
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Heng Fan, Jian-wei Le, Min Sun, and Jian-hua Zhu
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ACUTE kidney failure ,APOPTOSIS ,NITRIC-oxide synthases ,MITOCHONDRIA ,TRANSMISSION electron microscopes - Abstract
Objective(s): To investigate the protective effect of N-acetylcysteine (NAC) on septic acute kidney injury (SAKI) via regulating Sirtuin3 (SIRT3)-mediated mitochondrial dysfunction and apoptosis. Materials and Methods: By constructing SIRT3 knockout mice and culturing kidney tubular epithelial cells (KTECs), we assessed the changes of renal function and detected the protein expression of adenine nucleotide translocator (ANT), cyclophilin (CypD) and voltage-dependent anion channel (VDAC) using western-blotting, and simultaneously detected toll-like receptor 4 (TLR4), inhibitor of kappa B kinase (IKKβ), inhibitor of Kappa Bα (IκBα), and p65 protein expression. We observed mitochondrial damage of KTECs using a transmission electron microscope and assessed apoptosis by TdT-mediated dUTP Nick-End Labeling and flow cytometry. Results: SIRT3 deficiency led to the deterioration of renal function, and caused a significant increase in inducible nitric oxide synthase production, a decrease in mitochondrial volume, up-regulation of TLR4, IκBα, IKKβ, and p65 proteins, and up-regulation of ANT, CypD and VDAC proteins. However, NAC significantly improved renal function and down-regulated the expression of TLR4, IκBα, IKKβ, and p65 proteins. Furthermore, SIRT3 deficiency led to a significant increase in KTEC apoptosis, while NAC up-regulated the expression of SIRT3 and inhibited apoptosis. Conclusion: NAC has a significant protective effect on SAKI by inhibiting SIRT3-mediated mitochondrial dysfunction and apoptosis of KTECs. [ABSTRACT FROM AUTHOR]
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- 2024
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6. Sirtuin 3 deficiency promotes acute kidney injury induced by sepsis via mitochondrial dysfunction and apoptosis
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Heng Fan, Jian-wei Le, Min Sun, and Jian-hua Zhu
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acute kidney injury ,apoptosis ,mitochondria ,sepsis ,sirtuin3 ,Medicine - Abstract
Objective(s): To explore the regulation mechanism of Sirtuin 3 (SIRT3) on the mitochondrial function and apoptosis of acute kidney injury (AKI) in septic mice.Materials and Methods: The sepsis-induced AKI model was constructed in the wild-type and SIRT3 knockout (KO) mice, and the levels of serum creatinine (Scr) and plasma kidney injury molecule 1 (pKIM-1) in mice were detected by ELISA. The mitochondrial damage of kidney tubular epithelial cells (KTEC) was observed by electron microscopy, the apoptosis of KTEC was detected by TUNEL assay, and the mRNA levels of SIRT3, Bax, Caspase-3, and Bcl-2 were detected by RT-qPCR.Results: SIRT3 KO caused increased expression of Scr, pKIM-1, and inducible nitric oxide synthase protein in the kidneys of septic mice, and decreased the levels of superoxide dismutase, catalase, and mitochondrial complex enzymes I/II/III/IV. SIRT3 deficiency exacerbated histopathological and mitochondrial damage to the proximal tubules of the kidney. In addition, SIRT3 KO resulted in a significantly increased apoptosis of KTEC, increased the mRNA levels of Bax and Caspase-3, and decreased the mRNA levels of Bcl-2. Conclusion: Our study suggests that SIRT3 deficiency promotes sepsis-induced AKI via increasing oxidative stress, mitochondrial dysfunction, and inducing apoptosis.
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- 2021
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7. Feasibility and Efficacy of a Degradable Magnesium-Alloy GBR Membrane for Bone Augmentation in a Distal Bone-Defect Model in Beagle Dogs
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Zi-Yu Yan, Jian-Hua Zhu, Guan-Qi Liu, Zhi-Chao Liu, Chuan-Bin Guo, Nian-Hui Cui, and Jian-Min Han
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Biotechnology ,TP248.13-248.65 ,Inorganic chemistry ,QD146-197 - Abstract
We explored the feasibility and efficacy of a degradable magnesium (Mg) alloy guided bone regeneration (GBR) in the treatment of bone defects after tooth extraction. A GBR membrane (MAR-Gide (MG)) was used to treat a mandibular second molar (M2M)-distal bone defect (DBD). In eight beagle dogs, bilateral mandibular second and fourth premolars were hemi-sected. The distal roots were removed to create a two-wall bony defect of dimension 5 mm × 5 mm × 5 mm to simulate M2M-DBD. Thirty-two bone defects were assigned randomly into four groups according to GBR membranes (MG and Bio-Gide (BG)) applied and the time of killing (3 months and 6 months after surgery). The osteogenesis of bone defects and MG degradation were analyzed using micro-CT, histology (staining, tartrate-resistant acid phosphatase), and inductively coupled plasma mass spectrometry. MG did not increase the prevalence of infection, wound dehiscence, or subcutaneous emphysema compared with those using BG. Trabecular volume/total volume at 3 months (63.71 ± 10.4% vs. 59.97 ± 8.94%) was significantly higher in the group MG than that in the group BG. Implanted MG was degraded completely within 3 months, and “island-shaped” new bone was found near MG degradation products. A significant difference was not found in vertical bone height or percent of new bone formation (45.44 ± 12.28% vs. 43.49 ± 7.12%) between the groups. The concentration of rare-earth elements in mandibular lymph nodes of the group MG was significantly higher than that of the group BG (P≤0.017) but did not lead to histopathological changes. In summary, MG exhibited good biocompatibility and clinical applicability compared with BG in vivo. The osteogenic effect of MG could be enhanced by regulating the degradation rate of Mg-alloy.
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- 2022
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8. BAG2-Mediated Inhibition of CHIP Expression and Overexpression of MDM2 Contribute to the Initiation of Endometriosis by Modulating Estrogen Receptor Status
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Li-Juan Chen, Bin Hu, Zhi-Qiang Han, Jian-Hua Zhu, Xu Fan, Xue-Xing Chen, Zi-Ping Li, and Hao Zhou
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endometriosis ,estrogen receptor ,BAG2 ,CHIP ,MDM2 ,ubiquitin-proteasome pathway ,Biology (General) ,QH301-705.5 - Abstract
Endometriosis is an estrogen-dependent gynecological disease primarily affecting women of childbearing age, which gives rise to pelvic pain calling for multiple operations, and sometimes leading to infertility. However, the etiology of endometriosis remains poorly understood. In this study we investigated the roles of two Ubiquitin E3 Ligases, namely hsc70-interacting protein (CHIP) and mouse double minute 2 (MDM2), in the abnormal estrogenic activity in endometriosis. We first collected endometrial tissues from 91 cases of endometriosis and 78 cases of uterine myomas. Next, we established a murine endometriosis model by ectopic endometrial tissue implantation. In other studies, we isolated human endometrial stromal cells (HESCs) were isolated from the endometrial tissues, and performed HA- or FLAG-immunoprecipitation assays and immunoblotting with an anti-ubiquitin antibody to test the interactions among BAG2, CHIP, MDM2, estrogen receptor α (ERα), and ERβ. The expression of ERα was downregulated while that of ERβ, BAG2, and MDM2 was upregulated in human endometriosis and in the mouse model. CHIP degraded ERβ instead of ERα via the ubiquitin-proteasome pathway, while BAG2 impaired the CHIP-mediated degradation of ERβ in cultured HESCs derived from human endometriosis. The degradation of ERα by MDM2 in cultured endometriosis-HESCs also occurred through the ubiquitin-proteasome pathway. Knockdown of both BAG2 and MDM2 alleviated the development of endometriosis in mice. Our findings suggest that the interference of BAG2 and MDM2 may have therapeutic effects in endometriosis. Understanding better the molecular mechanisms underlying the regulation of the abnormal estrogenic activity in endometriosis is crucial for the advancement of targeted therapeutic strategies.
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- 2021
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9. Urinary neutrophil gelatinase-associated lipocalin, kidney injury molecule-1, N-acetyl-β-D-glucosaminidase levels and mortality risk in septic patients with acute kidney injury
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Heng Fan, Yu Zhao, Min Sun, and Jian-Hua Zhu
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sepsis ,acute kidney injury ,neutrophil gelatinase-associated lipocalin ,kidney injury molecule-1 ,N-acetyl--D-glucosaminidase ,Medicine - Published
- 2018
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10. The Role of Autophagy in Inflammatory Bowel Disease
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Bo-Zong Shao, Yi Yao, Jun-Shan Zhai, Jian-Hua Zhu, Jin-Ping Li, and Kai Wu
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inflammatory bowel disease ,autophagy ,inflammasome ,apoptosis ,mutation ,Physiology ,QP1-981 - Abstract
Inflammatory bowel disease (IBD) is an idiopathic intestinal inflammatory disease, including ulcerative colitis (UC) and Crohn’s disease (CD). The abnormality of inflammatory and immune responses in the intestine contributes to the pathogenesis and progression of IBD. Autophagy is a vital catabolic process in cells. Recent studies report that autophagy is highly involved in various kinds of diseases, especially inflammation-related diseases, such as IBD. In this review, the biological characteristics of autophagy and its role in IBD will be described and discussed based on recent literature. In addition, several therapies for IBD through modulating the inflammasome and intestinal microbiota taking advantage of autophagy regulation will be introduced. We aim to bring new insight in the exploration of mechanisms for IBD and development of novel therapeutic strategies against IBD.
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- 2021
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11. Carbonation Depth Model and Prediction of Hybrid Fiber Fly Ash Concrete
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Jing-shuang Zhang, Meng Cheng, and Jian-hua Zhu
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Engineering (General). Civil engineering (General) ,TA1-2040 - Abstract
The concrete is weakly alkaline, the alkalinity of the concrete will be reduced after being carbonized, and the protective effect of the concrete on the steel bar will be weakened, even leading to corrosion of the steel bar. In this paper, fly ash is used to replace cement in the same amount, and basalt fiber and polypropylene fiber are added in a certain amount to make hybrid fiber fly ash concrete. Through rapid carbonation test, the influence of carbonation time and fly ash content on carbonation performance of hybrid fiber fly ash concrete is studied. The curve is fitted according to a single factor carbonation model with fly ash content as the main parameter, and the fitting curve and prediction formula are obtained. The results show that, in the same carbonization time, compared with the concrete without fly ash, the concrete with fly ash content of 5%, 10%, 20%, and 30% has average carbonization depth promotion rates of 6.4%, 14.9%, 59.8%, and 73.5%. When the fly ash content varies in the range of 10%∼20%, the carbonation resistance of hybrid fiber concrete changes most sensitively. At the same fly ash content, with the increase of carbonization time, the carbonization depth of concrete increases by 41.7%∼62.3%; Through the verification of the fitting curve and fitting formula obtained after fitting, it is concluded that the error of the prediction formula of carbonation depth of hybrid fiber fly ash concrete is within 9.1%, and the error of carbonation depth of 14 d and 28 d is within 4.3%. Replacing cement with fly ash has certain engineering significance and can achieve the purpose of recycling waste materials.
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- 2020
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12. TAXODIOMERIA (TAXODIACEAE), AN INTERGENERIC HYBRID BETWEEN TAXODIUM AND CRYPTOMERIA FROM SHANGHAI, PEOPLE'S REPUBLIC OF CHINA
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Jian-Jun, Zhang, Shi-Hua, Pan, Zhu, Pan Shi-Hua, Wei-Jie, Wei-Jie, Zhu, Hui-Juan, Niu, Zheng-Ji, Ye, Jian-Hua, Zhu, Ping-Sheng, Hsu, and BioStor
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- 2003
13. Salidroside pretreatment protects against myocardial injury induced by heat stroke in mice
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Guo-dong Chen, Heng Fan, and Jian-Hua Zhu
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Medicine (General) ,R5-920 - Abstract
Objective To explore the protective effects and mechanisms of salidroside on myocardial injury induced by heat stroke (HS) in mice. Methods We pretreated mice with salidroside for 1 week and then established an HS model by exposure to 41.2°C for 1 hour. We then examined the effects of salidroside on survival. We also assessed the severity of cardiac injury by pathology, and analyzed changes in levels of myocardial injury markers, inflammatory cytokines, and oxidative stress. Results Salidroside pretreatment significantly reduced HS-induced mortality and improved thermoregulatory function. Salidroside also provided significant protection against HS-induced myocardial damage, and decreased the expression levels of cardiac troponin I, creatine kinase-MB, and lactate dehydrogenase. Moreover, salidroside attenuated HS-induced changes in the inflammation markers tumor necrosis factor-α, interleukin (IL)-6, and IL-10, and down-regulated the oxidative stress response indicated by thiobarbituric acid reactant substances, malondialdehyde, reduced glutathione, and superoxide dismutase. Conclusions Salidroside pretreatment protected against HS-induced myocardial damage, potentially via a mechanism involving anti-inflammatory and anti-oxidative effects.
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- 2019
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14. 14, 15-EET induces breast cancer cell EMT and cisplatin resistance by up-regulating integrin αvβ3 and activating FAK/PI3K/AKT signaling
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Jing Luo, Jian-Feng Yao, Xiao-Fei Deng, Xiao-Dan Zheng, Min Jia, Yue-Qin Wang, Yan Huang, and Jian-Hua Zhu
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Breast cancer ,14, 15-EET ,EMT ,Cisplatin resistance ,αvβ3/FAK/PI3K/AKT signaling ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Abstract Background 14,15-epoxyeicosatrienoic acid (14,15-EET) is an important lipid signaling molecule involved in the regulation of tumor metastasis, however, the role and molecular mechanisms of 14,15-EET activity in breast cancer cell epithelial-mesenchymal transition (EMT) and drug resistance remain enigmatic. Methods The 14, 15-EET level in serum and in tumor or non-cancerous tissue from breast cancer patients was measured by ELISA. qRT-PCR and western blot analyses were used to examine expression of integrin αvβ3. The role of 14, 15-EET in breast cancer cell adhesion, invasion was explored by adhesion and Transwell assays. The role of 14, 15-EET in breast cancer cell cisplatin resistance in vitro was determined by MTT assay. Western blot was conducted to detect the protein expressions of EMT-related markers and FAK/PI3K/AKT signaling. Xenograft models in nude mice were established to explore the roles of 14, 15-EET in breast cancer cells EMT and cisplatin resistance in vivo. Results In the present study, we show that serum level of 14, 15-EET increases in breast cancer patients and 14, 15-EET level of tumor tissue is higher than that of non-cancerous tissue. Moreover, 14, 15-EET increases integrin αvβ3 expression, leading to FAK activation. 14, 15-EET induces breast cancer cell EMT via integrin αvβ3 and FAK/PI3K/AKT cascade activation in vitro. Furthermore, we find that 14, 15-EET induces breast cancer cells EMT and cisplatin resistance in vivo, αvβ3 integrin and the resulting FAK/PI3K/AKT signaling pathway are responsible for 14, 15-EET induced-breast cancer cells cisplatin resistance. Conclusions Our findings suggest that inhibition of 14, 15-EET or inactivation of integrin αvβ3/FAK/PI3K/AKT pathway could serve as a novel approach to reverse EMT and cisplatin resistance in breast cancer cells.
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- 2018
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15. Capturing formaldehyde in cigarette smoke by zeolite and porous sorbents
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Xian Dan Sun, Jing Yang, Yi Cao, and Jian Hua Zhu
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A spectrophotometric method of pararosaniline hydrochloride is reported for rapid determination of formaldehyde (HCHO) content in cigarette smoke in common lab and it has been used to assess the removal of HCHO by zeolites and other porous sorbents conveniently. Through the evaluation in nitrogen flow and cigarette smoke, some porous sorbents were found to exert the attractive performance in capture of HCHO in smoke even in the harsh experiment, which is proven by ISO standard test and provided some candidates for environment protection.
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- 2022
16. New Design to Provide Absolute Protection Within a Certain Period for Biodegradable Magnesium Alloys
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Jian-Hua Zhu, Xinzhe Gao, Biying Shi, Jiawei Zou, Yu Ru Li, Ke Zeng, Qi Jia, and Heng Bo Jiang
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Biomedical Engineering ,Biophysics - Published
- 2023
17. Health insurance status and risk factors of mortality in patients with septic acute kidney injury in Ningbo, China
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Heng Fan, Yu Zhao, Guo-dong Chen, Min Sun, and Jian-Hua Zhu
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Medicine (General) ,R5-920 - Abstract
Objective To investigate the relationship between health insurance status and outcomes of septic acute kidney injury (AKI) related hospitalizations in an intensive care unit (ICU) in Ningbo, China. Methods For this retrospective study, information was extracted from patients notes and billing records for patients >18 years of age with a diagnosis of AKI admitted to the ICU department, Ningbo First Hospital from April 2013 to March 2018. Results Of the 368 patients with sepsis admitted to ICU, 167 (45%) developed AKI; 95 patients were insured and 72 were uninsured. Compared with insured patients, uninsured patients were younger, had higher Acute Physiology and Chronic Health Evaluation II (APACHE II) and Sequential Organ Failure Assessment (SOFA) scores, but had less catheter interventions and received less renal replacement therapy (RRT). Results from a multivariate analysis showed that independent predictors of ICU mortality were age, APACHE II scores, MODS scores, use of RRT and lack of insurance. Conclusions Uninsured patients with septic AKI were younger, stayed a shorter time in ICU, had higher illness severity scores and a higher ICU mortality than insured patients. Importantly a major risk factor for ICU mortality in this group was lack of insurance.
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- 2019
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18. Endoscope-Assisted Extracapsular Resection of Benign Parotid Tumors Via Temporal and Retroauricular Approach
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Jian-Hua Zhu, Zheng He, and Lei Zhang
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Otorhinolaryngology ,Surgery ,General Medicine - Abstract
To evaluate the feasibility of endoscope-assisted extracapsular resection of benign parotid tumors via temporal and retroauricular approach.A total of 12 patients with parotid gland tumors had endoscope-assisted extracapsular resection performed via temporal and retroauricular approach (4 versus 8) between January 2018 and January 2019.All tumors were benign with a median diameter of 2.32 ± 0.49 cm. The mean length of the skin incision was 3.5 ± 0.35 cm. The mean operating time 86.7 ± 10.8 minutes. The median blood loss was 30.4 ± 5.94 ml. The median volume of drainage was 27.1 ± 8.88 ml and the duration of drainage was 2 ± 0.71 days. The mean aesthetics scoring assigned by patients was 9.67 ± 0.51. Two patients had numbness of the earlobe and 1 patient developed a transient salivary sialocele. No facial nerve paresis was observed and no tumor recurrence occurred during the follow-up period.The minimally invasive endoscope-assisted extracapsular resection of benign parotid tumors provide both a safe and reliable technique for benign parotid tumors with excellent cosmetic results.
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- 2022
19. Flow Regime detection using gamma-ray-based multiphase flowmeter: a machine learning approach
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Jian Hua Zhu, Ritesh Munjal, Ani Sivaram, Santhiyapillai Rajeevan Paul, Jing Tian, and Guillaume Jolivet
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Computational Mathematics ,Applied Mathematics ,Modeling and Simulation ,Computational Mechanics ,Computer Science Applications - Published
- 2022
20. S-Nitrosoglutathione protects acute kidney injury in septic rats by inhibiting the activation of NLRP3 inflammasome.
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Heng Fan, Min Sun, Jian-wei Le, and Jian-hua Zhu
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ACUTE kidney failure ,NLRP3 protein ,INFLAMMASOMES ,MULTIENZYME complexes ,SPRAGUE Dawley rats - Abstract
Objective(s): We aimed to study the effect of S-nitroso glutathione (SNG) on acute kidney injury (AKI) in septic rats by regulating nucleotide oligomerization domain-like receptor protein 3 (NLRP3). Materials and Methods: Sprague Dawley rats were used to construct the AKI model, and biochemical methods were used to detect the levels of inflammatory factors and anti-oxidant enzymes in renal tissue. We observed the ultrastructural changes of renal tissue by transmission electron microscopy and detected the protein and mRNA levels of NLRP3, apoptosis-associated speck-like protein containing a caspase recruitment domain foci (ASC) and caspase-1 by western-blotting and RT-qPCR. Results: Cecal ligation and puncture induced renal tubular epithelial tissue damage in septic rats, resulting in decreased renal function, increased levels of inflammation and decreased levels of antioxidant enzymes in renal tissue, and aggravated mitochondrial damage, significantly decreased mitochondrial density and enzyme complex I/II/III/IV levels (all P<0.001), and increased the protein and mRNA expression of NLRP3, ASC, and caspase-1 (all P<0.001). However, after pretreatment with SNG, the pathological damage of renal tubular epithelial tissue was reduced, the renal function was improved, the level of inflammation in renal tissue decreased and the level of anti-oxidant enzymes increased, the density of mitochondria and the level of enzyme complex I/II/III/IV were significantly increased (all P<0.001), meanwhile the protein and mRNA levels of NLRP3, ASC, and caspase-1 were all decreased significantly (all P<0.05). Conclusion:: SNG protects AKI in septic rats by inhibiting NLRP3 inflammasome activation. [ABSTRACT FROM AUTHOR]
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- 2023
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21. [Countertraction method for reduction of irreducible subcoracoid dislocation of the shoulder joint with Hill-Sacks lesion]
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Ru-Yi, Zhang, Cai, Yun, Tao, Yang, Yi, Zhang, Jian-Hua, Zhu, Feng, Liu, Li-Chao, Zhang, and Peng, Su
- Abstract
To investigate clinical outcomes of countertraction method in treating irreducible subcoracoid dislocation of shoulder joint combined with Hill-Sacks injury.A total of 56 patients with irreducible subcoracoid dislocation of the shoulder joint combined with Hill-Sacks injury admitted from December 2013 to June 2020 were retrospectively analyzed. Under the anesthesia of shoulder joint cavity injection, the reduction was performed by using anti-traction method (experimental group) and traditional Hippocrates method (control group), 28 cases in each group. There were 11 males and 17 females in experimental group, with an average age of (61.95±19.32) years old, 9 cases on the left side, and 19 cases on the right side. Twelve males and 16 females in control group, with an average age of (63.13±12.75) years old, 11 cases on the left side, 17 cases on the right side. The curative effects between two groups were evaluated before and after operation, including the success rate of reduction, the duration of reduction, the distance from successful reduction to injury, complications and functional rehabilitation(Constant score of shoulder joint).The success rates of reduction in experimental group and control group were 92.86%(26/28) and 67.86% (19/28), respectively, and the difference was statistically significant (For patients with irreducible subcoracoid dislocation of the shoulder joint with Hill-Sacks injury, the countertraction method under anesthesia of the shoulder joint cavity achieved a higher success rate and few complications.
- Published
- 2022
22. Assessment of three-dimensional rotation of the shoulder complex and scapulohumeral rhythm during sagittal movement
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Peng Su, Feng Liu, Yi Zhang, Jian Hua Zhu, and Li Chao Zhang
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Rehabilitation ,Physical Therapy, Sports Therapy and Rehabilitation ,Orthopedics and Sports Medicine - Abstract
BACKGROUND: Due to the influence of spinal and respiratory movements, it is difficult to accurately measure the range of motion of each joint. OBJECTIVE: To conduct a three-dimensional (3D) measurement of each joint in the shoulder complex in different postures in the sagittal plane of the upper extremity. METHODS: Thirteen healthy adults with no history of shoulder surgery for trauma or chronic pain were enrolled in the present study. The computed tomography (CT) imaging data of the shoulder complex were acquired in four postures via the reconstruction and alignment of 3D images. The angles of the postural changes were measured, and rotation vectors were used for descriptions and statistical analyses. RESULTS: There was a statistical difference in the rotation angles between the dominant and non-dominant sides of the sternoclavicular joint when the posture changed from a resting position to a posterior inferior position. During the postural change from a resting position to a horizontal position, the regression coefficient (β) of the humerothoracic joint to the sternoclavicular joint was 0.191, and the β of the humerothoracic joint to the glenohumeral joint was 0.621. During the postural change from the horizontal position to the rear upper position, the β of the humerothoracic joint to the sternoclavicular joint was 0.316, and the β of the humerothoracic joint to the glenohumeral joint was 0.845. During the postural change from the resting position to the rear lower position, the β of the humerothoracic joint to the glenohumeral joint was 0.991. CONCLUSION: The application of the image alignment technique enabled the direct and accurate measurement of the bony structures of the shoulder joint. The helical approach accurately described the scapulohumeral rhythm during 3D motion. There was a scapulohumeral rhythm of the shoulder complex during 3D composite sagittal movement, with different ratios for different joints and postures.
- Published
- 2022
23. Early Sedation Depth and Clinical Outcomes in Mechanically Ventilated Patients with Sepsis
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Heng FAN, Min SUN, and Jian-hua ZHU
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No Keywords### ,Public aspects of medicine ,RA1-1270 - Abstract
No Abstract####
- Published
- 2018
24. Dexmedetomidine Based Sedation for Post-surgery Critically Ill Adults: A Meta-analysis of Randomized Controlled Trials
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Heng FAN, Yu ZHAO, Min SUN, Ji-Hui YE, Guo-Dong CHEN, and Jian-Hua ZHU
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Dexmedetomidine ,Sedation ,Mechanical ventilation ,Delirium ,Public aspects of medicine ,RA1-1270 - Abstract
Background: Using dexmedetomidine (Dex) as a sedative agent may benefit the clinical outcomes of post-surgery patients. We reviewed randomized controlled trials (RCTs) to assess whether use of a Dex could improve the outcomes in post-surgery critically ill adults. Methods: We searched Medline, Embase, PubMed, and the Cochrane databases for RCTs comparing Dex with propofol or a placebo in post-operative patients, all included RCTs should be published in English before Jul 2016. Citations meeting inclusion criteria were full screened, and trial available data were abstracted independently and the Cochrane risk of bias tool was used for quality assessment. Results: Sixteen RCTs involving 2568 patients were subject to this meta-analysis. The use of a Dex sedative regimen was associated with a reduce delirium prevalence [odd ratio (OR):0.33, 95% confidence intervals (CI): 0.24–0.45, I2= 5%, P
- Published
- 2017
25. Hierarchical Composites to Reduce N-Nitrosamines in Cigarette Smoke
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Yan Yan Li, Yi Cao, Ming Bo Yue, Jing Yang, and Jian Hua Zhu
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zeolite ,hierarchical composite ,cigarette smoke ,N-nitrosamine ,environment protection ,Technology ,Electrical engineering. Electronics. Nuclear engineering ,TK1-9971 ,Engineering (General). Civil engineering (General) ,TA1-2040 ,Microscopy ,QH201-278.5 ,Descriptive and experimental mechanics ,QC120-168.85 - Abstract
In order to reduce the harmful constituents in cigarette smoke, two hierarchical composites were synthesized. Based on, zeolites HZSM-5 or NaY fragments were introduced into the synthetic system of mesoporous silica SBA-15 or MCM-41 and assembled with the mesoporous materials. These porous composites combine the advantages of micro- and mesoporous materials, and exhibit higher effects than activated carbon on reducing tobacco specific nitrosamines (TSNA) and some vapor phase compounds in smoke.
- Published
- 2015
- Full Text
- View/download PDF
26. Letter to the Editor: 'Long-term physical impairments in survivors of COVID-19-associated ARDS compared with classic ARDS: A two-center study'
- Author
-
Heng Fan and Jian-hua Zhu
- Subjects
Critical Care and Intensive Care Medicine - Published
- 2023
27. New thermal releaser of menthol: Cellulose acetate film covered amorphous silica
- Author
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Wei-jian Shen, Jian Hua Zhu, Ling Gao, Ying Wang, Jie Ling Chen, Yu Kang Zhang, and Ying Hong
- Subjects
chemistry.chemical_compound ,Adsorption ,Sorbent ,chemistry ,Chemical engineering ,Thermal ,General Chemistry ,Gas chromatography ,Amorphous silica ,Menthol ,Porosity ,Cellulose acetate film ,Food Science - Abstract
A new way of controllable releasing menthol with amorphous silica is reported for the first time. Porous silica adsorbed menthol in 373‐413 K and then was covered with cellulose acetate film to form a carrier‐embedded menthol. The sealed menthol would be released at elevated temperatures once the cover fractured. Here, the influence of temperature and nature of sorbent on the adsorption of menthol along with the covering manner were investigated carefully, and the thermal release of menthol was studied with headspace gas chromatography (HS‐GC) method. Silica adsorbed about 400 mg g⁻¹ of menthol at the optimal adsorption conditions and released most of them at about 473 K. Preliminary application in non‐combustible cigarette proven the feasibility of thermal release of menthol with the covered silica carrier.
- Published
- 2021
28. Salidroside Protects Acute Kidney Injury in Septic Rats by Inhibiting Inflammation and Apoptosis
- Author
-
Heng Fan, Bin-jie Su, Jian-wei Le, and Jian-hua Zhu
- Subjects
Pharmacology ,Inflammation ,Drug Design, Development and Therapy ,NF-kappa B ,Pharmaceutical Science ,Apoptosis ,Acute Kidney Injury ,Kidney ,Rats ,Glucosides ,Phenols ,Sepsis ,Drug Discovery ,Animals ,RNA, Messenger - Abstract
Heng Fan,1,* Bin-jie Su,2,* Jian-wei Le,1 Jian-hua Zhu1 1Department of Intensive Care Unit, Ningbo First Hospital, Ningbo, Zhejiang Province, Peopleâs Republic of China; 2Department of Intensive Care Unit, Ningbo First Hospital Haishu Branch, Ningbo, Zhejiang Province, Peopleâs Republic of China*These authors contributed equally to this workCorrespondence: Jian-hua Zhu, Department of Intensive Care Unit, Ningbo First Hospital, No.59 Liuting Road, Ningbo, Zhejiang Province, 315010, Peopleâs Republic of China, Tel/Fax +86-574-87084625, Email zhujianhua201107@163.comPurpose: To clarify the protective effect and mechanism of salidroside (SLDS) on acute kidney injury (AKI) in septic rats.Methods: We pretreated rats with different doses of SLDS and analyzed the impact of SLDS on the survival of septic rats. We evaluated the levels of inflammatory factors in rats, the expression of NF-ÆB p65 in the kidney, and the apoptosis of kidney tubular epithelial cells (KTECs).Results: SLDS significantly decreased the mortality of septic rats, and it reduced the levels of TNF-α, IL-1β, and IL-17A in plasma and kidneys and decreased the levels of serum creatinine, plasma renal injury molecule-1 and plasma neutrophil gelatin-associated lipocalin. Moreover, SLDS could significantly decrease the expression of NF-ÆB p65 in kidney tissues and the apoptotic number of KETCs, while reducing the mRNA levels of Caspase-3 and Bax mRNA, and increasing the level of Bcl-2 mRNA.Conclusion: SLDS pretreatment protects against AKI in septic rats by inhibiting the inflammation of kidney and the apoptosis of KTECs.Keywords: salidroside, acute kidney injury, sepsis, apoptosis, inflammation
- Published
- 2022
29. Numerical Simulation of Differential Settlement Resistance for Reinforced Joint Between New and Existing Pavement with RoadMesh Steel Wire Mesh
- Author
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Xu-Dong Zha, Hao-Jun Liu, and Jian-Hua Zhu
- Published
- 2022
30. Systematic Analysis of Autophagy-Related Signature Uncovers Prognostic Predictor for Acute Myeloid Leukemia
- Author
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Hao Zhou, Hai-Tao Xia, Jian-Hua Zhu, Ziping Li, and X. Chen
- Subjects
Vascular Endothelial Growth Factor A ,0301 basic medicine ,Oncology ,medicine.medical_specialty ,Bioinformatics ,Cell Cycle Proteins ,Biology ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,Autophagy ,Biomarkers, Tumor ,Genetics ,medicine ,Humans ,Molecular Biology ,Survival analysis ,Endosomal Sorting Complexes Required for Transport ,Receiver operating characteristic ,Caspase 3 ,Proportional hazards model ,Area under the curve ,Membrane Transport Proteins ,Myeloid leukemia ,Cell Biology ,General Medicine ,Nomogram ,Gene signature ,Repressor Proteins ,Chromatin Assembly Factor-1 ,Leukemia, Myeloid, Acute ,030104 developmental biology ,030220 oncology & carcinogenesis ,Cohort ,Transcriptome - Abstract
Autophagy, a highly conserved cellular protein degradation process, has been involved in acute myeloid leukemia (AML). The present study aims to establish a novel, autophagy-related prognostic signature for prediction of AML prognosis. Differentially expressed autophagy-related genes in AML and healthy samples were screened using GSE1159. Univariate Cox regression analysis was applied to determine survival-associated autophagy-related genes in The Cancer Genome Atlas (TCGA) AML cohort. Lasso regression was performed to develop multiple-gene prognostic signatures. A novel six-gene signature (including CASP3, CHAF1B, KLHL24, OPTN, VEGFA, and VPS37C) DC was established for AML prognosis prediction. The Kaplan–Meier survival analysis revealed that patients in the high-risk score group had poorer overall survival (OS). The receiver operating characteristic (ROC) curve validated its good performance in survival prediction in TCGA AML cohort, and the area under the curve value was 0.817. Moreover, our signature could independently predict OS. A nomogram was constructed, including the six-gene signature and other clinical parameters, and predictive efficiency was confirmed using the ROC curve and calibration curve. Furthermore, gene set enrichment analyses identified several tumor-associated pathways that may contribute to explain the potential molecular mechanisms of our signature. Overall, we developed a new autophagy-associated gene signature and nomogram to predict OS of AML patients, which may help in clinical decision-making for AML treatment.
- Published
- 2020
31. Carbonation Depth Model and Prediction of Hybrid Fiber Fly Ash Concrete
- Author
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Jian-hua Zhu, Meng Cheng, and Jing-shuang Zhang
- Subjects
Cement ,Materials science ,Article Subject ,Carbonization ,Carbonation ,Metallurgy ,0211 other engineering and technologies ,02 engineering and technology ,010501 environmental sciences ,Engineering (General). Civil engineering (General) ,Steel bar ,01 natural sciences ,Corrosion ,Basalt fiber ,Fly ash ,021105 building & construction ,Fiber ,TA1-2040 ,0105 earth and related environmental sciences ,Civil and Structural Engineering - Abstract
The concrete is weakly alkaline, the alkalinity of the concrete will be reduced after being carbonized, and the protective effect of the concrete on the steel bar will be weakened, even leading to corrosion of the steel bar. In this paper, fly ash is used to replace cement in the same amount, and basalt fiber and polypropylene fiber are added in a certain amount to make hybrid fiber fly ash concrete. Through rapid carbonation test, the influence of carbonation time and fly ash content on carbonation performance of hybrid fiber fly ash concrete is studied. The curve is fitted according to a single factor carbonation model with fly ash content as the main parameter, and the fitting curve and prediction formula are obtained. The results show that, in the same carbonization time, compared with the concrete without fly ash, the concrete with fly ash content of 5%, 10%, 20%, and 30% has average carbonization depth promotion rates of 6.4%, 14.9%, 59.8%, and 73.5%. When the fly ash content varies in the range of 10%∼20%, the carbonation resistance of hybrid fiber concrete changes most sensitively. At the same fly ash content, with the increase of carbonization time, the carbonization depth of concrete increases by 41.7%∼62.3%; Through the verification of the fitting curve and fitting formula obtained after fitting, it is concluded that the error of the prediction formula of carbonation depth of hybrid fiber fly ash concrete is within 9.1%, and the error of carbonation depth of 14 d and 28 d is within 4.3%. Replacing cement with fly ash has certain engineering significance and can achieve the purpose of recycling waste materials.
- Published
- 2020
32. Ulinastatin and Thymosin a1 Therapy in Adult Patients with Se-vere Sepsis: A Meta-analysis with Trial Sequential Analysis of Randomized Controlled Trials
- Author
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Heng FAN, Yu ZHAO, Jian Hua ZHU, Ji Hui YE, and Xue Qing YAO
- Subjects
Public aspects of medicine ,RA1-1270 - Abstract
No Abstract
- Published
- 2016
33. Heat Transfer Characteristics of Multinozzle Air Impingement Jet during Die Steel Plate Cooling Progress
- Author
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Dong-mei Zhu, Yan-tao Wang, and Jian-hua Zhu
- Subjects
Mechanical engineering and machinery ,TJ1-1570 - Abstract
Aiming at the new die steel quenching equipment, using Fluent software, the effects of the nozzle spacing, height, injection pressure, and comprehensive factors on the heat transfer characteristics are studied. The results show that when the nozzle spacing and injection pressure are given, the heat transfer coefficient increases first and then decreases with the injection height increase, and the cooling uniformity is better; when the injection pressure is given, the injection height increases with the nozzle spacing increase under the maximum heat exchanger capability; when the nozzle spacing is given, the injection height increases with the injection pressure under the maximum heat exchanger capability; for the nozzle arrangement in the paper, there is a relationship between the injection height and nozzle spacing when the heat transfer is uniform, H ≈ 8 S . The results have important reference value for optimization design of the equipment and actual production process.
- Published
- 2015
- Full Text
- View/download PDF
34. Effect of visual perceptual learning on visual representation and binocular vision function of children with amblyopia
- Author
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Min Zhang, Yu-Chi Lin, Ping Jiang, and Jian-Hua Zhu
- Subjects
genetic structures ,children ,lcsh:Ophthalmology ,lcsh:RE1-994 ,visual representation ,visual function ,perceptual eye position ,visual perceptual learning ,eye diseases ,amblyopia - Abstract
AIM: To evaluate the effects of visual perceptual learning on visual representation and binocular vision function of children with amblyopia. METHODS: A total of 94 cases(94 eyes)children with amblyopia admitted to the ophthalmology clinic of our hospital from January 2014 to December 2015 were selected for the study and were grouped according to the degrees of amblyopia, and they were given visual perceptual learning for 3mo. The clinical efficacy and perceptual level of eye position and poor visual acuity before and after treatment were compared among groups, and Pearson correlation coefficient was used to analyze the relationship between difference of poor visual acuity and difference of perceptual eye position before and after treatment in children with amblyopia. RESULTS: The total clinical effective rate of children with mild amblyopia was higher than that of children with moderate or severe amblyopia(PP>0.05). The perception level of eye position after treatment of children with amblyopia was significantly lower than that before treatment(PPPPPPr=0.371, PCONCLUSION: Visual perceptual learning can effectively improve the visual representation and binocular vision function of children with amblyopia, and it is suitable for the clinical treatment of children with amblyopia.
- Published
- 2019
35. New efficient selective adsorbent of tobacco specific nitrosamines derived from discarded cigarette filters
- Author
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Jian Hua Zhu, Chun Ling Shi, Ying Wang, ShuoHao Li, Xiao Dan Sun, Da-wei Qi, Yang-zhong Wang, and Da Wu
- Subjects
Sorbent ,chemistry.chemical_element ,02 engineering and technology ,General Chemistry ,010402 general chemistry ,021001 nanoscience & nanotechnology ,Condensed Matter Physics ,01 natural sciences ,0104 chemical sciences ,Adsorption ,chemistry ,Chemical engineering ,Mechanics of Materials ,Selective adsorption ,medicine ,General Materials Science ,Tobacco-specific nitrosamines ,0210 nano-technology ,Mesoporous material ,Zeolite ,Carbon ,Activated carbon ,medicine.drug - Abstract
To expand the application of the principle of selective adsorption, new hierarchical porous carbon was fabricated from cigarette filters and cheap metal salts via one-pot synthesis, in order to selectively capture the tobacco-specific nitrosamines (TSNA) in solution. The type and amount of metal salt in the carbon precursor took charged of pore texture, electrical property and morphology, forming a new sorbent beyond activated carbon and zeolite in the selective liquid adsorption of TSNA. With the amount of FexO-doped of 10%–16.5%, new carbon sorbent captured the 29.4%–33.8% of TSNA in the tobacco extract solution though the solution contained thousands of components. Moreover, it exhibited a zeolite-like selectivity to remove 93% of 4-methylnitrosamino-1-3-pyridyl-1-butanone (NNK). The hierarchical sorbents combined the high adsorption capability of mesopore and the shape-selectivity of micropore, based on waste utilization and simply controllable process, offering a clue for preparation of new hierarchical material and resource regeneration and environmental protection.
- Published
- 2019
36. Insight into the efficient TSNA capturer derived from zeolite Hβ
- Author
-
Ying Wang, Chun Ling Shi, Yi Han Gao, Xiao Dan Sun, Jie Ling Chen, Yang Zhong Wang, Yi Shen, Da Wei Qi, Sai Jing Zheng, and Jian Hua Zhu
- Subjects
Pore size ,Sorbent ,Chemistry ,General Chemical Engineering ,High capacity ,02 engineering and technology ,General Chemistry ,010402 general chemistry ,021001 nanoscience & nanotechnology ,01 natural sciences ,Industrial and Manufacturing Engineering ,0104 chemical sciences ,law.invention ,Adsorption ,Chemical engineering ,law ,Environmental Chemistry ,Calcination ,Tobacco-specific nitrosamines ,0210 nano-technology ,Zeolite - Abstract
The thermal regeneration of zeolite Hβ adsorbed tobacco specific nitrosamines (TSNA) along with the impact of zeolitic pore size on the liquid adsorption of TSNA were investigated in this article for the first time. After calcination at 873 K, the regenerated Hβ zeolite exhibited a kind of self-activation to trap more TSNA in succeeding adsorption in tobacco solution, achieving the high capacity of 225 μg g−1. With the assistance of TG-MS technique, it was clear that no secondary pollution of volatile nitrosamines (VNA) occurred in the regeneration of Hβ zeolite. In order to seek cheap TSNA-capturer, three zeolites with different pore structures, Hβ, MCM-22 and NTY (the dealuminated NaY) zeolites were assessed in the TSNA adsorption in laboratory formulated surface water and tobacco solution to examine the influence of pore size. MCM-22 was the excellent selective sorbent of 4-methylnitrosamino-1-3-pyridyl-1-butanone (NNK), but its channels were easily clogged in tobacco solution. Zeolite Hβ showed a prominent TSNA adsorption in both solutions due to its pore size of 0.6–0.7 nm. The cheap zeolite NTY with the pore size of 0.74 nm exhibited a high adsorption capability of TSNA similar to Hβ in tobacco solution, making it a promising replacement for industrial applications.
- Published
- 2019
37. Prospect of robotic assistance for fully automated brachytherapy seed placement into skull base: Experimental validation in phantom and cadaver
- Author
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Xiao-Jing Liu, Jian-Hua Zhu, Jing Wang, Yong-Gui Wang, Chuan-bin Guo, and Meng Li
- Subjects
Male ,Computer science ,medicine.medical_treatment ,Brachytherapy ,ComputingMethodologies_IMAGEPROCESSINGANDCOMPUTERVISION ,Imaging phantom ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,0302 clinical medicine ,Cadaver ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Computer vision ,Skull Base ,Image fusion ,Phantoms, Imaging ,business.industry ,Radiotherapy Planning, Computer-Assisted ,Navigation system ,Hematology ,Cone-Beam Computed Tomography ,Robot control ,Oncology ,Head and Neck Neoplasms ,Needles ,Therapy, Computer-Assisted ,030220 oncology & carcinogenesis ,Robot ,Female ,Artificial intelligence ,Cadaveric spasm ,business - Abstract
To investigate the feasibility and accuracy of robot-assisted brachytherapy for skull base tumours.A custom robot system was tested on both phantom and cadaveric specimen. Cone beam CT (CBCT) images were transferred to the graphical user interface (GUI) for planning trajectories and the data were sent to the robot control unit. Following registration, the puncture needle was inserted into the target by the robot under navigation guidance, and seeds were implanted. Placement error was instantly displayed on the GUI; the result was verified after postoperative image scanning.A total of 150 seeds (100 for phantom experiments, 50 for cadaveric studies) were deposited by the robot system. In phantom experiments the mean placement error was 0.57 ± 0.21 mm (measured by the navigation system) vs. 1.41 ± 0.38 mm (measured by image fusion) (p 0.001); in cadaveric studies the corresponding figures were 0.60 ± 0.30 mm vs. 2.48 ± 0.32 mm (p 0.001). There was no significant difference for comparison of accuracy test in phantom experiments (p = 0.173) as well as in cadaveric studies (p = 0.354). Accuracy was better in the phantom experiment than in cadaveric studies (p 0.001).The performance of robot-assisted skull base brachytherapy is feasible and accurate. Dosimetric coverage will need to be demonstrated in further studies.
- Published
- 2019
38. A query on the Mg 2p binding energy of MgO
- Author
-
Jian Hua Zhu and Jie Ling Chen
- Subjects
Materials science ,010405 organic chemistry ,Binding energy ,Analytical chemistry ,Oxide ,chemistry.chemical_element ,General Chemistry ,010402 general chemistry ,01 natural sciences ,0104 chemical sciences ,Catalysis ,chemistry.chemical_compound ,chemistry ,X-ray photoelectron spectroscopy ,medicine ,Ferric ,Carbon ,medicine.drug - Abstract
The low Mg 2p value (47.0 eV) of MgO reported in Res Chem Intermed 44(2018)829 is carefully analyzed and discussed based on a series of X-ray photoelectron spectroscopy (XPS) experiments and literature results. Presence of carbon or ferric oxide did not change the binding energy (BE) of Mg 2p of MgO, and the Mg 2p peak of MgO should be above 49.0 eV instead of at 47.0 eV.
- Published
- 2019
39. New sucker-type precise capturer of tobacco specific nitrosamines derived from the SBA-15 in situ modified with polyaniline
- Author
-
Chun Ling Shi, He-ming Yao, Ying Wang, Xiao Dan Sun, Shuo Hao Li, Wei-miao Wang, Yang-zhong Wang, Jun-Wei Xiong, Da-wei Qi, and Jian Hua Zhu
- Subjects
Materials science ,Sorbent ,General Chemical Engineering ,02 engineering and technology ,General Chemistry ,010402 general chemistry ,021001 nanoscience & nanotechnology ,01 natural sciences ,Industrial and Manufacturing Engineering ,0104 chemical sciences ,chemistry.chemical_compound ,Aniline ,Adsorption ,chemistry ,Chemical engineering ,Polyaniline ,Zeta potential ,medicine ,Environmental Chemistry ,0210 nano-technology ,Selectivity ,Mesoporous material ,Activated carbon ,medicine.drug - Abstract
To design new mesoporous sucker-type selective sorbent for controlling environmental carcinogens like tobacco specific nitrosamines (TSNA), polyaniline (PANI) was controlled carefully to grow at different sites such as near the pore opening, in the channel or on the outside of SBA-15 by in one-pot synthetic and post-synthetic methods. The influences of aniline additional order, aniline to organosilicone ratio and with or without template are investigated in order to obtain the optimal growth position of PANI. Different location of PANI on SBA-15 was confirmed by TEM, N2 adsorption-desorption characterization and zeta potential measurement. PANI grows preferentially in the channel and then near the pore orifice when proper amount aniline is added previous to silicon source. If aniline is added later after the silicon source, PANI will grow mainly on the outside surface of SBA-15. The location of PANI is in the pore entrances once the aniline is put into the solution after template is removed. Resulting composites realize different selectivity for TSNA and tobacco alkaloids. 1P-S15 production possesses a best TSNA adsorptive capacity (23.2%), higher than commercial activated carbon (15.5%). FTIR spectrum of TSNA in 1P-S15 and quantum calculations demonstrated that the adsorption of TSNA is controlled by hydrogen bonding.
- Published
- 2018
40. Research and Countermeasure Analysis on the Development of Internet Financial Market in Rural Areas of China
- Author
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Rong-qiang Li, Jian-hua Zhu, and Xiao-ting Liao
- Subjects
Economic growth ,Countermeasure ,business.industry ,Financial market ,The Internet ,Business ,Rural area ,China - Published
- 2021
41. Pretreatment with S-Nitrosoglutathione Attenuates Septic Acute Kidney Injury in Rats by Inhibiting Inflammation, Oxidation, and Apoptosis
- Author
-
Jian-hua Zhu, Min Sun, Jianwei Le, and Heng Fan
- Subjects
Male ,medicine.medical_specialty ,Article Subject ,Renal function ,Inflammation ,Apoptosis ,Kidney ,Protective Agents ,General Biochemistry, Genetics and Molecular Biology ,Sepsis ,Rats, Sprague-Dawley ,chemistry.chemical_compound ,Internal medicine ,medicine ,Animals ,Creatinine ,TUNEL assay ,General Immunology and Microbiology ,biology ,business.industry ,urogenital system ,Acute kidney injury ,General Medicine ,Acute Kidney Injury ,medicine.disease ,Rats ,Nitric oxide synthase ,Oxidative Stress ,Endocrinology ,medicine.anatomical_structure ,chemistry ,S-Nitrosoglutathione ,biology.protein ,Medicine ,medicine.symptom ,business ,Research Article - Abstract
Objective. We aimed to investigate the protective effect of s-nitrosoglutathione (SNG) pretreatment on acute kidney injury (AKI) in septic rats. Methods. We constructed a rat model of sepsis by cecal ligation and puncture and observed the survival of the rats. We obtained kidney and blood samples from rats, observed the pathological damage to the kidney tissues, and evaluated kidney function and the expression levels of inflammatory factors. We also detected the expression of induced nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) in the kidneys by immunohistochemistry and evaluated the apoptosis of kidney tubular epithelial cells (KTEC) by TUNEL. Results. Pretreatment with SNG significantly reduced the mortality of septic rats, attenuated kidney pathological damage, and decreased the levels of serum creatinine, plasma neutrophil gelatinase-associated lipocalin, and plasma kidney injury molecule-1. Moreover, SNG pretreatment decreased the levels of TNF-α and IL-1β in serum and kidney and reduced the expressions of NO, iNOS, PGE2, and COX-2 in the kidneys. Furthermore, pretreatment with SNG significantly reduced the apoptotic rate of KTEC and decreased the levels of caspase-3 and Bax mRNA, but increased the level of Bcl-2 mRNA. Conclusion. Pretreatment with SNG has a protective effect on AKI in septic rats, and the specific mechanisms are related to inhibition of inflammation, oxidation, and apoptosis.
- Published
- 2021
- Full Text
- View/download PDF
42. Insight into the liquid adsorption of tobacco specific nitrosamines on ZIF-8
- Author
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Wen Bo Zhu, Ling Gao, Yu Kang Zhang, Qi Zhang, Ying Hong, Wei Jian Shen, Ying Wang, and Jian Hua Zhu
- Subjects
Mechanics of Materials ,General Materials Science ,General Chemistry ,Condensed Matter Physics - Published
- 2022
43. Smoking promotes the resorption of periodontal alveolar bone
- Author
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Jian-hua, Zhu, Ying, Wang, Zhong-nan, Zhao, and Ji-guang, Liu
- Published
- 2014
- Full Text
- View/download PDF
44. Selection of DNA aptamers against DC-SIGN protein
- Author
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Hui, Yan, Shan, Li, Lin-fu, Zhou, and Jian-hua, Zhu
- Published
- 2007
- Full Text
- View/download PDF
45. Comprehensive Characterization of the Prognosis Value of Alternative Splicing Events in Acute Myeloid Leukemia
- Author
-
Hao Zhou, Jian-Hua Zhu, Ziping Li, Hai-Tao Xiao, and X. Chen
- Subjects
0301 basic medicine ,Oncology ,medicine.medical_specialty ,Context (language use) ,Biology ,03 medical and health sciences ,Splicing factor ,0302 clinical medicine ,Internal medicine ,Genetics ,medicine ,Humans ,Molecular Biology ,Receiver operating characteristic ,Proportional hazards model ,Alternative splicing ,Myeloid leukemia ,Computational Biology ,Cell Biology ,General Medicine ,Prognosis ,Alternative Splicing ,Leukemia, Myeloid, Acute ,030104 developmental biology ,030220 oncology & carcinogenesis ,RNA splicing ,Biomarker (medicine) - Abstract
Increasing evidence have demonstrated that dysregulated alternative splicing (AS) events promoted tumor development and was correlated with worse prognosis in the context of certain malignancies. Nevertheless, a comprehensive examination of the prognosis role of AS events in acute myeloid leukemia (AML) has not yet been illuminated. In this study, univariate and multivariate Cox regression analysis were used to identify survival-related AS events and independent prognostic predictors. The interaction between splicing factors (SFs) and AS events was visualized by Cytoscape. A total of 3013 survival-associated AS events in 1977 genes were screened in 151 AML patients. Interestingly, the majority (2031 events) were revealed to be protective factors. Furthermore, the prediction models were constructed for each type of AS and all of them displayed good performance in predicting prognosis, considering their area under curve values of the receiver operating characteristic were all above 0.7. Notably, the splicing regulatory network displayed the underlying interaction networks between SFs and AS events. Taken together, our study demonstrated the survival-related AS events in AML and uncovered the possible association between SFs and prognostic AS events, which provide new prognostic biomarkers and aid to develop novel targets for AML therapy.
- Published
- 2020
46. Research on Virtual Device based Intelligent IoT Management and Test Method of Security Stability Control Systems
- Author
-
Dongliang Nan, Wang Tingwang, Jian-Hua Zhu, Bin Feng, Chen Long, and Zhao Qi
- Subjects
0209 industrial biotechnology ,business.industry ,Computer science ,Cloud computing ,02 engineering and technology ,Test method ,020901 industrial engineering & automation ,Electronic stability control ,Embedded system ,Control system ,0202 electrical engineering, electronic engineering, information engineering ,020201 artificial intelligence & image processing ,Virtual device ,Internet of Things ,business - Abstract
In this paper, a method based on virtual devices for testing and managing security stability control systems through intelligent IoT is studied. With the aid of the cloud computing intelligent IoT platform, stability control virtual devices are built on the basis of stability control devices in each substation through virtual technology, consisting a complete security stability control virtual system, to carry out management on operating and maintaining of the security stability control system. Through the virtual test of the stability control virtual devices, the large and complex stability control system strategy of the power grid can be effectively, reliably, complete, and efficiently joint commissioned without dropping out the actual devices in the security stability control virtual system. Furthermore, remote testing of security stability control systems can also be enabled by inputting test commands to different security stability control devices through virtual devices synchronously.
- Published
- 2020
47. Delayed‐Phase Thrombocytopenia in Patients of Coronavirus Disease 2019 (COVID‐19)
- Author
-
Wanxin Chen, Jian-Hua Zhu, Qiong Zhou, Zhiguo Zhang, Bohan Yang, Ping Wang, Ziping Li, X. Chen, Hao Zhou, and Peng Yang
- Subjects
Adult ,Male ,medicine.medical_specialty ,China ,clinical features ,Coronavirus disease 2019 (COVID-19) ,Lymphocyte ,Pneumonia, Viral ,Short Report ,thrombocytopenia ,lymphocyte ,SARS‐CoV‐2 ,Betacoronavirus ,Short Reports ,COVID‐19 ,Bone Marrow ,Internal medicine ,hemic and lymphatic diseases ,medicine ,cytokine ,Humans ,Platelet ,Longitudinal Studies ,Pandemics ,Aged ,Retrospective Studies ,business.industry ,Platelet Count ,SARS-CoV-2 ,Incidence (epidemiology) ,Mortality rate ,Incidence ,COVID-19 ,Retrospective cohort study ,Hematology ,Middle Aged ,Haematopoiesis ,medicine.anatomical_structure ,Female ,Bone marrow ,business ,Coronavirus Infections - Abstract
Coronavirus disease 2019 (COVID-19) can affect the haematopoietic system. Thrombocytopenia at admission was prevalent, while late-phase or delayed-phase thrombocytopenia (occurred 14 days after symptom onset) is rare. This retrospective, single-centre study screened 450 COVID-19 patients and enrolled 271 patients at the Union Hospital, Wuhan, China, from January 25 to March 9, 2020. COVID-19-associated delayed-phase thrombocytopenia occurred in 11·8% of enrolling patients. The delayed-phase thrombocytopenia in COVID-19 is prone to develop in elderly patients or patients with low lymphocyte count on admission. The delayed-phase thrombocytopenia is significantly associated with increased length of hospital stay and higher mortality rate. Delayed-phase nadir platelet counts demonstrated a significantly negative correlation with B cell percentages. We also provided and described bone marrow aspiration pathology of three patients with delayed-phase thrombocytopenia, showing impaired maturation of megakaryocytes. We speculated that immune-mediated platelet destruction might account for the delayed-phase thrombocytopenia in a group of patients. In addition, clinicians need to pay attention to the delayed-phase thrombocytopenia especially at 3-4 weeks after symptom onset.
- Published
- 2020
48. Delayed-Phase Thrombocytopenia in Patients of Coronavirus Disease 2019 (COVID-19)
- Author
-
Ziping Li, X. Chen, Hao Zhou, Wanxin Chen, Jian-Hua Zhu, Qiong Zhou, Bohan Yang, Peng Yang, and Ping Wang
- Subjects
medicine.medical_specialty ,biology ,business.industry ,Delayed phase ,medicine.disease ,Pneumonia ,medicine.anatomical_structure ,Internal medicine ,medicine ,biology.protein ,Platelet ,In patient ,Bone marrow ,Antibody ,business ,Interleukin 6 ,B cell - Abstract
The pandemic COVID-19 pneumonia has engulfed the entire world. Hematopoietic system can also be affected by COVID-19. Thrombocytopenia at admission was prevalent, while late-phase or delayed-phase thrombocytopenia is obscure. This retrospective single-center case series analyzed patients with COVID-19 at the Union Hospital, Wuhan, China, from January 25th to March 9th, 2020. Analysis began on March 11th, 2020. COVID-19 associated delayed-phase thrombocytopenia was occurred in 11.8% percent of enrolled patients. The delayed-phase thrombocytopenia in COVID-19 is prone to develop in elderly patients or patients with low lymphocyte count on admission. The delayed-phase thrombocytopenia is significantly associated with increased length of hospital stay and higher ICU admission rate. Delayed-phase nadir platelet counts demonstrated a high and significantly negative linear correlation with B cell percentages and serum IL-6 levels. We also presented bone marrow aspiration pathology of three patients with delayed-phase thrombocytopenia, showing impaired maturation of megakaryocytes. We speculated that the delayed-phase platelet destruction might be mediated by antibodies, and suggest immunoregulatory treatment in severe patients to improve outcomes. Besides, clinicians need to pay attention to the delayed-phase thrombocytopenia especially at 3-4 weeks after symptom onset.
- Published
- 2020
49. Fabricating a sustained releaser of heparin using SBA-15 mesoporous silica
- Author
-
Wei Gang Lin, Jian Hua Zhu, Wen Juan Qian, and Mi Mi Wan
- Subjects
Chromatography ,Materials science ,Carbonization ,Biomedical Engineering ,General Chemistry ,General Medicine ,Heparin ,Mesoporous silica ,chemistry.chemical_compound ,Adsorption ,chemistry ,Chemical engineering ,Triethoxysilane ,medicine ,General Materials Science ,medicine.drug - Abstract
The sustained release of heparin in sufficient amounts and over long time is a challenge to drive the development of functional materials. In this paper SBA-15 mesoporous silica is selected in the search for a favorable morphology and optimized surface state for the sustained release of heparin. In situ carbonization of the template in the as-synthesized sample enables SBA-15 to possess narrowed channels with rougher surfaces, while modification with (aminopropyl)triethoxysilane (APTES) through a one-pot synthesis offers SBA-15 with positive charges to attract heparin through electro-static interactions. The structure of modified SBA-15 samples is assessed with XRD (powder X-ray diffraction analysis), nitrogen adsorption–desorption and electron microscopy techniques, and their performance is evaluated in adsorption and release of heparin. These modifications improve the heparin adsorption in SBA-15 and thus promote its sustained release, prolonging the release-equilibrium time up to 60 days. Among them, the SBA-15 sample modified with APTES can trap three times as much heparin as the parent SBA-15, and the release ratio is elevated to 80% (that of SBA-15 is 38%), realizing the best performance of controlling heparin release to date.
- Published
- 2020
50. Expert Consensus on Procedures and Operations of Navigation-guided Needle Biopsy Techniques for Skull Base Tumours
- Author
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Jing, Wang, Chuan Bin, Guo, Jian Hua, Zhu, Yu Xing, Guo, Guang Yan, Yu, Yang, He, Wen Bo, Zhang, Yi, Zhang, Xin, Peng, Xiao Jing, Liu, Yan Pu, Liu, Xiao Ming, Gu, Wei Dong, Tian, Li, Lu, Zu Bing, Li, Shi Lei, Zhang, Guo Fang, Shen, Sheng De, Bao, Tie Jun, Li, Kai Yuan, Fu, Society Of Oral And Maxillofacial Surgery, and Chinese Stomatological Association
- Subjects
Skull Base ,Consensus ,Biopsy, Needle ,Humans ,Endoscopy ,Skull Base Neoplasms - Abstract
Skull base surgery is an interdisciplinary subject. The anatomical structures in the skull base related to oral and maxillofacial surgery include the parapharyngeal space, the pterygopalatine fossa and the infratemporal space. This operative area is one of the most challenging surgical areas in oral and maxillofacial surgery due to its deep site, complex anatomy and high risk. Obtaining pathological information of the tumour preoperatively may help surgeons optimise their treatment plan. Needle biopsy is one of the major minimally invasive techniques that allows preoperative pathological results to be obtained. The navigation technology, which is developing rapidly nowadays, provides a reliable assistance for deep tissue biopsy surgery. Experts from the Society of Oral and Maxillofacial Surgery, Chinese Stomatological Association formulated an expert consensus on the procedures and operations of navigation-guided needle biopsy techniques for skull base tumours, so as to standardise and promote the application and operation of navigation-guided needle biopsy for skull base tumours.
- Published
- 2020
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