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Objectives We aimed to evaluate the risk factors for moderate-to-severe bronchopulmonary dysplasia (BPD) and focus on discussing its relationship with the duration of initial invasive mechanical ventilation (IMV) in very preterm neonates less than 32 weeks of gestational age (GA). Methods We performed a prospective cohort study involving infants born at 23–31 weeks of GA who were admitted to 47 different neonatal intensive care unit (NICU) hospitals in China from January 2018 to December 2021. Patient data were obtained from the Sina-northern Neonatal Network (SNN) Database. Results We identified 6538 very preterm infants, of whom 49.5% (3236/6538) received initial IMV support, and 12.6% (823/6538) were diagnosed with moderate-to-severe BPD symptoms. The median duration of initial IMV in the moderate-to-severe BPD group was 26 (17–41) days, while in the no or mild BPD group, it was 6 (3–10) days. The incidence rate of moderate-to-severe BPD and the median duration of initial IMV were quite different across different GAs. Multivariable logistic regression analysis showed that the onset of moderate-to-severe BPD was significantly associated with the duration of initial IMV [adjusted odds ratio (AOR): 1.97; 95% confidence interval (CI): 1.10–2.67], late-onset neonatal sepsis (LONS), and patent ductus arteriosus (PDA). Conclusion In this multicenter cohort study, the duration of initial IMV was still relatively long in very premature infants, and the longer duration of initial IMV accounts for the increased risk of moderate-to-severe BPD.

Graphic abstract Paeonol, derived from natural plants (Moutan Cortex), has a wide range of biological effects, including anti-inflammatory and antitumor effects as well as favorable effects against cardiovascular and neurodegenerative diseases. The anti-inflammatory action is the main pharmacological activity of paeonol and has the greatest clinical relevance. However, the anti-inflammatory mechanism of paeonol has not been reported in sufficient detail. We systematically analyzed the anti-inflammatory mechanism of paeonol using network pharmacological databases and platforms, including TCMSP, Swiss TargetPrediction, OMIM, DrugBank, TTD, Jevnn, STRING11.0, and Metascape. Furthermore, we used high-throughput molecular docking method to prove the results of the above analyses, providing a reference for exploring the mechanism of paeonol and developing targeted drugs.

Introduction. As a novel global epidemic, corona virus disease 2019 (COVID-19) caused by SARS-CoV-2 brought great suffering and disaster to mankind. Recently, although significant progress has been made in vaccines against SARS-CoV-2, there are still no drugs for treating COVID-19. It is well known that traditional Chinese medicine (TCM) has achieved excellent efficacy in the treatment of COVID-19 in China. As a treasure-house of natural drugs, Chinese herbs offer a promising prospect for discovering anti-COVID-19 drugs. Hypothesis/Gap Statement. We proposed that Rhei Radix et Rhizome−Schisandrae Sphenantherae Fructus (RS) may have potential value in the treatment of COVID-19 patients by regulating immune response, protecting the cardiovascular system, inhibiting the production of inflammatory factors, and blocking virus invasion and replication processes. Aim. We aimed to explore the feasibility and molecular mechanisms of RS against COVID-19, to provide a reference for basic research and clinical applications. Methodology. Through literature mining, it is found that a Chinese herbal pair, RS, has potential anti-COVID-19 activity. In this study, we analysed the feasibility of RS against COVID-19 by high-throughput molecular docking and molecular dynamics simulations. Furthermore, we predicted the molecular mechanisms of RS against COVID-19 based on network pharmacology. Results. We proved the feasibility of RS anti-COVID-19 by literature mining, virtual docking and molecular dynamics simulations, and found that angiotensin converting enzyme 2 (ACE2) and 3C-like protease (3 CL pro) were also two critical targets for RS against COVID-19. In addition, we predicted the molecular mechanisms of RS in the treatment of COVID-19, and identified 29 main ingredients, 21 potential targets and 16 signalling pathways. Rhein, eupatin, (-)-catechin, aloe-emodin may be important active ingredients in RS. ALB, ESR1, EGFR, HMOX1, CTSL, and RHOA may be important targets against COVID-19. Platelet activation, renin secretion, ras signalling pathway, chemokine signalling pathway, and human cytomegalovirus infection may be important signalling pathways against COVID-19. Conclusion. RS plays a key role in the treatment of COVID-19, which may be closely related to immune regulation, cardiovascular protection, anti-inflammation, virus invasion and replication processes.

Previous studies have found that oxidative stress is the negative reaction of the imbalance between oxidation and antioxidation caused by free radicals, and it is the fuse of aging and many diseases. Scavenging the accumulation of free radicals in the body and inhibiting the production of free radicals are effective ways to reduce the occurrence of oxidative stress. In recent years, studies have found that oxidative stress has other effects on the body, such as anti-tumour. In this paper, the targets related to anti-oxidative stress were introduced, and they were divided into nuclear transcription factors, enzymes, solute carrier family 7, member 11 (SLC7A11) genes and iron death, ion channels, molecular chaperones, small molecules according to their different functions. In addition, we introduce the research status of agonists/inhibitors related to these targets, so as to provide some reference for the follow-up research and clinical application of anti-oxidative stress drugs.

The emergency of a new computing pattern must be supported by powerful mathematical theory, weak theoretical supported ideology does not have a strong vitality, and which will become vulnerable. As being a new theory, the DNA computing treated as a new computational pattern also need a lot of basic theoretical research system. This article describes the nature of DNA computing, given the equivalence of DNA computing pattern with traditional computer under the support of automata theory system, further analysis and understanding the DNA computing pattern.

In 2012, Wang Zuofei built up granularity-function and applied it to the measure of attribute importance and attribute reduction. On this basis, granularity-function based upon pessimistic and optimistic multi-granularity rough set is constructed. It is applied to the calculation of attribute importance and attribute reduction. According to the experimental results, the method can reduce the dimension of features and obviously improve the classification accuracy and efficiency.

KNN classifier is a simple, non-parametric, high efficiency algorithm. But it has the defect that the classification efficiency will increase as the enlargement of data scale. This paper put forward a new KNN classification method based on rough set on the research of algorithms presented by Yu Ying and Heping Gou. The innovation of this algorithm is that the kernel, negative domain and boundary region of variable precision rough set are used to be the indexes of measuring the intra-class, extra-class and the class boundary of training sample set. The samples of intra-class, extra-class and the class boundary that are to be classed have differential treatment when judging the category. In this way, the scale of training sample set is effectively reduced and the efficiency and precision of classification are improved. At last, the category function is improved to reflect the category of samples to be classed. The experimental results show that the method can obviously improve the classification efficiency and accuracy.

1.1. Objectiveː Many non-contact anterior cruciate ligament (ACL) injuries in female basketball athletes occur during the deceleration phase of sidestep cutting maneuvers. However, few studies have attempted to quantify the kinetic and kinematical parameters related to landing technique during sidestep cutting maneuvers by basketball players. The objective of this study was to evaluate the effects of forefoot and rearfoot landing techniques on trunk and lower extremity kinetic and kinematic parameters during sidestep cutting maneuvers in this population. 1.2. Methodsː Fourteen healthy female collegiate basketball athletes performed forefoot or rearfoot landing technique randomly during sidestep cutting maneuvers. The trunk and lower extremity kinetic and kinematic variables of the non-dominant leg were analyzed during landing. The variables between forefoot and rearfoot landings during these maneuvers were compared. 1.3. Resultsː Rearfoot landings showed increased peak knee flexion angle and extension moment during the deceleration phase of sidestep cutting maneuvers, as compared to forefoot landing (p

The thermodynamic and elastic properties of magnesium silicate (MgSiO3) perovskite at high pressure are investigated with the quasi-harmonic Debye model and the first-principles method based on the density functional theory. The obtained equation of state is consistent with the available experimental data. The heat capacity and the thermal expansion coefficient agree with the observed values and other calculations at high pressures and temperatures. The elastic constants are calculated using the finite strain method. A complete elastic tensor of MgSiO3 perovskite is determined in the wide pressure range. The geologically important quantities: Young's modulus, Poisson's ratio, Debye temperature, and crystal anisotropy, are derived from the calculated data.

First principles studies of structural, elastic, electronic and optical properties of tetragonal CaSiO3perovskite under pressure are reported using the pseudopotential plane wave method within the local density approximation (LDA). The calculated equilibrium lattice is in good agreement with the available experimental data. The elastic constants and their pressure dependence are calculated using the static finite strain technique. A linear pressure dependence of the elastic stiffnesses is found. Band structures show that tetragonal CaSiO3perovskite is a direct band gap material. In order to understand the optical properties of tetragonal CaSiO3perovskite, the dielectric function, absorption coefficient, optical reflectivity, refractive index, extinction coefficient, and electron energy loss are calculated for radiation up to 40 eV. This is the first quantitative theoretical prediction of the elastic, electronic and optical properties of tetragonal CaSiO3perovskite, and it still awaits experimental confirmation.

The electronic structure and optical properties of magnesium oxide (MgO) are investigated at the structural phase transition pressure using the plane-wave pseudo-potential density functional method within the generalized gradient approximation (GGA). Good agreement between the calculated lattice parameters and experimental results is obtained, and a direct energy gap of 3.72 eV is estimated in the GGA for the NaCl structure (B1) of MgO. The electronic structure of the CsCl-type structure (B2) is predicted near the structural phase transition pressure for the first time and discussed in detail. The dielectric function and optical properties such as reflectivity, absorption coefficient, refractive index, and electron energy-loss function are presented in a wide energy range between 0 and 60 eV. It is found that the reflectivity spectrum and energy-loss spectrum of the B1 phase at 0 GPa are consistent with experimental results.

To investigate the treatment results of fracture involved articular surface with absorbable screws and rods.From October 1995 to May 2002, 32 patients with fracture involved articular surface were treated with absorbable screws and rods with the materials of SR-PGA and SR-PLLA. Bone traction or plaster external fixation were carried out postoperatively.The followed-up period varied from 3 months to 78 months, with an average of 18.5 months. According to the articular function evaluation criteria, the results were excellent in 24 patients, good in 6 patients and fair in 2 patients. The excellent and good rate was 93.7%. The fractures healed, without dislocation, infection and local effusion.Internal fixation of absorbable screws and rods is a perfect procedure for treating fracture involved articular surface, which avoided the pain of taking out internal fixation materials of the second operation.