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Limited evidence supports the use of early endpoints to evaluate the success of initial treatment of extranodal NK/T-cell lymphoma (ENKTCL) in the modern era. We aim to analyze progression-free survival at 24 months (PFS24) and subsequent overall survival (OS) in a large-scale multicenter cohort of patients. 1790 patients were included from the China Lymphoma Collaborative Group (CLCG) database. Subsequent OS was defined from the time of PFS24 or progression within 24 months to death. OS was compared with age- and sex-matched general Chinese population using expected survival and standardized mortality ratio (SMR). Patients who did not achieve PFS24 had a median OS of 5.3 months after progression, with 5-year OS rate of 19.2% and the SMR of 71.4 (95% CI, 62.9–81.1). In contrast, 74% patients achieved PFS24, and the SMR after achieving PFS24 was 1.77 (95% CI, 1.34–2.34). The observed OS rate after PFS24 versus expected OS rate at 5 years was 92.2% versus 94.3%. Similarly, superior outcomes following PFS24 were observed in early-stage patients (5-year OS rate, 92.9%). Patients achieving PFS24 had excellent outcome, whereas patients exhibiting earlier progression had a poor survival. These marked differences suggest that PFS24 may be used for study design and risk stratification in ENKTCL.

Derived from our original nomogram study by using the risk variables from multivariable analyses in the derivation cohort of 1383 patients with extranodal NK/T-cell lymphoma, nasal-type (ENKTCL) who were mostly treated with anthracycline-based chemotherapy, we propose an easily used nomogram-revised risk index (NRI), validated it and compared with Ann Arbor staging, the International Prognostic Index (IPI), Korean Prognostic Index (KPI), and prognostic index of natural killer lymphoma (PINK) for overall survival (OS) prediction by examining calibration, discrimination, and decision curve analysis in a validation cohort of 1582 patients primarily treated with non-anthracycline-based chemotherapy. The calibration of the NRI showed satisfactory for predicting 3- and 5-year OS in the validation cohort. The Harrell’s C-index and integrated Brier score (IBS) of the NRI for OS prediction demonstrated a better performance than that of the Ann Arbor staging system, IPI, KPI, and PINK. Decision curve analysis of the NRI also showed a superior outcome. The NRI is a promising tool for stratifying patients with ENKTCL into risk groups for designing clinical trials and for selecting appropriate individualized treatment.

We aimed to determine the survival benefits of chemotherapy (CT) added to radiotherapy (RT) in different risk groups of patients with early-stage extranodal nasal-type NK/T-cell lymphoma (ENKTCL), and to investigate the risk of postponing RT based on induction CT responses. A total of 1360 patients who received RT with or without new-regimen CT from 20 institutions were retrospectively reviewed. The patients had received RT alone, RT followed by CT (RT + CT), or CT followed by RT (CT + RT). The patients were stratified into different risk groups using the nomogram-revised risk index (NRI). A comparative study was performed using propensity score-matched (PSM) analysis. Adding new-regimen CT to RT (vs RT alone) significantly improved overall survival (OS, 73.2% vs 60.9%, P < .001) and progression-free survival (PFS, 63.5% vs 54.2%, P < .001) for intermediate-risk/high-risk patients, but not for low-risk patients. For intermediate-risk/high-risk patients, RT + CT and CT + RT resulted in non-significantly different OS (77.7% vs 72.4%; P = .290) and PFS (67.1% vs 63.1%; P = .592). For patients with complete response (CR) after induction CT, initiation of RT within or beyond three cycles of CT resulted in similar OS (78.2% vs 81.7%, P = .915) and PFS (68.2% vs 69.9%, P = .519). For patients without CR, early RT resulted in better PFS (63.4% vs 47.6%, P = .019) than late RT. Risk-based, response-adapted therapy involving early RT combined with CT is a viable, effective strategy for intermediate-risk/high-risk early-stage patients with ENKTCL in the modern treatment era.

The present study investigated the survival benefit of non–anthracycline (ANT)-based vs ANT-based regimens in a large-scale, real-world cohort of patients with extranodal natural killer (NK)/T-cell lymphoma, nasal type (ENKTCL). Within the China Lymphoma Collaborative Group (CLCG) database (2000-2015), we identified 2560 newly diagnosed patients who received chemotherapy with or without radiotherapy. Propensity score matching (PSM) and multivariable analyses were used to compare overall survival (OS) and progression-free survival (PFS) between the 2 chemotherapy regimens. We explored the survival benefit of non–ANT-based regimens in patients with different treatments in early-stage disease and in risk-stratified subgroups. Non–ANT-based regimens significantly improved survivals compared with ANT-based regimens. The 5-year OS and PFS were 68.9% and 59.5% for non–ANT-based regimens compared with 57.5% and 44.5% for ANT-based regimens in the entire cohort. The clinical advantage of non–ANT-based regimens was substantial across the subgroups examined, regardless of stage and risk-stratified subgroup, and remained significant in early-stage patients who received radiotherapy. The survival benefits of non–ANT-based regimens were consistent after adjustment using multivariable and PSM analyses. These findings provide additional evidence supporting non–ANT-based regimens as a first-line treatment of patients with ENKTCL.

This study evaluated the survival benefit of intensity-modulated radiation therapy (IMRT) compared with 3-dimension conformal radiation therapy (3D-CRT) in a large national cohort of patients with early-stage extranodal nasal-type natural killer/T-cell lymphoma (NKTCL). This retrospective study reviewed patients with early-stage NKTCL treated with high-dose radiation therapy (RT; ≥45 Gy) at 16 Chinese institutions. Patients were stratified into 1 of 4 risk groups based on the number of risk factors: low risk (no factors), intermediate-low risk (1 factor), intermediate-high risk (2 factors), and high-risk (3-5 factors). Of the 1691 patients, 981 (58%) received IMRT, and 710 (42%) received 3D-CRT. Unadjusted 5-year overall survival (OS) and progression-free survival (PFS) were 75.9% and 67.6%, respectively, for IMRT compared with 68.9% (P = .004) and 58.2% (P < .001), respectively, for 3D-CRT. After propensity score match and multivariable analyses to account for confounding factors, IMRT remained significantly associated with improved OS and PFS. The OS and PFS benefits of IMRT persisted in patients treated with modern chemotherapy regimens. Compared with 3D-CRT, IMRT significantly improved OS and PFS for high-risk and intermediate-high–risk patients but provided limited benefits for low-risk or intermediate-low–risk patients. A risk-adapted survival benefit profile of IMRT can be used to select patients and make treatment decisions.

Background & Aims: Growing evidence has shown that M2-PK is involved in cancer diagnosis and prognosis. The overall diagnostic accuracy of the pyruvate kinase isoenzyme type M2 (M2-PK) in biliary tract carcinoma (BTC) remains controversial. We performed a meta-analysis to evaluate the diagnostic value of M2-PK for BTC.Methods: The online PubMed, Cochrane, Web of Science, and Embase databases were searched for eligible studies published until August 8th, 2017. The Quality Assessment for Diagnostic Accuracy Studies 2 (QUADAS-2) was used to evaluate study quality. All statistical analyses were conducted with Stata 12.0.Results: We included 7 studies from 5 articles with 410 patients with BTC and 438 controls. The pooled sensitivity, specificity, positive likelihood ratio (PLR), negative likelihood ratio (NLR), diagnostic odds ratio (DOR), and AUC for M2-PK in the diagnosis of BTC were 0.79 (95%CI 0.70-0.86), 0.81 (95%CI 0.71-0.88), 4.1 (95%CI 2.5-6.8), 0.26 (95%CI 0.16-0.41), 17.159 (95%CI 5.468-54.071), and 0.87 (95%CI 0.83-0.89), respectively. The same indicators assessed for CA19-9 were as follows: 0.70 (95%CI 0.62-0.77), 0.71 (95%CI 0.45-0.87), 2.38 (95%CI 1.2-4.73), 0.43 (95%CI 0.34-0.53), 6.28 (95%CI 2.4-16.44) and 0.73 (95%CI 0.69-0.77), respectively. Additionally, the diagnostic value of M2-PK varied based on characteristics of golden methods and different cut-off values.Conclusions: This meta-analysis showed that M2-PK had a better diagnostic accuracy for BTC compared with CA19-9, with moderate diagnostic performance. However, prospective studies are required to confirm its diagnostic value.

Purpose: The aim of this study was to determine the impact of analyzing age as a continuous variable on survival outcomes and treatment selection for extranodal nasal-type NK/T-cell lymphoma. Results: The risk of mortality increased with increasing age, without an apparent cutoff point. Patients’ age, as a continuous variable, was independently associated with overall survival after adjustment for covariates. Older early-stage patients were more likely to receive radiotherapy only whereas young-adult advanced-stage patients tended to receive non-anthracycline-based chemotherapy. A decreased risk of mortality with radiotherapy versus chemotherapy only in early-stage patients (HR, 0.347, P < 0.001) or non-anthracycline-based versus anthracycline-based chemotherapy in early-stage (HR, 0.690, P = 0.001) and advanced-stage patients (HR, 0.678, P = 0.045) was maintained in patients of all ages. Conclusions: These findings support making treatment decisions based on disease-related risk factors rather than dichotomized chronological age. Patients and Methods: Data on 2640 patients with extranodal nasal-type NK/T-cell lymphoma from the China Lymphoma Collaborative Group database were analyzed retrospectively. Age as a continuous variable was entered into the Cox regression model using penalized spline analysis to determine the association of age with overall survival (OS) and treatment benefits.

This cohort study assesses changes in survival probabilities and failure hazard after radiotherapy in adult patients with early-stage extranodal natural killer/T-cell lymphoma based on risk categories, previous survival, and treatment., Key Points Question How do survival probabilities change over time for patients with early-stage extranodal natural killer/T-cell lymphoma after radiotherapy? Findings In this cohort study of 2015 patients in China with early-stage natural killer/T-cell lymphoma, survival probabilities increased and failure hazard decreased over time in a risk-dependent manner after radiotherapy. Patients with an initially higher risk and constantly lower risk were identified. Meaning The posttreatment information on disease processes may permit risk-adapted therapy, follow-up, and counseling., Importance Prognosis of early-stage extranodal natural killer/T-cell lymphoma (NKTCL) is usually estimated and stratified at diagnosis, but how the prognosis actually evolves over time for patients who survived after curative treatment is unknown. Objective To assess conditional survival and failure hazard over time based on risk categories, previous survival, and treatment. Design, Setting, and Participants This retrospective cohort study reviewed the clinical data of 2015 patients with early-stage NKTCL treated with radiotherapy identified from the China Lymphoma Collaborative Group multicenter database between January 1, 2000, and December 31, 2015. Patients were stratified into low-, intermediate- and high-risk groups according to a previously established prognostic model. Median follow-up was 61 months for surviving patients. Data analysis was performed from December 1, 2017, to January 30, 2018. Exposures All patients received radiotherapy with or without chemotherapy. Main Outcomes and Measures Conditional survival defined as the survival probability, given patients have survived for a defined time, and annual hazard rates defined as yearly event rate. Results A total of 2015 patients were included in the study (mean [SD] age, 43.3 [14.6] years; 1414 [70.2%] male); 1628 patients (80.8%) received radiotherapy with chemotherapy, and 387 (19.2%) received radiotherapy without chemotherapy. The 5-year survival rates increased from 69.1% (95% CI, 66.6%-71.4%) at treatment to 85.3% (95% CI, 81.7%-88.2%) at year 3 for conditional overall survival and from 60.9% (95% CI, 58.3%-63.3%) at treatment to 84.4% (95% CI, 80.6%-87.6%) at year 3 for conditional failure-free survival. The annual hazards decreased from 13.7% (95% CI, 13.0%-14.3%) for death and 22.1% (95% CI, 21.0%-23.1%) for failure at treatment to less than 5% after 3 years (death: range, 0%-3.9% [95% CI, 3.7%-4.2%]; failure: 1.2% [95% CI, 1.0%-1.4%] to 4.2% [95% CI 3.9%-4.6%]). Intermediate-risk (11.4% [95% CI, 10.5%-12.3%]) and high-risk (21.6% [95% CI, 20.0%-23.2%]) patients had initially higher but significantly decreased death hazards after 3 years (

Background The purpose of this study was to determine the curability of early‐stage extranodal nasal‐type NK/T‐cell lymphoma (NKTCL) in response to radiotherapy and non‐anthracycline‐based chemotherapy in elderly patients. Methods In this multicenter study from the China Lymphoma Collaborative Group (CLCG) database, 321 elderly patients with early‐stage NKTCL were retrospectively reviewed. Patients received radiotherapy alone (n = 87), chemotherapy alone (n = 59), or combined modality therapy (CMT, n = 175). Patients were classified into low‐ or high‐risk groups using four prognostic factors. Observed survival in the study cohort vs expected survival in age‐ and sex‐matched individuals from the general Chinese population was plotted using a conditional approach and subsequently compared using a standardized mortality ratio (SMR). Results Radiotherapy conveyed a favorable prognosis and significantly improved survival compared to chemotherapy alone. The 5‐year overall survival (OS) and progression‐free survival (PFS) were 61.2% and 56.4%, respectively, for radiotherapy compared with 44.7% and 38.3%, respectively, for chemotherapy alone (P

Purpose This study aimed to clarify the benefit of radiotherapy (RT) in patients with early-stage extranodal NK/T-cell lymphoma (NKTCL) who achieve a complete response (CR) after asparaginase-containing chemotherapy (CT). Patients and methods Of 240 patients achieved a CR after asparaginase-containing CT, 202 patients received additional RT (CT + RT), and 38 patients did not (CT alone). Results Compared to CT alone, CT + RT significantly improved overall survival (OS), disease-free survival (DFS) and locoregional control (LRC). The 5-year OS, DFS and LRC rates were 84.9%, 76.2% and 84.9% for CT + RT, compared to 58.9% (P = 0.006), 43.6% (P = 0.001) and 62.1% (P = 0.026) for CT alone. The 5-year cumulative disease recurrence rate was 18.8% for CT + RT compared to 46.9% (P = 0.003) for CT alone. High-dose RT (≥50 Gy) significantly decreased the risk of locoregional recurrence. The 5-year cumulative locoregional failure rate was 35.5% for patients receiving Conclusions For patients with early-stage NKTCL who achieve a CR after asparaginase-containing CT, omission of RT results in frequent locoregional recurrence and a poor prognosis; RT is essential to improve locoregional control and survival.

The optimal combination and sequence of radiotherapy (RT) and chemotherapy (CT) for extranodal nasal-type natural killer/T-cell lymphoma (NKTCL) are not well-defined. The aim of this study was to create a risk-adapted therapeutic strategy for early-stage NKTCL. A total of 1273 early-stage patients from 10 institutions were reviewed. Patients received CT alone (n = 170), RT alone (n = 253), RT followed by CT (n = 209), or CT followed by RT (n = 641). A comprehensive comparative study was performed using multivariable and propensity score-matched analyses. Early-stage NKTCL was classified as low risk or high risk based on 5 independent prognostic factors (stage, age, performance status, lactate dehydrogenase, primary tumor invasion). RT alone and RT with or without CT were more effective than CT alone (5-year overall survival [OS], 69.6% and 67.7% vs 33.9%, P < .001). For low-risk patients, RT alone achieved a favorable OS (88.8%); incorporation of induction or consolidation CT did not provide additional benefit (86.9% and 86.3%). For high-risk patients, RT followed by CT resulted in superior OS (72.2%) compared with induction CT and RT (58.3%, P = .004) or RT alone (59.6%, P = .017). After adjustment, similar significant differences in OS were still observed between treatment groups. New CT regimens provided limited benefit in early-stage NKTCL. Risk-adapted therapy involving RT alone for low-risk patients and RT consolidated by CT for high-risk patients is a viable, effective strategy for early-stage NKTCL.

Hough Transform[has become a common method in the usage of line detection because of its robustness. It is important in computer vision and image analysis. Usually, the standard Hough transform method (SHT) transform the points in image space into parameter space and vote for all the possible patterns passing through that point. But, there are two serious problems in the standard method of line detection. The first is the high computation complexity and the second is the large storage requirements .In order to solve the two problems, this paper raise a fast-Hough transform algorithm base on pyramid algorithm. First of all we need to desample the primitive binary image with n times; and execute the Hough transform in the nth level image to get the parameter of straight line in this image, which is used in the n-1 level image. Finally we can get the parameter of lines in the primitive image. Experiments show that this method can extremely reduces the computational time.

This paper presents a multi-frame super-resolution (SR) reconstruction algorithm based on diffusion tensor regularization term. Firstly, L1-norm structure is used as data fidelity term, anisotropic diffusion equation with directional smooth characteristics is introduced as a prior knowledge to optimize reconstruction result. Secondly, combined with shock filter, SR reconstruction energy functional is established. Finally, Euler-Lagrange equation based on nonlinear diffusion model is exported. Simulation results validate that the proposed algorithm enhances image edges and suppresses noise effectively, which proves better robustness.

Various tone reproduction operators have been proposed to display high dynamic range images on low dynamic range (LDR) devices. Many recent computational photography techniques decompose an image into a piecewise smooth base layer, containing large scale variations in intensity, and a residual detail layer capturing the smaller scale details in the image. In these techniques, its important to control the scale of the extracted details and it is often needed to manipulate details in order to avoid the appearance of visual artifacts. In this paper, a new method is proposed to preserve details for high dynamic range images tone reproduction using multi-level image decomposition. We show that current base-detail decomposition techniques, based on the bilateral filter, are limited in their ability to extract detail at arbitrary scales. Thus, we achieve detail enhancement by applying the bilateral filter iteratively, and this process is called multi-level decomposition. By minimizing the proposed energy function, we can choose the proper decomposition level. Simulation results demonstrate that the proposed method can acquire better visual quality in detail enhancement while make the base smoothness.

The classical bilateral filtering algorithm is a non-linear and non-iterative image denoising method in spatial domain which utilizes the spatial information and the intensity information between a point and its neighbors to smooth the noisy images while preserving edges well. To further improve the image denoising performance, a spatially adaptive bilateral filtering image deonoising algorithm with low computational complexity is proposed. The proposed algorithm takes advantage of the local statistics characteristic of the image signal to better preserve the edges or textures while suppressing the noise. Experiment results show that the proposed image denoising algorithm achieves better performance than the classical bilateral filtering image denoising method.

The diffractive optical elements, with the negative dispersive characteristic and the random phase distributing to realize random phase modulation for wave-front, are not only helpful to simplify the optical system, but also improve the image quality, while putting it into the optical system. It can decrease the element numbers of the system and obtain a compact configuration that introducing diffractive optical element into the design of eyepiece. A hybrid diffractive-refractive wide-angle eyepiece, with a big exit pupil distance, is designed by using the Code V Optical Design Software. The features of the wide-angle eyepiece are 30mm effective focal length, 60°whole field-of-view (FOV), 30mm exit pupil distance and 6mm exit pupil diameter, and which consists of four lens and two diffractive elements. From the result of design, the MTF in the center field of the wide-angle eyepiece is over 0.55at 60lp/mm, at the same time, the MTFs in all fields are over 0.3 at 50lp/mm, which show that this wide-angle eyepiece has a great image quality.

This paper presents an improved high dynamic range image tone mapping method based on fast bilateral filtering. The algorithm first applied a bilateral filtering to the luminance channel of the image, the image is decomposed into an HDR base layer and an LDR detail layer. Then the HDR base layer is blurred with bilateral filtering again, get the details portion of the base layer, at the same time the dynamic range of the global base layer is compressed. Finally, the detail component and the compressed HDR base layer are recombined and the result is tone-mapped image for displaying. For color image, the color restoration converts luminance value into RGB color. Experimental results show that the proposed technique performed better than the conventional bilateral filtering, preserving more details and enhancing local contrast, giving decent visual effect and avoiding additional artifacts.

In this paper, we propose a new single super-resolution (SR) reconstruction algorithm via block sparse representation and regularization constraint. Firstly, discrete K-L transform is used to learn compression sub-dictionary according to the specific image block. Combined with threshold choice of training data, the transform bases are generated adaptively corresponding to the sparse domain. Secondly, Non-local Self-similarity (NLSS) regularization term is introduced into sparse reconstruction objective function as a prior knowledge to optimize reconstruction result. Simulation results validate that the proposed algorithm achieves much better results in PSNR and SSIM. It can both enhance edge and suppress noise effectively, which proves better robustness.

Optical equipments especially those for aerospace application are expected to work over a wide temperature range. The change of temperature could cause the refractive index change of infrared glass elements. Furthermore, it would lead to the defocus of the image surface and the performance degradation, so the method of temperature compensation must be adopted, which could make sure that optical system would adapt to the change of ambient temperature. A method of temperature compensation with mechanical passive compensation is briefly described, and an example is also given. The quality of image could be optimized through mechanical passive compensation,depending on the differences of metal and non-metallic thermal expansion coefficient. The results show that the optical system works stablely in the designed temperature range. It is of great importance to the athermalisation design of infrared optical system.

Due to the possession of advantages of passivity working mode, good disguise, and easy observation, infrared systems are used in a wide variety of applications. This paper using 640×480 uncooled detector designed a long-wave scan optical system with large field and large aperture working at 8.0μm～12μm, the Pixel Dimensions of the detector is 30μm. The F number of this system is 1.4 and focal length is 17mm, FOV is 63.6°, which extended to 143° by adopting dual-wedge prism rotating, the paper also given the extended field theory by the dual-wedge prism. Because there are a limited number of lens materials used in LWIR spectral bands, Germanium material and three aspheric surfaces were adopted to balance sphere aberrations and chromatic aberration. All above mentioned are intending to ensure the system has good imaging quality. The results show that the optical performance approximates to the diffraction limit and the design has better achromatic performance. The modulation transfer function (MTF) is above 0.5 at spatial frequency of 20lp/mm, energy concentration ratio is greater than 70% within the sensing element of the detector and Root Mean Square (RMS) value of spot diameter is smaller than the Pixel Dimensions. The system has advantages of simple structure, large aperture, high image quality etc.

The long-term survival benefit for radiotherapy (RT) in early-stage extranodal natural killer/T-cell lymphoma (NKTCL) is not known, and it is unclear whether improved locoregional control (LRC) translates into a survival benefit.To investigate the dose-dependent effect and potential survival benefits of RT on the basis of LRC improvements.Review of clinical data of patients with early-stage NKTCL at 10 institutions in China between 2000 and 2014. Radiotherapy dose as a continuous variable was entered into the Cox regression model by using penalized spline regression to allow for a nonlinear relationship between RT dose and events. Regression analysis was used to assess whether a linear correlation exists between LRC and progression-free survival (PFS) or overall survival (OS). Patients received chemotherapy (CT) alone, RT alone, or a combination. Chemotherapy alone was defined as 0 Gy.The association between LRC and OS or PFS.A total of 1332 patients (923 [69%] male; median age, 43 years [range, 2-87 years]) were reviewed. For patients treated with RT, median dose was 50 Gy (range, 10-70 Gy); 996 (86%) received at least 50 Gy, and 164 (14%) received 10 to 49 Gy. The risk of locoregional recurrence, disease progression, and mortality decreased sharply until 50 to 52 Gy. For patients receiving RT, high-dose RT (≥50 Gy) was associated with significantly better 5-year LRC (85% vs 73%; P .001), PFS (61% vs 50%; P = .004), and OS (70% vs 58%; P = .04) than low-dose RT (50 Gy). Improved LRC with high-dose RT was independent of the RT/CT sequence or initial response to CT. Radiotherapy yielded a dose-dependent effect on LRC (range, 41%-87%), PFS (18%-63%), and OS (33%-71%). Dose-response regression analysis revealed a linear correlation between 5-year LRC and 5-year PFS (correlation coefficient, r = 0.994, P .001; determination coefficient, R2 = 0.988) or 5-year OS (r = 0.985, P = .002; R2 = 0.97), which was externally validated using published data.The optimal dose was 50 Gy for patients with early-stage disease. The improved LRC was associated with prolonged survival. These findings emphasize the importance of RT in optimizing first-line therapy, and provide evidence for making treatment decisions and designing clinical trials.

Round robin (RR) algorithm has best user fairness, but the system throughput is low, Max C/I algorithm has highest throughput, but poor fairness, Proportional fairness (PF) algorithm makes a compromise between throughput and fairness, but focuses on the average throughput fairness. This paper proposes a frequency domain scheduling algorithm for TD-LTE under different loads (light, medium, and heavy loads), which is called M-RR algorithm. Simulation results show that the algorithm emphasizes on fairness in terms of resource usage, and ensure the system throughput.

In the paper, a design method of brushless DC motor drive controller and its pure hardware implementation on FPGA is proposed. First, we design each module of the controller, including the proportional integral (PI) speed and current PI regulator, current detection module, position and speed detection module, PWM generator and commutation control module, which focuses on a PI regulator and the current detection section. Then, the logical design structure diagrams and the timing simulation waveforms are given. Finally, the overall system circuit are implemented on FPGA which can improve system integration, stability and reliability and easier to modify and upgrade. Simulation and experiment results indicate that this controller design method is reasonable and has stable operation.

Infrared zoom lens system with cooled focal plane array (FPA) detector is widely used in military application. Relevant information about optical design can be got easily, but research on infrared zoom lens system with low cost and high image quality for commercial application is less. This paper design a Compact infrared zoom lens system with only four lenses, using an uncooled focal plane array (FPA) with 384×288 pixels with zoom ratio 3:1. Because of large F number and less lenses, transmission of the whole zoom system is greatly improved. NETD and MRTD of infrared system will be satisfying by this compact design. There is no special surface such as diffractive surface, HOE in zoom lens system, and only Ge and Znse infrared materials are chosen which result in lower production cost of infrared zoom lens system for commercial applications.

Automatic exposure control is the process of controlling the exposure time of the digital imaging system to obtain the desired image which can fit the human vision during the imaging process. A new automatic exposure algorithm for astronomical image is proposed. The pixel value weight is determined by exploring the maximum range of the image histogram. Additionally, the structure of the implementation based on FPGA and experiment results for real data are given. The experiment results show that the proposed algorithm can effectively achieve the real-time automatic exposure control.

Wavelet transform is widely used and has good effect on image denoising. Wavelet transform has unique advantages in dealing with the smooth area of image but is not so perfect in high frequency areas such as the edges. However, curvelet transform can supply this gap when dealing with the high frequency areas because of the characteristic of anisotropy. In this paper, we proposed a new method which is based on the combination of wavelet transform and curvelet transform. Firstly, we detected the edges of the noisy-image using wavelet transform. Based on the edges we divided the image into two parts: the smoothness and the edges. Then, we used different transform methods to dispose different areas of the image, wavelet threshold denoising is used in smoothness while FDCT denoising is used in edges. Experimental results showed that we could get better visual effect and higher PSNR, which indicated that the proposed method is better than using wavelet transform or curvelet transform respectively.

The white balance is an important parameter of digital camera which makes a great impact on the application of digital cameras. However, due to the limitations of hardware of digital camera, the output image of digital camera cannot restore true colors of the objects under the different light sources conditions. And existing automatic white balance (AWB) algorithms have many application restrictions, particularly the single color image, the algorithms always failure to adjust. To solve this problem, this paper proposes an optimized algorithm based on the gray world assumption and HSI color model. According to the R, G and B color components probability distribution, the algorithm adjusts the image by using the difference value of color. Experimental results show that our algorithm can adjust images in complex situations; meanwhile these confirm that this method is not only effective, but also has the advantage of easy realization.

Summary Nasopharyngeal mucoepidermoid carcinoma (MEC) is an extremely rare entity. To date, there is little published about its clinical characteristics and treatment outcomes. Between 1997 and 2009, 13 cases of MEC were confirmed and treated at the department of Radiation Oncology, Cancer Hospital of Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC). Nasal obstruction, bleeding and hearing loss were the most common presentations, whereas, neck mass, headache and cranial nerve palsy were uncommon. Tumors remained stable after either primary radiation therapy or post-operative radiation therapy for the residual, though the majority of them were high or high-intermediate grade tumors. Five patients, who received either primary surgery or salvage surgery, had positive surgical margins, however, all are alive with stable disease except one old patient died of heart failure. The overall median survival of our patients was 43 months, ranging from 8 to 80 months. Based on the present results, we recommend that primary surgery should be the standard of care for all non-metastatic tumors regardless of histopathologic grade, and post-operative radiation therapy should be considered under the circumstances of positive surgical margins, macroscopic residual tumors, and high grade carcinomas.

With the development of the digital airborne photo-grammetry technology, the more performances of the optical system for airborne mapping camera are required, such as the longer focal, the wider field of view (FOV), at the same time, the secondary spectrum correction becomes more important and difficult for the optical system design. A high performance optical system of airborne mapping camera with 200mm focus and2ω=60°FOV is designed in this paper. The range of work wavelength is from 430nm to 885nm. A two-layer HDOE with negative dispersive characteristic is used to eliminate the secondary spectrum in the process of optical system design. The diffraction efficiency of the designed two-layer HDOE is up to 90%. From the result of design, the MTFs in whole fields are over 0.5 at 90lp/mm, which shows that the system has a great image quality. Meantime, the thermal analysis is done at the temperature range between -20°C and 40°C, and the MTF curves of the system at-20°C ~40°C show that a great image quality is kept, which meets the design requirements.

Traditional Genetic algorithm in target tracking process,is quite effective in the global scope to search target position.However, once the background color and light intensity change.To monitor the state of the target depth movement is often difficult to locate the target accurately. However, complex method can make up for the lack of Genetic algorithms. In view of those, this paper integrates Complex method with traditional Genetic algorithms, uses the center coordinates of the candidate target and scaling coefficient to adjust the focus size as a parameter encoding, and takes the similarity between the target area and the target template as a fitness function,then searches the object in the overall and local scope in turn.The experiments show that the fusion algorithm can achieve accurate tracking of the position and the size of the target.

H.264 has adopted UMHexagonS algorithm as fast motion estimation algorithm for integer pixel formally, but this algorithm has some shortages such as search points are lots, quantity of operation is kind of big, costs much time, and so on. These need to be solved as soon as possible. This paper introduces and analyses UMHexagonS algorithm. In order to solve these problems, this paper brings forward classification strategy for search algorithm according to statistical properties of the motion vector prediction value, and improves the template based on original algorithm according to the characteristic of center bias of motion vector. The results of experiments show that the improved algorithm in this paper reduces the time of motion estimation by 15%~27%. At the meantime, it can ensure PSNR and rate basically unchanged.

There is overcapacity in China’s iron and steel industry. The average profit level of the whole industry was only 2.42 % in 2011. Structure of sales channels and sales costs of iron and steel enterprises influence the profit level to a large extent. Through analysis of characteristics of sales channels and channel cost structure in iron and steel enterprises, this paper questioned the generally accepted view that increasing the proportion of direct sales could boost profits. Moreover, this paper further made a comparison between direct sales cost and distribution cost. For comparison, the actual settlement data in an iron and steel enterprise were used. And this paper concludes that setting up sales channels in accordance with product category is a reasonable way to boost corporate profits in the sales link.

The Stabilized platform is used for isolating the vibration and disturbance of carrier and ensuring the stability of the line of sight (LOS). Proportional-integral-derivative (PID) control provides an efficient solution to control problems and make good performance in static precision. The fuzzy controller has good robust and is effective for the nonlinear time-varying system. Based on Advanced Scale Factor and Smooth Handover, this paper presents an Advanced Fuzzy PID Composite controller (A-FPID) to achieve high performance in static precision and dynamic characteristic for stabilized platform. Through the study on the A-FPID, the Scale Factor of defuzzification is adjusted by self-adaptive parameters to improve the control effects of fuzzy rules. A fuzzy switch is proposed when controller switches between fuzzy and PID to reduce non-smooth and jitter problems. The simulation results indicate that the A-FPID can obviously improve the system's dynamical performance and enhance its static precision for stabilized platform.

The infrared thermal imaging systems are widely used for distinguishing target radiation temperature difference and they can also be used to measure the absolute temperature of the target. There may be great difference between the true value and the measurement results in the actual application of the infrared thermal imaging systems, just because of the unstable condition and the lack of compensation of the imager's own heat radiation. In order to obtain the accurate temperature of the target in some special conditions, such as aircraft internal and pilotless platform, we present a stationary infrared thermal imaging system to gather the goal gradation images and a method to compensate the influence of the imager's own heat radiation and the unstable condition. In radiation calibration experiment, we establish corresponding relationships between the gradation difference and the temperature difference by using a goal blackbody and a cooperation calibration blackbody between 0°C and 150°C. We also analysis the relationships mentioned above under the normal temperature and the high temperature separately. The results show that the proposed method may be useful in increasing the temperature measurement precision.

The paper introduces a kind of super relative aperture condenser which has the strcuture of spherical Fresnel surface with catadioptric projection optical system, it would improve the condensing capacity and light efficiency substantially. The condenser is composed of two sections with a center and an outer ring, the center region adopted the basic structure of the Fresnel lens with the Fresnel of laplace domain continuous curve transmission type, and the outer structure which achieve light collimating or focusing by total reflection is stepped. The paperstudies the parameter and alforithm of this catadioptric dual-zone Fresnel condenser and gives the surface data of total reflection region. Based on the method of establishing the entity model, we design a set of lens with the relative aperture F=0.3, simulate the condensing ability of the lens by the simulation software, and verify that the lens have a very good effect on focusing.

To compare the treatment results of three-dimensional conformal radiotherapy (3D-CRT) and conventional radiotherapy (2D) for patients with locally advanced non-small-cell lung cancer (NSCLC).Five hundred and twenty seven patients with stage III NSCLC treated between Jan 2000 and Dec 2006 were included in this study. Among them, 253 cases were treated with 3D-CRT, and 274 with conventional radiotherapy. In the 3D group, 159 (62.8%) patients received chemoradiotherapy, 77 with total radiotherapy dose of60 Gy, 49 with 50 - 60 Gy. In the 2D group, 127 (46.4%) patients received chemoradiotherapy, 48 with total radiotherapy dose of60 Gy, 75 with 50 - 60 Gy.The 1-, 3-, 5-year overall survival rates (OS) and median survival time for patients treated with 3D-CRT were 73.3%, 26.1%, 14.4% and 20.1 months, respectively, and that of patients treated with 2D radiotherapy were 61.0%, 13.8%, 8.0% and 15.6 months, respectively (P = 0.002). The 1-, 3-, 5-year cause-specific survival rates (CSS) were 79.0%, 33.3%, and 20.8% for the 3D group and 65.1%, 16.7%, 11.2%, respectively, for the 2D group (P = 0.000). The 1-, 3-, and 5-year locoregional control rates were 71.6%, 34.3% and 31.0% for patients treated with 3D radiotherapy and 57.3%, 22.1% and 19.2%, respectively, for patients treated with 2D treatment (P = 0.002). The results of multivariate analysis showed that 3D-CRT, KPS, clinical tumor response and pretreatment hemoglobin level were independently associated with increased OS and CSS. No statistically significant differences were found between the radiation complications in the two groups.The results of our study demonstrate that 3D-conformal radiotherapy improves the survival rate in patients with stage III NSCLC compared with that of 2D radiation therapy.

The appliance of military was recognized more and more ,It is important that pod can bear the weight of the availability payload achieve the observation to the earth in 20km-100km area and work in the all-weather. The stable platform can load high imaging spectrometer, the thermal infrared imager, the infrared radiometer, the millimeter waves radar, the laser weapon and so on,in order to realize reconnaissance and attacking integrative and warning the long-distant missile. The stabilization accuracy of platform is prior to 20μrad and burden heavy load to the best of one's abilities. It used high precision velocity and acceleration gyroscope to fulfill the stabilization of the platform. Light-weight design by using new composite material and optimizing design. It was adapt to the near space environment better by structure design and simulation analysis.Enhance its basic frequency and sure the rigid of the frame platform .In addition, the structure of platform apply the two-axis and four-frame and use the method of FEA to fulfill the optimum design in order to attain the object of light-weight.In consider to the precision of the platform I establish the math model and make use of the monte carlo method to appraise and analysis the error that affect the precision of the platform. After emulating by the software of the Matlab to verify the results. It is apply the method that link the platform and aerocraft by mounting the no angular displacement shock absorbers on the elevator mechanism. This kind of design insulate the angular vibration and minish the linear vibration to ensure the image quality.