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Your search keyword '"Jian, Jie-Ming"' showing total 11 results
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11 results on '"Jian, Jie-Ming"'

6. Elevated Levels of Naturally-Occurring Autoantibodies Against the Extracellular Domain of p75NTR Aggravate the Pathology of Alzheimer’s Disease

Author

He, Chen-Yang, primary, Tian, Ding-Yuan, additional, Chen, Si-Han, additional, Jin, Wang-Sheng, additional, Cheng, Yuan, additional, Xin, Jia-Yan, additional, Li, Wei-Wei, additional, Zeng, Gui-Hua, additional, Tan, Cheng-Rong, additional, Jian, Jie-Ming, additional, Fan, Dong-Yu, additional, Ren, Jun-Rong, additional, Liu, Yu-Hui, additional, Wang, Yan-Jiang, additional, and Zeng, Fan, additional

Published
2022
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7. The Correlations of Plasma Liver-Type Fatty Acid-Binding Protein with Amyloid-β and Tau Levels in Patients with Alzheimer’s Disease

Author

Cheng, Yuan, primary, Jian, Jie-Ming, additional, He, Chen-Yang, additional, Ren, Jun-Rong, additional, Xu, Man-Yu, additional, Jin, Wang-Sheng, additional, Tan, Cheng-Rong, additional, Zeng, Gui-Hua, additional, Shen, Ying-Ying, additional, Chen, Dong-Wan, additional, Li, Hui-Yun, additional, Yi, Xu, additional, Zhang, Yuan, additional, Zeng, Fan, additional, and Wang, Yan-Jiang, additional

Published
2022
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9. Associations Between Plasma Klotho with Renal Function and Cerebrospinal Fluid Amyloid-β Levels in Alzheimer's Disease: The Chongqing Ageing & Dementia Study.

Author

Ren, Jun-Rong, Wang, Zhen, Cheng, Yuan, He, Chen-Yang, Jian, Jie-Ming, Fan, Dong-Yu, Shen, Ying-Ying, Chen, Dong-Wan, Li, Hui-Yun, Yi, Xu, Zeng, Gui-Hua, Tan, Cheng-Rong, Shi, An-Yu, Chen, Li-Yong, Mao, Qing-Xiang, Wang, Yan-Jiang, and Wang, Jun

Subjects
ALZHEIMER'S disease, CEREBROSPINAL fluid, KIDNEY physiology, ENZYME-linked immunosorbent assay, AGE factors in disease
Abstract

Background: The kidney-brain crosstalk has been involved in Alzheimer's disease (AD) with the mechanism remaining unclear. The anti-aging factor Klotho was reported to attenuate both kidney injury and AD pathologies. Objective: To investigate whether plasma Klotho participated in kidney-brain crosstalk in AD. Methods: We enrolled 33 PiB-PET-positive AD patients and 33 amyloid-β (Aβ)-negative age- and sex-matched cognitively normal (CN) controls from the Chongqing Ageing & Dementia Study (CADS). The levels of plasma Klotho, Aβ, and tau in the cerebrospinal fluid (CSF) were measured by enzyme-linked immunosorbent assay. Results: We found higher plasma Klotho and lower estimated glomerular filtration rate (eGFR) levels in AD patients compared with CN. The eGFR was positively associated with Aβ42, Aβ40 levels in CSF and negatively associated with CSF T-tau levels. Plasma Klotho levels were both negatively correlated with CSF Aβ42 and eGFR. Mediation analysis showed that plasma Klotho mediated 24.96% of the association between eGFR and CSF Aβ42. Conclusion: Renal function impacts brain Aβ metabolism via the kidney-brain crosstalk, in which the plasma Klotho may be involved as a mediator. Targeting Klotho to regulate the kidney-brain crosstalk provides potential therapeutic approaches for AD. [ABSTRACT FROM AUTHOR]

Published
2023
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10. Naturally Occurring Antibodies Against Bim Are Decreased in Alzheimer’s Disease and Attenuate Ad-type Pathologies in a Mouse Model

Author

Jian, Jie-Ming, primary, Fan, Dong-Yu, additional, Tian, Ding-Yuan, additional, Cheng, Yuan, additional, Sun, Pu-Yang, additional, Zeng, Gui-Hua, additional, He, Chen-Yang, additional, Wang, Ye-Ran, additional, Zhu, Jie, additional, Yao, Xiu-Qing, additional, Wang, Yan-Jiang, additional, and Liu, Yu-Hui, additional

Published
2021
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