17 results on '"Jia-long ZHU"'
Search Results
2. Effect of Fe2O3 on the pyrolysis of two demineralized coal using in-situ pyrolysis photoionization time-of-flight mass spectrometry
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Xue-hui Zhang, Jia-long Zhu, Hao-quan Hu, Lijun Jin, Yanpeng Ban, and Fanggang Liu
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chemistry.chemical_classification ,010405 organic chemistry ,business.industry ,Analytical chemistry ,chemistry.chemical_element ,02 engineering and technology ,Photoionization ,Mass spectrometry ,01 natural sciences ,Sulfur ,0104 chemical sciences ,020401 chemical engineering ,chemistry ,Coal ,0204 chemical engineering ,Time-of-flight mass spectrometry ,Aromatic hydrocarbon ,business ,Carbon ,Pyrolysis - Abstract
Influence of Fe2O3 on the pyrolysis products distribution of demineralized Hongshaquan (HSQ) and Daliuta (DLT) coal was investigated by a novel in-situ pyrolysis vacuum ultraviolet single photon ionization time-of-flight mass spectrometry. The experiment samples were obtained by mechanical mixing of Fe2O3 and demineralized coal from acid elution with the mass ratio of 10:1, 5:1 and 2:1. Due to the characteristics of in-situ sampling, soft ionization and high vacuum environment, the initial pyrolysis volatiles including alkenes, aromatic hydrocarbons, phenols, bi-phenols and a small amount of sulfur and nitrogen-containing substances can be detected. The results show that Fe2O3 has similar influence on the products distribution of two demineralized coal, and it is relatively stronger on DLT coal than that on HSQ. With the increase of Fe2O3 content, the light fraction content is promoted such as alkenes and aromatic hydrocarbons, but bi-phenols are obviously inhibited. Correspondingly, the heavy products are also decreased, and the evolution peak temperatures of the product increase. Fe2O3 is successively reduced to FeO and Fe while transforming heavy components into light components. The increase of aliphatic carbon (or aromatic hydrocarbon substituted carbon) during coal pyrolysis process is mainly responsible for the decrease pyrolysis peak temperature.
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- 2021
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3. The Application of Geodesic in Deployable Antenna Mesh Dividing
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Yu Zhu Duan, Fei Hu, Lei Zhang, Yi Chen Li, Yue Chao Guan, and Jia Long Zhu
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Computer Science::Robotics ,History ,Computer Science Applications ,Education - Abstract
Space deployable antennna has the characteristics of Lightweight, large diameter, high precision etc, which can meet the requirements of the launch vehicle carrying and payload’s Electromagnetic performance. Antenna’s mesh dividing have the direct bearing on payload’s Electromagnetic performance, geodesic mesh dividing has the advantage of shortest length of mseh line. but the equation solving of geodesic is complicated,which Impeding the geodesic’s application In academic and engineering fields. in this paper, a method has be proposed to solve the difficulty of geodesic equation solving. the solving result can be used in antenna’s mesh dividing, meanwhile the solving result can be used in Robot trajectory planning, Air route planning,Navigation route planning,Architectural structure design,etc. great care should be taken in constructing both.
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- 2022
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4. Study on the Flow Characteristics of Mixed Solid–Solid Particles
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Peng Liang, Xizhuang Qin, Xue-Long Lv, Yaqing Zhang, and Jia-Long Zhu
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Materials science ,Solid particle ,Flow (mathematics) ,General Chemical Engineering ,Mixing ratio ,General Chemistry ,Mechanics ,Moving bed - Published
- 2018
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5. Studies of granular bed filter for dust removal in the process of coal pyrolysis by solid heat carrier
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Peng Liang, Jia-Long Zhu, Juan Yu, Yaqing Zhang, and Xizhuang Qin
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Pressure drop ,Chemistry ,General Chemical Engineering ,02 engineering and technology ,General Chemistry ,021001 nanoscience & nanotechnology ,Combustion ,complex mixtures ,respiratory tract diseases ,law.invention ,020401 chemical engineering ,Chemical engineering ,law ,Particle-size distribution ,Particle ,Fluidized bed combustion ,Particle size ,0204 chemical engineering ,0210 nano-technology ,Pyrolysis ,Filtration - Abstract
Aiming at the optimization of the dust removal process in the poly-generation system of circulating fluidized bed (CFB) combustion/coal pyrolysis, a granular bed filter (GBF) is applied to the coal pyrolysis by solid heat carrier. By carrying out lab-scale experiments with a moving-bed pyrolyzer, the GBF model proposed by C. Tien et al. was used to describe the dust removal process of the dust-contained volatiles which has high temperature and high viscosity. The model applicability for real pyrolysis volatiles was verified. The results show that, the particle size distribution of the dust uncollected by the GBF is relatively concentrated. The majority particle size of uncollected dust is less than 20 μm, the mass fraction is ∼80%. The GBF is in a state of unsteady operation in the process of dust filtration. With the increase of operating time, the dust is gradually deposited in the GBF, then resulting in an increase of bed pressure drop. In the examined range, the calculational value of GBF efficiency is slightly lower than the experimental value. On the one hand, the filter media particles have a certain specific surface area, so that part of the dust-contained tar can be adsorbed on the filter media surface to achieve a better interception effect. On the other hand, the dust particle deposited in the GBF also plays an important role in dust capture. The C. Tien model results of the initial filtration efficiency can be used as the selection reference of the medium species and the physical properties of the GBF. The higher filter height, slower superficial gas velocity, and smaller size of medium are conducive to decrease the dust content in the pyrolysis products. This study can provide basic data for the dust removal process in the poly-generation system of CFB combustion/coal pyrolysis.
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- 2017
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6. Simulation of large coal particles pyrolysis by circulating ash heat carrier toward the axial dimension of the moving bed
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Peng Liang, Xiwang Zhang, Jia-Long Zhu, Shi-Xue Zhou, Xiao-Hang Wang, and Yaqing Zhang
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Imagination ,Chemical substance ,Chemistry ,business.industry ,020209 energy ,General Chemical Engineering ,media_common.quotation_subject ,Energy value of coal ,Energy Engineering and Power Technology ,Mineralogy ,02 engineering and technology ,law.invention ,Fuel Technology ,020401 chemical engineering ,Magazine ,Chemical engineering ,law ,Heat transfer ,0202 electrical engineering, electronic engineering, information engineering ,Coal ,0204 chemical engineering ,business ,Science, technology and society ,Pyrolysis ,media_common - Abstract
A heat transfer, reaction, pyrolysis mathematical model for the non-isothermal coal particles by using circulating ash as heat carrier toward the moving bed has been established. Combined with the Thermogravimetry-Mass spectrometry technology and Coats–Redfern integral method, the model has the ability to predict the temperature distribution of pyrolysis gas-coal-ash as well as the evolution characteristics of the main volatile products (such as CH 4 , CO 2 , H 2 , CO, C 2 H 4 , C 2 H 6 , C 6 H 6 , C 7 H 8 , C 8 H 10 , C 10 H 8 ). The results show that, the maximum temperature difference between the core and surface of coal (10 mm) has reached 406 K at the bed height of 0.05 m. The layer closer to the coal core has a higher but later peak value of the devolatilization rate. The evolution of the main volatile products is concentrated at the bed height of 0.08–0.24 m. The velocity of the moving bed, blending ratio of ash to coal, coal particle size, preheating temperature of coal and initial temperature of ash have obvious influence on the devolatilization process. Radiation is the most significant factor affecting the devolatilization behavior. The model can be applied to different coal species. This study can provide a theoretic foundation for the amplification design of the moving-bed reactor in the poly-generation system.
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- 2016
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7. Effect of circulating ash on sulfur conversion characteristics in the coal polygeneration process
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Xiao-Hang Wang, Yaqing Zhang, Jia-Long Zhu, Wanmin Jiang, and Peng Liang
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inorganic chemicals ,020209 energy ,General Chemical Engineering ,Heat carrier ,Inorganic chemistry ,Energy Engineering and Power Technology ,chemistry.chemical_element ,02 engineering and technology ,Combustion ,complex mixtures ,020401 chemical engineering ,0202 electrical engineering, electronic engineering, information engineering ,Coal ,Char ,0204 chemical engineering ,business.industry ,Chemistry ,technology, industry, and agriculture ,respiratory system ,Sulfur ,Fuel Technology ,Scientific method ,Environmental chemistry ,Particle size ,business ,Pyrolysis - Abstract
Sulfur transformation in the polygeneration process of Xinzhou high-sulfur coal employing a circulating ash heat carrier was studied using a fixed bed reactor. Circulating ash was effective in capturing the gaseous sulfur, along with ~ 80% of H2S, 59% of COS, 55% of CS2, and 48% of SO2. Sulfur mass balance calculations revealed that 30.88% of the total sulfur content was retained in the circulating ash at 600 °C. The sulfur retention capacity of the ash was promoted by an increase in temperature, an increase in the ash to coal mass ratio, and a decrease in ash particle size. Sulfur captured in the circulating ash released lower quantities of SO2 than the sulfur remaining in the char during combustion. Furthermore, CaO and Fe2O3 played a dominant role in the sulfur retention of the circulating ash, and the sulfur retention capacity of Fe2O3 was superior to that of CaO during pyrolysis. X-ray diffraction results indicated that the sulfur captured by CaO and Fe2O3 was converted into CaS and FeS. However, FeS was easily oxidized to Fe2O3, accompanied by the emission of SO2, while CaS tended to be oxidized to CaSO4 during combustion.
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- 2016
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8. Secondary Catalytic Reaction of Circulating Ash on the Primary Volatiles of Coal Pyrolysis
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Yaqing Zhang, Juan Yu, Jia-Long Zhu, Xizhuang Qin, and Peng Liang
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Primary (chemistry) ,Waste management ,Renewable Energy, Sustainability and the Environment ,Chemistry ,business.industry ,020209 energy ,technology, industry, and agriculture ,Energy Engineering and Power Technology ,02 engineering and technology ,respiratory system ,Combustion ,complex mixtures ,respiratory tract diseases ,Catalysis ,Nuclear Energy and Engineering ,otorhinolaryngologic diseases ,0202 electrical engineering, electronic engineering, information engineering ,Coal ,Fluidized bed combustion ,business ,Waste Management and Disposal ,Pyrolysis ,Coal pyrolysis ,Civil and Structural Engineering - Abstract
In view of the polygeneration technology of coal pyrolysis/circulating fluidized bed combustion, circulating ash and coal were layered in the pyrolysis reactor to investigate the secondary ...
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- 2017
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9. Practice of and Reflection on Medical Consortium by County-Level Hospitals Trusted to Provincial-Level Leading Hospitals
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Wei-Wei Du, Jin Chen, Hong Hu, and Jia-Long Zhu
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Reflection (computer programming) ,business.industry ,Service level ,Referral system ,Business ,Internal governance ,Public relations ,County level ,health care economics and organizations ,Municipal level ,Management - Abstract
Building new regional medical consortium in the model of trusting county-level hospitals to provincial-level large-scale public third-level grade-A hospitals can optimize the allocation of medical resources, promote two-way referral system and rational shunting of patients, and drive multi-sited practice of physicians. Furthermore, it can constantly improve regional medical service level, and achieve the goal of medical reform—comprehensive reform of county-level public hospitals. By introducing general situation where two county-level hospitals are trusted to Hubei Provincial People’s Hospital, this study analyses its operation performance and existing problems, and then puts forwards developmental countermeasures and recommendations for provincial-level hospitals to hold county-level hospitals in trust to build a medical consortium, including driving reorganization of medical resources, making clear roles of all the parties concerned, clarifying internal governance structure of hospitals under trust, reinforcing policy guidance, enhancing internal developmental force of trusteeship, intensifying supporting, and improving functions of medical consortium incrementally.
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- 2017
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10. Practice and Reflections on 'Direct-billing Service' of Commercial Health Insurance in Hospitals: Experience of a Provincial-level Hospital in China
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Jia-Long Zhu, Jin Chen, Hong Hu, and Wei-Wei Du
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Service (business) ,Finance ,Actuarial science ,Health management system ,business.industry ,media_common.quotation_subject ,Self-insurance ,Big data ,010501 environmental sciences ,Payment ,01 natural sciences ,Municipal level ,03 medical and health sciences ,0302 clinical medicine ,Health insurance ,030212 general & internal medicine ,Business ,China ,health care economics and organizations ,0105 earth and related environmental sciences ,media_common - Abstract
The direct-billing collaboration between medical institutions and commercial health insurance institutions is an internationally applied method of commercial health insurance claims. This paper discusses the reasons why the direct-billing service of medical institutions is currently limited, including the trivial size of commercial health insurance and hospitals’ concern on cost control, by taking the practice of direct-billing service in a certain hospital in Wuhan as an example. It also summarizes the problems encountered in the operation, including the refusal to medical payment, the risks in excessive medical care, the increasing costs of medical institutions and acting against the equalization principle of medical service. The author then proposes several advices on the direct-billing service operated by hospitals, in terms of strengthening the risk control, taking part into the “Big Data” health management, reforming HIS system united with commercial insurance institutions and adjusting the pricing system of direct-billing service.
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- 2017
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11. Contribution of Cardiac and Arterial Baroreceptors to Enhanced Vasopressin Release During Hemorrhage with Autonomic Blockade
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Jia Long Zhu and R. J. Leadley
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medicine.medical_specialty ,Vasopressin ,Baroreceptor ,Scopolamine Derivatives ,Blood Pressure ,Hemorrhage ,Pressoreceptors ,Autonomic Nervous System ,Hexamethonium ,Plasma renin activity ,General Biochemistry, Genetics and Molecular Biology ,Norepinephrine (medication) ,Norepinephrine ,Dogs ,Heart Rate ,Reference Values ,Internal medicine ,Renin ,Renin–angiotensin system ,medicine ,Animals ,Cardiac Output ,Afferent Pathways ,business.industry ,Heart ,N-Methylscopolamine ,Denervation ,Blockade ,Arginine Vasopressin ,Autonomic nervous system ,Blood pressure ,Endocrinology ,Female ,business ,medicine.drug - Abstract
During episodes of blood loss, several apparently redundant mechanisms are activated to maintain arterial blood pressure. This study was designed to examine one such compensatory mechanism involving enhanced vasopressin release during hemorrhage when the autonomic nervous system (ANS) is pharmacologically blocked. First, to confirm that this compensatory mechanism exists in canines, conscious dogs were hemorrhaged under normal conditions and during ANS blockade. In dogs with intact cardiac nerves (intact, n = 7), hemorrhage at 0.8 ml/kg/min increased plasma vasopressin (PAVP) from 3.0 +/- 0.7 to 6.6 +/- 2.4 and 78 +/- 50 pg/ml at blood losses of 10 and 20 ml/kg, respectively. At the same amount of blood loss during hemorrhage with ANS blockage, PAVP was enhanced significantly from 33 +/- 17 to 230 +/- 90 and 610 +/- 270 pg/ml. ANS blockade did not, however, alter the hemorrhage-induced increases in plasma renin activity. Next, to examine the afferent mechanisms responsible for the enhanced PAVP response, cardiac-denervated dogs (CD, n = 9) were hemorrhaged with and without ANS blockade. Without blockade, PAVP increased from 3.7 +/- 0.9 to 5.2 +/- 0.8 and 26 +/- 11 pg/ml at blood losses of 10 and 20 ml/kg. PAVP was significantly higher in response to hemorrhage with ANS blockade, increasing from 17 +/- 6 to 76 +/- 18 and 330 +/- 80 pg/ml. The rise in PAVP in the CD dogs suggested that peripheral baroreceptors were involved in eliciting vasopressin release under these conditions. Therefore, the influence of arterial baroreceptors was examined by infusing norepinephrine during hemorrhage in order to maintain blood pressure constant. Under these conditions, PAVP increased significantly in the intact dogs at 10 ml/kg blood loss, but did not change in the CD dogs. These results demonstrate that the enhanced release of AVP during hemorrhage with ANS blockade can be mediated either by cardiac or arterial baroreceptors; however, the maximum response is elicited only when both sets of receptors are functioning normally.
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- 1995
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12. Cardiorenal Reflexes Do Not Attenuate the Renal Effects of Infused Atriopeptin in Conscious Dogs
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Jia Long Zhu and R. J. Leadley
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medicine.medical_specialty ,Natriuresis ,Urination ,Diuresis ,Hemodynamics ,Blood Pressure ,Kidney ,General Biochemistry, Genetics and Molecular Biology ,Dogs ,Atrial natriuretic peptide ,Heart Rate ,Internal medicine ,Renin ,medicine ,Animals ,Cardiac Output ,Infusions, Intravenous ,Aldosterone ,Dose-Response Relationship, Drug ,business.industry ,Osmolar Concentration ,Sodium ,Heart ,Stroke Volume ,Denervation ,Cardiovascular physiology ,Arginine Vasopressin ,medicine.anatomical_structure ,Endocrinology ,Potassium ,Reflex ,Female ,Vascular Resistance ,business ,Atrial Natriuretic Factor ,Antidiuretic - Abstract
Low-dose infusions of atriopeptin produce only a modest diuresis and natriuresis. However, these infusions also decrease atrial pressures, a change that has been postulated to elicit an antidiuretic and antinatriuretic reflex from cardiac receptors and thereby to attenuate the direct renal effects of atriopeptin. To determine whether the renal effects of intravenously administered atriopeptin might be attenuated by a cardiorenal reflex, we infused alpha-human atrial natriuretic peptide (alpha-hANP) into cardiac-denervated and sham-operated (normal) conscious dogs. Following a control period, alpha-hANP was infused into each dog at 12.5, 25, or 50 ng.kg-1.min-1 for 1 hr. Infusion of alpha-hANP at 50 ng.kg-1.min-1 produced similar decreases in left atrial pressure in both normal and cardiac-denervated dogs (peak changes, -1.6 +/- 0.8 vs -2.4 +/- 0.9 mm Hg, respectively). Increases in urine flow (peak changes, 0.13 +/- 0.05 vs 0.20 +/- 0.06 ml/min) and sodium excretion (peak changes, 56 +/- 22 vs 70 +/- 11 microEq/min) also were not different between groups. The lower doses of alpha-hANP also elicited renal and hemodynamic responses in the cardiac-denervated dogs that did not differ significantly from those in the normal dogs. These data indicate that the diuresis and natriuresis elicited by intravenously administered alpha-hANP are not attenuated by a cardiorenal reflex in conscious dogs.
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- 1992
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13. Effects of endothelin-1 and sarafotoxin S6b on regional hemodynamics in the conscious dog
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K. L. Goetz, Jia Long Zhu, and R. J. Leadley
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Cardiac output ,medicine.medical_specialty ,Consciousness ,Physiology ,Hemodynamics ,Vasodilation ,Blood Pressure ,Viper Venoms ,Dogs ,Heart Rate ,Physiology (medical) ,Internal medicine ,Medicine ,Animals ,Vasoconstrictor Agents ,Cardiac Output ,business.industry ,Endothelins ,Stroke Volume ,Blood flow ,Endothelin 1 ,Endocrinology ,Regional Blood Flow ,Renal blood flow ,Circulatory system ,Injections, Intravenous ,cardiovascular system ,Female ,Vascular Resistance ,business ,Endothelin receptor - Abstract
Endothelin, a potent vasoconstrictor, also is capable of producing transient vasodilation in some situations. We examined the changes in regional hemodynamics in response to constant infusions of endothelin-1 (ET-1) at 5, 10, or 20 ng.kg-1.min-1 for 1 h into conscious dogs. The dogs were instrumented with ultrasonic flow probes for measurement of blood flow in the ascending aorta (cardiac output) and in the coronary, mesenteric, renal, and iliac arteries. A compound structurally similar to ET-1, sarafotoxin S6b (S6b), was also infused in identical experiments to determine whether the responses to these two peptides might differ. Basal plasma levels of immunoreactive ET-1 averaged approximately 6 pg/ml. After 55 min of infusion of ET-1 at 5, 10, and 20 ng.kg-1.min-1, plasma immunoreactive ET-1 increased to approximately 55, 130, and 520 pg/ml, respectively. When given at 20 ng.kg-1.min-1, ET-1 increased total peripheral resistance and arterial pressure and decreased cardiac output and heart rate. ET-1 decreased coronary, mesenteric, and renal blood flow but did not change iliac flow. In comparison with ET-1, S6b produced relatively smaller changes in total peripheral resistance, cardiac output, heart rate, and coronary, mesenteric, and renal blood flow. Iliac resistance did not change in response to ET-1, but it increased during infusions of S6b. Similar but less pronounced responses were observed when these peptides were infused at 5 and 10 ng.kg-1.min-1. The regional variability in the hemodynamic response to ET-1 and the difference in regional responses to ET-1 and S6b are consistent with the existence of heterogenous receptor subtypes for these peptides.
- Published
- 1991
14. Evidence that urodilatin, rather than ANP, regulates renal sodium excretion
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Rupert Gerzer, K. L. Goetz, Christian Drummer, Jia Long Zhu, R. J. Leadley, and Fritz Fiedler
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medicine.medical_specialty ,medicine.medical_treatment ,Urine ,Kidney ,Excretion ,chemistry.chemical_compound ,Dogs ,Atrial natriuretic peptide ,Heart Conduction System ,Internal medicine ,medicine ,Animals ,Diuretics ,Saline ,Cyclic GMP ,Chemistry ,Sodium ,Radioimmunoassay ,General Medicine ,Urodilatin ,Denervation ,Peptide Fragments ,Endocrinology ,medicine.anatomical_structure ,Nephrology ,Renal sodium excretion ,Female ,Atrial Natriuretic Factor - Abstract
Urodilatin, a closely related member of the atrial peptide family, was discovered recently in human urine. Urodilatin (ANP 95-126) is believed to be produced within the kidney and is natriuretic; evidence indicates that most of the ANP-like immunoreactivity in the kidney elutes with urodilatin rather than with ANP. Moreover, urodilatin is little affected by renal enzymes that inactivate atriopeptin. To determine the relative importance of urodilatin versus ANP in the regulation of renal sodium excretion, we studied intact and cardiac-denervated conscious dogs under three experimental conditions: (1) spontaneous sodium excretion, (2) intravenous infusion of saline, and (3) left atrial distension. Urodilatin was measured in urine with a newly developed radioimmunoassay that selectively measures urodilatin without any cross-reactivity with alpha-human atrial natriuretic peptide (alpha-hANP); alpha-hANP was measured in plasma by radio-immunoassay because it is rapidly inactivated in the kidney by enzymatic activity. In each group of experiments, sodium excretion correlated better with urodilatin than it did with circulating alpha-hANP. The correlation coefficient (r value) between urodilatin excretion and renal sodium excretion exceeded 0.8 in 13 of 18 experiments and was below 0.6 in only 2 experiments. On the other hand, the correlation between circulating atriopeptin and sodium excretion exceeded 0.8 in only 3 of 18 experiments and was below 0.6 in 10 experiments. A negative correlation between plasma atriopeptin and renal sodium excretion was observed during left atrial distension in the cardiac-denervated dogs. These results and other considerations suggest that urodilatin, rather than atriopeptin, is the member of the ANP family that is primarily involved in the regulation of renal sodium excretion.
- Published
- 1990
15. Effects of endothelin-1 and sarafotoxin S6b on regional hemodynamics in the conscious dog.
- Author
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LEADLEY JR., ROBERT J., JIA LONG ZHU, and GOETZ, KENNETH L.
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- 1991
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16. Cardiovascular, renal, and endocrine responses to intravenous endothelin in conscious dogs
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J. B. Madwed, B. C. Wang, R. J. Leadley, K. L. Goetz, and Jia Long Zhu
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medicine.medical_specialty ,Vasopressin ,Vasopressins ,Physiology ,Kidney ,chemistry.chemical_compound ,Dogs ,Reference Values ,Physiology (medical) ,Internal medicine ,Renin–angiotensin system ,medicine ,Animals ,Infusions, Intravenous ,Aldosterone ,business.industry ,Angiotensin II ,Endothelins ,Hemodynamics ,Hormones ,Free water clearance ,Kinetics ,Endocrinology ,Epinephrine ,Blood pressure ,chemistry ,Renal physiology ,Female ,Endothelium, Vascular ,Peptides ,business ,Endothelin receptor ,medicine.drug - Abstract
Endothelin is a recently discovered vasoconstrictor peptide that is synthesized in certain vascular endothelial cells. We have identified the cardiovascular, renal, and hormonal responses that can be elicited in conscious dogs by intravenous administration of endothelin at rates of 10 and 30 ng.kg-1.min-1 for 60 min (0.24 and 0.72 nmol.kg-1/1-h infusion). Each dose of endothelin increased total peripheral resistance, arterial pressure, and left atrial pressure and decreased heart rate and cardiac output. Hematocrit increased by 4.8% (NS) and 22.9% (P less than 0.01) in response to the lower and higher infusion rates, respectively. Urinary sodium excretion, urine osmolality, and osmolar clearance decreased and free water clearance increased. The lower dose of endothelin decreased plasma norepinephrine and increased plasma atriopeptin. The higher dose increased plasma levels of vasopressin, renin, aldosterone, norepinephrine, epinephrine, and atriopeptin. The higher infusion rate of the peptide caused one or more brief vomiting episodes in four of five dogs. Although it is not yet known whether endothelin is a circulating hormone, it is clear that this peptide is capable of causing profound cardiovascular, renal, and endocrine alterations in conscious dogs. The possible relevance of these observations to physiological processes and to pathological conditions such as hypertension remains to be established.
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- 1988
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17. Endothelin and sarafotoxin produce dissimilar effects on renal blood flow, but both block the antidiuretic effects of vasopressin
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Peter Bie, R. J. Leadley, K. L. Goetz, Bin Ching Wang, Jia Long Zhu, and Jeffrey B. Madwed
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medicine.hormone ,medicine.medical_specialty ,Vasopressin ,Vasopressins ,Diuresis ,Viper Venoms ,Kidney ,General Biochemistry, Genetics and Molecular Biology ,Endothelins ,Kidney Concentrating Ability ,Dogs ,Internal medicine ,medicine ,Animals ,Chemistry ,Endocrinology ,medicine.anatomical_structure ,Regional Blood Flow ,Renal blood flow ,cardiovascular system ,medicine.symptom ,Endothelin receptor ,Peptides ,Vasoconstriction ,Antidiuretic - Abstract
Human endothelin, a 21-residue peptide produced by vascular endothelial cells, was infused intravenously into trained conscious dogs at a rate of 20 ng.kg-1.min-1 for 1 hr. Endothelin produced a renal vasoconstriction that persisted during a 40-minute recovery period. Sarafotoxin S6b, a closely related 21-residue peptide that has been isolated from the venom of the burrowing asp, was also infused into the same conscious dogs at 20 ng.kg-1.min-1. Sarafotoxin produced a renal vasodilation that persisted throughout the infusion; when the infusion ended, however, renal blood flow decreased rapidly to below control levels. Both endothelin and sarafotoxin produced marked decreases in urine osmolality even though plasma vasopressin remained normal, thus indicating that these peptides inhibit the antidiuretic effects of vasopressin. These results imply that a broad spectrum of structure-activity relationships may exist among analogues of this unique group of 21-residue peptides.
- Published
- 1989
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