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This paper introduces the design and development of a water management system based on .NET platform. The system collects various data of the source well and transmits it to the monitoring terminal via the mobile network. After processing, the data will be displayed on the management interface, and the changes of the parameters of the water source wells will be displayed in real time, so that the managers can realize the remote control of the water source wells. The system has a water sales function, realizes the integration of water sale and monitoring, and has the design of fault alarming. In view of the actual application environment and the characteristics of several existing monitoring systems, this paper designs a multilayer structure water tank monitoring system with expansibility and compatibility. The system has the characteristics of high security and strong expansibility, which provides great convenience for water management and has good application prospect.

Objective: Crocin has been proposed as a promising candidate for cancer chemoprevention. The purpose of this investigation was to investigate the chemopreventive action and the possible mechanisms of crocin against human colon cancer cells in vitro. Methods: Cell proliferation was examined using MTT assay and the cell cycle distribution fractions were analyzed using fow cytometric analysis after propidium iodide staining. Apoptosis was detected using theTUNEL Apoptosis Detection Kit with laser scanning confocal microscope. DNA damage was assessed using the alkaline single-cell gel electrophoresis assay, while expression levels of p53, cdk2, cyclinA and P21 were examined by Western blot analysis. Results: Treatment of SW480 cells with crocetin (0.2, 0.4, 0.8 mmol/L) for 48 h signifcantly inhibited their proliferation in a concentration-dependent manner. Crocetin (0.8 mmol/L) signifcantly induced cell cycle arrest through p53-independent mechanisms accompanied by P21 induction. Crocetin (0.8 mmol/L) caused cytotoxicity in the SW480 cells by enhancing apoptosis and decreasing DNA repair capacity in a time-dependent manner. Conclusions: This report provides evidence that crocetin is a potential anticancer agent, which may be used as a chemotherapeutic drug.