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Your search keyword '"Jia, Xuewen"' showing total 33 results
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33 results on '"Jia, Xuewen"'

18. Effect of salinity on growth performance and resistance of the clam Cyclina sinensis against Vibrio parahaemolyticus infection

Author

Ni, Qian, Li, Wenqian, Jia, Xuewen, Dong, Zhiguo, Ge, Hongxing, Ni, Qian, Li, Wenqian, Jia, Xuewen, Dong, Zhiguo, and Ge, Hongxing

Abstract

We examined the growth performance, immune parameters and the susceptibility to Vibrio parahaemolyticus in the clam Cyclina sinensis, which had been reared at different salinity levels of 10‰, 20‰ and 30‰ for 60 days. At the end of the feeding experiment, the biggest shell length and body weight was found in 20‰, followed by 30‰ and 10‰. No significant differences in superoxide dismutase (SOD) activity were observed among the clams held in 10‰, 20‰ and 30‰. Na+/K+ -ATPase (NKA) activity of the clams held in 20‰ and 30‰ were significantly lower than that in group 10‰. The lowest activities of lysozyme (LZM) and glutamic-pyruvic transaminase (GPT) were found in group 10‰. The Integrated Biomarker Response index (IBR) values of the clams had an inverse relationship with salinity: 11.28, 3.40 and 2.85 in 10‰, 20‰ and 30‰, respectively. At the end of the feeding experiment, the clams were infected with V. parahaemolyticus. As time after infection goes on, the survival rate of clams reared in 20‰ was not significantly different with the other two treatments from 24 to 48h after infection. However, from 72 to 120h after infection, it was significantly lower than those reared in 10‰, while it was significantly higher than those reared in 30‰. It is concluded that the clam C. sinensis reared in 10‰ seawater may reduce growth performance and immune ability, whereas increase resistance against V. parahaemolyticus infection.

Published
2021

21. Haplotype Analysis of Candidate Genes Involved in Inflammation and Oxidative Stress and the Susceptibility to Preeclampsia

Author

Chen, Aiping, primary, Zhao, Huifang, additional, Wang, Jingli, additional, Zhang, Ru, additional, Liu, Jingjing, additional, Zhao, Xin, additional, Li, Congying, additional, Jia, Xuewen, additional, Li, Xueying, additional, Lin, Yan, additional, Guo, Mingzhen, additional, Li, Sai, additional, Liu, Chao, additional, Li, Yuan, additional, and Liu, Shiguo, additional

Published
2020
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23. Identification of SEPP1 polymorphisms is not a genetic risk factor for preeclampsia in Chinese Han women

Author

Wu, Hong, Jia, Xuewen, Zhao, Hong, Huang, Youmin, Liu, Chang, Huang, Zuzhou, Li, Shunjun, and Wang, Jingli

Subjects
preeclampsia, SEPP1, Clinical Trial/Experimental Study, single-nucleotide polymorphism, susceptibility, Research Article
Abstract

Background: SEPP1 encodes selenoprotein P, which involved in oxidative stress and plays an important role in the development of preeclampsia (PE). The aim of this study was to investigate the association between PE and genetic variants of SEPP1 in Chinese Han women. Methods: In all, 2434 unrelated pregnant women were recruited, including 1034 PE cases and 1400 normal pregnant controls. TaqMan allelic discrimination real-time PCR method was used to genotype the 2 polymorphisms of rs7579 and rs230813 in SEPP1. Results: No statistically significant difference in genotypic or allelic frequencies were found at the 2 genetic variants in SEPP1 between PE patients and controls (rs7579: genotype χ2 = 2.417, P = .299 and allele χ2 = 0.197, P = .761, odds ratio 1.049, 95% confidence interval 0.744–1.151; rs230813: genotype χ2 = 3.273, P = .195 and allele χ2 = 0.252, P = .615, odds ratio 0.971, 95% confidence interval 0.864–1.091). There were also no statistically significant differences in genetic distributions between mild/severe PE or early/late-onset PE and control subgroups. Conclusion: Our data indicate that the 2 genetic variants of rs7579 and rs230813 in SEPP1 may not play a role in the pathogenesis of PE in Chinese Han Women.

Published
2017

28. Norcantharidin inhibits viability and induces cell cycle arrest and apoptosis in osteosarcoma.

Author

Zhu, Yingchun, Mi, Yunfeng, Wang, Zheyang, Jia, Xuewen, and Jin, Zhanping

Subjects
RAPAMYCIN, CELL cycle, BONE tumors, CELL survival, TUMORS in children, OSTEOSARCOMA
Abstract

Osteosarcoma is the most frequent malignant bone tumor in children and adolescents. Norcantharidin (NCTD) is a purified component from blister beetles and has been identified to exert antitumor effects in a variety of cancer types. However, the antitumor effect of NCTD in osteosarcoma remains to be elucidated. In the current study, it was first demonstrated that NCTD inhibited proliferation and induced G2/M-phase arrest and cell apoptosis in human osteosarcoma cells. Furthermore, NCTD significantly decreased the phosphorylation of Akt and the mammalian target of rapamycin in human osteosarcoma cells. These results suggest that NCTD is a promising candidate for the treatment of osteosarcoma patients in the future. [ABSTRACT FROM AUTHOR]

Published
2019

29. Evaluation of Glutathione Peroxidase 4 role in Preeclampsia

Author

Peng, Xinguo, primary, Lin, Yan, additional, Li, Jinling, additional, Liu, Mengchun, additional, Wang, Jingli, additional, Li, Xueying, additional, Liu, Jingjing, additional, Jia, Xuewen, additional, Jing, Zhongcui, additional, Huang, Zuzhou, additional, Chu, Kaiqiu, additional, and Liu, Shiguo, additional

Published
2016
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33. elk1 /miR-462-731 Feedback Loop Regulates Macrophages Polarization and Phagocytosis in Grass Carp ( Ctenopharyngodon idella ).

Author

He Y, Liu Y, Yang Y, Liu Y, Jia X, Shen Y, Xu X, and Li J

Subjects
Animals, Feedback, Macrophages, Phagocytosis, Phosphatidylinositol 3-Kinases, Carps genetics, Carps metabolism, MicroRNAs genetics, MicroRNAs metabolism
Abstract

MicroRNA clusters are microRNAs (miRNAs) that are distributed in close proximity on chromosomes. In this study, we report a miRNA cluster identified from grass carp ( Ctenopharyngodon idella ), miR-462-731, which plays a positive role in host antibacterial immunity. The expression of miR-462-731 was disrupted after infection by Aeromonas hydrophila . Transcription factor ETS transcription factor ELK1 was identified to bind to the promoter of the miR-462-731 cluster and suppress its expression. In addition, miR-731 negatively regulates the expression of elk1 , forms an elk1/miR-462-731 double negative feedback loop. In addition, we found that miR-731 directly targets ezrin a ( ezra ), participates in inducing PI3K/AKT signaling in macrophage, to induce macrophage polarization to the M1 phenotype with stronger phagocytosis. Our results demonstrate a novel elk1/miR-462-731 feedback loop. The data deepen our understanding of the relationship between macrophage polarization and phagocytosis in teleost fish., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2022 He, Liu, Yang, Liu, Jia, Shen, Xu and Li.)

Published
2022
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