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2. The role of two-component regulatory system in β-lactam antibiotics resistance

Author

Zheng Chengkun, Li Lingzhi, Jia Mengdie, Zhou Xiaohui, Ge Haojie, Meng Hongmei, Li Yang, and Gu Dan

Subjects
0301 basic medicine, Histidine Kinase, medicine.drug_class, 030106 microbiology, Antibiotics, Drug resistance, Biology, beta-Lactams, Microbiology, beta-Lactam Resistance, beta-Lactamases, 03 medical and health sciences, Antibiotic resistance, Bacterial Proteins, polycyclic compounds, medicine, Bacteria, Histidine kinase, Membrane Proteins, Agriculture, Gene Expression Regulation, Bacterial, Two-component regulatory system, Anti-Bacterial Agents, Multiple drug resistance, Response regulator, 030104 developmental biology, Efflux
Abstract

The irrational use of antibiotics in agriculture and in the medical field has led to a variety of pathogenic microorganisms that produce drug resistance and even multidrug resistance. B-lactam is one of the most widely used antibiotics to treat infectious diseases. Resistance to β-lactam resistance can be primarily due to the presence β-lactamase, mutation of β-lactam targets and overexpression of efflux pumps. Two-component regulatory systems are composed of histidine kinase and response regulator that regulate gene expression under different environmental conditions. In this review, we summarized the mechanisms by which β-lactam resistance is developed and the role of the two-component regulatory system in β-lactam resistance.

Published
2018

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