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BACKGROUND: The Editorial Board of EJNMMI Radiopharmacy and Chemistry releases a biannual highlight commentary to update the readership on trends in the field of radiopharmaceutical development. MAIN BODY: This selection of highlights provides commentary on 21 different topics selected by each coauthoring Editorial Board member addressing a variety of aspects ranging from novel radiochemistry to first-in-human application of novel radiopharmaceuticals. CONCLUSION: Trends in radiochemistry and radiopharmacy are highlighted. Hot topics cover the entire scope of EJNMMI Radiopharmacy and Chemistry, demonstrating the progress in the research field in many aspects.

BACKGROUND: The Editorial Board of EJNMMI Radiopharmacy and Chemistry releases a biyearly highlight commentary to update the readership on trends in the field of radiopharmaceutical development. RESULTS: This commentary of highlights has resulted in 23 different topics selected by each member of the Editorial Board addressing a variety of aspects ranging from novel radiochemistry to first in man application of novel radiopharmaceuticals and also a contribution in relation to MRI-agents is included. CONCLUSION: Trends in (radio)chemistry and radiopharmacy are highlighted demonstrating the progress in the research field being the scope of EJNMMI Radiopharmacy and Chemistry.

Using molecular imaging techniques, radionuclide-labeled molecular probes can provide noninvasive and real-time visualization of specific biochemical processes in the living humans and pathological process of various human diseases at the molecular level, which will pave the way to precision medicine. 99mTc-radiopharmaceuticals is playing significant roles in the diagnosis of human diseases and efficacy monitoring of therapeutic strategies together with single photon emission computed tomography imaging modality. This review provided an overview of current status of 99mTc-radiopharmaceuticals used in clinic and clinical trials. Possible future trends in the field of 99mTc-radiopharmaceuticals were discussed. Investigation on the new targets or new biochemical processes as targets and basic technetium chemistry including exploring novel labeling methods and novel technetium building blocks were addressed. Development on the novel 99mTc-radiopharmaceuticals with high affinity, selectivity and specificity for the imaging of unique targets or specific biochemical processes together with 99mTc-labeling methods suitable for clinical use will accelerate the clinical translation of new 99mTc-radiopharmaceuticals.

Fritillaria cirrhosa D. Don (Liliaceae) is an endangered perennial bulbous plant and its dry bulb is a valuable medicinal material with antitussive and expectorant effects. Nevertheless, lack of resources and expensive prices make it difficult to meet clinical needs. This study presents a regeneration system aimed at overcoming the challenge of inadequate supply in F. cirrhosa, focusing on: (1) callus induction, (2) bulblets and adventitious bud induction, and (3) artificial seed production. Callus development was achieved in 84.93% on Murashige and Skoog (MS) medium fortified with 1.0 mg·L-1 picloram. The optimal medium for callus differentiation into regenerated bulblets was MS medium supplemented with 1.0 mg·L-1 6-benzyladenine (6-BA) and 0.2 mg·L-1 α-naphthaleneacetic acid (NAA). Subsequently, bulblets and adventitious buds were induced from regenerated bulblet sections cultured on MS medium fortified with 0.3 mg·L-1 6-BA + 1.0 mg·L-1 2,4-dichlorophenoxyacetic acid (2,4-D), 2.0 mg·L-1 6-BA + 0.5 mg·L-1, and the induction rates were 88.17% and 84.24%, respectively. The regenerated bulblets were transplanted into a substrate of humus soil, river sand, and pearlite (1:1:1) after low-temperature treatment. The germination rate was 42.80% after culture for 30 days. Regenerated bulblets were used for encapsulations in liquid MS medium containing 3% sucrose (w/v) + 0.5 mg·L-1 NAA + 2.0 mg·L-1 6-BA + 3% sodium alginate (w/v) with a 10 min exposure to 2% CaCl2. Under non-aseptic conditions, the germination rate reached 81.67%, while the rooting rate was 20.56% after 45 days. The capsule added 1.0 g·L-1 carbendazim and 1.0 g·L-1 activated carbon was the best component of artificial seeds. This study successfully established an efficient regeneration system for the rapid propagation of F. cirrhosa, involving in vitro bulblet regeneration and artificial seed production. This method introduces a novel approach for efficient breeding and germplasm preservation, making it suitable for large-scale industrial resource production. [ABSTRACT FROM AUTHOR]

Starting with the approach of representing traditional patterns with CAD in interior design, this paper analyzes the scenarios of application of traditional patterns realized through graphics, images and models and sets out that it is essential to analyze basic laws and characteristics of patterns as well as their fixed and variable elements and apply them appropriately to the interior space in order to achieve the purpose. The analysis on variable elements of traditional patterns is carried out from three aspects, namely the appropriate embellishment of colored painting, direct application of traditional partition boards and innovation based on traditional patterns.