171 results on '"Ji Hyang Lee"'
Search Results
2. The effect of type of anesthesia on intra-and postoperative blood loss at elective cesarean section
- Author
-
Jeong Eun Kim, Ji Hyang Lee, Eun Ju Kim, Myung Woo Min, Jong Seouk Ban, and Sang Gon Lee
- Subjects
blood loss ,cesarean section ,general anesthesia ,hemoglobin ,spinal anesthesia ,Anesthesiology ,RD78.3-87.3 - Abstract
BackgroundIn cesarean section (c-sec) it is known that women receiving spinal anesthesia have decreased intraoperative blood loss compared to women receiving general anesthesia. However, we should always consider postoperative bleeding (postpartum bleeding) that may follow. The amount of postpartum bleeding can be substantial. Therefore, we sought to evaluate the effect of type of anesthesia retrospectively on intra- and postoperative blood loss by comparing the changes of postoperative Hb, Hct at c-sec.MethodsWe retrospectively compared the medical records of 287 elective c-sec patients. We excluded medical and obstetric conditions that may predispose such patients to increased blood loss. Subsequent detailed record analysis included 152 patients that received spinal anesthesia (group S), and 135 patients that received sevoflurane for general anesthesia (group G).ResultsIn comparison with the preoperative Hb, rates of Hb in the 1st postoperative day in group S significantly decreased compared to group G, but there was no significant difference in decreasing rates of Hb in the 3rd postoperative day between groups S and G. Estimated blood loss (EBL) of the intraoperative and operative day in group S was significantly lower compared to group G, but there was no significant difference in EBL of 1st and 2nd postoperative day between groups S and G.ConclusionsWe conclude that group S had a decrease in blood loss between the intraoperative and operative day and there was no significant differences in postoperative blood loss compared with group G.
- Published
- 2012
- Full Text
- View/download PDF
3. Anesthetic experience of a patient with tracheomegaly -A case report
- Author
-
Mi Young Kim, Eun Joo Kim, Byung Woo Min, Jong Suk Ban, Sang Kon Lee, and Ji Hyang Lee
- Subjects
tracheobronchomegaly ,tracheomegaly ,tracheostomy tube ,Anesthesiology ,RD78.3-87.3 - Abstract
Tracheomegaly or tracheobronchomegaly is a rare syndrome that consists of marked dilatation of the trachea and the major bronchi, and this is usually due to a congenital defect of the elastic and muscle fibers of the tracheobroncheal tree. Physicians have had only limited experience with performing anesthesia in patients with this type of syndrome. This syndorme is diagnosed by roentenological investigation and this condition is frequently associated with chronic respiratory infection and partial airway obstruction. In this report, we present a case of performing tracheostomy for a patient with tracheomegaly, and this was probably secondary to mechanical ventilator therapy. The regular tracheostomy tube did not provided sufficient length to allow the cuff to lie properly in the trachea in this patient. Because of the peri-cuff air leakgae and hypercapnea after tracheostomy, we needed a longer tracheostomy tube. But we didn't have such a tube and we didn't know any other method, so we couldn't perform tracheostomy. Therefore, we introduced a method of reducing the length of the endotracheal tube to a suitable size until a longer tracheostomy tube can be obtained for those patients having tracheomegaly.
- Published
- 2010
- Full Text
- View/download PDF
4. Epidural anesthesia for the patient with type IV spinal muscular atrophy -A case report
- Author
-
Seon Jin Kim, Eun Ju Kim, Byung Woo Min, Jong Seouk Ban, Sang Gon Lee, and Ji Hyang Lee
- Subjects
epidural anesthesia ,spinal muscular atrophy ,Anesthesiology ,RD78.3-87.3 - Abstract
Spinal muscular atrophy (SMA) is a rare lower motor neurone disease in which anesthetic management is often difficult as a result of muscle weakness, hypersensitivity to non-depolarizing neuromuscular blocking agent, and succinylcholine induced hyperkalemia. We describe a 50-year-old patient with type IV SMA for synovectomy. We decided to use an epidural technique to avoid muscle relaxants and tracheal intubation. After operation, there was no exacerbation of neurologic signs and symptoms.
- Published
- 2010
- Full Text
- View/download PDF
5. Combined spinal-epidural anesthesia for cesarean section in a patient with Moyamoya disease -A case report
- Author
-
Kwang Suk Shim, Eun Ju Kim, Ji Hyang Lee, Sang Gon Lee, Jong Seouk Ban, and Byung Woo Min
- Subjects
combined spinal-epidural anesthesia ,ephedrine ,moyamoya disease ,phenylephrine ,Anesthesiology ,RD78.3-87.3 - Abstract
Moyamoya disease is a rare progressive occlusive disease of the internal carotid arteries. We report a case of combined spinal-epidural anesthesia in a patient with Moyamoya disease presenting for Cesarean section. Hypotension associated with spinal anesthesia for Cesarean section is the most common and serious adverse effect despite the use of uterine displacement and volume preload. We continuously infused phenylephrine and ephedrine to prevent hypotension. The intraoperative hemodynamic state was stable. The patient had no significant postoperative complications.
- Published
- 2010
- Full Text
- View/download PDF
6. Ascertaining injury risk issues through big data analysis: text-mining based analysis of national emergency response data
- Author
-
Jin-Young Won, Yu-Rim Lee, Myeong-Heum Cho, Yun-Tae Kim, and Ji-Hyang Lee
- Subjects
injury ,text-mining ,EMS data ,novelty ,scalability ,health policy ,Public aspects of medicine ,RA1-1270 - Abstract
ObjectivesInjury prevention can be achieved through various interventions, but it faces challenges due to its comprehensive nature and susceptibility to external environmental factors, making it difficult to detect risk signals. Moreover, the reliance on standardized systems leads to the construction and statistical analysis of numerous injury surveillance data, resulting in significant temporal delays before being utilized in policy formulation. This study was conducted to quickly identify substantive injury risk problems by employing text mining analysis on national emergency response data, which have been underutilized so far.MethodsWith emerging issue and topic analyses, commonly used in science and technology, we detected problematic situations and signs by deriving injury keywords and analyzing time-series changes.ResultsIn total, 65 injury keywords were identified, categorized into hazardous, noteworthy, and diffusion accidents. Semantic network analysis on hazardous accident terms refined the injury risk issues.ConclusionAn increased risk of winter epidemic fractures due to extreme weather, self-harm due to depression (especially drug overdose and self-mutilation), and falls was observed in older adults. Thus, establishing effective injury prevention strategies through inter-ministerial and interagency cooperation is necessary.
- Published
- 2024
- Full Text
- View/download PDF
7. Blood transcriptome differentiates clinical clusters for asthma
- Author
-
Jin An, MD, PhD, Seungpil Jeong, PhD, Kyungtaek Park, PhD, Heejin Jin, PhD, Jaehyun Park, PhD, Eunsoon Shin, PhD, Ji-Hyang Lee, MD, PhD, Woo-Jung Song, MD, PhD, Hyouk-Soo Kwon, MD, PhD, You Sook Cho, MD, PhD, Jong Eun Lee, PhD, Sungho Won, PhD, and Tae-Bum Kim, MD, PhD
- Subjects
Asthma ,Cluster ,Transcriptome ,Pathway ,Immunologic diseases. Allergy ,RC581-607 - Abstract
Background: In previous studies, several asthma phenotypes were identified using clinical and demographic parameters. Transcriptional phenotypes were mainly identified using sputum and bronchial cells. Objective: We aimed to investigate asthma phenotypes via clustering analysis using clinical variables and compare the transcription levels among clusters using gene expression profiling of the blood. Methods: Clustering analysis was performed using 6 parameters: age of asthma onset, body mass index, pack-years of smoking, forced expiratory volume in 1 s (FEV1), FEV1/forced vital capacity, and blood eosinophil counts. Peripheral blood mononuclear cells (PBMCs) were isolated from whole blood samples and RNA was extracted from selected PBMCs. Transcriptional profiles were generated (Illumina NovaSeq 6000) and analyzed using the reference genome and gene annotation files (hg19.refGene.gft). Pathway enrichment analysis was conducted using GO, KEGG, and REACTOME databases. Results: In total, 355 patients with asthma were included in the analysis, of whom 72 (20.3%) had severe asthma. Clustering of the 6 parameters revealed 4 distinct subtypes. Cluster 1 (n = 63) had lower predicted FEV1 % and higher pack-years of smoking and neutrophils in sputum. Cluster 2 (n = 43) had a higher proportion and number of eosinophils in sputum and blood, and severe airflow limitation. Cluster 3 (n = 110) consisted of younger subjects with atopic features. Cluster 4 (n = 139) included features of late-onset mild asthma. Differentially expressed genes between clusters 1 and 2 were related to inflammatory responses and cell activation. Th17 cell differentiation and interferon gamma-mediated signaling pathways were related to neutrophilic inflammation in asthma. Conclusion: Four clinical clusters were differentiated based on clinical parameters and blood eosinophils in adult patients with asthma form the Cohort for Reality and Evolution of Adult Asthma in Korea (COREA) cohort. Gene expression profiling and molecular pathways are novel means of classifying asthma phenotypes.
- Published
- 2024
- Full Text
- View/download PDF
8. Effects of bepotastine, a nonsedating H1-antihistamine, for the treatment of persistent cough and allergic rhinitis: a randomised, double-blind, placebo-controlled trial
- Author
-
Ji-Hyang Lee, Ji-Yoon Oh, Hyouk-Soo Kwon, Tae-Bum Kim, You Sook Cho, and Woo-Jung Song
- Subjects
Medicine - Abstract
Background Empirical therapy with oral histamine-1 receptor antagonists (H1RAs) is often used for patients with suspected upper airway cough syndrome. No placebo-controlled trials with nonsedating H1RAs (nsH1RAs) have evaluated validated cough outcomes. The objective of the present study was to assess the effect of an nsH1RA, bepotastine, on cough outcomes in patients with allergic rhinitis and persistent cough. Methods A randomised, double-blind, placebo-controlled trial was conducted. Adult patients with persistent cough (>3 weeks in duration) and symptomatic allergic rhinitis were recruited and randomly assigned to receive either bepotastine or placebo at a 1:1 ratio. The primary outcome was cough-specific quality of life assessed using the Leicester Cough Questionnaire (LCQ). Secondary outcomes included cough severity visual analogue scale (VAS), throat VAS, Cough Hypersensitivity Questionnaire, Sinonasal Outcome Test-22 score and drug adverse events. Results Between October 2021 and September 2022, 50 participants (43 females; mean age 46.28 years; median cough duration 3 months) were assigned to either the bepotastine 10 mg twice daily or placebo group in a 1:1 ratio. After 2 weeks of treatment, both bepotastine and placebo groups showed significant improvements in the LCQ scores, but there was no significant difference in the magnitude of change between the groups (3.45±2.10 versus 3.04±2.94, p=0.576). Secondary outcomes were also comparable. Conclusions Despite the relatively small sample size, our study clearly demonstrated that a 2-week treatment with bepotastine did not provide therapeutic benefits for cough outcomes. These findings suggest against the use of nsH1RAs with the intention of improving cough outcomes, even in patients with persistent cough and allergic rhinitis.
- Published
- 2023
- Full Text
- View/download PDF
9. Roles of real-world evidence in severe asthma treatment: challenges and opportunities
- Author
-
Youngsoo Lee, Ji-Hyang Lee, So Young Park, Ji-Ho Lee, Joo-Hee Kim, Hyun Jung Kim, Sang-Heon Kim, Kian Fan Chung, and Woo-Jung Song
- Subjects
Medicine - Abstract
Recent advances in asthma research have led to the development of novel biologicals that hinder the pathological actions of key molecules in severe asthma. Traditional randomised controlled studies (RCTs), the gold standard for evaluating the efficacy and safety of medical interventions with excellent internal validity, have proven the clinical benefits and favourable safety profiles of type 2 biologicals in severe asthma. However, RCTs are not always ideal because of shortcomings such as limited external validity and practical issues in the management of severe asthma that cannot be solved through strictly designed clinical trials. Thus, the applicability of their findings may be questioned because treatment adherence is frequently poor in the real world. Real-world evidence includes a wide range of real-world data (RWD) collected from multiple sources in clinical practice, such as electronic medical records, healthcare insurance claims and retrospective or prospective patient registries. RWD may help clinicians decide how to manage patients with severe asthma. Real-world evidence is also gaining attention in addressing clinical questions not answered by traditional RCTs. Because there are various types of RWD with different possibilities and limitations, it is important to decide which type of RWD could be “fit for purpose” to address a specific question. This narrative review discusses the challenges and opportunities of RWD for evaluating the effectiveness and clinical outcomes of biological treatments for severe asthma.
- Published
- 2023
- Full Text
- View/download PDF
10. Precision Medicine Intervention in Severe Asthma (PRISM) study: molecular phenotyping of patients with severe asthma and response to biologics
- Author
-
Ji-Hyang Lee, Piers Dixey, Pank Bhavsar, Katie Raby, Nazanin Kermani, Marc Chadeau-Hyam, Ian M. Adcock, Woo-Jung Song, Hyouk-Soo Kwon, Sei-Won Lee, You Sook Cho, Kian Fan Chung, and Tae-Bum Kim
- Subjects
Medicine - Abstract
Severe asthma represents an important clinical unmet need despite the introduction of biologic agents. Although advanced omics technologies have aided researchers in identifying clinically relevant molecular pathways, there is a lack of an integrated omics approach in severe asthma particularly in terms of its evolution over time. The collaborative Korea–UK research project Precision Medicine Intervention in Severe Asthma (PRISM) was launched in 2020 with the aim of identifying molecular phenotypes of severe asthma by analysing multi-omics data encompassing genomics, epigenomics, transcriptomics, proteomics, metagenomics and metabolomics. PRISM is a prospective, observational, multicentre study involving patients with severe asthma attending severe asthma clinics in Korea and the UK. Data including patient demographics, inflammatory phenotype, medication, lung function and control status of asthma will be collected along with biological samples (blood, sputum, urine, nasal epithelial cells and exhaled breath condensate) for omics analyses. Follow-up evaluations will be performed at baseline, 1 month, 4–6 months and 10–12 months to assess the stability of phenotype and treatment responses for those patients who have newly begun biologic therapy. Standalone and integrated omics data will be generated from the patient samples at each visit, paired with clinical information. By analysing these data, we will identify the molecular pathways that drive lung function, asthma control status, acute exacerbations and the requirement for daily oral corticosteroids, and that are involved in the therapeutic response to biological therapy. PRISM will establish a large multi-omics dataset of severe asthma to identify potential key pathophysiological pathways of severe asthma.
- Published
- 2023
- Full Text
- View/download PDF
11. Assessment of Treatment Response in Patients With Severe Asthma Using Visual and Quantitative Analysis of Chest CT.
- Author
-
Han Na Lee, Jin An, Miji Lee, Hye Jeon Hwang, Jooae Choe, Jihye Yoon, Ji-Hyang Lee, Min-Hye Kim, Young-Joo Cho, Sang Min Lee, Tae-Bum Kim, and Joon Beom Seo
- Published
- 2024
- Full Text
- View/download PDF
12. Efficacy of non-sedating H1-receptor antihistamines in adults and adolescents with chronic cough: A systematic review
- Author
-
Ji-Hyang Lee, Ji Won Lee, Jin An, Ha-Kyeong Won, So-Young Park, Ji-Ho Lee, Sung-Yoon Kang, Yoshihiro Kanemitsu, Hyun Jung Kim, and Woo-Jung Song
- Subjects
Non-sedating H1-receptor antihistamine ,Asthma ,Allergic rhinitis ,Atopic cough ,Chronic cough ,Immunologic diseases. Allergy ,RC581-607 - Abstract
Background: Nasal symptoms frequently coexist in patients with chronic cough, and non-sedating H1-receptor antihistamines (nsH1RAs) are often prescribed for cough management in several countries. However, recommendations on the use of nsH1RAs vary among chronic cough guidelines. This study aimed to examine the efficacy of nsH1RAs over placebos in adolescents or adults with chronic cough or allergic respiratory conditions that may present as chronic cough. Methods: Electronic databases were searched for studies published until November 2020. Randomized placebo-controlled trials of nsH1RAs reporting cough endpoints in adolescents or adults with chronic cough or cough-associated allergic respiratory conditions (allergic rhinitis, allergic asthma, or atopic cough) were included. Results: A total of 10 placebo-controlled trials were identified. Three studies (one study each involving allergic rhinitis, allergic rhinitis with comorbid asthma, and atopic cough) described baseline and post-treatment cough scores, and all reported significant improvements in subjective cough scores; however, the magnitude of improvement was greater in the 2 studies of patients with atopic cough (relative improvement in cough frequency score: −36.6 ± 8.4%) or seasonal allergic rhinitis-associated cough (cough frequency score: −44.0 ± 7.3% and cough intensity score: −65.7 ± 8.3%) than in the 1 study of allergic rhinitis patients with comorbid asthma (−4.0 ± 1.3%). Meanwhile, the other 7 trials found conflicting results but lacked information on the baseline cough score and did not use validated cough measurement tools; thus, their clinical relevance could not be determined. Conclusion: Despite the widespread use of nsH1RAs in patients with chronic cough, only a few clinical trials examining their benefits on cough outcomes have been conducted. There may be a subgroup of patients, particularly those with seasonal allergic rhinitis-associated cough or atopic cough, whose cough may improve with nsH1RA treatment. However, adequately powered trials with validated cough measurement tools are warranted to confirm the role of nsH1RAs in the management of patients with allergic phenotypes of chronic cough.
- Published
- 2021
- Full Text
- View/download PDF
13. Chest computed tomography scan utilization and diagnostic outcomes in chronic cough patients with normal chest X-rays: analysis of routinely collected data of a tertiary academic hospital
- Author
-
Jin An, Ji-Hyang Lee, Youngsang Yoo, Hyouk-Soo Kwon, Jae-Seung Lee, Sei Won Lee, Tae-Bum Kim, Yeon-Mok Oh, You Sook Cho, Sang-Do Lee, and Woo-Jung Song
- Subjects
Pulmonary and Respiratory Medicine - Published
- 2023
14. The role of allergen-specific IgE in predicting allergic symptoms on dog and cat exposure among Korean pet exhibition participants
- Author
-
Sung-Yoon Kang, Min-Suk Yang, So-Young Park, Jung-Hyun Kim, Ha-Kyeong Won, Oh Young Kwon, Ji-Hyang Lee, Ye-Won Kang, Jae-Woo Jung, Woo-Jung Song, Sae-Hoon Kim, Sang Min Lee, and Sang Pyo Lee
- Subjects
Allergy ,Cats ,Dogs ,Skin prick test ,Specific IgE ,Immunologic diseases. Allergy ,RC581-607 - Abstract
Background: The values of the skin prick test (SPT) and allergen-specific IgE (sIgE) measurement in predicting dog and cat allergies remain unclear. We aimed to evaluate the usefulness of SPT and sIgE measurement in predicting self-reported allergic symptoms during exposure to dogs and cats in Korean adults. Methods: A total of 552 participants in a pet exhibition in Korea completed questionnaires regarding exposure to dog or cat and the development of allergic symptoms during exposure. Study participants also underwent SPT using 3 different commercially available reagents, and had their blood drawn for measurement of serum total IgE and dog/cat-dander-IgE using ImmunoCAP®. Results: Measurement of sIgE for dog and cat dander allergens provided the highest positive and negative predictive values and sensitivity, but not specificity (58%, 87.2%, 67.9%, and 93.1% for allergic symptoms on dog exposure; 64.7%, 83.2%, 74.8%, and 88.9% for those on cat exposure, respectively), in predicting self-reported allergic symptoms on dog and cat exposure. The sIgE level consistently exhibited the highest area under the receiver operating characteristic curve (0.749 and 0.719 for allergic symptoms on dog and cat exposure, respectively). Careful interpretation of SPT and sIgE measurements maximized the positive and negative predictive values, sensitivity, and specificity for predicting allergic symptoms on dog exposure (71.4%, 87.3%, 75.3%, and 99.3%) and those on cat exposure (71.4%, 85.3%, 79.3%, and 98.9%). Conclusions: The measurement of dog and cat dander sIgE levels may be useful for the exclusion of allergic symptoms related to pet exposure. Collective interpretation of SPT and sIgE tests facilitates identification of allergic symptoms on dog or cat exposure, giving a better rule-in test result.
- Published
- 2020
- Full Text
- View/download PDF
15. Roles of real-world evidence in severe asthma treatment: challenges and opportunities
- Author
-
Youngsoo Lee, Ji-Hyang Lee, So Young Park, Ji-Ho Lee, Joo-Hee Kim, Hyun Jung Kim, Sang-Heon Kim, Kian Fan Chung, and Woo-Jung Song
- Subjects
Pulmonary and Respiratory Medicine - Abstract
Recent advances in asthma research have led to the development of novel biologicals that hinder the pathological actions of key molecules in severe asthma. Traditional randomised controlled studies (RCTs), the gold standard for evaluating the efficacy and safety of medical interventions with excellent internal validity, have proven the clinical benefits and favourable safety profiles of type 2 biologicals in severe asthma. However, RCTs are not always ideal because of shortcomings such as limited external validity and practical issues in the management of severe asthma that cannot be solved through strictly designed clinical trials. Thus, the applicability of their findings may be questioned because treatment adherence is frequently poor in the real world. Real-world evidence includes a wide range of real-world data (RWD) collected from multiple sources in clinical practice, such as electronic medical records, healthcare insurance claims and retrospective or prospective patient registries. RWD may help clinicians decide how to manage patients with severe asthma. Real-world evidence is also gaining attention in addressing clinical questions not answered by traditional RCTs. Because there are various types of RWD with different possibilities and limitations, it is important to decide which type of RWD could be “fit for purpose” to address a specific question. This narrative review discusses the challenges and opportunities of RWD for evaluating the effectiveness and clinical outcomes of biological treatments for severe asthma.
- Published
- 2022
16. An Experimental Study on Fire Prevention in Buildings Using Emergency Extinguishing Equipment in the Presence of Flying Sparks from Wildfires
- Author
-
Jin-Suk Kwon, Tae-Hwe Park, Young Min Shin, You Ri Lim, and Ji Hyang Lee
- Abstract
This study empirically verified the ability of emergency extinguishing equipment installed on the east coast of Gangwon-do to protect private houses and facilities that are adjacent to forest. A simulated wildfire was used to confirm the equipment’s effectiveness by analyzing the ignition of nearby homes and facilities, the spread of flames, and the fire characteristics in the presence of flying sparks. The experiment was repeated a total of four times by applying a preemptive water stream from the emergency extinguishing equipment onto the roof and wall of the facility. The experimental results showed, distinct differences in the ignition time, combustion range, and temperature distribution of the facility depending on whether it was exposed to a preemptive water stream. It was confirmed that the preemptive water stream had a significant effect on preventing the spread of combustion and establishing the initial golden time for the fire.
- Published
- 2022
17. Exacerbation of Chronic Spontaneous Urticaria Following COVID-19 Vaccination in Omalizumab-Treated Patients
- Author
-
Ji-Hyang Lee, Eunyong Shin, Hyun-Kyoung Kim, Woo-Jung Song, Hyouk-Soo Kwon, Tae-Bum Kim, and You Sook Cho
- Subjects
Immunology and Allergy - Published
- 2023
18. Cough Presentation and Cough-Related Healthcare Utilization in Tertiary Care: Analysis of Routinely Collected Academic Institutional Database
- Author
-
Jin An, Ji-Hyang Lee, Ha-Kyeong Won, Yewon Kang, Hyouk-Soo Kwon, Jae-Seung Lee, Sei Won Lee, Tae-Bum Kim, Yeon-Mok Oh, You Sook Cho, Sang-Do Lee, Hee-Bom Moon, and Woo-Jung Song
- Subjects
Pulmonary and Respiratory Medicine ,Cough ,Tertiary Healthcare ,Chronic Disease ,Hypersensitivity ,Humans ,Female ,Middle Aged ,Patient Acceptance of Health Care ,Asthma ,Retrospective Studies - Abstract
Background: Most knowledge on cough epidemiology was obtained from questionnaire surveys of general populations or small focused studies of patients visiting specialist clinics. Routinely collected data (RCD) from electronic health records (EHR) are useful sources for studying disease epidemiology, but their use was limited in chronic cough. The present study aimed to investigate cough presentation and cough-related healthcare utilization, using the RCD of patients referred with cough.Methods: This is a retrospective cohort study utilizing an academic institutional EHR database. Cough cases were identified using the text search for the chief complaint indicating “cough” in the structured case report form. Using the information, we constructed a retrospective cohort of patients with subacute or chronic cough. Baseline demographics, medical history, concomitant symptoms, and diagnostic tests were analyzed. Healthcare utilization during 1 year since the baseline visit was assessed for drug prescriptions, additional diagnostic tests, outpatient visits, and hospitalization.Results: Among a total of 28,312 new referrals, cough was the chief complaint in 13,223 cases (46.7%). Based on the selection criteria, 3,810 subacute and 7,150 chronic cough patients were finally included. A common demographic profile was middle-aged woman (mean age 52.1 years, and female 63%). Patients had a median three accompanying symptoms (interquartile range: 2–5). Abnormal throat sensation (globus, tickling, or dryness) was the most common (about 70%), but symptoms suggesting nasal diseases, asthma, or acid reflux were also frequent. During the first year, both of subacute and chronic cough patients required multiple drug prescriptions, diagnostic tests, and outpatient visits, but the degree of utilization was higher in patients with chronic cough. Codeine-containing drugs were given to 21.5% of patients with chronic cough, and oral antibiotics to 23.7% and oral steroids to 9.9%.Conclusions: Cough is a common chief complaint among new referrals to tertiary specialist clinics. Cough is accompanied by multiple symptoms and is associated with healthcare utilization, particularly more in patients with chronic cough. Further studies are needed to understand their long-term health outcomes and reduce the disease burden.
- Published
- 2022
19. Study on the Proposed Expansion of the Fire Engine Priority Signal System to Ensure Golden Time
- Author
-
Tae-Hee Park, Ji-Hyang Lee, Jun Lee, Sang-Jo Lee, and Jin-Suk Kwon
- Abstract
The golden period is a concept in disaster response target-time management. It refers to the centralized response time required to maximize lives saved in an emergency. The National Fire Agency estimates that the golden period arrival time of fire engines is seven minutes. However, the arrival rate has dropped by about 68% in the last five years. Concessions and special provisions for the violation of laws are permitted to enable the swift response of fire engines. Despite this, the vehicles still cannot reach their destinations timeously. In this study, the effectiveness of the priority signal system was investigated using construction status and dispatch data. VISSIM, a traffic flow simulation software, was used to simulate the effectiveness of the priority signal system introduced to Cheong-ju city. This study can be used as the basis for the systematic construction of priority signal systems and further investigation on the topic.
- Published
- 2022
20. Safety and outcomes of 'at-home self-provocation tests' in patients with mild NSAID-induced urticaria/angioedema (NIUA)
- Author
-
So-Young Park, Young-Sang Yoo, Jin-Young Huh, Daegeun Lee, Jae-Woo Jung, Ji-Hyang Lee, Woo-Jung Song, Tae-Bum Kim, You-Sook Cho, and Hyouk-Soo Kwon
- Subjects
Pulmonary and Respiratory Medicine ,Immunology ,Immunology and Allergy - Published
- 2023
21. Electronic medical record–based machine learning predicts the relapse of asthma exacerbation
- Author
-
Ji-Hyang Lee, Chaelin Hong, Ji Seon Oh, and Tae-Bum Kim
- Subjects
Pulmonary and Respiratory Medicine ,Immunology ,Immunology and Allergy - Published
- 2023
22. Blockade of sphingosine‐1‐phosphate receptor 4 pathway has anti‐inflammatory effects in a murine model of allergic airway inflammation
- Author
-
Mini Jeong, Sin‐Jeong Kim, Kyomoon Koo, A Ryang Lee, Min Ju Pyo, Hyun Jae Shim, Keun‐Ai Moon, Ji‐Hyang Lee, Chung Hwan Hong, Jae Hyun Kim, Hyunkyung Cho, Eun Hee Koh, Ki‐Up Lee, Sanghee Kim, Sun‐Young Yoon, and You‐Sook Cho
- Subjects
Immunology ,Immunology and Allergy - Published
- 2023
23. A Suitability Assessment of the Functional Content Platform for Firefighter’s Stress Reduction (part 2)
- Author
-
Tae-Hee Park, Tae-Sun Kim, Jung-Hwa Park, Young-Tae Jun, Ji-Hyang Lee, Chi-Jung Kim, and Jin-Suk Kwon
- Abstract
Firefighters are constantly exposed to dangers in disaster sites and they need a plan to safeguard their mental health. There are various programs in place, such as mental and physical health stabilization rooms, to reduce stress and prevent mental illnesses. While these are easily accessible during work, they are lacking in function. To effectively decrease the stress of firefighters, a beam projector set, a speaker, a LED lamp were installed in an independent booth, called a activity healing room. Such rooms were built in fire stations and its effects on stress were analyzed. The indicator was based on measurement of a respiration rate and a heart rate. Additionally, for the qualitative analysis, mental health interviews of firefighters confirmed stress reduction. The results of this study are expected to be used as baseline data to enhance psychological resilience in firefighters and to revitalize their mental and physical health using stabilization rooms.
- Published
- 2022
24. Relationship between asthma and sarcopenia in the elderly: a nationwide study from the KNHANES
- Author
-
Ha-Kyeong Won, Yewon Kang, Jin An, Ji-Hyang Lee, Woo-Jung Song, Hyouk-Soo Kwon, You Sook Cho, Hee-Bom Moon, Il-Young Jang, and Tae-Bum Kim
- Subjects
Pulmonary and Respiratory Medicine ,Pediatrics, Perinatology and Child Health ,Immunology and Allergy - Abstract
Few studies have investigated the relationship between asthma and sarcopenia. We aimed to examine the relationship between asthma and sarcopenia in a community-dwelling geriatric population, especially regarding lung function and asthma control.A cross-sectional dataset from the Korean National Health and Nutrition Examination Survey 2008-2011 was utilized. Data regarding asthma history, age at asthma onset, recent asthma exacerbations, and hospitalization for asthma exacerbations were obtained using structured questionnaires. Appendicular skeletal muscle was calculated as the sum of the skeletal muscle mass, and physical activity was assessed using the International Physical Activity Questionnaire.Asthma presented an estimated incidence of 6.17 ± 0.37% in the elderly. Groups were divided and analyzed according to asthma, muscle mass, and physical activity. Sarcopenia was associated with aging, male sex, smoking history, low body mass index (BMI), and reduced lung function with or without asthma. Sarcopenic asthma had a younger onset and reduced physical activity than non-sarcopenic asthma. Obstructive patterns were more frequent in asthmatics exhibiting low or moderate physical activity levels than in those with high activity, but asthma control was not associated with sarcopenia and physical activity. Multivariate logistic regression analyses showed that compared with control, sarcopenic asthma was associated with FEV1 60%, and airway obstruction, and with aging, male, and lower BMI, compared with non-sarcopenic asthma.Our findings suggest that decreased muscle mass and physical activity levels contribute to reduced lung function in elderly asthmatics. Furthermore, sarcopenic asthma was associated with aging, low BMI, and reduced lung function in the elderly.
- Published
- 2022
25. Label-free imaging and evaluation of characteristic properties of asthma-derived eosinophils using optical diffraction tomography
- Author
-
Min Ju Pyo, Sang-Yeob Kim, Ji won Lee, Tae-Keun Kim, Yeonhee Shin, Chan-Gi Pack, You Sook Cho, A.Ryang Lee, and Ji Hyang Lee
- Subjects
Cytoplasm ,Pathology ,medicine.medical_specialty ,Optical diffraction ,Biophysics ,Vacuole ,Cytoplasmic Granules ,Biochemistry ,Imaging, Three-Dimensional ,Organelle ,medicine ,Humans ,Tomography, Optical ,Eosinophilia ,Pulmonary Eosinophilia ,Lung ,Molecular Biology ,Label free ,Asthma ,Cell Nucleus ,Chemistry ,Cell Biology ,respiratory system ,medicine.disease ,respiratory tract diseases ,Eosinophils ,Case-Control Studies ,Vacuoles ,Tomography ,Single-Cell Analysis ,medicine.symptom - Abstract
Optical diffraction tomography (ODT), an emerging imaging technique that does not require fluorescent staining, can measure the three-dimensional distribution of the refractive index (RI) of organelles. In this study, we used ODT to characterize the pathological characteristics of human eosinophils derived from asthma patients presenting with eosinophilia. In addition to morphological information about organelles appearing in eosinophils, including the cytoplasm, nucleus, and vacuole, we succeeded in imaging specific granules and quantifying the RI values of the granules. Interestingly, ODT analysis showed that the RI (i.e., molecular density) of granules was significantly different between eosinophils from asthma patients and healthy individuals without eosinophilia, and that vacuoles were frequently found in the cells of asthma patients. Our results suggest that the physicochemical properties of eosinophils derived from patients with asthma can be quantitatively distinguished from those of healthy individuals. The method will provide insight into efficient evaluation of the characteristics of eosinophils at the organelle level for various diseases with eosinophilia.
- Published
- 2022
26. Development and linguistic validation of the Korean version of the Severe Asthma Questionnaire
- Author
-
Sung-Yoon Kang, Kyung-Min Ahn, Ji-Hyang Lee, Soo Jie Chung, Kyoung-Hee Sohn, So Young Park, Tae-Bum Kim, and Woo-Jung Song
- Subjects
Pulmonary and Respiratory Medicine - Published
- 2023
27. Objective cough frequency monitoring in real-world practice
- Author
-
Woo-Jung Song, Alyn H. Morice, Ji Hyang Lee, and Eva Millqvist
- Subjects
Pulmonary and Respiratory Medicine ,business.industry ,Cough Frequency ,Editorials ,Medicine ,food and beverages ,Medical emergency ,business ,medicine.disease ,respiratory tract diseases - Abstract
For those of us seeing patients with chronic cough, there is one great advantage in comparison with other specialities dealing with recurrent symptoms such as migraine, chronic pain, and psychiatric conditions. We can measure cough., There are possibilities and obstacles to the use of objective cough monitoring in real-world practice. Advances in technology will overcome the difficulties and continuous real-time cough monitoring will then provide a valuable tool in cough management. https://bit.ly/3lu5cfk
- Published
- 2021
28. Different impacts of blood and sputum eosinophil counts on lung function and clinical outcomes in asthma: findings from the COREA cohort
- Author
-
Duong Duc, Pham, Ji-Hyang, Lee, Ju-Young, Kim, Jin, An, Woo-Jung, Song, Hyouk-Soo, Kwon, You Sook, Cho, and Tae-Bum, Kim
- Subjects
Eosinophils ,Pulmonary and Respiratory Medicine ,Leukocyte Count ,Sputum ,Humans ,Lung ,Asthma ,Respiratory Function Tests - Abstract
Purpose Blood (EOS-B) and sputum (EOS-S) eosinophil counts may contribute differently to asthma pathogenesis. We compared the impact of the baseline EOS-B and EOS-S levels on lung function, asthma control, and exacerbation in Korean asthma patients.MethodsAsthma patients with baseline EOS-B (n=4257) and EOS-S (n=1049) levels from a multicenter cohort (COREA) were included. Pulmonary function test (%FEV1 predicted), asthma control test (ACT), and asthma exacerbation incidence were followed-up every 3 months for one year. Linear mixed effect models and survival analyses were used to examine the association between eosinophilic groups defined by EOS-B or EOS-S and outcomes. ResultsHigh eosinophilic groups were associated with a low baseline value and a high improvement in the %FEV1 predicted and ACT scores over time. The magnitude of group difference in %FEV1 predicted was 2-fold higher in the EOS-S versus EOS-B classification (mean and 95% CI: 4.7 (0.6-8.8) versus 2.0 (0.2-3.7) for the baseline value and -1.5 (-2.3 to -0.8) versus -0.8(-1.1 to -0.4) for the slope of change), whereas it was identical in ACT score. The magnitude of the impact increased linearly with the elevation of the cut-off level for the EOS-B but remained stable for the EOS-S classification. Patients with an elevation of both their EOS-B and EOS-S showed a higher increment in the %FEV1 predicted and ACT over time. Neither the EOS-B nor EOS-S was associated with asthma exacerbation. ConclusionEOS-S and EOS-B contribute differently to the clinical outcomes and should be taken into account independently to improve asthma care.
- Published
- 2022
29. Eosinophil Extracellular Traps Pave the Way for the Identification of Novel Therapeutics in Severe Asthma
- Author
-
Ji-Hyang Lee and You Sook Cho
- Subjects
Pulmonary and Respiratory Medicine ,Immunology ,Immunology and Allergy - Published
- 2022
30. Assessing the Suitability of Virtual Reality Content for Stress Reduction among Firefighters
- Author
-
Tae-Hee Park, Ji-Hyang Lee, and Su-Young Kim
- Subjects
Stress (mechanics) ,Stress reduction ,03 medical and health sciences ,0302 clinical medicine ,Human–computer interaction ,Virtual reality ,030223 otorhinolaryngology ,Psychology ,030227 psychiatry - Abstract
As disaster sites diversify, the need for firefighting is steadily increasing. The stress and anxiety experienced by firefighters at work can cause lack of sleep and chronic fatigue. Firefighters are at risk of suffering from post-traumatic stress disorders due to the physical and mental injuries experienced at disaster sites; accordingly, fire departments within each province have set up mental and physical stability rooms to support primary recovery. However, due to lack of scientific effect verification and low utilization rate, these rooms are currently used for purposes other than their intended use. Virtual reality (VR) has recently been used as an intervention for stress reduction and treatment of depression. In order to examine the effectiveness of VR content, a mobile mental and physical stability room was constructed and operated on 124 firefighters. The results of the qualitative analysis showed an effect on stress, but the quantitative analysis revealed no significant difference.
- Published
- 2020
31. Adverse drug reactions of montelukast and pranlukast: Analysis of the Korea database
- Author
-
Eun-Yong, Shin, Ju-Hae, Jin, Min-Kyoung, Kang, Young-Sang, Yoo, Ji-Hyang, Lee, Woo-Jung, Song, Hyouk-Soo, Kwon, You Sook, Cho, Hee-Bom, Moon, and Tae-Bum, Kim
- Abstract
Leukotriene receptor antagonists are recommended to treat asthma and allergic rhinitis. Although they had been used for a long time, recent studies have reported neuropsychiatric adverse drug reactions are associated with montelukast.This study analyzed the adverse drug reactions of montelukast and pranlukast, which are the two most frequently prescribed leukotriene receptor antagonists, respectively in Korea.This study retrospectively reviewed ADRs of 5,426 montelukast and 1,146 pranlukast reported in the Korea Adverse Event Reporting System between January 2014 and December 2018.When both drugs are classified by system organ class, the most adverse drug reactions were related to the gastro-intestinal system, followed by psychiatric events. The reported adverse drug reactions for both drugs were more common in women, and the ratio of adverse drug reactions to prescriptions was highest in the elderly. Women aged 19 to 64 years reported more than twice as many adverse drug reactions than men of the same age, and more than 5 times in insomnia.When prescribing montelukast and pranlukast, attention would need to digestive and sleep disorders, especially women aged 19 to 64. After prescribing montelukast, physicians would need to pay more attention to agitation (5/396378 vs 0/82475), bad or vivid dreams (6/396378 vs 0/82475), anxiety (11/396378 vs 0/82475), depression (14/396378 vs 1/82475), tremor (53/396378 vs 7/82475), irritability (5/396378 vs 1/82475), insomnia (159/396378 vs 25/82475), and headache (68/396378 vs 10/82475), compared to when prescribing pranlukast. Further prospective research needs to elucidate the relationship between neuropsychiatric events and montelukast.
- Published
- 2022
32. Impact of asthma, chronic obstructive pulmonary disease (COPD), and asthma-COPD overlap on the prognosis of coronavirus disease 2019
- Author
-
Eunyong Shin, Juhae Jin, Seo Young Park, Young Sang Yoo, Ji-Hyang Lee, Jin An, Woo-Jung Song, Hyouk-Soo Kwon, You Sook Cho, Hee-Bom Moon, Jung-Bok Lee, and Tae-Bum Kim
- Subjects
Immunology and Allergy ,Dermatology - Abstract
The effects of asthma, chronic obstructive pulmonary disease (COPD), or asthma-COPD overlap (ACO) on coronavirus disease 2019 (COVID-19) remain unclear.We aimed to investigate the effects of chronic obstructive airway diseases such as asthma, COPD, and ACO on COVID-19.In total, 5625 hospitalized patients with COVID-19 were divided into asthma, COPD, ACO, and control groups. A multivariate logistic regression analysis was performed to identify factors affecting the COVID-19 mortality rate. To find out whether chronic obstructive airway diseases such as asthma, COPD, and ACO affect COVID-19 mortality, 1:4 matching was performed, except for the ACO group alone due to a small number of patients.The mortality rates of asthma, COPD, and ACO groups were about 2.3, 4.8, and 5.5 times higher than that of the control group, respectively. Although not statistically significant, the survival probability tended to decrease (asthma, COPD, and combined groups of asthma and ACO, hazard ratio [HR]: 1.84, 1.31, and 1.89, respectively). The survival probability of the combined groups of COPD, ACO, and asthma and the combined groups of COPD and ACO was significantly lower than that of the matched control group (HR: 3.00 and 1.99, respectively).Compared to patients with COVID-19 without chronic obstructive airway disease, patients with these comorbidities are more likely to require oxygen and mechanical ventilators and have a higher mortality rate, which can be considered when classifying and monitoring patients in the era of COVID-19. Therefore, further studies are needed to evaluate the effect of chronic obstructive airway disease, especially ACO, on COVID-19 mortality.
- Published
- 2022
33. Perspectives on chronic cough in Korea
- Author
-
Woo-Jung Song and Ji-Hyang Lee
- Subjects
Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,Tuberculosis ,Eosinophilic bronchitis ,business.industry ,Disease ,medicine.disease ,respiratory tract diseases ,03 medical and health sciences ,Chronic cough ,0302 clinical medicine ,030228 respiratory system ,Quality of life ,Epidemiology ,Review Article on the 3rd International Cough Conference ,medicine ,GERD ,Etiology ,030212 general & internal medicine ,medicine.symptom ,Intensive care medicine ,business - Abstract
Chronic cough is a common condition, and generally affects about 3% of Korean adults with a significant influence on quality of life (QoL). Despite continued clinical and academic efforts, there are unmet needs for chronic cough prevention and management in Korea. Epidemiologically, there are two major challenges: an aging population and air pollution. Korea is one of the most rapidly aging countries, and the relative proportion of elderly to younger people is expected to double within the next two decades. Air pollution is a major concern, but there is very limited evidence on the effects of air pollutant on cough in Korean patients. Clinically, upper and lower airway diseases, such as rhinitis/rhinosinusitis and cough variant asthma/eosinophilic bronchitis, are reported to account for about 75% of chronic cough in Korean adults, which formed the basis in formulating clinical practice guidelines. However, further studies are warranted to resolve clinical uncertainty, particularly for the evaluation and treatment of upper airway conditions in chronic cough. The prevalence of gastroesophageal reflux disease (GERD) is increasing, thus its relevance to cough among Koreans may warrant re-evaluation. Infection-associated chronic cough, such as tuberculosis, is another continuing concern. The proportion of chronic refractory or unexplained cough is assumed to be 10–20% among patients visiting referral clinics for chronic cough. This review presents our perspectives on current epidemiological and clinical issues of chronic cough in Korea, and addresses major knowledge gaps and future research priorities.
- Published
- 2020
34. Metagenome analysis using serum extracellular vesicles identified distinct microbiota in asthmatics
- Author
-
Jinho Yang, Chan Sun Park, Woo-Jung Song, Hyouk-Soo Kwon, Ha-Kyeong Won, Yoon-Keun Kim, Hae-Sim Park, Tae-Bum Kim, Jun-Pyo Choi, You Sook Cho, and Ji Hyang Lee
- Subjects
0301 basic medicine ,DNA, Bacterial ,Male ,lcsh:Medicine ,Extracellular vesicles ,Article ,03 medical and health sciences ,Extracellular Vesicles ,0302 clinical medicine ,medicine ,Humans ,Microbiome ,lcsh:Science ,Asthma ,Gastrointestinal tract ,Multidisciplinary ,biology ,Bacteria ,Microbiota ,lcsh:R ,Verrucomicrobia ,Bacteroidetes ,Diagnostic marker ,Diagnostic markers ,Middle Aged ,biology.organism_classification ,medicine.disease ,030104 developmental biology ,030228 respiratory system ,Metagenomics ,Case-Control Studies ,Immunology ,Metagenome ,Female ,lcsh:Q - Abstract
Different patterns of bacterial communities have been reported in the airways and gastrointestinal tract of asthmatics when compared to healthy controls. However, the blood microbiome of asthmatics is yet to be investigated. Therefore, we aimed to determine whether a distinct serum microbiome is observed in asthmatics by metagenomic analysis of serum extracellular vesicles (EVs). We obtained serum from 190 adults with asthma and 260 healthy controls, from which EVs were isolated and analyzed. The bacterial composition of asthmatics was significantly different from that of healthy controls. Chao 1 index was significantly higher in the asthma group, while Shannon and Simpson indices were higher in the control group. At the phylum level, Bacteroidetes was more abundant in asthmatics, while Actinobacter, Verrucomicrobia, and Cyanobacteria were more abundant in healthy controls. At the genus level, 24 bacterial genera showed differences in relative abundance between asthmatics and controls, with linear discriminant analysis scores greater than 3. Further, in a diagnostic model based on these differences, a high predictive value with a sensitivity of 0.92 and a specificity of 0.93 was observed. In conclusion, we demonstrated distinct blood microbiome in asthma indicating the role of microbiome as a potential diagnostic marker of asthma.
- Published
- 2020
35. Prevalence and impact of comorbid laryngeal dysfunction in asthma: A systematic review and meta-analysis
- Author
-
Ha-Kyeong Won, Woo-Jung Song, Ji Hyang Lee, You Sook Cho, Hee-Bom Moon, Jin An, Tae-Bum Kim, Hyouk-Soo Kwon, James H. Hull, and Yewon Kang
- Subjects
Adult ,medicine.medical_specialty ,Immunology ,Laryngoscopy ,Computed tomography ,Comorbidity ,Laryngeal Diseases ,03 medical and health sciences ,0302 clinical medicine ,Quality of life ,Internal medicine ,Prevalence ,medicine ,Vocal cord dysfunction ,Humans ,Immunology and Allergy ,030212 general & internal medicine ,Prospective cohort study ,Asthma ,medicine.diagnostic_test ,business.industry ,medicine.disease ,030228 respiratory system ,Meta-analysis ,business - Abstract
Background Laryngeal or vocal cord dysfunction has long been regarded as a mimic of asthma; however, recent evidence indicates that it may be a significant comorbid condition in patients with asthma. Objective We aimed to systematically estimate the prevalence of comorbid laryngeal dysfunction (LD) in adults with asthma and characterize its clinical impact on asthma. Methods Electronic databases were searched for relevant studies published until June 2019. Studies were included if LD was objectively defined by direct visualization of laryngeal movement. Outcomes included the prevalence of LD and its association with clinical asthma indicators, such as severity, control, and quality of life. Random effects meta-analyses were performed to calculate the estimates. Results A total of 21 studies involving 1637 patients were identified. Overall, the pooled prevalence of LD in adults with asthma was 25% (95% CI = 15%-37%; I2 = 96%). Prevalence estimates differed according to the diagnostic test utilized, with the lowest overall prevalence (4% [95% CI = 0%-10%; I2 = 90%]) seen when LD was diagnosed by resting laryngoscopy without external stimuli; however, it was much higher when diagnosed by laryngoscopy studies utilizing an external trigger, such as exercise (38% [95% CI = 24%-53%; I2 = 90%]) or in studies using a computed tomography–based diagnostic protocol (36% [95% CI = 24%-49%; I2 = 78%]). Only 7 studies reported the associations between LD and clinical asthma indicators; inconsistencies between studies limited meaningful conclusions. Conclusion LD may be a common comorbidity in asthma, affecting about 25% of adult patients. Further prospective studies are needed to better characterize its clinical impact and the benefits of detecting and managing LD in patients with asthma.
- Published
- 2020
36. Neuromuscular blockade reversal with sugammadex versus pyridostigmine/glycopyrrolate in laparoscopic cholecystectomy: a randomized trial of effects on postoperative gastrointestinal motility
- Author
-
Jihyun An, Eun Ju Kim, Kyeongyoon Woo, Hyunkyum Kim, Heeyun Noh, and Ji Hyang Lee
- Subjects
Adult ,Male ,glycopyrrolate ,Muscarinic Antagonists ,Anticholinergic agents ,gastrointestinal motility ,Sevoflurane ,Sugammadex ,defecation ,lcsh:RD78.3-87.3 ,Postoperative Complications ,medicine ,Humans ,Prospective Studies ,Rocuronium ,Glycopyrrolate ,Clinical Research Article ,business.industry ,Middle Aged ,flatulence ,Anesthesiology and Pain Medicine ,Cholecystectomy, Laparoscopic ,Pyridostigmine ,lcsh:Anesthesiology ,Anesthesia ,Neuromuscular Blockade ,sugammadex ,Drug Therapy, Combination ,Female ,Pyridostigmine Bromide ,cholinergic antagonists ,Cholinesterase Inhibitors ,business ,Propofol ,pyridostigmine bromide ,Neuromuscular Nondepolarizing Agents ,medicine.drug - Abstract
Background Acetylcholinesterase inhibitors (e.g., pyridostigmine bromide) are used for neuromuscular blockade (NMB) reversal in patients undergoing surgery under general anesthesia (GA). Concurrent use of anticholinergic agents (e.g., glycopyrrolate) decreases cholinergic side effects but can impede bowel movements. Sugammadex has no cholinergic effects; its use modifies recovery of gastrointestinal (GI) motility following laparoscopic cholecystectomy compared to pyridostigmine/glycopyrrolate. This study evaluated the contribution of sugammadex to the recovery of GI motility compared with pyridostigmine and glycopyrrolate. Methods We conducted a prospective study of patients who underwent laparoscopic cholecystectomy. Patients were randomly allocated to the experimental group (sugammadex, Group S) or control group (pyridostigmine-glycopyrrolate, Group P). After anesthesia (propofol and rocuronium, and 2% sevoflurane), recovery was induced by injection of sugammadex or a pyridostigmine-glycopyrrolate mixture. As a primary outcome, patients recorded the time of their first passage of flatus (‘gas-out time’) and defecation. The secondary outcome was stool types. Results One-hundred and two patients participated (Group S [n = 49], Group P [n = 53]). Mean time from injection of NMB reversal agents to gas-out time was 15.03 (6.36–20.25) h in Group S and 20.85 (16.34–25.86) h in Group P (P = 0.001). Inter-group differences were significant. Time until the first defecation as well as types of stools was not significantly different. Conclusions Sugammadex after laparoscopic cholecystectomy under GA resulted in an earlier first postoperative passage of flatus compared with the use of a mixture of pyridostigmine and glycopyrrolate. These findings suggest that the use of sugammadex has positive effects on the recovery of GI motility.
- Published
- 2020
37. Emergency cesarean section performed in a patient with confirmed severe acute respiratory syndrome Coronavirus-2 -a case report
- Author
-
Jihyun An, Dong Hwan Lee, Eun Ju Kim, Kyeongyoon Woo, Hak Youle Park, and Ji Hyang Lee
- Subjects
0301 basic medicine ,medicine.medical_specialty ,Emergency Cesarean Section ,Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ,Case Report ,World health ,lcsh:RD78.3-87.3 ,03 medical and health sciences ,0302 clinical medicine ,Anesthesiology ,Pandemic ,medicine ,Severe acute respiratory syndrome coronavirus 2 ,030212 general & internal medicine ,Personal protective equipment ,Pandemics ,Pregnancy ,business.industry ,Pregnant women ,Outbreak ,COVID-19 ,medicine.disease ,030104 developmental biology ,Anesthesiology and Pain Medicine ,lcsh:Anesthesiology ,Emergency medicine ,business ,Cesarean section ,Coronavirus Infections - Abstract
Background: Since the first case of severe acute respiratory syndrome Coronavirus-2 (SARS-CoV-2) occurred in Wuhan in December 2019, the virus has spread globally. The World Health Organization declared the virus outbreak a pandemic on March 11, 2020. On January 19, 2020, a 35-year-old woman who returned from China was confirmed as the first SARS-CoV-2 infected case in Korea. Since then, it has spread all over Korea.Case: We report the first case of a SARS-CoV-2 positive woman delivering a baby through cesarean section at 37+6 weeks of pregnancy in the Republic of Korea.Conclusions: This case suggested that negative pressure operating room, skillful medical team, and enhanced personal protective equipment including N95 masks, surgical cap, double gown, double gloves, shoe covers, and powered air-purifying respirator are required at the hospital for safe delivery in such a case.
- Published
- 2020
38. Soluble ACE2 and TMPRSS2 Levels in the Serum of Asthmatic Patients
- Author
-
Ji-Hyang Lee, Chae Eun Lee, Youngsang Yoo, Eunyong Shin, Jin An, Seo Young Park, Woo-Jung Song, Hyouk-Soo Kwon, You Sook Cho, Hee-Bom Moon, and Tae-Bum Kim
- Subjects
Adult ,Male ,SARS-CoV-2 ,Serine Endopeptidases ,Age Factors ,COVID-19 ,General Medicine ,Middle Aged ,Asthma ,Adrenal Cortex Hormones ,Humans ,Female ,Angiotensin-Converting Enzyme 2 ,Aged - Abstract
Angiotensin-converting enzyme 2 (ACE2) and transmembrane protease serine subtype 2 (TMPRSS2) are key proteins mediating viral entry of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Although gene expressions of ACE2 and TMPRSS2 have been analyzed in various organs and diseases, their soluble forms have been less studied, particularly in asthma. Therefore, we aimed to measure circulating ACE2 and TMPRSS2 in the serum of asthmatics and examine their relationship with clinical characteristics.Clinical data and serum samples of 400 participants were obtained from an asthma cohort. The soluble ACE2 (sACE2) and soluble TMPRSS2 (sTMPRSS2) level was measured by enzyme-linked immunosorbent assay, and the values underwent a natural log transformation. Associations between sACE2 and TMPRSS2 levels and various clinical variables were analyzed.The patients younger than 70 years old, those with eosinophilic asthma (eosinophils ≥ 200 cells/µL), and inhaled corticosteroids (ICS) non-users were associated with higher levels of sACE2. Blood eosinophils and fractionated exhaled nitric oxide levels were positively correlated with serum ACE2. In contrast, lower levels of sTMPRSS2 were noted in patients below 70 years and those with eosinophilic asthma, while no association was noted between ICS use and sTMPRSS2. The level of sTMPRSS2 also differed according to sex, smoking history, coexisting hypertension, and forced expiratory volume in 1 second/forced vital capacity (FEV1/FVC) ratio. The proportion of sputum neutrophils was positively correlated with sTMPRSS2, while the FEV1/FVC ratio reported a negative correlation with sTMPRSS2.The levels of ACE2 and TMPRSS2 were differently expressed according to age, ICS use, and several inflammatory markers. These findings suggest variable susceptibility and prognosis of SARS-CoV-2 infection among asthmatic patients.
- Published
- 2022
39. Health-Related Quality of Life and Its Determinants in Chronic Cough: The Korean Chronic Cough Registry Study
- Author
-
Noeul Kang, Ha-Kyeong Won, Ji-Hyang Lee, Ji-Su Shim, Sung-Yoon Kang, Han-Ki Park, Eun-Jung Jo, Seung Eun Lee, Min-Hye Kim, Sang-Heon Kim, Sae-Hoon Kim, Yoon-Seok Chang, Byung-Jae Lee, Woo-Jung Song, and Min-Woo Jo
- Subjects
Pulmonary and Respiratory Medicine ,Immunology ,Immunology and Allergy - Published
- 2023
40. Novel Strategy for the Prevention of Recurrent Hypersensitivity Reactions to Radiocontrast Media Based on Skin Testing
- Author
-
Bomi Seo, Yewon Kang, So Young Park, Hee-Bom Moon, Ha-Kyeong Won, Oh Young Kwon, Woo-Jung Song, You Sook Cho, Ji Hyang Lee, Jin An, Tae-Bum Kim, and Hyouk-Soo Kwon
- Subjects
Adult ,Hypersensitivity, Immediate ,Male ,Immunology ,Iodine Compounds ,Contrast Media ,Computed tomography ,Culprit ,Drug Hypersensitivity ,Iodinated contrast media ,Recurrence ,Humans ,Immunology and Allergy ,Medicine ,In patient ,reproductive and urinary physiology ,Aged ,Skin Tests ,Radiocontrast Media ,medicine.diagnostic_test ,business.industry ,Intradermal skin test ,Middle Aged ,equipment and supplies ,Hypersensitivity reaction ,Anesthesia ,embryonic structures ,Female ,Premedication ,business ,circulatory and respiratory physiology - Abstract
Background Hypersensitivity reactions to iodinated contrast media (ICM) is a persistent clinical issue with increased use of computed tomography. With the evidence indicating underlying allergic mechanisms, there have been studies regarding the skin tests using ICM. Objective This study aimed to evaluate the intradermal skin test (IDT) as a tool for preventing recurrent hypersensitivity reactions to ICM in patients with prior reactions to a known culprit agent. Methods Sixty-nine patients who had experienced immediate hypersensitivity reactions to ICM were included in the study. All patients underwent IDT with 7 different ICMs, including the causative ICM. We analyzed clinical data from 38 patients who were reexposed to ICMs, grouped by the IDT results to their original culprit ICM. Results Thirty-eight patients showed positive IDT results to the culprit ICM (CULPRIT+), whereas 31 patients showed negative results (CULPRIT−). Sixteen patients from the CULPRIT+ group and 22 from the CULPRIT− group were subsequently exposed to an ICM. In the CULPRIT+ group, 4 of the 5 patients who were subsequently exposed to an IDT-positive ICM reexperienced hypersensitivity reactions. When patients were exposed to IDT-negative ICM as an alternative, hypersensitivity reactions were not observed. In the CULPRIT− group, IDT-positive ICMs did not provoke hypersensitivity reactions whereas 2 patients using IDT-negative ICMs experienced hypersensitivity reactions. Conclusions When the IDT results are positive for the culprit ICM, additional IDTs with other ICMs are needed to select a safe alternative. If the IDT results are negative against the culprit ICM, further IDTs might not play a role in selecting a safe alternative.
- Published
- 2019
41. Intradermal testing increases the accuracy of an immediate-type cefaclor hypersensitivity diagnosis
- Author
-
Ji-Hyang Lee, Chan Sun Park, Min Ju Pyo, A. Ryang Lee, Eunyong Shin, Young-Sang Yoo, Woo-Jung Song, Tae-Bum Kim, You-Sook Cho, and Hyouk-Soo Kwon
- Subjects
Pulmonary and Respiratory Medicine ,Immunology ,Immunology and Allergy - Abstract
Hypersensitivity reactions to cefaclor have increased in accordance with its frequent use. However, only limited data are available on the diagnostic value of skin tests for these conditions, particularly intradermal tests (IDTs).To evaluate the clinical usefulness of IDT compared to the ImmunoCAP test in patients with cefaclor-induced immediate-type hypersensitivity.We conducted a retrospective chart review from January 2010 to June 2020 of adult subjects from 2 tertiary hospitals in Korea with a history of suspected immediate-type hypersensitivity to cefaclor, and who had undergone ImmunoCAP and IDT.Overall, 131 subjects diagnosed with cefaclor hypersensitivity were included in the analysis. Fifty-nine patients (59/131, 45.04%) were positive in both IDT and ImmunoCAP. Fifty-four (54/131, 41.22%) and 6 (6/131, 4.58%) subjects showed positive results only with IDT or the ImmunoCAP test, respectively. Twelve subjects (12/131, 9.16%) were negative by both tests but reacted positively in a drug provocation test. The frequency of IDT positivity was similar regardless of the severity of reactions. However, positivity of ImmunoCAP was lower in subjects with mild reactions compared to those with anaphylaxis. Regarding the diagnosis of cefaclor hypersensitivity, the overall sensitivity of IDT and ImmunoCAP was 0.863 and 0.496, respectively while the specificity was 1. The combination of IDT and ImmunoCAP further increased this sensitivity to 0.908.IDT was more sensitive than ImmunoCAP for the diagnosis of cefaclor allergy, regardless of the severity of the hypersensitivity reaction. Therefore, we recommend a combination of IDT and ImmunoCAP for the diagnosis of cefaclor hypersensitivity.
- Published
- 2021
42. Eosinophil granule proteins: what they can tell us about asthma
- Author
-
Tae-Bum Kim and Ji Hyang Lee
- Subjects
Pulmonary and Respiratory Medicine ,Eosinophils ,Eosinophil Granule Proteins ,business.industry ,Immunology ,Medicine ,Humans ,Blood Proteins ,business ,medicine.disease ,Asthma - Published
- 2021
43. Epidemiology of adult chronic cough: disease burden, regional issues, and recent findings
- Author
-
Jin An, Seung Eun Lee, Sung-Yoon Kang, So Young Park, Youngsang Yoo, Ji-Ho Lee, Ji Hyang Lee, Min-Hye Kim, Woo-Jung Song, Yoon-Seok Chang, and Yoshihiro Kanemitsu
- Subjects
Longitudinal outcome ,medicine.medical_specialty ,Epidemiology ,business.industry ,Cough reflex ,Asia-Pacific ,Burden of disease ,Dermatology ,Disease ,respiratory tract diseases ,Current Review ,Chronic cough ,Quality of life (healthcare) ,Cough ,Health care ,Immunology and Allergy ,Medicine ,Risk factor ,medicine.symptom ,business ,Intensive care medicine ,Disease burden - Abstract
Chronic cough is a common medical condition that has a significant impact on patients’ quality of life. Although it was previously considered a symptom of other disorders, it is now regarded as a pathologic state that is characterized by a deviation from the intrinsic protective functions of the cough reflex, especially in adults. There are several factors that may underlie the cough reflex hypersensitivity and its persistence, such as age, sex, comorbidities, viral infection, exposure to irritants or environmental pollutants, and their interactions may determine the epidemiology of chronic cough in different countries. With a deeper understanding of disease pathophysiology and advanced research methodology, there are more attempts to investigate cough epidemiology using a large cohort of healthcare population data. This is a narrative overview of recent findings on the disease burden, risk factors, Asia-Pacific issues, and longitudinal outcomes in adults with chronic cough. This paper also discusses the approaches utilizing routinely collected data in cough research.
- Published
- 2021
44. Delayed local reactions after the first administration of the ChAdOx1 nCoV‐19 vaccine
- Author
-
Woo-Jung Song, Hyouk-Soo Kwon, Seongman Bae, Eunyong Shin, Hee-Sung Kim, Tae-Bum Kim, Jiwon Jung, Ji Hyang Lee, You Sook Cho, and Sung-Han Kim
- Subjects
2019-20 coronavirus outbreak ,Vaccines ,COVID-19 Vaccines ,Coronavirus disease 2019 (COVID-19) ,business.industry ,Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ,Immunology ,MEDLINE ,Immunization, Secondary ,COVID-19 ,Virology ,Letter to the Editors ,ChAdOx1 nCoV-19 ,Immunology and Allergy ,Medicine ,Humans ,business ,Administration (government) ,Local Reaction ,Letter to the Editor - Published
- 2021
45. Genome-wide association study of Korean asthmatics: a comparison with UK asthmatics
- Author
-
Sanghun Lee, Kian Fan Chung, Woo-Jung Song, Ji Hyang Lee, Jin An, Tae-Bum Kim, Hyouk Soo Kwon, Ah Ra Do, Ian M. Adcock, Sile Hu, Sungho Won, You Sook Cho, Woo Jin Kim, Hae Yeon Kang, and Hee Bom Moon
- Subjects
Pulmonary and Respiratory Medicine ,Genome-wide association study ,Allergy ,GENETICS ,Immunology ,IL1RL1 ,Single-nucleotide polymorphism ,human leukocyte antigen ,medicine ,Genetic predisposition ,Immunology and Allergy ,SNP ,Asthma ,Genetic association ,RISK ,Science & Technology ,Korea ,EXACERBATED RESPIRATORY-DISEASE ,business.industry ,Odds ratio ,asthma ,ALLELES ,medicine.disease ,United Kingdom ,Original Article ,business ,Life Sciences & Biomedicine - Abstract
Purpose Although genome-wide association studies (GWASs) represent the most powerful approach for identifying genes that influence asthma, to date, no studies have established genetic susceptibility to asthma in the Korean population. This study aimed to identify genetic variants associated with adult Korean asthmatics and compare them with the significant single nucleotide polymorphisms (SNPs) of UK asthmatics from the UK Biobank. Methods Patients were defined as having asthma if they were diagnosed by a doctor or taking medications for asthma. Controls were defined as individuals without asthma or chronic obstructive pulmonary disease. We performed quality control, genotype imputation, GWAS, and PrediXcan analyses. In the GWAS, a P value of < 5 × 10−8 was considered significant. We compared significant SNPs between Korean and UK patients with asthma. Results A total of 1,386 asthmatic patients and 5,205 controls were analyzed. The SNP rs1770, located near the human leukocyte antigen (HLA)-DQB1, was the most significant SNP (P = 4.5 × 10−10). In comparison with 24 SNPs in a GWAS of UK asthmatics, six SNPs were significant with the same odds ratio (OR) direction, including signals related to type 2 inflammation (e.g., IL1RL1, TSLP, and GATA3) and mucus plugging (e.g., MUC5AC). HLA-DQA1 showed an opposite OR direction. The HLA-DQB1 gene demonstrated significantly imputed mRNA expression in the lung tissue and whole blood. Conclusions The SNP rs1770 of HLA-DQB1 was the most significant in Korean asthmatics. Similarities and discrepancies were found in the genetic variants between Korean and UK asthmatics. GWAS of Korean asthmatics should be replicated and compared with those of GWAS of other ethnicities.
- Published
- 2021
46. Adverse Reactions of the Second Dose of the BNT162b2 mRNA COVID-19 Vaccine in Healthcare Workers in Korea
- Author
-
Miseo Kim, Seongman Bae, Joon Seo Lim, Seonhee Kwon, Jiwon Jung, Hyouk Soo Kwon, So Yun Lim, Jiyeon Joo, Yun Woo Lee, Eun Ok Kim, Ji Hyang Lee, Sun Hee Kwak, Tae-Bum Kim, and Sung-Han Kim
- Subjects
Adult ,Male ,medicine.medical_specialty ,COVID-19 Vaccines ,Coronavirus disease 2019 (COVID-19) ,Health Personnel ,education ,Brief Communication ,Preventive & Social Medicine ,03 medical and health sciences ,Young Adult ,0302 clinical medicine ,Age groups ,Internal medicine ,medicine ,Humans ,030212 general & internal medicine ,Prospective Studies ,Young adult ,Prospective cohort study ,Adverse effect ,BNT162 Vaccine ,Aged ,business.industry ,SARS-CoV-2 ,Vaccination ,Adverse Reaction ,COVID-19 ,General Medicine ,Middle Aged ,Systemic reaction ,Chills ,BNT162b2 ,Female ,medicine.symptom ,business - Abstract
We conducted a prospective, mobile-based survey on the self-reported adverse reactions in healthcare workers (HCWs) who received both doses of the BNT162b2 mRNA vaccine. Of the 342 HCWs who completed the two-dose vaccination, 265 (77.5%) responded to the survey at least once. Overall, the rates of adverse reactions were higher after the second dose compared with the first dose (89.1% vs. 80.1%, P = 0.006). The most common systemic reactions were muscle ache (69.1%), fatigue (65.7%), headache (48.7%), chills (44.2%), and fever (32.1%), and were notably more common after the second dose vaccine as well. We also noted a sex difference in which the frequency of adverse reactions after the second dose of the vaccine was significantly higher in females, which was not observed after the first dose. The rates of adverse reactions were lower in older age groups, and the rates and severities of the adverse reactions decreased during the 3-day period following vaccination., Graphical Abstract
- Published
- 2021
47. Comparison of sugammadex and pyridostigmine bromide for reversal of rocuronium-induced neuromuscular blockade in short-term pediatric surgery: a prospective randomized study
- Author
-
Joonyoung Huh, Ji Hyang Lee, Eun Ju Kim, Jihyun An, Jongcheol Son, Kyeongyoon Woo, and Hyun Kim
- Subjects
medicine.medical_specialty ,Neuromuscular Blockade ,business.industry ,General Medicine ,Neuromuscular monitoring ,Sugammadex ,Anesthesia ,Pediatric surgery ,medicine ,Pyridostigmine Bromide ,Prospective randomized study ,Rocuronium ,business ,medicine.drug - Published
- 2019
48. A pilot study on the role of autonomic function testing in predicting hypotension in patients undergoing cesarean section under spinal anesthesia
- Author
-
Hyun Kim, Heeyun Noh, Jongcheol Son, Jihyun An, Eun Ju Kim, Kyeongyoon Woo, and Ji Hyang Lee
- Subjects
Autonomic function ,Autonomic nervous system ,Parasympathetic nervous system ,Sympathetic nervous system ,medicine.anatomical_structure ,business.industry ,Anesthesia ,Section (typography) ,medicine ,Spinal anesthesia ,In patient ,General Medicine ,business - Published
- 2019
49. Use of laryngeal mask after repeated endotracheal intubation failure in a patient with tracheobronchopathia osteochondroplastica: case report
- Author
-
Jong Chul Son, Sang Gyun Kim, Hyun Kim, Ji Hyang Lee, Jihyun An, and Eun Ju Kim
- Subjects
Laryngeal mask airway ,business.industry ,Anesthesia ,Medicine ,Endotracheal intubation ,respiratory system ,business ,Tracheobronchopathia-osteochondroplastica ,Difficult intubation - Abstract
We report a case of difficult endotracheal intubation in a patient with tracheobronchopathia osteochondroplastica. A 65-year-old man was scheduled to undergo ulnar nerve decompression and ganglion excisional biopsy under general anesthesia. During induction of general anesthesia, an endotracheal tube could not be advanced through the vocal cords due to resistance. A large number of nodules were identified below the vocal cords using a Glidescope® video-laryngoscopy, and fiberoptic bronchoscopy revealed irregular nodules on the surface of the entire trachea and the main bronchus below the vocal cords. Use of a small endotracheal tube was attempted and failed. a laryngeal mask airway (LMA Supreme ™) rather than further intubation was successfully used to maintain the airway.
- Published
- 2018
50. Efficacy of non-sedating H1-receptor antihistamines in adults and adolescents with chronic cough: A systematic review
- Author
-
Yoshihiro Kanemitsu, Ha-Kyeong Won, Jin An, Ji Hyang Lee, Ji-Ho Lee, Hyun Jung Kim, Woo-Jung Song, Sung-Yoon Kang, So Young Park, and Ji Won Lee
- Subjects
Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,Immunology ,Histamine H1 receptor ,Article ,Allergic rhinitis ,Internal medicine ,Cough Frequency ,Chronic cough ,medicine ,Immunology and Allergy ,Clinical significance ,In patient ,Atopic cough ,Asthma ,business.industry ,RC581-607 ,medicine.disease ,respiratory tract diseases ,Clinical trial ,medicine.symptom ,Immunologic diseases. Allergy ,business ,Non-sedating H1-receptor antihistamine ,Nasal symptoms - Abstract
Background Nasal symptoms frequently coexist in patients with chronic cough, and non-sedating H1-receptor antihistamines (nsH1RAs) are often prescribed for cough management in several countries. However, recommendations on the use of nsH1RAs vary among chronic cough guidelines. This study aimed to examine the efficacy of nsH1RAs over placebos in adolescents or adults with chronic cough or allergic respiratory conditions that may present as chronic cough. Methods Electronic databases were searched for studies published until November 2020. Randomized placebo-controlled trials of nsH1RAs reporting cough endpoints in adolescents or adults with chronic cough or cough-associated allergic respiratory conditions (allergic rhinitis, allergic asthma, or atopic cough) were included. Results A total of 10 placebo-controlled trials were identified. Three studies (one study each involving allergic rhinitis, allergic rhinitis with comorbid asthma, and atopic cough) described baseline and post-treatment cough scores, and all reported significant improvements in subjective cough scores; however, the magnitude of improvement was greater in the 2 studies of patients with atopic cough (relative improvement in cough frequency score: −36.6 ± 8.4%) or seasonal allergic rhinitis-associated cough (cough frequency score: −44.0 ± 7.3% and cough intensity score: −65.7 ± 8.3%) than in the 1 study of allergic rhinitis patients with comorbid asthma (−4.0 ± 1.3%). Meanwhile, the other 7 trials found conflicting results but lacked information on the baseline cough score and did not use validated cough measurement tools; thus, their clinical relevance could not be determined. Conclusion Despite the widespread use of nsH1RAs in patients with chronic cough, only a few clinical trials examining their benefits on cough outcomes have been conducted. There may be a subgroup of patients, particularly those with seasonal allergic rhinitis-associated cough or atopic cough, whose cough may improve with nsH1RA treatment. However, adequately powered trials with validated cough measurement tools are warranted to confirm the role of nsH1RAs in the management of patients with allergic phenotypes of chronic cough.
- Published
- 2021
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.