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301 results on '"Ji, Yuhua"'

1. Multilineage-differentiating stress-enduring cells alleviate neuropathic pain in mice by secreting TGF-b and IL-10

Author

Zhao, Yayu, Fei, Ying, Cai, Yunyun, Wei, Zhongya, Chen, Ying, Ji, Yuhua, Chen, Xue, Zhang, Dongmei, and Chen, Gang

Subjects
Quantitative Biology - Tissues and Organs, Quantitative Biology - Quantitative Methods
Abstract

Neuropathic pain is a chronic condition characterized by damage to and dysfunction of the peripheral or central nervous system. There are currently no effective treatment options available for neuropathic pain, and existing drugs often provide only temporary relief with potential side effects. Multilineage-differentiating stress-enduring (Muse) cells are characterized by high expansion potential, a stable phenotype and strong immunosuppression. These properties make them attractive candidates for therapeutics for neuropathic pain management. In this study, we conducted a series of experiments to evaluate the effect of Muse cells on neuropathic pain. Muse cells from different species demonstrated analgesic potential by reversing CCI-induced neuropathic pain. Protein profiling revealed a high degree of similarity between Muse cells and BMSCs. The intrathecal injection of Muse cells effectively reduced neuropathic pain in various mouse models, resulting in better analgesic effects than the administration of equivalent low doses of BMSCs. Immunohistochemical analysis and qPCR revealed the ability of Muse cells to inhibit spinal cord neuroinflammation caused by SNI. In addition, Transwell and ELISA revealed that Muse cells migrated through the injured dorsal root ganglion (DRG) via the CCR7-CCL21 chemotactic axis. In addition, the secretion of TGF-b and IL-10 by Muse cells was identified as the mechanism underlying the analgesic effect of Muse cells. The capacity of Muse cells to mitigate neuroinflammation and produce analgesic effects via the modulation of TGF-b and IL-10 underscores their potential as promising therapeutic approaches for the treatment of neuropathic pain.

Published
2025

9. Characterization of sciatic nerve myelin sheath during development in C57BL/6 mice.

Author

Chen, Yuhan, Shang, Tongxin, Sun, Junjie, Ji, Yuhua, Gong, Leilei, Li, Aihong, Ding, Fei, Shen, Mi, and Zhang, Qi

Subjects
PERIPHERAL nerve injuries, SCIATIC nerve, SCHWANN cells, NERVE tissue proteins, TRANSMISSION electron microscopy
Abstract

Myelin sheath plays important roles in information conduction and nerve injury repair in the peripheral nerve system (PNS). Enhancing comprehension of the structure and components of the myelin sheath in the PNS during development would contribute to a more comprehensive understanding of the developmental and regenerative processes. In this research, the structure of sciatic nerve myelin sheath in C57BL/6 mice from embryonic day 14 (E14) to postnatal 12 months (12M) was observed with transmission electron microscopy. Myelin structure appeared in the sciatic nerve as early as E14, and the number and thickness of myelin lamellar gradually increased with the development until 12M. Transcriptome analysis was performed to show the expressions of myelin‐associated genes and transcriptional factors involved in myelin formation. The genes encoding myelin proteins (Mag, Pmp22, Mpz, Mbp, Cnp and Prx) showed the same expression pattern, peaking at postnatal day 7 (P7) and P28 after birth, whereas the negative regulators of myelination (c‐Jun, Tgfb1, Tnc, Cyr61, Ngf, Egr1, Hgf and Bcl11a) showed an opposite expression pattern. In addition, the expression of myelin‐associated proteins and transcriptional factors was measured by Western blot and immunofluorescence staining. The protein expressions of MAG, PMP22, MPZ, CNPase and PRX increased from E20 to P14. The key transcriptional factor c‐Jun co‐localized with the Schwann cells Marker S100β and decreased after birth, whereas Krox20/Egr2 increased during development. Our data characterized the structure and components of myelin sheath during the early developmental stages, providing insights for further understanding of PNS development. [ABSTRACT FROM AUTHOR]

Published
2024
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10. Communicative Language Teaching through Sandwich Stories for EFL Children in China.

Author

Ji, Yuhua

Abstract

Presents a discussion of two problems with communicative language teaching textbooks for English-as-a-foreign-language children in China. Provides an explanation of the rationale for the use of stories and sandwich stories, and gives a demonstration of sandwich stories being used in the classroom. (Author/VWL)

Published
1999

29. Figure S6 from Discovery and Characterization of ZL-2201, a Potent, Highly Selective, and Orally Bioavailable Small-molecule DNA-PK Inhibitor

Author

Lal, Shruti, primary, Bhola, Neil E., primary, Sun, Bee-Chun, primary, Chen, Yuping, primary, Huang, Tom, primary, Morton, Vivian, primary, Chen, Kevin X., primary, Xia, Shanghua, primary, Zhang, Haoyu, primary, Parikh, Nehal S., primary, Ye, Qiuping, primary, Veiby, O. Petter, primary, Bellovin, David I., primary, and Ji, Yuhua, primary

Published
2023
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30. FIGURE 3 from Discovery and Characterization of ZL-2201, a Potent, Highly Selective, and Orally Bioavailable Small-molecule DNA-PK Inhibitor

Author

Lal, Shruti, primary, Bhola, Neil E., primary, Sun, Bee-Chun, primary, Chen, Yuping, primary, Huang, Tom, primary, Morton, Vivian, primary, Chen, Kevin X., primary, Xia, Shanghua, primary, Zhang, Haoyu, primary, Parikh, Nehal S., primary, Ye, Qiuping, primary, Veiby, O. Petter, primary, Bellovin, David I., primary, and Ji, Yuhua, primary

Published
2023
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31. FIGURE 1 from Discovery and Characterization of ZL-2201, a Potent, Highly Selective, and Orally Bioavailable Small-molecule DNA-PK Inhibitor

Author

Lal, Shruti, primary, Bhola, Neil E., primary, Sun, Bee-Chun, primary, Chen, Yuping, primary, Huang, Tom, primary, Morton, Vivian, primary, Chen, Kevin X., primary, Xia, Shanghua, primary, Zhang, Haoyu, primary, Parikh, Nehal S., primary, Ye, Qiuping, primary, Veiby, O. Petter, primary, Bellovin, David I., primary, and Ji, Yuhua, primary

Published
2023
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32. FIGURE 5 from Discovery and Characterization of ZL-2201, a Potent, Highly Selective, and Orally Bioavailable Small-molecule DNA-PK Inhibitor

Author

Lal, Shruti, primary, Bhola, Neil E., primary, Sun, Bee-Chun, primary, Chen, Yuping, primary, Huang, Tom, primary, Morton, Vivian, primary, Chen, Kevin X., primary, Xia, Shanghua, primary, Zhang, Haoyu, primary, Parikh, Nehal S., primary, Ye, Qiuping, primary, Veiby, O. Petter, primary, Bellovin, David I., primary, and Ji, Yuhua, primary

Published
2023
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33. TABLE 2 from Discovery and Characterization of ZL-2201, a Potent, Highly Selective, and Orally Bioavailable Small-molecule DNA-PK Inhibitor

Author

Lal, Shruti, primary, Bhola, Neil E., primary, Sun, Bee-Chun, primary, Chen, Yuping, primary, Huang, Tom, primary, Morton, Vivian, primary, Chen, Kevin X., primary, Xia, Shanghua, primary, Zhang, Haoyu, primary, Parikh, Nehal S., primary, Ye, Qiuping, primary, Veiby, O. Petter, primary, Bellovin, David I., primary, and Ji, Yuhua, primary

Published
2023
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34. Table S1 from Discovery and Characterization of ZL-2201, a Potent, Highly Selective, and Orally Bioavailable Small-molecule DNA-PK Inhibitor

Author

Lal, Shruti, primary, Bhola, Neil E., primary, Sun, Bee-Chun, primary, Chen, Yuping, primary, Huang, Tom, primary, Morton, Vivian, primary, Chen, Kevin X., primary, Xia, Shanghua, primary, Zhang, Haoyu, primary, Parikh, Nehal S., primary, Ye, Qiuping, primary, Veiby, O. Petter, primary, Bellovin, David I., primary, and Ji, Yuhua, primary

Published
2023
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35. FIGURE 2 from Discovery and Characterization of ZL-2201, a Potent, Highly Selective, and Orally Bioavailable Small-molecule DNA-PK Inhibitor

Author

Lal, Shruti, primary, Bhola, Neil E., primary, Sun, Bee-Chun, primary, Chen, Yuping, primary, Huang, Tom, primary, Morton, Vivian, primary, Chen, Kevin X., primary, Xia, Shanghua, primary, Zhang, Haoyu, primary, Parikh, Nehal S., primary, Ye, Qiuping, primary, Veiby, O. Petter, primary, Bellovin, David I., primary, and Ji, Yuhua, primary

Published
2023
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36. Supplementary Methods from Discovery and Characterization of ZL-2201, a Potent, Highly Selective, and Orally Bioavailable Small-molecule DNA-PK Inhibitor

Author

Lal, Shruti, primary, Bhola, Neil E., primary, Sun, Bee-Chun, primary, Chen, Yuping, primary, Huang, Tom, primary, Morton, Vivian, primary, Chen, Kevin X., primary, Xia, Shanghua, primary, Zhang, Haoyu, primary, Parikh, Nehal S., primary, Ye, Qiuping, primary, Veiby, O. Petter, primary, Bellovin, David I., primary, and Ji, Yuhua, primary

Published
2023
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37. FIGURE 4 from Discovery and Characterization of ZL-2201, a Potent, Highly Selective, and Orally Bioavailable Small-molecule DNA-PK Inhibitor

Author

Lal, Shruti, primary, Bhola, Neil E., primary, Sun, Bee-Chun, primary, Chen, Yuping, primary, Huang, Tom, primary, Morton, Vivian, primary, Chen, Kevin X., primary, Xia, Shanghua, primary, Zhang, Haoyu, primary, Parikh, Nehal S., primary, Ye, Qiuping, primary, Veiby, O. Petter, primary, Bellovin, David I., primary, and Ji, Yuhua, primary

Published
2023
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38. TABLE 1 from Discovery and Characterization of ZL-2201, a Potent, Highly Selective, and Orally Bioavailable Small-molecule DNA-PK Inhibitor

Author

Lal, Shruti, primary, Bhola, Neil E., primary, Sun, Bee-Chun, primary, Chen, Yuping, primary, Huang, Tom, primary, Morton, Vivian, primary, Chen, Kevin X., primary, Xia, Shanghua, primary, Zhang, Haoyu, primary, Parikh, Nehal S., primary, Ye, Qiuping, primary, Veiby, O. Petter, primary, Bellovin, David I., primary, and Ji, Yuhua, primary

Published
2023
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39. Discovery and characterization of ZL-2201, a potent, highly selective, and orally bioavailable small-molecule DNA-PK inhibitor

Author

Lal, Shruti, primary, Bhola, Neil E., additional, Sun, Bee-Chun, additional, Chen, Yuping, additional, Huang, Tom, additional, Morton, Vivian, additional, Chen, Kevin X, additional, Xia, Shanghua, additional, Zhang, Haoyu, additional, Parikh, Nehal S, additional, Ye, Qiuping, additional, Veiby, O. Petter, additional, Bellovin, David I, additional, and Ji, Yuhua, additional

Published
2023
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40. Data from Discovery and characterization of ZL-2201, a potent, highly selective, and orally bioavailable small-molecule DNA-PK inhibitor

Author

Lal, Shruti, primary, Bhola, Neil E., primary, Sun, Bee-Chun, primary, Chen, Yuping, primary, Huang, Tom, primary, Morton, Vivian, primary, Chen, Kevin X, primary, Xia, Shanghua, primary, Zhang, Haoyu, primary, Parikh, Nehal S, primary, Ye, Qiuping, primary, Veiby, O. Petter, primary, Bellovin, David I, primary, and Ji, Yuhua, primary

Published
2023
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47. Research study data

Author

Estrada, Marcus, Ji, Yuhua, and Chen, Dexiang

Abstract

This registration contains the data described in the article "Development of a freeze-dried, heat-stable influenza subunit vaccine formulation".

Published
2022
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49. Abstract 2594: Discovery and characterization of ZL-2201, a potent, highly-selective, and orally bioavailable small-molecule DNA-PK inhibitor

Author

Lal, Shruti, primary, Sun, Bee-Chun, additional, Chen, Yuping, additional, Huang, Tom, additional, Bhola, Neil, additional, Morton, Vivian, additional, Chen, Kevin, additional, Xia, Shanghua, additional, Zhang, Haoyu, additional, Ye, Qiuping, additional, Veiby, Petter, additional, Bellovin, David I., additional, and Ji, Yuhua, additional

Published
2022
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50. The acetylome of adult mouse sciatic nerve

Author

Shen, Mi, primary, Chen, Zixin, additional, Ming, Mengru, additional, Cheng, Zhenghui, additional, Sun, Junjie, additional, Liang, Qingyun, additional, Shang, Tongxin, additional, Zhang, Qi, additional, Zhou, Songlin, additional, Ji, Yuhua, additional, and Ding, Fei, additional

Published
2022
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