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Your search keyword '"Ji, Seunghee"' showing total 10 results
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10 results on '"Ji, Seunghee"'

1. Correction to “Structure–Activity Relationship of Truncated 2,8-Disubstituted-Adenosine Derivatives as Dual A2A/A3 Adenosine Receptor Antagonists and Their Cancer Immunotherapeutic Activity”

Author

Kim, Gibae, primary, Hou, Xiyan, additional, Byun, Woong Sub, additional, Kim, Gyudong, additional, Jarhad, Dnyandev B., additional, Lee, Grim, additional, Hyun, Young Eum, additional, Yu, Jinha, additional, Lee, Chang Soo, additional, Qu, Shuhao, additional, Warnick, Eugene, additional, Gao, Zhan-Guo, additional, Kim, Ji Yong, additional, Ji, Seunghee, additional, Shin, Hyunwoo, additional, Choi, Jong-Ryoul, additional, Jacobson, Kenneth A., additional, Lee, Hyuk Woo, additional, Lee, Sang Kook, additional, and Jeong, Lak Shin, additional

Published
2024
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2. Structure–Activity Relationship of Truncated 2,8-Disubstituted-Adenosine Derivatives as Dual A2A/A3 Adenosine Receptor Antagonists and Their Cancer Immunotherapeutic Activity

Author

Kim, Gibae, primary, Hou, Xiyan, additional, Byun, Woong Sub, additional, Kim, Gyudong, additional, Jarhad, Dnyandev B., additional, Lee, Grim, additional, Hyun, Young Eum, additional, Yu, Jinha, additional, Lee, Chang Soo, additional, Qu, Shuhao, additional, Warnick, Eugene, additional, Gao, Zhan-Guo, additional, Kim, Ji Yong, additional, Ji, Seunghee, additional, Shin, Hyunwoo, additional, Choi, Jong-Ryoul, additional, Jacobson, Kenneth A., additional, Lee, Hyuk Woo, additional, Lee, Sang Kook, additional, and Jeong, Lak Shin, additional

Published
2023
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3. Structure–Activity Relationship of Truncated 2,8-Disubstituted-Adenosine Derivatives as Dual A2A/A3 Adenosine Receptor Antagonists and Their Cancer Immunotherapeutic Activity.

Author

Kim, Gibae, Hou, Xiyan, Byun, Woong Sub, Kim, Gyudong, Jarhad, Dnyandev B., Lee, Grim, Hyun, Young Eum, Yu, Jinha, Lee, Chang Soo, Qu, Shuhao, Warnick, Eugene, Gao, Zhan-Guo, Kim, Ji Yong, Ji, Seunghee, Shin, Hyunwoo, Choi, Jong-Ryoul, Jacobson, Kenneth A., Lee, Hyuk Woo, Lee, Sang Kook, and Jeong, Lak Shin

Published
2023
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4. Structure–Activity Relationship of Truncated 2,8-Disubstituted-Adenosine Derivatives as Dual A2A/A3Adenosine Receptor Antagonists and Their Cancer Immunotherapeutic Activity

Author

Kim, Gibae, Hou, Xiyan, Byun, Woong Sub, Kim, Gyudong, Jarhad, Dnyandev B., Lee, Grim, Hyun, Young Eum, Yu, Jinha, Lee, Chang Soo, Qu, Shuhao, Warnick, Eugene, Gao, Zhan-Guo, Kim, Ji Yong, Ji, Seunghee, Shin, Hyunwoo, Choi, Jong-Ryoul, Jacobson, Kenneth A., Lee, Hyuk Woo, Lee, Sang Kook, and Jeong, Lak Shin

Abstract

Based on hA2AAR structures, a hydrophobic C8-heteroaromatic ring in 5′-truncated adenosine analogues occupies the subpocket tightly, converting hA2AAR agonists into antagonists while maintaining affinity toward hA3AR. The final compounds of 2,8-disubstituted-N6-substituted 4′-thionucleosides, or 4′-oxo, were synthesized from d-mannose and d-erythrono-1,4-lactone, respectively, using a Pd-catalyst-controlled regioselective cross-coupling reaction. All tested compounds completely antagonized hA2AAR, including 5dwith the highest affinity (Ki,A2A= 7.7 ± 0.5 nM). The hA2AAR–5dX-ray structure revealed that C8-heteroaromatic rings prevented receptor activation-associated conformational changes. However, the C8-substituted compounds still antagonized hA3AR. Structural SAR features and docking studies supported different binding modes at A2AAR and A3AR, elucidating pharmacophores for receptor activation and selectivity. Favorable pharmacokinetics were demonstrated, in which 5ddisplayed high oral absorption, moderate half-life, and bioavailability. Also, 5dsignificantly improved the antitumor effect of anti-PD-L1 in vivo. Overall, this study suggests that the novel dual A2AAR/A3AR nucleoside antagonists would be promising drug candidates for immune-oncology.

Published
2023
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5. Correction to "Structure–Activity Relationship of Truncated 2,8-Disubstituted-Adenosine Derivatives as Dual A2A/A3 Adenosine Receptor Antagonists and Their Cancer Immunotherapeutic Activity".

Author

Kim, Gibae, Hou, Xiyan, Byun, Woong Sub, Kim, Gyudong, Jarhad, Dnyandev B., Lee, Grim, Hyun, Young Eum, Yu, Jinha, Lee, Chang Soo, Qu, Shuhao, Warnick, Eugene, Gao, Zhan-Guo, Kim, Ji Yong, Ji, Seunghee, Shin, Hyunwoo, Choi, Jong-Ryoul, Jacobson, Kenneth A., Lee, Hyuk Woo, Lee, Sang Kook, and Jeong, Lak Shin

Published
2024
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6. Correction to “Structure–Activity Relationship of Truncated 2,8-Disubstituted-Adenosine Derivatives as Dual A2A/A3Adenosine Receptor Antagonists and Their Cancer Immunotherapeutic Activity”

Author

Kim, Gibae, Hou, Xiyan, Byun, Woong Sub, Kim, Gyudong, Jarhad, Dnyandev B., Lee, Grim, Hyun, Young Eum, Yu, Jinha, Lee, Chang Soo, Qu, Shuhao, Warnick, Eugene, Gao, Zhan-Guo, Kim, Ji Yong, Ji, Seunghee, Shin, Hyunwoo, Choi, Jong-Ryoul, Jacobson, Kenneth A., Lee, Hyuk Woo, Lee, Sang Kook, and Jeong, Lak Shin

Published
2024
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8. Aminoxy-linked rhodamine hydroxamate as fluorescent chemosensor for Fe3+ in aqueous media

Author

Moon, Kyung-Soo, Yang, Young-Keun, Ji, Seunghee, and Tae, Jinsung

Subjects
*RHODAMINE B, *HYDROXAMIC acids, *FLUORESCENCE, *IRON ions, *CHEMICAL detectors, *BINDING sites, *STOICHIOMETRY
Abstract

Abstract: A novel feric ion-selective rhodamine-based fluorescent chemosensor, which contains a bis-aminoxy chain moiety, has been developed. The multi-dentate binding site of rhodamine fluorophore shows selective detection of ferric iron over other biologically important metal ions in aqueous media and also shows 1:1 binding stoichiometry. [Copyright &y& Elsevier]

Published
2010
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10. Structure-Activity Relationship of Truncated 2,8-Disubstituted-Adenosine Derivatives as Dual A 2A /A 3 Adenosine Receptor Antagonists and Their Cancer Immunotherapeutic Activity.

Author

Kim G, Hou X, Byun WS, Kim G, Jarhad DB, Lee G, Hyun YE, Yu J, Lee CS, Qu S, Warnick E, Gao ZG, Kim JY, Ji S, Shin H, Choi JR, Jacobson KA, Lee HW, Lee SK, and Jeong LS

Subjects
Humans, Androgen Receptor Antagonists, Immunotherapy, Purinergic P1 Receptor Antagonists, Structure-Activity Relationship, Thionucleosides chemistry, Thionucleosides pharmacology, Adenosine pharmacology, Neoplasms
Abstract

Based on hA 2A AR structures, a hydrophobic C8-heteroaromatic ring in 5'-truncated adenosine analogues occupies the subpocket tightly, converting hA 2A AR agonists into antagonists while maintaining affinity toward hA 3 AR. The final compounds of 2,8-disubstituted- N 6 -substituted 4'-thionucleosides, or 4'-oxo, were synthesized from d-mannose and d-erythrono-1,4-lactone, respectively, using a Pd-catalyst-controlled regioselective cross-coupling reaction. All tested compounds completely antagonized hA 2A AR, including 5d with the highest affinity ( K i,A 2A = 7.7 ± 0.5 nM). The hA 2A AR- 5d X-ray structure revealed that C8-heteroaromatic rings prevented receptor activation-associated conformational changes. However, the C8-substituted compounds still antagonized hA 3 AR. Structural SAR features and docking studies supported different binding modes at A 2A AR and A 3 AR, elucidating pharmacophores for receptor activation and selectivity. Favorable pharmacokinetics were demonstrated, in which 5d displayed high oral absorption, moderate half-life, and bioavailability. Also, 5d significantly improved the antitumor effect of anti-PD-L1 in vivo . Overall, this study suggests that the novel dual A 2A AR/A 3 AR nucleoside antagonists would be promising drug candidates for immune-oncology.

Published
2023
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